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Cardiovascular Diseases clinical trials

View clinical trials related to Cardiovascular Diseases.

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NCT ID: NCT03841838 Recruiting - Clinical trials for Cardiovascular Diseases

Comparison of Energy Drink and Moxifloxacin on Cardiovascular Variables: A Randomized Controlled Trial

Start date: February 15, 2019
Phase: N/A
Study type: Interventional

Many adults in the United States regularly consumer energy drinks. Currently, the safety of energy drinks is still questionable and there are many reports associating energy drinks with adverse events including hospitalizations and deaths. Previous research shows that energy drink can affect heart rhythm and elevate blood pressure. However, these studies use a high volume of energy drinks and do not have an active control group as a comparator. The purpose of this study is to study if energy drinks can significantly affect heart rhythm and elevate blood pressure when compared to an active control and placebo.

NCT ID: NCT03841786 Not yet recruiting - Clinical trials for Cardiovascular Diseases

Effect of Phosphorus Additives on the Metabolome in Healthy Adults

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

This study evaluates the effect of phosphorus supplementation on the human metabolome. The investigators will do so by conducting a cross-over study in healthy adults consuming a study diet (normal diet supplemented by neutral sodium phosphorus, 1 gram/day) for seven days and a control diet (normal diet supplemented by sodium and potassium chloride only) for seven days with a 28 day wash-out period in between. Untargeted metabolomic analyses will be done in serum samples obtained at the end of each diet period.

NCT ID: NCT03841669 Not yet recruiting - Clinical trials for Cardiovascular Diseases

Exercise, Brain, and Cardiovascular Health

eBACH
Start date: April 2019
Phase: N/A
Study type: Interventional

eBACH is a randomized intervention to determine the effects of aerobic exercise on brain structure and function, as well as to determine how exercise-induced training effects relate to cardiovascular function via related brain changes.

NCT ID: NCT03841474 Recruiting - Depression Clinical Trials

The Recovery of Cardiovascular Patients With Depression

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

Cardiovascular disease increases the risk of depression and vice versa. Many cardiovascular patients are subjected to percutaneous coronary intervention (PCI). Potential biomarkers for the development, the course and the recovery of both diseases are in the focus of interest of many studies. One of the biomarkers that stands out is brain derived neurotrophic factor (BDFN). BDNF plays a significant role in regulating vascular growth and repair but also stimulates the survival, differentiation, and conservation of neurons. The aim of the study is to detect the depression in patients undergoing PCI and to determine the impact of psychiatric treatment on the functional recovery and on the changes of BDNF.

NCT ID: NCT03840863 Recruiting - Clinical trials for Cardiovascular Diseases

Effects of Chronic Energy Drink Consumption on Cardiometabolic Endpoints

Start date: February 2019
Phase: N/A
Study type: Interventional

Many people use energy drinks (EDs) regularly, but the overall health concerns are still unknown. There are many energy drink products that contain a mixture of caffeine and other energy-boosting ingredients and supplements which can affect parameters related to the heart, blood pressure and blood glucose. Several previous studies have shown that energy drinks may affect heart rhythm and blood pressure significantly. As energy drinks are sugar-sweetened beverages, long-term use may also affect the body's metabolism, including cholesterol, blood sugars, and weight. The purpose of this study is to learn if drinking energy drinks everyday may affect a person's cardiometabolic health.

NCT ID: NCT03839394 Not yet recruiting - HIV Clinical Trials

Case Managers for CVD Risk Reduction in HIV Clinic

Start date: January 2020
Phase: N/A
Study type: Interventional

The purpose of the study is to assess the efficacy of a case manager/social worker administered, telephone-based educational curriculum in improving cardiovascular disease related outcomes among HIV-infected clinic patients.

NCT ID: NCT03837925 Not yet recruiting - Clinical trials for Cardiovascular Diseases

Pharmaco-metabolomic Effects of Statins: METASTATINE

METASTATINE
Start date: April 1, 2019
Phase: Phase 3
Study type: Interventional

Statins are effective in cardio-vascular prevention by lowering LDL-Cholesterol levels but also through other mechanisms poorly understood. Our hypothesis is that some of these effects are mediated by microbiota alteration, leading to diminution of expression of microbiota derived pro-atherogenic metabolites.

NCT ID: NCT03835793 Not yet recruiting - Clinical trials for Cardiovascular Diseases

Health After eaRly Menopause Due to Oophorectomy

HARMOny
Start date: February 21, 2019
Phase:
Study type: Observational

Risk-Reducing Salpingo-Oophorectomy (RRSO) at the age of 35 to 45 years is recommended for women with a high genetic risk for ovarian cancer. While this procedure decreases the risk of ovarian cancer by 80-96%, it also results in an immediate menopause. Current research on potential adverse effects of premenopausal risk-reducing salpingo-oophorectomy, such as increased risk of cardiovascular disease, compromised bone health, cognitive dysfunction and reduced quality of life, is limited, mostly due to short follow up. The investigators will conduct a multicenter cross-sectional study nested in a cohort of BRCA mutation carriers from 8 Dutch centers for hereditary cancer. Eligible participants are women who underwent RRSO before the age of 45. The participants will be frequency-matched on current age with women above the age of 55 without RRSO or with RRSO after the age of 55. Participants will complete an online questionnaire containing various questions about lifestyle, medical history, risk factors for cardiovascular disease, bone health, cognition and quality of life. Participants will be asked to visit one of the participating hospitals for a blood test, a cardiovascular assessment and a DEXA scan for determining bone mineral density. Afterwards participants will be requested to perform the online Amsterdam Cognition Scale.

NCT ID: NCT03835013 Not yet recruiting - Clinical trials for Cardiovascular Diseases

A Comparison of the Haemodynamic and Metabolic Effects of Intravenous Glucagon-like Peptide-1, Glucagon and Glucagon-like Peptide-1:Glucagon Co-agonism in Healthy Male Participants

COCOA
Start date: February 1, 2019
Phase: N/A
Study type: Interventional

The study seeks to explore the cardiovascular effects of co-agonism at two peptide receptors, GLP-1 and glucagon. Peptides will be intravenously infused, both in isolation, and combination into healthy male participants. Overall, the aim of the study is to further our understanding on the role these endogenous substances play (both in isolation and combination) in haemodynamic regulation.

NCT ID: NCT03830970 Recruiting - Clinical trials for Cardiovascular Diseases

Dose Effect of Canned Mixed Beans on Blood Cholesterol in Healthy Adults With Elevated Cholesterol

Start date: February 15, 2019
Phase: N/A
Study type: Interventional

The Bean Study will examine the effects of consuming varying doses of canned mixed beans on blood cholesterol levels in healthy adults with elevated blood cholesterol levels.