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Heart Failure clinical trials

View clinical trials related to Heart Failure.

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NCT ID: NCT03882710 Completed - Clinical trials for Diastolic Heart Failure

Metoprolol XR in Heart Failure With Normal Ejection Fraction

Start date: January 2010
Phase: Phase 2
Study type: Interventional

In contrast to the treatment of HF with reduced EF, information to guide the pharmacological therapy of patients with HFNEF are lacking and there is no evidence based treatment for patients with HFNEF. Thus, present treatment strategies for HFNEF are largely based on assumptions regarding its pathophysiological mechanisms and on extrapolations from proven strategies used in systolic HF. Till now, no study enlightens the efficacy and safety of beta blockers in HFNEF in a randomised controlled manner although the role of beta blockers in HF with impaired systolic function has been sufficiently time tested leading to their therapeutic approval in that condition. Keeping in view the small reported benefit of beta blockers in HFNEF as mentioned above, there is a need to provide a conclusive proof of their role in this condition as well. Hence, investigators planned to test the efficacy and safety of metoprolol CR in patients with HFNEF in a randomised double blind placebo controlled trial.

NCT ID: NCT03870074 Completed - Clinical trials for Heart Failure With Reduced Ejection Fraction

CPET Predicts Long-term Survival and Positive Response to CRT

Start date: October 2009
Study type: Observational

The study tested the usefulness of cardiopulmonary exercise test (CPET) in selection of potential responders to CRT.

NCT ID: NCT03857906 Completed - Heart Failure Clinical Trials

Evaluation of Prophylactic Use of a Preoperative IABP in High-Risk Coronary Artery Bypass Graft Surgery

Start date: October 21, 2014
Study type: Observational [Patient Registry]

Background: The intra-aortic balloon balloon pump (IABP) has been used as a method of percutaneous circulatory assistance high surgical risk patients undergoing coronary artery bypass graft surgery (CABG); Although its applicability has been questioned by clinical trials showing poor impact to reduce the mortality due to cardiogenic shock associated with postoperative acute myocardial infarction (AMI), the real benefit reducing mortality in the postoperative context (PO) has not been determined examined through a prospective study with an adequate design. Objective: To compare PO complications such as mortality, perioperative infarction and other complications in patients with high surgical risk undergoing CABG in comparison with controls.

NCT ID: NCT03850808 Completed - Heart Failure Clinical Trials

LV Dysfunction Following Pacemaker Placement

Start date: September 2013
Study type: Observational

Several studies have confirmed the link between chronic RV apical pacing and the development of heart failure and LV systolic dysfunction in some patients 1,2. However, questions continue to remain unanswered in regard to the adverse effects of RV pacing such as the exact amount of RV pacing that is detrimental to cardiac function and which subsets of patients are most at risk for developing cardiac dysfunction from chronic RV pacing. Rates of permanent pacemaker implantation have been increased over the last twenty years with expanding indications to include permanent pacing after AV node ablation for the treatment of drug refractory atrial fibrillation and other atrial tachy-arrhythmias. The current standard of practice is to minimize RV pacing however in patients that have had an AV node ablation right ventricular pacing cannot be avoided therefore it is important to identify if this particular group of patients is at an increased risk for developing worsening cardiac function. The purpose of this study is to compare cardiac function over time between patients that have undergone AV node ablation versus patients that have had pacemaker implantation for AV node dysfunction.

NCT ID: NCT03831204 Completed - Heart Failure Clinical Trials

Systolic Time Intervals a Prognostic Tool of Heart Failure in Emergency Departement (STI/AHF)

Start date: July 20, 2017
Study type: Observational

The performance of STIs and clinical scores alone and their combination to predict short term prognosis of acute decompensated heart failure.

NCT ID: NCT03728075 Completed - Clinical trials for Chronic Heart Failure

Neuromuscular Electrical Stimulation in Chronic Heart Failure Patient

Start date: January 21, 2017
Phase: N/A
Study type: Interventional

The purpose of the study is investigate the effects of NMES in regulation of serum IL-6 and IL-15 in chronic heart failure patients who received standard inpatient cardiac rehabilitation protocol

NCT ID: NCT03722069 Completed - Clinical trials for Heart Failure,Congestive

Dietary Sodium Intake in Acute Heart Failure

Start date: July 20, 2014
Phase: N/A
Study type: Interventional

This study is design to assess two levels of dietary sodium intake in the treatment of patients with Acute Decompensated Heart Failure.

NCT ID: NCT03717779 Completed - Dyspnea; Cardiac Clinical Trials

Contribution LUS in the Diagnosis of Acute Heart Failure (AHF) in Patients Admitted to the ED

Start date: January 2, 2016
Study type: Observational

This study assesses the potential of lung ultrasonography to diagnose heart failure.

NCT ID: NCT03710057 Completed - Clinical trials for Chronic Heart Failure

Effect of Ivabradine in Lowering Heart Rate and Quality of Life in Chronic Heart Failure Patients

Start date: December 1, 2016
Study type: Observational

Elevated Heart rate (HR) (≥ 70 bpm) is one of the contributing factors in increasing the burden of hospitalization among Heart Failure patient. Ivabradine is a novel, selective and specific in inhibiting a Funny current in sinoatrial node Node and approved as an alternative therapy for Chronic Heart Failure (CHF) patients. CHF patients when treated with Ivabradine reported 39%, and 30% reduction in mortality and hospitalization rate respectively. Patient were treated with Ivabradine 5mg twice daily to determine its effect in lowering Heart rate and the Quality of Life (QOL) in Chronic Heart Failure patients

NCT ID: NCT03701854 Completed - Clinical trials for Heart Failure Patients

Physical Impairments in Heart Failure Patients With Pacemakers

Start date: January 1, 2017
Study type: Observational

Despite major breakthroughs that have recently been made in pacemakers implanted in heart failure (HF) patients, it is clear that functional impairments and symptoms often remain. However, only limited studies have investigated exercise capacity, muscle strength, pulmonary function, dyspnea, and fatigue in pacemaker implanted HF patients. Therefore, investigators aimed to compare the aforementioned outcomes in patients and healthy controls.