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Heart Failure clinical trials

View clinical trials related to Heart Failure.

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NCT ID: NCT03504891 Recruiting - Clinical trials for Chronic Systolic Heart Failure

Cardiac MRI for Optimal Heart Failure Outcomes With CRT Upgrades

Start date: January 1, 2018
Phase: Phase 1
Study type: Interventional

This study will investigate the use of cardiac MRI in patients with standard ICDs and pacemakers to inform how cardiac resynchronization therapy (CRT) can best be implemented in these patient and which patients are the best candidates for CRT.

NCT ID: NCT03501355 Recruiting - Pacemaker Clinical Trials

Effects of Inspiratory Muscle and Endurance Training in Heart Failure Patients With Pacemaker

Start date: November 2, 2017
Phase: N/A
Study type: Interventional

It is well-known that not only peripheral muscles, but also respiratory muscles muscle weakness and deconditioning play an important role in low exercise capacity of patients with HF. Exercise training has been shown to improve exercise tolerance and quality of life in patients with heart disease. However, hearth failure patients with pacemaker such as implantable cardioverter defibrillators (ICDs), cardiac resynchronization pacemakers or defibrillators (CRT-P or CDT-D) have additional specific issues when performing exercise. No study investigated the effects of different inspiratory muscle training protocols. For this reason, we aimed to investigate the effects of inspiratory muscle training on outcomes in hearth failure patients with pacemaker

NCT ID: NCT03499236 Not yet recruiting - Heart Failure Clinical Trials

Reducing Lung CongestIon Symptoms in Advanced Heart Failure

RELIEVE-HF
Start date: May 15, 2018
Phase: N/A
Study type: Interventional

The objective of the RELIEVE-HF study is to provide reasonable assurance of safety and effectiveness of the V-Wave Interatrial Shunt System by improving meaningful clinical outcomes in patients with New York Heart Association (NYHA) functional class III or ambulatory class IV heart failure (HF), irrespective of left ventricular ejection fraction, who at baseline are treated with guideline-directed drug and device therapies.

NCT ID: NCT03497871 Recruiting - Clinical trials for Heart Failure, Congestive

Personal Decision Support System for Heart Failure Management

HeartMan
Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Despite the availability of evidence-based guidelines for disease management in patients with congestive heart failure (CHF), the uptake of these guidelines in clinical practice is sub-optimal and adherence rates are disappointing. Within the HeartMan project, a personal e-health system was developed to help CHF patients manage their disease, with the ultimate goal to improve health-related quality of life (HRQoL). The system uses wrist-band sensors to monitor patients' physical activity and physiological parameters. These data are connected to a decision support system, providing medical advice to patients concerning physical exercise, nutrition, medication intake, clinical measurements, environment management, and mental support. The decision support system is based on predictive models, clinical care guidelines and expert knowledge. The advice will be personalized according to each individual patient's medical and psychological profile, and will be presented to the patient through the user interface of a mobile application on a smartphone. A proof of concept trial with a 1:2 (control:intervention) randomization protocol was designed. The sample size calculation was based on primary outcome data from the previous CHIRON project, showing that 90 patients are needed to show at least -5.8 (± 6 to 8 s.d.) beats/min difference in average daily awake heart rate difference - as a fundamental parameter correlating with patient reported HRQoL - with 90% power between the two groups. Data collection will include an estimation of exercise capacity based on a six-minute walking test, and questionnaire assessments using standardized instruments. The trial will be initiated in two countries. In order to account for possible dropouts, 60 patients will be enrolled in Italy and 60 in Belgium (20 control and 40 intervention patients in each country). Target patients are stable ambulatory CHF patients (NYHA class 2-3; reduced left ventricular ejection fraction ≤40%). Eligible patients will be recruited by their treating physician from collaborating medical centers in both countries; they will be enrolled in the trial after giving informed consent for participation. After baseline assessment, patients will be randomized into either the intervention (duration of 6 months) or control (usual care) condition. Data collection will be repeated at the end of the trial.

NCT ID: NCT03495505 Not yet recruiting - Heart Failure Clinical Trials

CT Guided WiSE-CRT

Start date: August 2018
Phase: N/A
Study type: Interventional

This feasibility study will use CT scanning to identify the optimal location for placement of the WiSE-CRT system.

NCT ID: NCT03494933 Not yet recruiting - Clinical trials for Chronic Heart Failure

Re-evaluation of Optimal Re-synchronisation Therapy in Patients With Chronic Heart Failure

RESET-CRT
Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The objective of the study is to demonstrate that in patients with chronic heart failure who receive optimal medical treatment for this condition and have indication for Cardiac Resynchronisation Therapy, the implantation of a pacemaker (index group) is not inferior to defibrillator (control group) with respect to all-cause mortality.

NCT ID: NCT03493516 Recruiting - Clinical trials for Congestive Heart Failure

Prediction of ARrhythmic Events With Positron Emission Tomography II

PAREPET II
Start date: April 8, 2018
Phase:
Study type: Observational

Sudden cardiac death continues to be a major contributor to mortality in patients with ischemic cardiomyopathy. While implantable defibrillators can prevent death from ventricular arrhythmias, our current approach to identify patients at highest risk primarily rests on demonstrating a reduction in left ventricular ejection fraction less than 35%. The purpose of this observational cohort study is to prospectively test whether this can be enhanced by quantifying the amount of sympathetic denervation, left ventricular end-diastolic volume or brain natriuretic peptide levels.

NCT ID: NCT03492788 Recruiting - Clinical trials for Heart Failure, Systolic

Optimizing CRT With ECGI

optCRT
Start date: December 28, 2017
Phase: N/A
Study type: Interventional

CRT is delivered from two electrodes on opposite sides of the heart [right (RV) and left ventricle (LV)] delivering stimulation for more efficient heart beats. There is flexibility in the sequence and temporal staggering of the stimulation from these two electrodes with a different optimum for different patients. However, standard techniques to figure out the optimal stimulation strategy like standard 12-lead surface electrical recording (ECG) or routine ultrasound have failed. The investigators have developed ECG imaging (ECGI) with 250 electrode surface recording combined with CT scan to reconstruct high resolution 4-dimensional panoramic electrical maps of the heart. The study seeks to enroll 56 patients undergoing CRT in a clinical trail to evaluate short and long term impact of using ECGI for optimal programming of CRT.

NCT ID: NCT03492580 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease

Start date: February 22, 2018
Phase:
Study type: Observational

The primary purpose of study is to estimate the incidence and comparative effect on health outcomes: 1) hospitalization for heart failure, 2) below knee lower extremity amputation. The date of first exposure to the particular drug(s) in the database, where the exposure start is between 1-April-2013 to 15-May-2017 and outcome data for these participants will be analyzed and reported in this study.

NCT ID: NCT03491969 Not yet recruiting - Clinical trials for Ischemic Heart Failure

Clinical Study of Lipoic Acid on Ischemic Heart Failure

Start date: May 1, 2018
Phase: Phase 4
Study type: Interventional

The study will evaluate the efficacy of alpha-lipoic acid(α-LA) on mortality in patients with ischemic heart failure (NYHA Class II - IV and EF =< 45%).