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Heart Failure clinical trials

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NCT ID: NCT03312387 Recruiting - Clinical trials for Heart Failure, Diastolic

Muscle, Essential Amino Acids, and eXercise in Heart Failure

Start date: September 19, 2017
Phase: N/A
Study type: Interventional

Half of heart failure patients have preserved ejection fraction (HFpEF). Like patients with reduced ejection fraction (HFrEF), HFpEF patients suffer from exercise intolerance (low VO2max), which reduces physical function, quality of life, and survival. Strikingly, there is no medication proven to increase survival for HFpEF patients. Whereas exercise intolerance in HFrEF patients is the result of cardiovascular limitations, physical dysfunction in HFpEF patients is largely the result of peripheral abnormalities in skeletal muscle. Indeed, research in HFpEF patients identified that physical function and VO2peak are directly related to leg lean mass, and drugs focused on improving cardiovascular function have failed to improve VO2peak. Unfortunately, no therapy has been identified for this population that can concurrently improve cardiovascular and muscle health. The need for improved muscle therapies is reinforced by the fact that HFpEF patients are commonly older adults who are predisposed to muscle wasting. Strategic essential amino acid (EAA) ingestion has been shown to improve the adaptive response of muscle to exercise. Therefore, the investigators will determine, in HFpEF patients, the extent to which ingesting a strategic mixture of EAAs during an acute aerobic exercise training program enhances the response to this exercise strategy.

NCT ID: NCT03310099 Recruiting - Obesity Clinical Trials

Unsaturated Fatty Acids Enriched-diet to Improve Cardiorespiratory Fitness in Obese Patients: a Feasibility Study

Start date: October 16, 2017
Phase: N/A
Study type: Interventional

The investigators hypothesize that a dietary intervention aimed at increasing unsaturated fatty acids (UFA) consumption is feasible and has the potential to improve cardiorespiratory fitness in symptomatic obese heart failure with preserved ejection fraction (HFpEF) patients.

NCT ID: NCT03305393 Recruiting - Heart Failure Clinical Trials

Implementation of a Protocol Utilizing Adaptive CRT in a Normal AV Conduction, CRT Non-Response Population at Generator Replacement

Start date: June 11, 2017
Phase: N/A
Study type: Interventional

IMPROVE RESPONSE is a physician initiated research study. It is a prospective, non-randomized, multi-center, post-market, U.S. Cardiac Resynchronization Therapy (CRT) in heart failure (HF) observational study. The purpose of this clinical study is to test the hypothesis that market-released CRT devices, which contain the AdaptivCRT (aCRT) algorithm have an incremental benefit in improving CRT response in a chronic CRT non responder population with left bundle branch block (LBBB) and normal atrio-ventricular (AV) condition compared to CRT devices with traditional biventricular pacing delivery methods at generator replacement.

NCT ID: NCT03300791 Recruiting - Heart Failure Clinical Trials

Predictive Models of Readmission in Heart Failure

Start date: September 28, 2017
Phase: N/A
Study type: Observational

This is a prospective nested case-control study. Our goals are to create predictive models to readmissions for heart failure and also to define profiles for patients who are readmitted during the first month after the index episode. Patients who will be admitted in five hospitals in spain by the reason of a heart failure will be recruited during 18 months. Those who will be readmitted in a hospital up to a month after the index episode will be considered cases. Controls will be selected from the initial cohort of hospitalized patients.

NCT ID: NCT03294512 Recruiting - Heart Failure Clinical Trials

Pilot and Feasibility Study of a MAWDS (Medications, Activity, Weight, Diet and Symptoms) Heart Failure Mobile Platform

Start date: September 28, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to create a smartphone app that delivers the educational content of the current Intermountain MAWDS* program and allows patients to enter and track their MAWDS data within the app; and to determine if a broad-scale project can be conducted within the limits of currently available technology. Information from this study will be used to design a larger study that is powered to assess the association between data obtained via a MAWDS app and heart failure outcomes. (*MAWDS- Medications, Activity, Weight, Diet, Symptoms)

NCT ID: NCT03289481 Recruiting - Clinical trials for Heart Failure With Normal Ejection Fraction

Treatment of HFpEF With Nitrate Supplement

Start date: March 20, 2017
Phase: N/A
Study type: Interventional

The objective of this project is to determine if Neo40, a nitric oxide generating lozenge, when consumed twice daily by subjects with HFpEF, will increase exercise tolerance, decrease symptoms and improve quality of life for patients.

NCT ID: NCT03288701 Recruiting - Clinical trials for Heart Failure; With Decompensation

Smart SCALEs for Treatment Guidance in Decompensated Heart Failure

Start date: September 4, 2017
Phase: N/A
Study type: Interventional

In this trial the measurement of whole body water will be compared to the standard method of measuring the body weight as treatment guidance in patients with decompensated heart failure. The Withings' Body Cardio Scale will be used to quantify the whole body water by using bioelectrical impedance analysis.

NCT ID: NCT03288194 Recruiting - Heart Failure Clinical Trials

Improving Quality of Life in Heart Failure

Start date: October 2015
Phase: N/A
Study type: Interventional

This research study has been designed to test the efficacy of telephone-delivered Problem-Solving Treatment (PST) for improving the quality of life (QoL) in outpatients with stable heart failure (HF).

NCT ID: NCT03286127 Recruiting - Cancer Clinical Trials

Palliative Outcome Evaluation Muenster I

Start date: September 11, 2017
Phase: N/A
Study type: Observational

For patients with an advanced disease and their families an excellent and compassionate care is essential. However, in hospitals optimal end-of-life care is not yet fully realized and patient's needs are often not met. Palliative care is able to increase patients' quality of life and to carefully meet their and their families' needs. To improve the awareness of unmet needs patient-reported outcome measurement has been the pivot of latest palliative care research. Besides the improvement of care outcome measurement allows the evaluation of the quality of palliative care and comparisons on a national and international level. The aim of the present study is to evaluate the quality of palliative care in different settings (palliative care unit, inpatient and outpatient consultation teams) using the Integrated Palliative Care Outcome Scale (IPOS). The IPOS has been lately developed as improved follow-up version of the Palliative Care Outcome Scale (POS) integrating most important questions and simultaneously being brief and comprehensive. The study is planned as a multi-centric observational study. Primary endpoint is the reduction of symptom burden of patients. The clinical study hypothesis bases on the assumption that palliative care can change the symptom burden, measured by a change in the IPOS overall profile score, and that there might be a difference in the size of the effect depending on the caring setting.

NCT ID: NCT03281122 Recruiting - Heart Failure Clinical Trials

A Study of BMS-986224 in Healthy Subjects and Heart Failure Patients With Reduced Ejection Fraction

Start date: September 22, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is test the safety and tolerability of BMS-986224 and its effects on the body in healthy subjects and subjects with chronic heart failure with reduced ejection fraction