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Chronic Heart Failure clinical trials

View clinical trials related to Chronic Heart Failure.

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NCT ID: NCT03667989 Recruiting - Clinical trials for Chronic Heart Failure

SPECT-based Prediction and Evaluation of CRT Efficacy in CHF

MIBGinCRT
Start date: September 1, 2017
Phase: N/A
Study type: Interventional

This study evaluates the state of the cardiac sympathetic activity and the severity of ventricular dyssynchrony in chronic heart failure patients and assesses the capabilities of radionuclide indication methods in determining the prognosis and evaluating the results of cardiac resynchronization therapy in chronic heart failure patients.

NCT ID: NCT03655925 Recruiting - Clinical trials for Chronic Heart Failure

Human Leucocyte Antigen G and Chronic Heart Failure

Start date: October 11, 2017
Phase:
Study type: Observational

The Human leukocyte antigen G (HLA-G) is a non-classical, major histocompatibility complex class I (MHC-I) protein that modulates the immune response, inhibiting it in most cases. Physiologically expressed in the cells of some tissues, it increases in inflammatory reactions. Inflammation appears to play an important role in the development of chronic heart failure. This study aims to evaluate the levels of soluble HLA-G in patients with heart failure and to investigate the relationships between HLA-G and other clinical-functional parameters of the disease. Investigators hypothesize that the plasma levels of HLA-G could correlate with the clinical status of heart failure and could provide indications on patient's prognosis.

NCT ID: NCT03615157 Recruiting - Clinical trials for Chronic Heart Failure

Effects of a Home-based Exercise Program on Functional Capacity and Quality of Life in Heart Failure Patients

Start date: January 15, 2018
Phase: N/A
Study type: Interventional

Heart failure (HF) is a multisystemic disease leading to exercise intolerance and fatigue. Supervised physical training improves functional capacity, quality of life and reduces hospital admissions in HF patients. In this way, home physical training may be a good alternative to patients who, for any reason, cannot perform supervised training. Objective: To asses the effects of a home-based training program on functional capacity, sedentary lifestyle and quality of life of patients with chronic HF compared to supervised training.

NCT ID: NCT03603743 Completed - Clinical trials for Chronic Heart Failure

High Intensity Interval Training vs Moderate Intensity and Continuous Training in Chronic Heart Failure

HRVFIT2
Start date: May 7, 2015
Phase: N/A
Study type: Interventional

Purpose: Exaggerated sympathetic nervous system (SNS) activity associated with low heart rate variability (HRV) is considered as a trigger of cardiac arrhythmias and sudden death. Regular exercise training is efficient to improve autonomic balance. In 2013, the investigators published that a single session of an optimized short-high intensity interval exercise with passive recovery (HIIT) protocol was efficient in chronic heart failure (CHF) patients for enhancing vagal tone and to decrease arrhythmias in the 24-h post exercise period when compared to a single session of moderate intensity continuous exercise (MICT). Nevertheless the effects of HIIT training performed on several weeks have never yet been studied on the parameters described by Coumel's triangle (the arrhythmogenic substrate, the trigger factor as premature ventricular contraction and the modulation factors of which the most common is the autonomic nervous system). The aim of this study was to verify the superiority of HIIT to enhance parasympathetic activity, cardiorespiratory fitness and cardiac function when compared to MICT in a short and intense cardiac rehabilitation program.

NCT ID: NCT03597646 Completed - Clinical trials for Chronic Heart Failure

The Effect of Kinesio Taping on Pulmonary Function and Functional Capacity in Patients With Chronic Heart Failure

Start date: September 8, 2016
Phase: N/A
Study type: Interventional

This randomised controlled study investigates the effect of Kinesio Taping on pulmonary function, respiratory muscle strength, functional capacity, functional mobility, hand grip strength, quality of life and level of depression in patients with chronic heart failure (CHF). The study also compares effects of Kinesio Taping and Inspiratory Muscle Training (IMT). There were 3 study groups: The experimental group received Kinesio Taping; the breathing exercise group received IMT; and the control group received no interventions.

NCT ID: NCT03494933 Recruiting - Clinical trials for Chronic Heart Failure

Re-evaluation of Optimal Re-synchronisation Therapy in Patients With Chronic Heart Failure

RESET-CRT
Start date: August 20, 2018
Phase: N/A
Study type: Interventional

The objective of the study is to demonstrate that in patients with chronic heart failure who receive optimal medical treatment for this condition and have indication for Cardiac Resynchronisation Therapy, the implantation of a pacemaker (index group) is not inferior to defibrillator (control group) with respect to all-cause mortality.

NCT ID: NCT03474315 Not yet recruiting - Clinical trials for Chronic Heart Failure

Interactive Patient's Assistant - LUCY

Start date: April 2018
Phase:
Study type: Observational [Patient Registry]

Patients with chronic heart failure (CHF) and reduced left ventricle ejection fraction benefit from cardiac resynchronization therapy (CRT) and implantable cardioverter defibrillator (ICD). Currently used devices, besides delivering low and high-energy therapies, record patient's activity and many hemodynamic parameters. However, increasing numbers of patient with CRT and ICD devices produce overload of cardiology centers where patients are admitted to ambulatory visits. Contrarily, there are technological possibilities for remote monitoring proven to be effective in recognizing damage of the implanted device and risk of exacerbation of chronic heart failure. Patients' registries show that majority of ambulatory visits are unproductive and do not result in significant modification of device's parameters. Promising experiences with application of data mining and machine learning techniques allow us to assume probable benefits from using modern methods of data analysis in determination of requirement for ambulatory follow-up on basis of data gathered through telemonitoring and clinical assessment of a patient. Aim of the study is to find multivariate model predicting the requirement for ambulatory follow-up of IECD.

NCT ID: NCT03416361 Not yet recruiting - Clinical trials for Chronic Heart Failure

VItamiN D treatIng Chronic heArT Failure (the Effect of Vitamin D Supplementation in Patients With Heart Failure)

VINDICATE2
Start date: March 1, 2018
Phase: N/A
Study type: Interventional

VINDICATE 2 will be a randomised, placebo-controlled, parallel group, double-blind study of vitamin D versus placebo in otherwise optimally-managed patients with CHF due to LVSD and vitamin D deficiency (<50nmol/L). The intervention will be a daily dose of 4000IU (100µg) per day or matching placebo for a minimum of 2 years and a maximum of 4 years.

NCT ID: NCT03388593 Recruiting - Clinical trials for Chronic Heart Failure

Study of the Survival of Recombinant Human Neuregulin-1β in Chronic Heart Failure (CHF) Patients

Start date: July 23, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate efficacy of rhNRG-1 in reducing the death rate of heart failure subjects with baseline NT-proBNP level ≤1600 pg/mL and NYHA class II to III.

NCT ID: NCT03351400 Recruiting - Clinical trials for Chronic Heart Failure

Japanese OMI Treatment With Kit-positive Cells for Enhanced Regeneration

JOKER
Start date: November 15, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the safety and effectiveness of intracoronary infusion of autologous cardiac stem cells in patients with ischemic cardiomyopathy.