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Congestive Heart Failure clinical trials

View clinical trials related to Congestive Heart Failure.

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NCT ID: NCT03493516 Recruiting - Clinical trials for Congestive Heart Failure

Prediction of ARrhythmic Events With Positron Emission Tomography II

Start date: April 8, 2018
Study type: Observational

Sudden cardiac death continues to be a major contributor to mortality in patients with ischemic cardiomyopathy. While implantable defibrillators can prevent death from ventricular arrhythmias, our current approach to identify patients at highest risk primarily rests on demonstrating a reduction in left ventricular ejection fraction less than 35%. The purpose of this observational cohort study is to prospectively test whether this can be enhanced by quantifying the amount of sympathetic denervation, left ventricular end-diastolic volume or brain natriuretic peptide levels.

NCT ID: NCT03465605 Not yet recruiting - Clinical trials for Congestive Heart Failure

Frailty Assesment in the Congestive Heart Failure Clinic

Start date: April 2018
Study type: Observational [Patient Registry]

Frailty is known as an independent risk factor for morbidity and mortality in older cardiac patients, including patients with congestive heart failure. It is an important factor taken into the cardiologists decision making in the clinic, and influences the intensity of follow up treatment, invasive intervention and the need to ensure a stronger social support system for the patient. Frailty assessment is usually made subjectively by the cardiologist, known in the literature as eyeball testing. In this study the investigators will compare the cardiologists subjective eyeball testing to objective frailty assessment tests based on Fried score and Edmonton frail scale

NCT ID: NCT03449121 Not yet recruiting - Clinical trials for Congestive Heart Failure

Study for Breathing Interventions in Congestive Heart Failure

Start date: November 2018
Phase: N/A
Study type: Interventional

Slow breathing may reduce stress. Adults with congestive heart failure have higher stress than the general population. This study will examine if using slow breathing is feasible among adults with heart failure.

NCT ID: NCT03422991 Recruiting - Clinical trials for Congestive Heart Failure

Cohort of Heart Failure Patients

Start date: December 15, 2017
Phase: N/A
Study type: Interventional

This is a prospective cohort study of patients with Heart Failure with an eighteen-month follow-up aimed to collect all demographic, clinical, biological and para-clinical data to study population characteristics, assess prognosis markers and occurrence of HF treatment side effects. Congestive Heart failure is a frequent pathology and its prevalence increases with age. Its prognosis stays pejorative despite years of major therapeutical progress. In recent trials, all-cause mortality rates at 1-year reach up to 20% and 50% at 5 years. Medical care of congestive heart failure is based on precise international recommendations. The association of Beta-Blockers, renin-angiotensin system blockers, mineralocorticoid receptor antagonists, represent the basis of the pharmacological treatment. Cardiac resynchronization treatment and implantable cardioverter-defibrillator are additional efficient treatments that reduce events in appropriately selected patients. Despite these improvements, the prognostic of congestive heart failure in registers is worse than those observed in randomized trials. This can be explained by differences in congestive heart failure patient populations and/or by a less rigorous medical care where treatments are not optimized. The evaluation of medical care in congestive heart failure is today of utmost importance. Integrating new pharmacological molecules, medical devices and the application of new recommendations have major interest for documentation and practical changes. The main objective of this cohort will be to evaluate the evolution of the 12-month quality of life score of a HF patient and the characteristics and treatments associated with it.

NCT ID: NCT03366649 Recruiting - Clinical trials for Coronary Artery Disease

Improving Mitral Repair for Functional Mitral Regurgitation

Start date: March 2018
Phase: N/A
Study type: Interventional

The investigators are interested in determining the best surgical technique to correct functional mitral regurgitation, as there is currently not one technique that is established to work better than the other. The technique used in current clinical practice is undersizing mitral annuloplasty (UMA), in which a prosthetic ring is implanted onto the mitral valve to correct the leakage. Though widely adopted, durability of the repair is less, as 58% of the patients present with recurrent FMR within 2 years. There are no specific algorithms to predict who might have UMA failure, but research indicates that some geometric indices might be strong predictors. The investigators are interested in testing the hypothesis that, elevated lateral inter-papillary muscle separation (IPMS) is a predictor of post-UMA recurrence of FMR at 12 months. In the first part of this study, the study team will measure lateral IPMS before surgery, and relate to post-surgery FMR severity at discharge/30 days, 6 months and 12 months. A relatively newer technique is papillary muscle approximation (PMA), in which a suture draws together the two muscles that connect the mitral valve to the heart muscle prior to performing UMA. This reduces the lateral inter-papillary muscle separation (IPMS) and is expected to improve the durability of UMA. In the second part of this study, the investigators will perform PMA and UMA together and determine if FMR severity is reduced at discharge/30 days, 6 months and 12 months.

NCT ID: NCT03339310 Recruiting - Heart Failure Clinical Trials

Evaluation of the Safety and Efficacy of the 2-lead OPTIMIZER® Smart System

Start date: October 23, 2017
Phase: N/A
Study type: Interventional

This is a multicenter, prospective, single-arm study of the Optimizer Smart System with 2-leads

NCT ID: NCT03332186 Recruiting - Clinical trials for Congestive Heart Failure

A Study of Experimental Medication BMS-986231 in Patients With Different Levels of Kidney Function

Start date: March 15, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate experimental medication BMS-986231 in patients with different levels of kidney function.

NCT ID: NCT03321279 Enrolling by invitation - Diabetes Clinical Trials

Social Incentives to Increase Mobility

Start date: January 11, 2018
Phase: N/A
Study type: Interventional

This study aims to assess the effectiveness of a social incentive-based gamification intervention to increase physical activity in the 3 months after hospital discharge.

NCT ID: NCT03279861 Withdrawn - Hypertension Clinical Trials

Sacubitril-valsartan Versus Usual Anti-hypertensives in LVAD

Start date: November 2017
Phase: Phase 4
Study type: Interventional

This pilot, feasibility study evaluates the efficacy of sacubitril-valsartan (Entresto) versus usual anti-hypertensive medications in patients with left ventricular assist devices (LVAD). It also measures diurnal blood pressure variations in the context of continuous flow physiology.

NCT ID: NCT03266029 Recruiting - Clinical trials for Congestive Heart Failure

Clinical Evaluation of Cordio App in Adult Patients With CHF

Start date: May 24, 2015
Phase: N/A
Study type: Observational

Observational study on CHF patients at four sites in Israel. After signing informed consent and undergoing screening assessments, eligible patients will record a sentence and/or counting into a smartphone and/or recording machine. The app will upload the vocal data to the sponsor's servers for analysis.