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Heart Failure clinical trials

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NCT ID: NCT03751904 Withdrawn - Clinical trials for Heart Failure,Congestive

Early Feasibility Study to Assess Safety and Device Performance of AcoustiCareā„¢

Start date: January 25, 2019
Phase: N/A
Study type: Interventional

AcoustiCareTM is a non-invasive clinical tool used for the detection of intracardiac pressures using heart sounds in patients with heart failure.

NCT ID: NCT03519477 Withdrawn - Clinical trials for Heart Failure,Congestive

Comprehensive Medication Monitoring on Heart Failure Patient Outcomes

Start date: September 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the clinical utility of comprehensive medication monitoring using the Patient Medication Profile to improve heart failure patient medication therapy and associated outcomes relative to usual care in a hospital setting.

NCT ID: NCT03452683 Withdrawn - Heart Failure Clinical Trials

e-Diary in Heart Failure

Start date: April 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the efficacy and feasibility of using a smartphone application to monitor symptoms and weight in patients with advanced heart failure.

NCT ID: NCT03449121 Withdrawn - Clinical trials for Congestive Heart Failure

Study for Breathing Interventions in Congestive Heart Failure

Start date: November 2018
Phase: N/A
Study type: Interventional

Slow breathing may reduce stress. Adults with congestive heart failure have higher stress than the general population. This study will examine if using slow breathing is feasible among adults with heart failure.

NCT ID: NCT03415906 Withdrawn - Heart Failure Clinical Trials

Influences of Angiotensin-neprilysin Inhibition on Sympathetic Activity in Heart Failure

Start date: December 14, 2017
Phase: Phase 2
Study type: Interventional

The autonomic nervous system plays an important role in controlling the circulation. Increased sympathetic activity has detrimental effects in patients with heart failure. The purpose of this study is to test the hypothesis that combined angiotensin receptor + neprilysin inhibition results in lower sympathetic activity than angiotensin receptor inhibition alone.

NCT ID: NCT03340233 Withdrawn - Healthy Clinical Trials

Understanding the Mechanisms of Diastolic Dysfunction

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

Heart failure is a clinical syndrome marked by breathlessness, even at low levels of exertion, general fatigue, and fluid retention and is estimated to affect 5.1 million people in the United States. Heart failure with preserved ejection fraction (HFpEF) means that the heart pumps enough blood to the body, but patients still have terrible symptoms. It is estimated to account for about 50% of all heart failure cases. Experts agree that impaired filling of the heart, perhaps due to "stiffness" of the heart muscle itself, critically underlies HFpEF. There is currently no clinical technique for measuring heart muscle (myocardial) stiffness; the very definition of "myocardial stiffness" remains poorly established. Consequently, the ability to study the mechanisms that underlie HFpEF is virtually non-existent, and limited treatment options will persist without significant advances. The objective of this project is to use an Equilibrium-Material-Stability (EMS) framework that couples patient-specific clinical MRI and heart pressure data in a computational model of the heart to diagnose changes in myocardial stiffness. The central hypothesis is that the new EMS framework for understanding the mechanisms of diastolic dysfunction in HFpEF will be more sensitive and outperform currently available approaches.

NCT ID: NCT03298009 Withdrawn - Heart Failure Clinical Trials

Impact of a Short-term Treatment With Canagliflozin (Canacardia-HF)

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

It is a mechanistic proof-of-concept study to demonstrate how SGLT-2 inhibitors (Canagliflozin) may have a beneficial role on cardiac energetic efficiency. Patients with type 2 diabetes and with HF diagnosed for at least 3 months will be selected. The participants will be randomized to a double-blind, crossover 2-week placebo vs. Cana 100 mg once daily, an interventional trial with a one-month washout period in between. At the term of the two-week placebo and canagliflozin treatment periods (visits 2 and 4), each participant will undergo an identical postprandial metabolic study with positron emission tomography (PET) and stable isotopic tracer methods.

NCT ID: NCT03279861 Withdrawn - Hypertension Clinical Trials

Sacubitril-valsartan Versus Usual Anti-hypertensives in LVAD

Start date: November 2017
Phase: Phase 4
Study type: Interventional

This pilot, feasibility study evaluates the efficacy of sacubitril-valsartan (Entresto) versus usual anti-hypertensive medications in patients with left ventricular assist devices (LVAD). It also measures diurnal blood pressure variations in the context of continuous flow physiology.

NCT ID: NCT03227393 Withdrawn - Clinical trials for Heart Failure, Systolic

The Effect of Yoga on Cardiac Sympathetic Innervation Evaluated by I-123 mIBG

Start date: September 30, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate if yoga practice will reduce cardiac sympathetic activity and subsequently cardiac arrhythmias.

NCT ID: NCT03160625 Withdrawn - Clinical trials for Heart Failure With Preserved Ejection Fraction

Evaluation of Rate Adaptive Pacing on Chronotropic Response in Preserved Ejection Fraction HF

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

RESPOND-HF is a prospective, multi-center, non-significant risk pilot study with cross-over design. The purpose of the study is to investigate if rate adaptive pacing has the potential to provide benefit to HF patients with preserved ejection fraction, referred to as HFpEF patients. Findings from this pilot study may be used to guide subsequent efforts to design and conduct a prospective, randomized, multi-center pivotal trial powered to show improvement in patient outcomes.