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Heart Failure clinical trials

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NCT ID: NCT03447392 Completed - Heart Failure Clinical Trials

Discharge Education of Integrated Traditional and Western Medicine Reduces Re-hospitalization in Patients With Chronic Heart Failure

Start date: August 21, 2017
Phase: N/A
Study type: Interventional

Although interventions combining patient education and postdischarge management have demonstrated benefits in patients with chronic heart failure, the benefit attributable to patient education alone is not known. The investigators hypothesized that a patient discharge education program would improve clinical outcomes in patients with chronic heart failure.

NCT ID: NCT03410966 Completed - Atrial Fibrillation Clinical Trials

Atrial Fibrillation Ablation

Start date: January 1, 2013
Phase: N/A
Study type: Interventional

Objective. Atrial fibrillation (AF) recurrence after catheter ablation (CA) is a relevant clinical problem. Methods. 123 patients with paroxysmal AF will be identified and screened for participation in this randomized, prospective, double blind, controlled placebo multicenter trial. 109 patients will be randomly assigned and enrolled in the study trial. Enrolled patients will receive magnetic atrial resonance and then will be treated by CA to receive pulmonary vein isolation (PVI). In this patients cytokines, inflammatory markers, and biomarkers such as ST2 protein and B type natriuretic peptide (BNP) will be evaluated at baseline, after CA, and during follow up. These biomarkers will be correlated to clinical outcomes (AF recurrences and heart failure progression and hospitalizations), and to fibrotic atrium extension as evaluated by magnetic resonance.

NCT ID: NCT03402490 Completed - Clinical trials for Diastolic Heart Failure

Enhancement of Physical Activity in Elderly Patients With Diastolic Heart Failure by a Motivational Intervention

Start date: June 18, 2013
Phase: N/A
Study type: Interventional

The aim of our pilot study is to evaluate the feasibility, acceptance and efficacy of motivational interviewing (MI) to support elderly patients with heart failure with preserved ejection fraction (HFpEF) in maintaining or starting physical activity (PA).

NCT ID: NCT03395951 Completed - Heart Failure Clinical Trials

Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients

Start date: October 1, 2014
Phase: N/A
Study type: Observational

Within clinical settings observation of hemodynamic changes (e.g. mean systemic filling pressure, cardiac output) in critically ill patients with a clinical indication for deresuscitation with intravenous diuretic therapy.

NCT ID: NCT03393793 Completed - Heart Failure Clinical Trials

HEart trAnsplantation Registry of piTie-Salpetriere University Hospital

Start date: January 1, 2009
Phase: N/A
Study type: Observational

Heart transplantation (HTx) is a procedure which is hindered by several complications. The HEARTS registry aims to allow the analysis of risk factors of all post-HTx complications. It consists in an exhaustive data collection at the moment of inclusion, i.e. HTx, knowing that patients underwent a full-fledged evaluation beforehand to evaluate their aptitude to being transplanted. Post-HTx complications include but is not limited to: all-cause mortality, AMR, ACR, CAV, AKI, sepsis, cancer, psychological disorders, metabolic disorders.

NCT ID: NCT03389841 Completed - Heart Failure Clinical Trials

Home Care for the Patient With Heart Failure: Can Caregiver Education Prevent Hospital Admissions?

Start date: August 1, 2013
Phase: N/A
Study type: Interventional

The study is aimed to evaluate if the education of the caregiver is able to reduce hospital admissions of patients with heart failure assisted at home.

NCT ID: NCT03366181 Completed - Heart Failure Clinical Trials

Anti Arrhythmic Therapies and Sudden Cardiac Deaths

Start date: November 1, 2017
Phase: N/A
Study type: Observational

Failing heart negative remodeling alterations might provide electrical heterogeneity and cardiac remodeling, thus potentially contributing to the occurrence of ventricular arrhythmia and subsequent sudden cardiac death (SCD). In this study we have prospectively investigated whether serum markers of heart failure (ultra sensitive Troponin , B type Natriuretic Peptide (BNP), C reactive protein (CRP), and ST protein) could be used as predictors for the occurrence of malignant ventricular arrhythmias in patients who had received an Implantable Cardioverter Defibrillator (ICD) for primary prevention.

NCT ID: NCT03307707 Completed - Heart Failure Clinical Trials

New Heart Failure Biomarkers in Early Stage Chronic Kidney Disease-Mineral and Bone Disorder

Start date: June 15, 2015
Phase: N/A
Study type: Observational

the objective of this study is to : -Determinate wether the circulating levels of iFGF23 and klotho can be a predictor biomarker of HF in patients with CKD-MBD.

NCT ID: NCT03287141 Completed - Heart Failure Clinical Trials

CPAP Versus Bi-level in Chronic Heart Failure

Start date: October 19, 2015
Phase: N/A
Study type: Interventional

Introduction: Dyspnea and fatigue are the main clinical symptoms of heart failure and primarily responsible for exercise intolerance found in this syndrome. Now, It is known that the use of NIV in CPAP mode applied before exercise increases exercise tolerance in people with heart failure; however, it's not yet known if the bi-level mode is able to generate similar or even better results, due to pressure increase of the ventilatory support in this modality. Moreover, it is possible that there is influence between the pressure levels set in the NIV and the magnitude of its effect on the exercise in this population Objective: 1) test for differences between the acute effects of NIV on exercise tolerance in patients with HF, when applied CPAP or bi-level mode; and 2) check for discrepancies in the acute effects of Bi-level mode on the physical performance of these individuals, when applied at different pressure levels. Methodology: This is a controlled, randomized, double-blind and cross-over clinical trial, to be composed of 45 volunteers of both genders, aged between 30 and 80 years, with chronic heart failure, functional class II and III (New York Heart Association) in clinical stability. The experiment will be carried out on four different days, with a 48-hour interval between them, in which NIV will be used in the following modes: Bi-level with minimum parameters (EPAP = 6 cmH2O and IPAP = 12 cmH2O), Bi-level with maximum parameters EPAP = 8 cmH2O and IPAP = 14 cmH2O) and CPAP (6 cmH2O). Thus, all the volunteers will participate in the four TGC. During the tests, distance walking, perceived levels of fatigue and dyspnea, affective response, as well as other physiological variables will be analyzed. Statistical analysis, the ANOVA test for repeated measurements will be used, followed by the Bonferroni post-test, considering p-value less than or equal to 0.05 as statistically significant. Expected Results: This work is expected to improve the therapeutic management of HF patients, assisting in the implementation and improvement of methods to improve dyspnea and muscle fatigue, thus increasing tolerance to exercise.

NCT ID: NCT03282136 Completed - Heart Failure Clinical Trials

Incretin and CRTd.

Start date: September 1, 2017
Phase: Phase 4
Study type: Interventional

Incretin therapy is a treatment for type 2 diabetes (T2DM) affected by heart failure (HF). In this study the investigators will recruit T2DM patients affected by HF with depressed ejection fraction and treated by Cardiac resynchronization therapy (CRT). These patients will randomly be treated by incretin v/s conventional hypoglicemic drugs. In this patients investigators will report at follow up CRT-d responders rate, mortality, and hospital admission for HF worsening. Incretin may reduce hospital admissions for HF in T2DM v/s conventional hypoglicemic drugs.