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Heart Failure clinical trials

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NCT ID: NCT04945018 Recruiting - Heart Failure Clinical Trials

A Study of iPS Cell-derived Cardiomyocyte Spheroids (HS-001) in Patients With Heart Failure (LAPiS Study)

LAPiS
Start date: April 19, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this clinical study is to evaluate the safety and efficacy of HS-001 CS transplanted into severe heart failure patients with underlying ischemic heart disease for 26 weeks after transplantation.

NCT ID: NCT04944706 Recruiting - Clinical trials for Chronic Heart Failure With Preserved Ejection Fraction

Efficacy and Safety of Qishenyiqi Dripping Pills for Treating Chronic Heart Failure With Preserved Ejection Fraction

Start date: July 27, 2021
Phase: Phase 2
Study type: Interventional

Main objective: To evaluate the efficacy, safety and clinical dose exploration of Qishen Yiqi dripping pills in the treatment of chronic heart failure with preserved ejection fraction. Exploratory research objective: To explore the changes of endogenous substances in vivo before and after drug administration, to interpret the mechanism of drug action through metabolomics and systems biology methods, and to find potential clinical biomarkers for exploratory subgroup analysis of clinical trials.

NCT ID: NCT04941794 Recruiting - Type 2 Diabetes Clinical Trials

Biomarkers as Predictors of Chronic Heart Failure in Patients With Type 2 Diabetes

Start date: July 1, 2021
Phase:
Study type: Observational

A cohort study on patients with type 2 diabetes to investigate possible biomarkers as predictors of chronic heart failure.

NCT ID: NCT04939077 Recruiting - Myocardial Ischemia Clinical Trials

Treatment of Heart Failure Using Human Umbilical Cord Mesenchymal Stem Cells(hUC-MSC)

Start date: November 27, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This study is an exploratory clinical study to observe the improvement of heart function before and after the treatment by human umbilical cord mesenchymal stem cells, and the purpose is to evaluate the safety and effectiveness of human umbilical cord mesenchymal stem cells in the treatment of heart failure. The study is a randomized parallel controlled study. Patients receive a review of which main content includes symptom improvement, cardiac function improvement, and adverse events.

NCT ID: NCT04938661 Recruiting - Heart Failure Clinical Trials

Improving Cardiac Rehabilitation Outcomes Through Mobile Case Management (iCARE)

iCARE
Start date: July 8, 2021
Phase: N/A
Study type: Interventional

The purpose of this research is to find out if doing cardiac rehab at home, or a mix of cardiac rehab at home and in the clinic, is as effective as coming in to the clinic for cardiac rehab.

NCT ID: NCT04931550 Recruiting - Heart Failure Clinical Trials

Clinical Study of Impact of Different Pacing Site in Patients

Start date: August 1, 2020
Phase:
Study type: Observational

At present, cardiac pacing has been widely used in the treatment of bradyarrhythmias and heart failure, which can effectively improve the survival rate of patients. With the rapid development of technology, different sites can be chosen to pace, such as right atrial appendage, the atrial septum and the right atrial wall in the atrium, His bundle, left bundle branch area, right ventricular apex, outflow tract, and left ventricular pacing via coronary vein in the ventricle. There are few studies comparing the long-term efficacy and safety of different pacing sites in daily practice. This study aims to observe the efficacy and safety of cardiac pacing at different sites in short and long term, and to compare the advantages and disadvantages of pacing at different sites.

NCT ID: NCT04921293 Recruiting - Clinical trials for Heart Failure With Reduced Ejection Fraction

Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With Reduced Ejection Fraction

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

This randomized controlled trial will evaluate the effect of a ketogenic diet and/or exogenous administration of ketone bodies vs conventional diet on the ejection fraction of patients with non-ischemic chronic heart failure, measuring MRI biomarkers.

NCT ID: NCT04919733 Recruiting - Heart Failure Clinical Trials

Fluoroscopy Reduction or Elimination in CIED Implants

Start date: January 3, 2020
Phase: N/A
Study type: Interventional

CIED implants require different amounts of fluoroscopy; using 3-D mapping systems, these times could be reduced to near zero fluoroscopy. The investigators aim to describe to what extent fluoroscopy times are reduced on a routine basis on CIED implants

NCT ID: NCT04919447 Recruiting - Heart Failure Clinical Trials

Clinical Study of LBBP

Start date: June 1, 2021
Phase:
Study type: Observational

At present, cardiac pacing has been widely used in the treatment of bradyarrhythmias and heart failure, which can effectively improve the survival rate of patients. With the rapid development of technology, you can choose to pace the heart in different parts. The atrium can choose the right atrial appendage, the atrial septum and the right ventricular side wall. The right ventricle can choose to be paced in the His bundle, right ventricular apex and ventricular septal outflow tract. The right ventricle can choose the pacing positions including left bundle branch pacing and left ventricular pacing via coronary vein. There are few studies comparing the long-term efficacy and safety of different pacing programs in daily practice. This study is to observe the short-term and long-term effects and safety of different parts of cardiac pacing, and compare the advantages and disadvantages of different parts of cardiac pacing.

NCT ID: NCT04917159 Recruiting - Clinical trials for Chronic Heart Failure

Acceptance and Commitment Therapy for Patients With Chronic Heart Failure and Their Caregivers on Their Quality of Life

Start date: June 10, 2022
Phase: N/A
Study type: Interventional

This study is to examine whether group-based Acceptance and Commitment Therapy in the patient-caregiver dyads with Chronic Heart Failure is effective in improving dyadic health-related quality of life, dyadic psychological symptoms, caregiver burden, the rate of patient's readmission, and patient's self-care behavior in comparison with those dyads receiving health education over three-month post intervention.