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Heart Failure clinical trials

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NCT ID: NCT03960515 Completed - Heart Failure Clinical Trials

Cardiovascular Profiles in Rheumatoid Arthritis

RA-HF
Start date: June 22, 2016
Phase:
Study type: Observational

Cardiovascular disease is the leading cause of death in RA patients. This increased risk may be apparent even before the clinical recognition of RA. The optimal approach for identification of patients with increased CV risk has yet to be fully established and a substantial proportion of RA patients at high risk remain unidentified. Heart failure (HF) has been recently recognized as an important contributory factor to the excess CV mortality associated with RA (more than myocardial ischemia), and RA patients with concomitant HF have twice the risk of CV death compared with patients with RA alone. HF in RA typically presents with occult or atypical clinical symptomatology, tend to be managed less aggressively and have poorer outcomes. For developing effective preventive strategies, the evaluation of patients in early asymptomatic stages is of great importance. The investigators propose to perform an observational longitudinal study (with cases and controls) including RA patients (with and without HF) from a single centre to determine cardiovascular profiles that may be associated with higher risk for developing symptomatic HF and CV events. For this purpose the investigators will use clinical, echocardiographic, serum biomarker, and genetic data

NCT ID: NCT03951740 Completed - Clinical trials for Coronary Artery Disease

Validation of Two Wrist-worn Devices for the Assessment of Energy Expenditure in Cardiac Patients.

Start date: October 11, 2017
Phase: N/A
Study type: Interventional

Improving physical activity is a core component of secondary prevention and cardiac (tele)rehabilitation. Commercially available activity trackers are frequently used to monitor and promote physical activity in cardiac patients. However studies on the validity of these devices in cardiac patients are scarce. The aim of this study is to determine the accuracy and responsiveness of two wrist-worn activity trackers, Fitbit Charge 2 (FC2) and Mio Slice (MS), for the assessment of energy expenditure (EE) in cardiac patients.

NCT ID: NCT03931200 Completed - Heart Failure Clinical Trials

Demographic and Clinical Characteristics, Treatment Patterns and Clinical Outcomes of Heart Failure Patients in China

Start date: April 30, 2019
Phase:
Study type: Observational

This is a non-interventional, multicenter, retrospective study assessing demographic characteristics, clinical characteristics, management and outcome of patients with a HF (heart failure) diagnosis utilizing real world data derived from HF Center Database. This database collects the data of HF from patients hospitalized between March 2010 to Dec 2018 in more than 300 hospitals across China.

NCT ID: NCT03913780 Completed - Heart Failure Clinical Trials

Impact of the Aerobic Exercise Versus Exercise of Force on the Hemodynamic, Lipidic, Anthropometric and Psychological Variables of Patients With Cardiac Failure

Start date: April 2016
Phase: N/A
Study type: Interventional

Introduction and objectives: At the global level, cardiovascular diseases are the leading cause of mortality. Currently, rehabilitation programs are shown as an effective treatment to mitigate the effects of heart failure. The main objective is to compare the effects of aerobic exercise and strength in patients with heart failure after a cardiovascular rehabilitation program. Methods and materials: Randomized controlled trial over a period of 3 years with patients with heart failure distributed in 3 groups (Aerobic exercise, aerobic exercise plus upper limb -MMSS- training, aerobic exercise plus training of lower limb -MMII-). Blood samples were taken to determine blood glucose levels and lipid profile. In addition, tests for aerobic capacity, maximum heart rate, anthropometry, depression, anxiety, clinical and hemodynamic parameters. The tests were performed before and after 24 training sessions, 60 min, 3 times a week for two months.

NCT ID: NCT03903198 Completed - Acute Heart Failure Clinical Trials

Care Pathways of Acute Heart Failure Patients: Impact on In-hospital Mortality.

Start date: June 2014
Phase:
Study type: Observational

The investigators conducted a prospective observational study to describe the different pre-hospital and in-hospital pathways of patients with acute heart failure (AHF) and their association with in-hospital mortality.

NCT ID: NCT03895073 Completed - Heart Failure Clinical Trials

HEart fAiluRe evaluaTion Questionnaire

HEART
Start date: September 1, 2018
Phase:
Study type: Observational

The "four-point" questionnaire by Severo and his associates was weighted in 2011 in the Portuguese population and aims to characterize the severity of the symptoms of heart failure by providing a way to minimize the reliability of the NYHA classification. The questionnaire consists of four closed questions, three possible single-choice answers, coded 0, 1 or 2, and has been translated into Greek in accordance with the internationally-based methodology, with forward-backward translation.

NCT ID: NCT03893760 Completed - Heart Failure Clinical Trials

Assessment of Right Ventricular Function in Advanced Heart Failure

Start date: October 2016
Phase:
Study type: Observational

We examined the feasibility and reliability of a combined echocardiographic and right heart catheterization (RHC) approach for right ventriculo/arterial (R-V/A) coupling assessment in HF patients with dilated cardiomyopathy (D-CMP).

NCT ID: NCT03882710 Completed - Clinical trials for Diastolic Heart Failure

Metoprolol XR in Heart Failure With Normal Ejection Fraction

HFNEF
Start date: January 2010
Phase: Phase 2
Study type: Interventional

In contrast to the treatment of HF with reduced EF, information to guide the pharmacological therapy of patients with HFNEF are lacking and there is no evidence based treatment for patients with HFNEF. Thus, present treatment strategies for HFNEF are largely based on assumptions regarding its pathophysiological mechanisms and on extrapolations from proven strategies used in systolic HF. Till now, no study enlightens the efficacy and safety of beta blockers in HFNEF in a randomised controlled manner although the role of beta blockers in HF with impaired systolic function has been sufficiently time tested leading to their therapeutic approval in that condition. Keeping in view the small reported benefit of beta blockers in HFNEF as mentioned above, there is a need to provide a conclusive proof of their role in this condition as well. Hence, investigators planned to test the efficacy and safety of metoprolol CR in patients with HFNEF in a randomised double blind placebo controlled trial.

NCT ID: NCT03870074 Completed - Clinical trials for Heart Failure With Reduced Ejection Fraction

CPET Predicts Long-term Survival and Positive Response to CRT

CPET-CRT
Start date: October 2009
Phase:
Study type: Observational

The study tested the usefulness of cardiopulmonary exercise test (CPET) in selection of potential responders to CRT.

NCT ID: NCT03857906 Completed - Heart Failure Clinical Trials

Evaluation of Prophylactic Use of a Preoperative IABP in High-Risk Coronary Artery Bypass Graft Surgery

IABP-HR
Start date: October 21, 2014
Phase:
Study type: Observational [Patient Registry]

Background: The intra-aortic balloon balloon pump (IABP) has been used as a method of percutaneous circulatory assistance high surgical risk patients undergoing coronary artery bypass graft surgery (CABG); Although its applicability has been questioned by clinical trials showing poor impact to reduce the mortality due to cardiogenic shock associated with postoperative acute myocardial infarction (AMI), the real benefit reducing mortality in the postoperative context (PO) has not been determined examined through a prospective study with an adequate design. Objective: To compare PO complications such as mortality, perioperative infarction and other complications in patients with high surgical risk undergoing CABG in comparison with controls.