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Depression clinical trials

View clinical trials related to Depression.

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NCT ID: NCT03951376 Recruiting - Depressive Symptoms Clinical Trials

Universal Preventive Resilience Intervention to Improve and Promote Mental Health for Teenagers

UPRIGHT
Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Adolescence is a period of many physical, mental, emotional, and social changes. It is also associated with risk behaviour conducts. Nonetheless, not all youths under disadvantage, adversity, or exposure to risk factors experience negative mental health outcomes. The concept of RESILIENCE provides one possible explanation for the ability of some individuals to maintain positive mental health. Resilience is thus the ability of an individual or community to adapt to life challenges or adversities while maintaining mental health and well-being. The increasing prevalence of mental disorders amongst children (around 10-20% of young people) makes positive mental health promotion in schools necessary through intervention programmes. UPRIGHT (Universal Preventive Resilience Intervention Globally implemented in schools to improve and promote mental Health for Teenagers) is a research and innovation project funded by the European Union´s Horizon 2020 programme (No. 754919). UPRIGHT general aim is to promote mental well-being and prevent mental disorders in youth by enhancing resilience capacities. It has been designed as a whole school approach addressing early adolescents, their families and the school community to finally create a real mental well-being culture at schools.

NCT ID: NCT03951350 Not yet recruiting - Depression Clinical Trials

Mediterranean Lifestyle Program in the Prevention and Treatment of Depression

Start date: May 2019
Phase: N/A
Study type: Interventional

Objective: To analyze the effectiveness and cost-utility as a coadjuvant treatment of subclinical, mild or moderate depression of the recommendations of Mediterranean lifestyles intervention in primary care patients.The effectiveness of a monitoring by Information and communications technology (ICTs), and the effectiveness of the intervention in chronic comorbid pathology will also be analyzed. Methodology: Design: Randomized multicentre pragmatic clinical trial in 3 parallel groups. Subjects: Primary care patients with subclinical, mild or moderate depression. Sample Size: We will recruit 250 patients to achieve a reduction of at least 4.8 points on the Beck depression scale. Interventions: 1. Usual antidepressant treatment with psychological advice and / or psychotropic drugs by the primary care physician (Treatment As Usual - TAU). 2. TAU + Mediterranean lifestyle (ML). Program that will work weekly in 6 sessions of 2 hours in a group to improve the following aspects: daily physical activity + adherence to the Mediterranean diet pattern + sleep hygiene + careful exposure to the ambient light. 3. TAU + ML + ICTs: recommendations of Mediterranean lifestyle (previous point) + monitoring using ICTs. Measurements: The main variable will be the depressive symptomatology evaluated by the BDI II and the secondary variables will be the quality of life, the use of health and social resources, and personal variables related to adherence to the program.

NCT ID: NCT03950661 Completed - Obesity Clinical Trials

Walking Green: The Effects of Walking in Forested and Urban Areas

NUWG
Start date: June 1, 2016
Phase: N/A
Study type: Interventional

This research hypothesizes that moderate physical activity in a "green environment" (e.g. a forest preserve path) has increased benefits on psychological measures (stress, anxiety, mood, depression, attention) and on physiological measures (Heart Rate Variability, Blood Glucose, Salivary Cortisol) when directly compared to activity in a "gray environment" (urban or suburban sidewalks). The study design is a randomized crossover design in which each subject is assigned randomly to a group which determines the order in which participants will walk in each location. Subjects will take three 50-minute walks per location in one week, with half of the subjects taking the urban walks first as per group assignment. Control data are collected on days when participants do not walk. Physiological data are taken during walks and control periods (heart rate, heart rate variation). Biomarker samples (saliva, dried blood spots) are taken on selected days. Psychological data are take before and after walks and control periods.

