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Heart Failure clinical trials

View clinical trials related to Heart Failure.

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NCT ID: NCT03306017 Not yet recruiting - Clinical trials for Cardiac Insufficiency

Effects of Left Ventricular Assist Device Implantation on the Phenotype of Blood Platelets and Leucocytes

DAV-Hémo
Start date: October 2017
Phase: N/A
Study type: Interventional

To compare in vivo platelet and leukocyte activation and phenotype before and after Left ventricular assist device (LAVD) implantation

NCT ID: NCT03305692 Not yet recruiting - Clinical trials for Heart Failure, Systolic

ECG Belt vs. Echocardiographic Optimization of CRT

Start date: October 2017
Phase: N/A
Study type: Interventional

Cardiac resynchronization therapy (CRT) has been a valuable intervention for patients with systolic heart failure for over 15 years. Despite years of research, there is a still a 25-40% non-responder rate depending on the outcomes measured. CRT optimization is a term used to describe the act of individualizing the therapy (CRT programming) for an individual patient. This is not often performed, but when it is, echocardiography is utilized. Recent work of body surface mapping using a novel system called the ECG Belt has shown a relationship between measures of electrical dyssynchrony and acute and chronic heart pumping function. This study will compare outcomes of patients randomized to either echocardiographic or ECG Belt optimization of CRT devices.

NCT ID: NCT03305393 Recruiting - Heart Failure Clinical Trials

Implementation of a Protocol Utilizing Adaptive CRT in a Normal AV Conduction, CRT Non-Response Population at Generator Replacement

Start date: June 11, 2017
Phase: N/A
Study type: Interventional

IMPROVE RESPONSE is a physician initiated research study. It is a prospective, non-randomized, multi-center, post-market, U.S. Cardiac Resynchronization Therapy (CRT) in heart failure (HF) observational study. The purpose of this clinical study is to test the hypothesis that market-released CRT devices, which contain the AdaptivCRT (aCRT) algorithm have an incremental benefit in improving CRT response in a chronic CRT non responder population with left bundle branch block (LBBB) and normal atrio-ventricular (AV) condition compared to CRT devices with traditional biventricular pacing delivery methods at generator replacement.

NCT ID: NCT03302910 Not yet recruiting - Acute Heart Failure Clinical Trials

Short Stay Unit vs Hospitalization in Acute Heart Failure

SSU-AHF
Start date: November 1, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

The majority of the over one million annual AHF hospitalizations originate from the emergency department. Admitting and re-admitting lower risk AHF patients who don't need prolonged hospitalization may increase their risk for poor outcomes and decrease their quality of life: Safe alternatives to hospitalization from the ED are needed. We propose a strategy-of-care, short stay unit management of AHF (i.e. less than 24 hours), will lead to improved outcomes for lower risk AHF patients.

NCT ID: NCT03300791 Recruiting - Heart Failure Clinical Trials

Predictive Models of Readmission in Heart Failure

REIC
Start date: September 28, 2017
Phase: N/A
Study type: Observational

This is a prospective nested case-control study. Our goals are to create predictive models to readmissions for heart failure and also to define profiles for patients who are readmitted during the first month after the index episode. Patients who will be admitted in five hospitals in spain by the reason of a heart failure will be recruited during 18 months. Those who will be readmitted in a hospital up to a month after the index episode will be considered cases. Controls will be selected from the initial cohort of hospitalized patients.

NCT ID: NCT03300427 Not yet recruiting - Heart Failure Clinical Trials

The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients

TurkuPET
Start date: January 31, 2018
Phase: Phase 4
Study type: Interventional

The study will assess the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on cardiac oxygen consumption and the efficiency of cardiac work in patients with NYHA II-III heart failure (HF) and reduced systolic function using 11C-acetate positron emission tomography (PET) and echocardiography.

NCT ID: NCT03298009 Not yet recruiting - Heart Failure Clinical Trials

Impact of a Short-term Treatment With Canagliflozin (Canacardia-HF)

Canacardia
Start date: November 1, 2017
Phase: N/A
Study type: Interventional

It is a mechanistic proof-of-concept study to demonstrate how SGLT-2 inhibitors (Canagliflozin) may have a beneficial role on cardiac energetic efficiency. Patients with type 2 diabetes and with HF diagnosed for at least 3 months will be selected. The participants will be randomized to a double-blind, crossover 2-week placebo vs. Cana 100 mg once daily, an interventional trial with a one-month washout period in between. At the term of the two-week placebo and canagliflozin treatment periods (visits 2 and 4), each participant will undergo an identical postprandial metabolic study with positron emission tomography (PET) and stable isotopic tracer methods.

NCT ID: NCT03297918 Not yet recruiting - Heart Failure Clinical Trials

Impact of a Structural Phonation Training on Respiratory Muscle Function in Patients With Structural Heart Disease

Start date: December 2017
Phase: N/A
Study type: Interventional

Most patients with complex congenital heart disease and cardiomyopathy from acquired heart disease have reduced exercise capacity. Exercise capacity is associated with respiratory muscle strength and function. If structured respiratory muscle training positively influences respiratory muscle function in patients with structural heart disease is not well known. The aim of this study is to investigate whether regular singing lessons and breathing exercises improve respiratory muscle strength in patients with congenital or acquired structural heart disease.

NCT ID: NCT03297164 Not yet recruiting - Heart Failure Clinical Trials

Incidence Rate of Heart Failure After Acute Myocardial Infarction With Optimal Treatment

Start date: October 2017
Phase: N/A
Study type: Observational

The main purpose of this study is to build a multi-center, prospective and regionally representative acute myocardial infarction(AMI) cohort´╝îand build a study platform for heart failure caused by AMI; To explore the 1 year incidence rate of heart failure after AMI given the optimized treatment and the treatment model affecting the incidence rate of heart failure, and finally to reduce the incidence rate of heart failure by 5%.

NCT ID: NCT03296813 Not yet recruiting - Heart Failure Clinical Trials

TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure

TRANSFORM-HF
Start date: August 14, 2018
Phase: Phase 4
Study type: Interventional

TRANSFORM-HF is a large-scale, pragmatic, randomized, unblinded clinical effectiveness study comparing torsemide versus furosemide as treatment for heart failure. Approximately 6,000 patients with heart failure will be enrolled. The primary objective of the TRANSFORM-HF study is to compare the treatment strategy of torsemide versus furosemide on clinical outcomes over 12 months in patients with heart failure who are hospitalized.