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Chronic Thromboembolic Pulmonary Hypertension clinical trials

View clinical trials related to Chronic Thromboembolic Pulmonary Hypertension.

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NCT ID: NCT03757481 Not yet recruiting - Clinical trials for Deep Vein Thrombosis

Long-term Outcome After Heparin and Edoxaban Versus Heparin Plus Vit K Antagonists for Acute DVT and PE

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Centers that participated in the Hokusai VTE trial will be invited to collect follow of previously enrolled patients at least 2 years after the index VTE.

NCT ID: NCT03729544 Not yet recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Computerized Decision Support to Increase Detection of Chronic Thromboembolic Pulmonary Hypertension in Patients With Prior Pulmonary Embolism

CTEPH-DETECT
Start date: February 1, 2019
Phase: N/A
Study type: Interventional

To address the knowledge gap that exists among providers resulting in underdiagnosis of chronic thromboembolic pulmonary hypertension (CTEPH), the investigators have devised this 400-patient single-center Quality Improvement Initiative in the form of a randomized controlled trial of an EPIC Best Practice Advisory (BPA) on-screen alert versus no notification to increase echocardiographic screening for CTEPH and the diagnosis of CTEPH in patients with prior pulmonary embolism (PE) and symptoms/signs suggestive of pulmonary hypertension or recent pulmonary testing suggesting unexplained respiratory symptoms at 3 months. Aim #1: To determine the impact of a Best Practice Advisory (BPA), using the EPIC Electronic Health Record computerized decision support (CDS) software, on echocardiographic screening for CTEPH in patient with prior PE and symptoms/signs suggestive of pulmonary hypertension or recent pulmonary testing suggesting unexplained respiratory symptoms. Aim #2: To determine the impact of an EPIC BPA on the diagnosis of CTEPH in patient with prior PE and symptoms/signs suggestive of pulmonary hypertension or recent pulmonary testing suggesting unexplained respiratory symptoms.

NCT ID: NCT03689244 Not yet recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery

SELECT
Start date: January 1, 2019
Phase: Phase 3
Study type: Interventional

Selexipag is available in many countries for the treatment of pulmonary arterial hypertension (PAH). Due to the similarities between PAH and chronic thromboembolic pulmonary hypertension (CTEPH) and the observed efficacy of other PAH medicines in CTEPH, it is believed that selexipag could benefit to patients with CTEPH. This study aims to assess the efficacy and safety of selexipag in subjects with inoperable or persistent/recurrent CTEPH.

NCT ID: NCT03579862 Recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Identification of Heritable CTEPH

Start date: December 25, 2013
Phase:
Study type: Observational

Some patients who have blood clots come down with a life-threatening condition known as Chronic Thromboembolic Pulmonary Hypertension (CTEPH), which is high blood pressure only in the arteries of the lungs. This study seeks to understand more about the genetics causes of CTEPH by obtaining blood samples and examining family histories.

NCT ID: NCT03470207 Recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

The Prospective Risk Factor Evaluation & Discovery In CTEPH Study

PREDICT PH
Start date: April 17, 2018
Phase: N/A
Study type: Interventional

This research study wants to find markers in the blood that may help to predict a patient's future risk of developing a disease called CTEPH. The study also wants to see if active monitoring for signs and symptoms of CTEPH after a pulmonary embolism (a blood clot in the lungs) can improve the diagnosis of CTEPH. Patients who enroll in this study will have periodic blood draws and clinic and/or phone follow-up to monitor for signs and symptoms of CTEPH. Patients' medical records will also be reviewed for information related to pulmonary embolisms and/or CTEPH.

NCT ID: NCT03388476 Active, not recruiting - Lung Diseases Clinical Trials

Endtidal Carbon Dioxide for Earlier Detection of Pulmonary Hypertension

EARLIER
Start date: May 2, 2018
Phase: N/A
Study type: Interventional

Measurement of the endtidal carbon dioxide by capnography to exclude or to ensure the diagnosis pulmonary hypertension. The aim of the study is to obtain an endtidal carbon dioxide cut-off value for the diagnostic algorithm for pulmonary hypertension as an easily measurable and cheap diagnostic tool in patients with suspicion of pulmonary hypertension.

NCT ID: NCT03349164 Recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Registry of Patients With Chronic Thromboembolic Pulmonary Hypertension in Novosibirsk Region

NCTEPHR
Start date: January 1, 2017
Phase: N/A
Study type: Observational

There will be assessment of patients after acute pulmonary embolism for the development of CTEPH

NCT ID: NCT03273257 Recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study)

Start date: August 17, 2018
Phase: Phase 2
Study type: Interventional

This is a randomised, double-blind, placebo-controlled, multicentre, multinational, prospective study in patients with operable chronic thromboembolic pulmonary hypertension (CTEPH) prior to pulmonary endarterectomy (PEA) with high preoperative pulmonary vascular resistance (PVR). Patients will be randomised in a 1:1 ratio to receive riociguat or matching placebo for 3 months before undergoing PEA. The primary objective of this study is to assess the efficacy of riociguat on preoperative PVR compared to placebo in patients with operable CTEPH.

NCT ID: NCT03245268 Recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

International BPA Registry

Start date: March 2, 2018
Phase:
Study type: Observational [Patient Registry]

The International Balloon Pulmonary Angioplasty (BPA) Registry is a prospective, multi-center, long-term observational project. Scheduled to start data collection in Q4 2017, the registry will run for approximately four years with a follow-up time for each patient of at least two years. Its primary objective is to investigate the efficacy and safety of BPA intervention in patients with chronic thromboembolic pulmonary hypertension (CTEPH) not amenable to pulmonary endarterectomy (PEA).

NCT ID: NCT03199131 Active, not recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

The Right Ventricle in Chronic Pressure Overload: Identifying Novel Molecular Targets for Functional Imaging

MVD
Start date: February 20, 2017
Phase: N/A
Study type: Interventional

Chronically elevated pulmonary pressures do not immediately result in right ventricular failure. During the initial period of exposure, the RV adapts to the increased afterload by altering its metabolism and morphology so as to meet the increased work requirement. Several, interconnected adaptive mechanisms have been proposed, including myocyte hypertrophy, a switch in the primary fuel used for ATP generation, increased angiogenesis, and decreased production of mitochondrial reactive oxygen species. While adaptation is initially successful in many cases, it is temporary, and after an uncertain period of time, the ventricle begins to fail. This transition from a compensated to decompensated state is difficult to predict clinically, and patients with different etiologies of CPOS progress to overt RV failure over significantly different time periods. This variability hinders the implementation of treatments that are tailored to a specific disease stage.