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Heart Failure clinical trials

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NCT ID: NCT03882580 Recruiting - Metabolic Disorder Clinical Trials

Reporting, Evaluating, Preventing and Treating the Cardiotoxicity Induced by Anticancer Drugs During a Specific Cardio-oncology Consult and Follow up in Routine Care

UNICO
Start date: March 1, 2019
Phase:
Study type: Observational

Several Drugs used in routine care in oncology induce rare but often severe or fatal cardiovascular or metabolic side effects. This study will investigate, evaluate, report and treat the cardiovascular side effects of anticancer drugs, through a specific cardiovascular routine checkup and follow-up taking place in several Cardio-oncology programs throughout France. The different including centers will be: Assistance Publique - Hôpitaux de Paris (APHP.6: Pitié-Salpétrière, Saint Antoine and Tenon's hospitals, Paris, France).

NCT ID: NCT03877328 Recruiting - Heart Failure Clinical Trials

BioTechCOACH-ForALL: Development of Mental and Physical Exercise Systems, Clinical Recording, Supervisory Analytical Large-scale Data and Virtual Guidance of Vulnerable Population Groups

Start date: July 18, 2018
Phase: N/A
Study type: Interventional

This would be a single center, parallel, two group randomized controlled pilot study that is designed to assess the feasibility and efficacy of the Virtual Coach Program in elderly patients with heart failure.

NCT ID: NCT03874312 Recruiting - Clinical trials for Advanced Heart Failure

Ultrasound-assessed Internal Jugular Vein Distensibility in Advanced Chronic Heart Failure (US-IJVD in CHF)

US-IJVD-CHF
Start date: October 18, 2017
Phase:
Study type: Observational

Prospective validation of the ultrasound-assessed internal jugular vein distensibility (JVD) ratio to identify patients with systolic chronic heart failure and right atrial pressure (RAP) of 7 or less mmHg measured by the right heart catheterization. In a calibration cohort, a threshold ratio will be identified, above which the RAP is normal with the highest accuracy. This diagnostic tool with a defined threshold of the JVD ratio will be assessed in a second prospective validation cohort.

NCT ID: NCT03871803 Recruiting - Clinical trials for Heart Failure With Normal Ejection Fraction

β-blockers Withdrawal in Patients With HFpEF and Chronotropic Incompetence: Effect on Functional Capacity (Preserve-HR)

Preserve-HR
Start date: October 1, 2018
Phase: Phase 4
Study type: Interventional

The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex and multifactorial. Chronotropic incompetence has emerged as a crucial mechanism, particularly in elderly patients. Betablockers, drugs with negative chronotropic effect, are commonly used in HFpEF, despite current evidence does not support its routine use in these patients. The aim of this work is to evaluate the effect of betablockers withdrawal in patients with HFpEF and chronotropic incompetence on functional capacity assessed by the peak oxygen consumption at maximal exercise (peakVO2) at 15 and 30 days after the intervention

NCT ID: NCT03863626 Recruiting - Clinical trials for Acute Decompensated Heart Failure

Exploring Diuretics Effective Management in Acute Decompensated Heart Failure, EDEMA Trial

EDEMA
Start date: January 31, 2019
Phase: N/A
Study type: Interventional

1. Evaluate efficacy and safety of continuous infusion of IV Frusemide compared to IV shots in acute decompensated heart failure ADHF 2. Evaluate superiority of time-adjusted metolazone to morning frusemide IV shots compared to irrespective administration (at random times) to overcome diuretic resistance

NCT ID: NCT03859466 Recruiting - Clinical trials for Heart Failure Patients

Safety and Efficacy of Cardiac Shockwave Therapy in Patients Undergoing Coronary Artery Bypass Grafting

CAST
Start date: November 16, 2018
Phase: N/A
Study type: Interventional

Safety and Efficacy of Cardiac Shockwave Therapy (CAST) in patients undergoing coronary artery bypass grafting

NCT ID: NCT03857633 Recruiting - Heart Failure Clinical Trials

MRI Assessment of Myocardial Fibrosis Associated With Monocyte Phenotype in End Stage Renal Failure

CM3
Start date: February 1, 2019
Phase:
Study type: Observational

Firstly, this study aims to understand how cardiac fibrosis mediated by inflammatory microvascular disease evolves during advanced chronic kidney disease and end stage renal failure and importantly how this changes with commencement on renal replacement therapy (haemodialysis and peritoneal dialysis) using sequential cardiac MRI imaging. This method of imaging is non-invasive, provides significantly more data than echocardiography, is reproducible and accurate, has been validated in numerous studies and does not involve exposure to ionising radiation. Secondly, this study aims to examine the changes in monocyte subsets and biochemical profile in peripheral blood prior to, during and after commencement on renal replacement therapy. The investigators hypothesis would be that renal failure causes alteration in monocyte subset phenotype resulting in increased circulating inflammatory monocytes (human CD14high CD16high), initiating pro-inflammatory cytokine expression and thereby accelerating inflammatory cardiovascular disease and development of myocardial fibrosis.

NCT ID: NCT03857022 Recruiting - Heart Failure Clinical Trials

A Study to Evaluate the Effects of EECP in Patients With Heart Failure

Start date: November 22, 2018
Phase: N/A
Study type: Interventional

The aims of this proposal are to investigate whether external enhanced counterpulsation (EECP) can facilitate heart failure (HF) patient weaning from intravenous infusion of positive inotropic agent, and thus decrease the length of hospital stay. The major adverse cardiovascular event (MACE) rate, including death and hospitalization for heart failure, will be monitored for 6 months if patients can be released from hospital. Exercise tolerance (6-minute walking distance) and plasma brain natriuretic peptide (BNP) level will be checked at the end of 6th month.

NCT ID: NCT03856736 Recruiting - Heart Failure Clinical Trials

Aerobic Exercise and Telomere Length in Patients With Heart Failure.

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

The present study will analyze and compare the chronic effects of two different protocols of aerobic exercise in subjects with heart failure on telomere length.

NCT ID: NCT03855982 Recruiting - Myocarditis Clinical Trials

Monitoring Drug-induced Myocarditis (CardiTOX)

CardiTOX
Start date: February 25, 2019
Phase:
Study type: Observational

Several drugs and chemotherapies seem to induce myocarditis. This study investigates reports of myocarditis, including the International classification of disease ICD-10 for treatments in the World Health Organization (WHO) global Individual Case Safety Report (ICSR) database (VigiBase).