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Chronic Thromboembolic Pulmonary Hypertension clinical trials

View clinical trials related to Chronic Thromboembolic Pulmonary Hypertension.

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NCT ID: NCT03349164 Recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Registry of Patients With Chronic Thromboembolic Pulmonary Hypertension in Novosibirsk Region

NCTEPHR
Start date: January 1, 2017
Phase: N/A
Study type: Observational

There will be assessment of patients after acute pulmonary embolism for the development of CTEPH

NCT ID: NCT03273257 Not yet recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study)

Start date: February 2018
Phase: Phase 2
Study type: Interventional

This is a randomised, double-blind, placebo-controlled, multicentre, multinational, prospective study in patients with operable chronic thromboembolic pulmonary hypertension (CTEPH) prior to pulmonary endarterectomy (PEA) with high preoperative pulmonary vascular resistance (PVR). Patients will be randomised in a 1:1 ratio to receive riociguat or matching placebo for 3 months before undergoing PEA. The primary objective of this study is to assess the efficacy of riociguat on preoperative PVR compared to placebo in patients with operable CTEPH.

NCT ID: NCT03245268 Not yet recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

International BPA Registry

Start date: November 2017
Phase: N/A
Study type: Observational [Patient Registry]

The International Balloon Pulmonary Angioplasty (BPA) Registry is a prospective, multi-center, long-term observational project. Scheduled to start data collection in Q4 2017, the registry will run for approximately four years with a follow-up time for each patient of at least two years. Its primary objective is to investigate the efficacy and safety of BPA intervention in patients with chronic thromboembolic pulmonary hypertension (CTEPH) not amenable to pulmonary endarterectomy (PEA).

NCT ID: NCT03199131 Recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

The Right Ventricle in Chronic Pressure Overload: Identifying Novel Molecular Targets for Functional Imaging

MVD
Start date: February 20, 2017
Phase: N/A
Study type: Interventional

Chronically elevated pulmonary pressures do not immediately result in right ventricular failure. During the initial period of exposure, the RV adapts to the increased afterload by altering its metabolism and morphology so as to meet the increased work requirement. Several, interconnected adaptive mechanisms have been proposed, including myocyte hypertrophy, a switch in the primary fuel used for ATP generation, increased angiogenesis, and decreased production of mitochondrial reactive oxygen species. While adaptation is initially successful in many cases, it is temporary, and after an uncertain period of time, the ventricle begins to fail. This transition from a compensated to decompensated state is difficult to predict clinically, and patients with different etiologies of CPOS progress to overt RV failure over significantly different time periods. This variability hinders the implementation of treatments that are tailored to a specific disease stage.

NCT ID: NCT03198910 Active, not recruiting - Clinical trials for Pulmonary Hypertension

Retrospective Data Analysis of Data From the Zurich PH Registry

Start date: June 2, 2017
Phase: N/A
Study type: Observational

The collected data from the Zurich Registry for pulmonary Hypertension (PH) are evaluated in a retrospective analysis. This study examines the number of patients and their exact diagnoses who are treated at the University Hospital of Zurich and potentially other participating in the Zurich Registry. Other demographic parameters such as age, gender and body-mass-index are also part of the evaluation. Furthermore, the analysis will focus on the newest guidelines on PH. Therefore, it will be checked how many patients would fulfill the therapeutic goals in terms of New York Heart Classification (NYHA), 6-minute walk distance, sign of right heart failure and N-terminal pro-brain-natriuretic peptide(NTproBNP). Additionally, the study examines on how the patients are treated. Despite the different kind of Drugs, the focus lies on the combination therapy (single, double, triple) and the impact the therapy had on the patients.

NCT ID: NCT03195543 Recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Assessment of Blood Coagulation Disorders in Patients With Pulmonary Hypertension

Start date: March 12, 2015
Phase: N/A
Study type: Observational

The objective of the present study is to assess blood coagulation disorders in patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension. The investigators aim to evaluate any possible coagulation abnormalities related to the patients' primary disease and any possible effects the pulmonary hypertension- specific therapy may have on hemostasis.

NCT ID: NCT03102294 Not yet recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Inspiratory Muscle Training in Chronic Thromboembolic Pulmonary Hypertension

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

Inspiratory muscle training for 8 weeks in patients with chronic thromboembolic pulmonary hypertension.

NCT ID: NCT03074539 Recruiting - Clinical trials for Sleep Disordered Breathing

Sleep Disorder Breathing in Chronic Thromboembolic Pulmonary Hypertension

Start date: February 1, 2017
Phase: N/A
Study type: Interventional

There is evidence for a high prevalence of Sleep Disorder Breathing (SDB) in patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Central Sleep Apnea, Cheyne-Stokes Breathing and Obstructive Sleep Apnea appear to occur in CTEPH. However, there is no information on the impact of CTEPH treatment modalities on concomitant SDB. Furthermore, the use of PAP therapy in CTEPH has not yet been investigated. CTEPH is a rare and serious disease and there may be a bidirectional association of SDB and CTEPH. This study plans to investigate the prevalence of SDB in CTEPH and compare it to datasets of large epidemiological studies on SDB. Furthermore, the impact of CTEPH treatment on SDB will be analyzed and CTEPH patients for possible PAP treatment will be defined.

NCT ID: NCT02964390 Recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Balloon Pulmonary Angioplasty in Non-operable CTEPH Patients

Start date: July 2013
Phase: N/A
Study type: Interventional

Balloon pulmonary angioplasty (BPA) emerged as a potential therapeutic option for non-operable patients with chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this study was to evaluate the safety and efficacy of BPA in patients disqualified from surgery or suffered from persistent CTEPH despite pulmonary endarterectomy. This is a interventional study analyzing the benefits and the risk of BPA. Clinical evaluation, including: functional capacity, 6-minutes walking test, haemodynamics, biomarkers, cardiopulmonary exercise test, echocardiography, electrocardiography and QoL assessment with Short Form 36 (SF36) questionnaire was performed before the initiation therapy of BPA, and 3-6 months after last session of BPA.

NCT ID: NCT02745106 Recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Interventional Treatment of Residual Pulmonary Hypertension in Patients After Pulmonary Thromboendarterectomy

Start date: August 2015
Phase: Phase 2
Study type: Interventional

The study evaluates the technique of non-drug treatment of residual pulmonary hypertension in patients with chronic thromboembolic pulmonary hypertension after pulmonary thromboendarterectomy.