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Myocardial Ischemia clinical trials

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NCT ID: NCT03841474 Recruiting - Depression Clinical Trials

The Recovery of Cardiovascular Patients With Depression

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

Cardiovascular disease increases the risk of depression and vice versa. Many cardiovascular patients are subjected to percutaneous coronary intervention (PCI). Potential biomarkers for the development, the course and the recovery of both diseases are in the focus of interest of many studies. One of the biomarkers that stands out is brain derived neurotrophic factor (BDFN). BDNF plays a significant role in regulating vascular growth and repair but also stimulates the survival, differentiation, and conservation of neurons. The aim of the study is to detect the depression in patients undergoing PCI and to determine the impact of psychiatric treatment on the functional recovery and on the changes of BDNF.

NCT ID: NCT03835923 Not yet recruiting - Clinical trials for Diabetes Mellitus, Type 2

Lifestyle Intervention in Chronic Ischemic Heart Disease and Diabetes

LeIKD
Start date: February 2019
Phase: N/A
Study type: Interventional

Chronic ischemic heart disease and diabetes mellitus type II have one of the highest morbidity and mortality rates. Especially in the presence of both diseases, these risks increase exponentially. The aim of this program is to reduce cardiovascular risk factors by promoting individual health literacy and a healthy lifestyle, thereby improving metabolism and reducing the progress of the disease as well as mortality. Patients will receive individual exercise prescriptions and nutritional recommendations. This lifestyle intervention is accompanied by step counters, heart rate sensors, blood glucose meters and smartphones to allow regional implementation in different areas in Germany. In total, 1500 patients with diabetes mellitus type II and chronic ischemic heart disease will participate in the trial. The project examines whether the intervention positively affects metabolic health and lifestyle behaviors, increases health literacy, and reduces cardiovascular events of these high risk patients. Furthermore, the effectiveness of the intervention will be compared between urban and rural areas.

NCT ID: NCT03834155 Not yet recruiting - Clinical trials for Coronary Artery Disease

Enhancing Cardiac Rehabilitation Through Behavioral Nudges

Start date: April 1, 2019
Phase: N/A
Study type: Interventional

Adherence to cardiac rehabilitation is poor, and worse for minorities, women, and those with lower levels of education. Patients less likely to be referred to and complete cardiac rehab are at highest risk of adverse outcomes and thus have the most to gain from participation in cardiac rehab. To improve participation, healthcare systems need to limit barriers to enrollment and promote adherence to rehabilitation.

NCT ID: NCT03832504 Recruiting - Clinical trials for Coronary Artery Disease

Identifying Strategies to Alleviate Cardiovascular Stress in Coronary Patients During Heatwaves

Start date: January 27, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the optimal cooling strategies to alleviate cardiovascular strain of coronary artery disease individuals during a simulated North American and Australian heatwave.

NCT ID: NCT03830554 Completed - Clinical trials for Coronary Heart Disease

Effect of Atlas Cedar Wood Essential Oil Aromatherapy on Sleep Quality of Patients After Coronary Heart Disease

Start date: July 30, 2018
Phase: N/A
Study type: Interventional

Sleep-wake disturbances were found to be a common problem among patients with CHD either earlier during hospitalization or/ and after discharge Although there is an evidence that sleep-wake disturbanes occur in high rate among patients with CHD little was found about assessment and management of this problem. This randomized controlled study will assess sleep quality of stable CHD patients who were admitted for undergoing coronary angiography electively. Then it will test the hypothesis that atlas cedar wood essential oil aromatherapy have a positive effect on sleep quality of CHD patients.

NCT ID: NCT03829046 Not yet recruiting - Clinical trials for Coronary Artery Disease

The Effects of Evolocumab in Patients With Myocardial Microvascular Dysfunction

Start date: April 1, 2019
Phase: Phase 4
Study type: Interventional

Experimental models have linked lipid lowering therapies with systemic inflammation; however, relatively little is known about this network in clinical populations and specifically how it changes with PCSK9 inhibition. The aim of the study is to define how PCSK9 inhibition alters the circulating monocyte populations and to systematically profile the transcriptional and proteomic responses to TLRS and how these responses are modulated by PCSK9 inhibition in the peripheral blood mononuclear cells (PBMC) clinical samples and relate these molecular signatures to clinical.

NCT ID: NCT03825250 Recruiting - Clinical trials for Coronary Artery Disease

The Val-CARD Trial

Val-CARD
Start date: November 6, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The Val-CARD trial aims to answer the question: "Does the drug sodium valproate reduce complications affecting the heart and kidneys in patients having heart operations?" Sodium valproate is a drug commonly used in the treatment of epilepsy. Recently it has been shown to protect against heart and kidney damage in laboratory tests. This has led to trials evaluating whether it can prevent heart and kidney damage in patients. The investigators wish to evaluate whether treatment with sodium valproate for a short period can reduce levels of organ damage following heart surgery by measuring this in blood tests, exercise tests, a special x-ray measuring body fat content, a walk exercise and muscle strength tests. The investigators now want to establish if sodium valproate works by making the heart and kidney more resistant to any injury that results from the use of the heart lung machine.

NCT ID: NCT03825224 Not yet recruiting - Clinical trials for Coronary Artery Disease

Evaluation of MyoStrain™ in Clinical Practice

Start date: February 4, 2019
Phase:
Study type: Observational

Evaluate MyoStrain cardiac MRI pulse sequence in Clinical practice

NCT ID: NCT03824600 Recruiting - Clinical trials for Coronary Artery Disease

Physiological Patterns of Coronary Artery Disease

Start date: November 24, 2017
Phase:
Study type: Observational [Patient Registry]

Registry of patients undergoing invasive fractional flow reserve measurement using a motorized device.

NCT ID: NCT03822949 Not yet recruiting - Myocardial Ischemia Clinical Trials

Bright Light Therapy in Patients Undergoing Cardiac Surgery

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I levels after surgery. In addition, we hypothesize that light therapy leads to Per2 dependent metabolic optimization in the human cardiac tissue. Therefore, a small piece of human heart tissue from the right atrium will be collected during cardiac cannulation, which will be otherwise discarded.