Clinical Trials Logo

Heart Failure With Reduced Ejection Fraction clinical trials

View clinical trials related to Heart Failure With Reduced Ejection Fraction.

Filter by:

NCT ID: NCT03816306 Recruiting - Clinical trials for Heart Failure With Reduced Ejection Fraction

Six Months Clinical and Echocardiographic Outcome of ARNI LCZ696 Therapy in HFrEF Patients

Start date: June 1, 2018
Phase:
Study type: Observational

To evaluate the clinical and echocardiographic outcome of LCZ696 therapy in HFrEF (NYHA Class II - IV and EF =≤ 40%).patients, in addition to the efficacy of LCZ696 in reducing mortality and rehospitalisation rate.

NCT ID: NCT03803111 Not yet recruiting - Clinical trials for Heart Failure With Reduced Ejection Fraction

Effects of Iron Therapy and Exercise Training in Patients With Heart Failure and Iron Deficiency

IronEx
Start date: February 2019
Phase: N/A
Study type: Interventional

It is the aim of the study to prove, if intravenous supplementation with ferric carboxymaltose in iron-deficient patients with heart failure with reduced ejection fraction (HFrEF) leads to better exercise training effects compared to exercise training without previous iron supplementation.

NCT ID: NCT03780803 Recruiting - Clinical trials for Pulmonary Hypertension

Effect of Home Rehabilitation on State of Patients With PAH, HFREF and IHD

Start date: February 1, 2016
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the influence of physical training and respiratory rehabilitation performed by patients at home on quality of life, symptoms, physical endurance, force of respiratory and skeletal muscles and body mass composition in patients with pulmonary arterial hypertension (PAH) or left ventricular heart failure with reduced ejection fraction - HFREF), or ischemic heart disease and evaluation the number of stem cells, natural lymphoid cells and distribution of subpopulations of monocytes (including proangiogenic monocytes) in examined persons and evaluation of theirs eventual influence of the course of disease.

NCT ID: NCT03759392 Not yet recruiting - Clinical trials for Heart Failure With Reduced Ejection Fraction

Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure

METEORIC-HF
Start date: February 28, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effect of treatment with omecamtiv mecarbil compared with placebo on exercise capacity as determined by cardiopulmonary exercise testing following 20 weeks of treatment with omecamtiv mecarbil or placebo

NCT ID: NCT03746938 Recruiting - Clinical trials for Heart Failure With Reduced Ejection Fraction

First in Humans to Evaluate Collagen Patches With Stem Cells in Patients With Ischemic Left Ventricular Dysfunction

CARDIOMESH
Start date: November 13, 2018
Phase: Phase 1
Study type: Interventional

It´s a first open-label trial in humans to evaluate the safety and efficacy of epicardial delivery of collagen patches with adipose-derived stem cells in patients with ischemic heart disease and left ventricular dysfunction that remain symptomatic despite optimal medical treatment.

NCT ID: NCT03701880 Active, not recruiting - Clinical trials for Heart Failure With Reduced Ejection Fraction

Early Use of Ivabradine in Heart Failure

Ivabradine
Start date: September 16, 2018
Phase: N/A
Study type: Interventional

The aim of the work is to Evaluate the efficacy, quality of life and safety of early addition of ivabradine to B-blocker in reduced EF heart failure patients after acute decompensation compared to the standard treatment.

NCT ID: NCT03644446 Recruiting - Clinical trials for Heart Failure With Reduced Ejection Fraction

Bisoprolol Plasma Residual Concentrations in Chronic Heart Failure

PREVALENT
Start date: November 2, 2017
Phase:
Study type: Observational [Patient Registry]

This study evaluate the dosage of bisoprolol plasma residual concentrations in chronic heart failure with mild to reduced ejection fraction adult patients by dose and renal function.

NCT ID: NCT03614169 Recruiting - Clinical trials for Heart Failure With Reduced Ejection Fraction

Direct HIS-pacing as an Alternative to BiV-pacing in Symptomatic HFrEF Patients With True LBBB

HISalternative
Start date: September 9, 2018
Phase: N/A
Study type: Interventional

The present study will randomize 50 symptomatic heart failure patients with severely reduced left ventricular ejection fraction (LVEF) and a true left bundle branch block to either direct HIS-pacing or biventricular pacing and follow them for at least six months. The outcome is how often it is possible to achieve HIS-pacing at implant and during follow-up and if HIS-pacing leads to differences in symptoms or measurable clinical parameters as compared to biventricular pacing.

NCT ID: NCT03574857 Enrolling by invitation - Heart Failure Clinical Trials

Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance

Start date: June 2018
Phase: Phase 4
Study type: Interventional

The primary objective of the study is to compare efficacy of metolazone and chlorothiazide as add-on therapy in patients refractory to loop diuretics with heart failure with a reduced ejection fraction (HFrEF). This will be a single-center randomized pilot study.

NCT ID: NCT03551756 Not yet recruiting - Clinical trials for Coronary Artery Disease

Assessment of Biomarkers in Patients With Decompensated Heart Failure and Underlying Coronary Artery Disease

Start date: June 2018
Phase:
Study type: Observational

Assessment of Biomarkers in Patients with Decompensated Heart Failure and Underlying Coronary Artery Disease