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Heart Failure clinical trials

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NCT ID: NCT03369938 Recruiting - Heart Failure Clinical Trials

Exercise Training in Patients With Left Ventricular Assist Device

Ex-VAD
Start date: December 4, 2017
Phase: N/A
Study type: Interventional

The objective of the study is to test whether 12 weeks of structured supervised exercise training on top of usual care improves functional capacity in patients with end-stage heart failure with continuous flow left ventricular assist device (LVAD).

NCT ID: NCT03367104 Recruiting - Heart Failure Clinical Trials

Narrow QRS HF Patients Assessed by ECG Belt

Start date: November 14, 2017
Phase: N/A
Study type: Observational

The purpose of this study is to quantitate electrical dyssynchrony in heart failure (HF) patients with a narrow QRS complexes (≤ 130 ms) using the ECG Belt. This is a pilot study that is designed to provide data that can be used in designing and implementing a prospective study of cardiac resynchronization therapy (CRT) in narrow QRS patients selected and optimized using the ECG Belt.

NCT ID: NCT03366649 Recruiting - Clinical trials for Coronary Artery Disease

Improving Mitral Repair for Functional Mitral Regurgitation

IMPROVE-FMR
Start date: December 31, 2017
Phase: N/A
Study type: Interventional

The investigators are interested in determining the best surgical technique to correct functional mitral regurgitation, as there is currently not one technique that is established to work better than the other. The technique used in current clinical practice is undersizing mitral annuloplasty (UMA), in which a prosthetic ring is implanted onto the mitral valve to correct the leakage. Though widely adopted, durability of the repair is less, as 58% of the patients present with recurrent FMR within 2 years. There are no specific algorithms to predict who might have UMA failure, but research indicates that some geometric indices might be strong predictors. The investigators are interested in testing the hypothesis that, elevated lateral inter-papillary muscle separation (IPMS) is a predictor of post-UMA recurrence of FMR at 12 months. In the first part of this study, the study team will measure lateral IPMS before surgery, and relate to post-surgery FMR severity at discharge/30 days, 6 months and 12 months. A relatively newer technique is papillary muscle approximation (PMA), in which a suture draws together the two muscles that connect the mitral valve to the heart muscle prior to performing UMA. This reduces the lateral inter-papillary muscle separation (IPMS) and is expected to improve the durability of UMA. In the second part of this study, the investigators will perform PMA and UMA together and determine if FMR severity is reduced at discharge/30 days, 6 months and 12 months.

NCT ID: NCT03356288 Recruiting - Asthma Clinical Trials

The General Breathing Record Study

GBRS
Start date: August 9, 2017
Phase: N/A
Study type: Observational

This study will test the use of a new handheld device (called the N-Tidal C), that measures a person's tidal breath carbon dioxide, in diagnosing the cause of someone's breathlessness. It will also evaluate whether this device can detect when a person's breathing problem is getting worse.

NCT ID: NCT03354689 Recruiting - Clinical trials for Cardiovascular Abnormalities

Transcutaneous Electrical Nerve Stimulation and Cardiac Sympathetic Overdrive in Heart Failure

Start date: March 20, 2017
Phase: N/A
Study type: Observational

Introduction: Cardiac sympathetic drive provides inotropic support to the failing heart and preserves cardiovascular homeostasis. Nonetheless, as myocardial insult evolves, this compensatory response leads to a progressive decline in contractile function, increases the vulnerability to arrhythmias and constitutes an independent mortality predictor. Despite advanced pharmacological therapies, side effects and persistent cardiac sympathetic overdrive highlights the modulation of the adrenergic system as a primary target for non-pharmacological strategies in the heart failure (HF) treatment. In this scenario, we will propose cervicothoracic transcutaneous electrical nerve stimulation (TENS) as a non-pharmacological therapy to attenuate cardiac sympathetic overdrive in patients with heart failure. Methods: In this prospective, randomized, sham-controlled, double-blind crossover trial, ten (10) HF patients under optimal pharmacological treatment will be randomly assigned to either an in-home cervicothoracic transcutaneous electrical nerve stimulation therapy (TENS: 30 min twice a day with 80 Hz frequency and pulse duration of 150 μs) or a sham control intervention (SHCI) for two weeks. Following a two-month washout phase from TENS/SHCI, patients crossed over and started the opposite condition. Washout rate and heart-to-mediastinum ratio (planar 123l-metaiodobenzylguanidine myocardial scintigraphy images), indexes of cardiac sympathetic activity and innervation density, muscle sympathetic nerve activity (microneurography) and brachial artery blood flow (Doppler ultrasound) during dynamic handgrip exercise will be obtained at the beginning and end of each condition.

NCT ID: NCT03351400 Recruiting - Clinical trials for Chronic Heart Failure

Japanese OMI Treatment With Kit-positive Cells for Enhanced Regeneration

JOKER
Start date: November 15, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the safety and effectiveness of intracoronary infusion of autologous cardiac stem cells in patients with ischemic cardiomyopathy.

NCT ID: NCT03349593 Recruiting - Heart Failure Clinical Trials

Prevalence of Hypovolemia and Heart Failure in Non-cardiac Surgery

Start date: February 1, 2017
Phase: N/A
Study type: Observational

Prevalence of biventricular function of the heart and preoperative level of venous return is not known in non-cardiac non-morbid obese population. The aim of the study is to assess the preoperative function of the heart and status of hypovolemia on the day of surgery.

NCT ID: NCT03346278 Recruiting - Clinical trials for Myocardial Infarction

Text Message Intervention to Improve Cardiac Rehab Participation

Start date: November 7, 2017
Phase: N/A
Study type: Interventional

Cardiac rehabilitation (CR) is strongly recommended for patients with coronary heart disease. However, patient enrollment and completion of cardiac rehabilitation is low. This study will examine if a mobile phone intervention that uses a text messaging program can successfully promote participation in cardiac rehabilitation.

NCT ID: NCT03345446 Recruiting - Clinical trials for Heart Failure With Reduced Ejection Fraction

Circulating RNAs in Acute Congestive Heart Failure

CRUCiAL
Start date: August 17, 2016
Phase: N/A
Study type: Observational

The purpose of this American Heart Association-funded and NIH-funded study is to examine circulating RNAs in the acute CHF setting, how they change with decongestive therapy, and their function in vitro and in vivo. The investigators are testing the hypothesis that ex-RNA levels change significantly during decongestion therapy and can be used as a marker of those individuals who respond to CHF therapy (in terms of cardiac structure or outcome). Additionally, the translational research design allows the investigators to assay the effects of these RNAs on tissue phenotypes in vitro.

NCT ID: NCT03342690 Recruiting - Clinical trials for Chronic Heart Failure

Drug Use Investigation of Selara Tablets (an Investigation for Chronic Heart Failure)

Start date: July 5, 2017
Phase: N/A
Study type: Observational

Secondary Data Collection Study; Safety And Effectiveness Of Selara Under Japanese Medical Practice