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Heart Failure clinical trials

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NCT ID: NCT02859636 Terminated - Cardiac Failure Clinical Trials

Pronostic Value of Endothelial Dysfunction in Heart Failure

Pro-ICARD
Start date: October 2012
Phase: N/A
Study type: Observational

The main objective is to evaluate the pronostic value of endothelial dysfonction in acute heart failure on a combined criteria associating cardiovascular mortality, nex hospitalisation for decompensated heart failure, cardiac graft or ventricular assistance 2 month and 1 year before acute heart failure.

NCT ID: NCT02772146 Terminated - Heart Failure Clinical Trials

A Clinical Study of the Safety and Efficacy of a Wearable Device (CLS UF) That Delivers Continuous Administration of Glucose to Recirculated Peritoneal Dialysis Fluid for the Purpose of Ultrafiltration in Patients With Congestive Heart Failure

Start date: May 11, 2016
Phase: N/A
Study type: Interventional

A single-center, prospective, non-randomized, clinical and first-in-human study. Each patient will be studied during a single treatment session of ten hours. The device will be connected to an existing, standard PD catheter that the patient will be using routinely prior to the study (i.e. a peritoneal dialysis catheter will not be specifically inserted for the study). The patient will be hospitalized for observation during the test day and during the night following the study session. Ultrafiltration volume, dialysate glucose concentrations, blood glucose concentrations as well the patient's acceptability and tolerance of the wearable device will be evaluated.

NCT ID: NCT02693002 Terminated - Menopause Clinical Trials

Estrogen Diastolic Heart Failure

Start date: February 2016
Phase: Phase 4
Study type: Interventional

Peri-menopausal women will be randomized to hormone replacement therapy or placebo for 12 weeks to determine if markers of systolic and diastolic function change by echocardiography as well as laboratory markers of heart failure, including b-type natriuretic peptide (BNP).

NCT ID: NCT02625922 Terminated - Clinical trials for Chronic Heart Failure

Study of the Effect of Serelaxin on High-sensitivity Cardiac Troponin I (Hs-cTnI) Release in Patients With Chronic Heart Failure

RELAX-Cardio
Start date: February 5, 2016
Phase: Phase 2
Study type: Interventional

This is a multicenter, randomized, double-blind, crossover, placebo-controlled, Phase II clinical study to evaluate the effect of serelaxin versus placebo (both in addition to SoC) on the release of hs-cTnI, in patients with CHF after an exercise testing session.

NCT ID: NCT02596477 Terminated - Clinical trials for Chronic Heart Failure

Evaluation of Vepoloxamer in Chronic Heart Failure

Start date: October 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate whether vepoloxamer can provide a blood chemical marker and functional benefit to damaged heart muscle cells. This will be evaluated by measurement of blood-based laboratory markers, exercise tolerance, and echocardiograms. In addition, the safety and blood levels of vepoloxamer in subjects with chronic heart failure will be evaluated.

NCT ID: NCT02543632 Terminated - Heart Failure Clinical Trials

PARACHUTE V PercutAneous Ventricular RestorAtion in Chronic Heart FailUre Due to Ischemic HearT DiseasE.

P5
Start date: August 2015
Phase: N/A
Study type: Observational [Patient Registry]

Prospective, multi-center, post-market, non-randomized, nested-control, observational study of the CE marked CardioKinetix Parachute Implant System.

NCT ID: NCT02505867 Terminated - Heart Failure Clinical Trials

The Role of Sleep Disordered Breathing in Heart Failure Admissions

Start date: November 2014
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effect of in-hospital diagnosis and treatment of sleep disordered breathing (SDB) on post-discharge mortality and readmissions in- hospitalized patients with acute heart failure syndrome and reduced ejection fraction (HFrEF).

NCT ID: NCT02470312 Terminated - Heart Failure Clinical Trials

MediGuide Registry

Start date: August 18, 2015
Phase: N/A
Study type: Observational [Patient Registry]

The goal of this registry/observational study is to collect data on the clinical utility of MediGuide™ system in cardiac resynchronization therapy (CRT) implantation and electrophysiology (EP) procedures.

NCT ID: NCT02406820 Terminated - Heart Failure Clinical Trials

Correlating Noninvasive Cardiovascular Measures to Left Ventricular End Diastolic Pressure in Heart Failure

Start date: April 2015
Phase: N/A
Study type: Observational

HF001 is a prospective observational study utilizing non-invasive medical devices that may be able to discriminate changes in heart failure while acutely decompensated patients undergo routine interventional therapies in a hospital setting. Subjects will be monitored using CVInsight™ [CVI] via a finger and/or forehead sensor, while performing an isometric handgrip stress test (IHGST). Changes in the CVI signal will be analyzed and correlated to standard assessments of heart failure including pulmonary artery catheter (PAC) pressures, blood pressure (BP), patient symptoms, and physical exam findings. The results of this study will be used to develop a powered study to determine if a new configuration of non-invasive monitoring devices can be used to monitor heart failure status more sensitively than current non-invasive techniques.

NCT ID: NCT02375399 Terminated - Clinical trials for Congestive Heart Failure

New Echocardiographic Parameters for Prediction of Response to Cardiac Resynchronization Therapy

NEW-CRT
Start date: March 2015
Phase: N/A
Study type: Observational

Echocardiography parameters for cardiac dyssynchrony had no predictive value in current multicentric prospective studies concerning cardiac resynchronization therapy. Comprehensive echocardiography and new parameters as 2D and 3D strain, as well as 3D echo have been analyzed, but their definite value has not been proven yet.