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Depression clinical trials

View clinical trials related to Depression.

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NCT ID: NCT03571412 Completed - Clinical trials for Major Depressive Disorder

Antidepressive Effect on 5 Herz (Hz) rTMS Over Dorsomedial Prefrontal Cortex and Left Dorsolateral Prefrontal Cortex

Start date: August 8, 2016
Phase: N/A
Study type: Interventional

This study evaluates the efficacy of 5Hz repetitive Transcranial Magnetic Stimulation (rTMS) over Left Dorsolateral Prefrontal Cortex and Dorsomedial Prefrontal Cortex on Major Depressive Disorder (MDD).

NCT ID: NCT03571386 Not yet recruiting - Depression Clinical Trials

Mechanisms of Mindfulness-based Interventions

MBI
Start date: July 2018
Phase:
Study type: Observational

Mindfulness-based Interventions (MBIs) are a family of standardized cognitive and behavioral therapies that focus on cultivating mindfulness-related skills for improving maladaptive cognitive, emotional, and behavioral processes. MBIs have been developed for a wide range of problems, disorders, and populations and are increasingly available in a variety of health settings. This mixed methods study proposes to investigate proposed neurobiological, physiological, psycho-social-behavioral, and cognitive mechanisms by which MBIs may improve health outcomes.

NCT ID: NCT03569475 Recruiting - Clinical trials for Major Depressive Disorder

Efficacy, Safety, and Tolerability of Levomilnacipran ER in Pediatric (7-17 Years) With Major Depressive Disorder

Start date: July 6, 2018
Phase: Phase 3
Study type: Interventional

The objective of this study is to evaluate the efficacy, safety, and tolerability of levomilnacipran compared with placebo in pediatric outpatients (7-17 years) with major depressive disorder (MDD)

NCT ID: NCT03567681 Enrolling by invitation - Bipolar Depression Clinical Trials

Comparison of Two Forms of Oxcarbazepine for the Treatment of Bipolar Depression

Start date: June 13, 2018
Phase: Phase 4
Study type: Interventional

Consenting subjects with Bipolar depression will remain under the care of their local (psychiatric) care provider and be randomized to a six week course of one of two forms of oxcarbazepine (extended release or immediate release. Study outcomes will be assessed based on outcome measures administered to the subject at home by a computer simulated rater. Local care providers will receive "pre-assessment" reports ahead of each clinical visit, rate the Clinical Global Impression for Severity, and evaluate adverse effects. The primary outcome variable is "treatment effectiveness" operationally defined as the response rate X the completion rate.

NCT ID: NCT03567330 Recruiting - Anxiety Clinical Trials

African American Families Fighting Parental Cancer Together

Start date: June 28, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to test the usefulness of a family-based program for African American parents/primary caregivers with newly diagnosed solid tumor cancer and their adolescent children. The program is designed to promote family communication reduce and depressive symptoms for adolescence.

NCT ID: NCT03567083 Recruiting - Depression Clinical Trials

Implementation of Problem Management Plus (PM+) in Adult Syrian Refugees in Turkey: Pilot

STRENGTHS
Start date: June 23, 2018
Phase: N/A
Study type: Interventional

To implement Problem Management Plus (PM+) in Syrian refugees with this pilot study in Turkey with the aim of informing the definitive RCT about drop-out rates and estimated effect sizes.

NCT ID: NCT03566069 Not yet recruiting - Depression, Anxiety Clinical Trials

Intranasal Oxytocin as Enhancer of Psychotherapy Outcomes in Severe Mental Illness

Start date: June 2018
Phase: Phase 2
Study type: Interventional

Intranasal administration of Oxytocin (OT) has been found to improve social communication skills and encoding of social cues. Studies indicate that the provision of OT enhances the ability to develop trust 1, to improve the benefits of social support during social stress induction tasks 2 and to increase positive communication during couples' conflict discussions 3. These studies, and many others, point to the potential beneficial effects of OT as a facilitator of relationship-focused processes such as psychotherapy. Studies assessing the effect of OT as a possible outcome enhancer in psychotherapy for clinical populations are scarce, and their findings are largely inconsistent 4. Reasons for this state of affairs include the complexity of recruitment in this population; the provision of single-dose OT, which tends to cause a lower and insufficient effect 5; and methodological constraints, such as the lack of a control group 6 or insufficient probing of interpersonal factors 7. In this study we intend to overcome these constraints by evaluating the impact of intranasal administration of OT in patients suffering from acute stages of anxiety and depression disorders and undergoing intensive, relationship-focused psychotherapy during psychiatric hospitalization. One-hundred-and-twenty admitted patients with anxiety and depression disorders will be randomized and double-blindly allocated to two groups: (a) psychotherapy + OT (n=60), and (b) psychotherapy + placebo (n=60). Patients will be followed for three weeks, beginning at the start of their hospitalization, and will be assessed for the severity of their anxiety and depression symptoms; their working alliance with their therapist; and their treatment outcome after each session. Psychotherapy will be delivered twice a week. Intranasal OT will be administered twice a day. This study can provide insights regarding the potential involvement of OT in the trajectories leading to the production of detectable changes in brain activity following psychotherapy. Additionally, it can support the development of an integrating model combining recent findings in psychotherapy research pertaining to the significant role of therapeutic alliance in psychotherapy outcome, and findings from neuroimaging studies. Finally, provision of OT as a psychotherapy enhancer can facilitate a rapid therapeutic response and subsequently replace aggressive psychiatric medication usage, needed to create a rapid decrease of distress during psychiatric admissions.

NCT ID: NCT03564847 Recruiting - Depression Clinical Trials

Learning Through Play (LTP) Plus Intervention for Depressed Fathers (LTP Plus Dads)

LTP Plus Dads
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the clinical and cost effectiveness of culturally adapted group parenting intervention delivered by non-specialists and community health workers for depressed fathers.

NCT ID: NCT03564431 Recruiting - T2DM Clinical Trials

The Imaging Genetic Study of Type 2 Diabetes and Depression

Start date: December 1, 2017
Phase:
Study type: Observational

To investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the Type 2 Diabetes Patient With Depression.

NCT ID: NCT03564067 Recruiting - Clinical trials for Major Depressive Disorder

MARt-Depression Trial

Start date: July 5, 2018
Phase: N/A
Study type: Interventional

This is an open label pilot feasibility study that will recruit 15 participants. The purpose of the pilot study will be to evaluate the feasibility of open label Transcranial direct current stimulation (tDCS) in combination with computerized cognitive behavior therapy (cCBT) to maintain wellness following an acute course of Electroconvulsive therapy (ECT) for up to 6 months.