NCT ID: NCT03949465 Not yet recruiting - Clinical trials for Postpartum Depression

rTMS for Peripartum Depression

Start date: July 2019
Phase: Phase 4
Study type: Interventional

Repetitive Transcranial Magnetic Stimulation (rTMS) is a neuromodulatory technique that is effective in major depression. There is preliminary evidence suggesting that rTMS is effective in peripartum depression as well, however this comes from a number of very small studies. The objective is to study the effectiveness of rTMS in peripartum depression. The investigators will do so using an open label design in which participants will receive rTMS for four weeks. The focus is on clinical improvement in depressive symptoms; however the investigators will also look at other aspects such as perinatal anxiety and maternal-infant bonding as measured by self-report questionnaires.

NCT ID: NCT03947827 Not yet recruiting - Clinical trials for Treatment Resistant Depression

Minocycline as Adjunctive Treatment for Treatment Resistant Depression

MINDEP2
Start date: August 2019
Phase: Phase 3
Study type: Interventional

Major depressive disorder (MDD) is a leading cause of disability worldwide. Up to 50% of patients experience treatment resistant depression (TRD), which accounts for a vast majority of disease burden. Current medications for TRD have limited efficacy and can be associated with intolerable side effects. Therefore, there is a need for finding new treatment targets. Accumulating evidence suggests some patients with MDD including those with TRD, display brain inflammation. Thus, patients with TRD may benefit from medications that can reduce this inflammation. Minocycline is an antibiotic which can cross the blood-brain barrier and has effects on several systems implicated in depression. The principal investigator led the first pilot study of minocycline as an add-on treatment in TRD demonstrating that it led to a significant reduction in depressive symptoms compared to placebo and these findings require replication in a larger sample to confirm the efficacy and tolerability of this treatment approach. This study is a 12 week, double-blind, placebo-controlled trial of minocycline as add-on treatment for patients suffering from a major depressive episode who have failed to respond to at least two adequate trials of antidepressant treatment. After screening and randomization to the two parallel arms of the trial, 50 patients will receive minocycline added to treatment as usual (TAU) and 50 patients will receive placebo added to TAU. Clinical assessment will include the Hamilton Depression Rating Scale (HAMD-17), Clinical Global Impression scale (CGI), Patient Health Questionnaire (PHQ-9), and the Generalized Anxiety Disorder scale (GAD-7) at each study visit (screening, baseline, week 2, 6, and 12). Side effects checklists will be undertaken at each visit. Minocycline will be started at 100 mg once daily and will be increased to 100 mg twice daily at two weeks. Secondary outcomes include inflammatory biomarkers measured at baseline, weeks 6 and 12. This trial will provide further evidence of minocycline's efficacy and acceptability as a treatment option for patients with TRD and provide insights into its mechanism of action.

NCT ID: NCT03945136 Recruiting - Depression Clinical Trials

Implementation of Brief Dynamic Interpersonal Therapy at the VA

DIT
Start date: March 15, 2016
Phase:
Study type: Observational

The goal of the proposed project is to collect data from clinician files and the electronic medical record to describe the clinical implementation of Brief Dynamic Interpersonal Therapy (DIT), an individual psychotherapy for depression and anxiety, at the VA through psychology staff and trainees between 2012-present.

NCT ID: NCT03944733 Not yet recruiting - Clinical trials for Iron Deficiency Anemia

Iron Status, Maternal Depressive Symptoms, and Mother-child Interactions

IDinteract
Start date: June 1, 2019
Phase: N/A
Study type: Interventional

This study aims to examine the relation between iron status and maternal-child interactions as well as maternal depressive symptoms in mothers from central Pennsylvania.

NCT ID: NCT03944213 Recruiting - Depression Clinical Trials

Resting-state Functional Connectivity Throughout a Course of iTBS in Major Depression

Start date: July 23, 2018
Phase:
Study type: Observational

This study aims to investigate changes in functional connectivity over a four week treatment course with intermittent theta burst stimulation (iTBS) in patients with major depressive disorder (MDD). To this end, seven weekly resting-state fMRI (rs-fMRI) scans at 7 tesla (7T) will precede, accompany and follow the iTBS treatment course. By obtaining several samples of the modulatory effects of iTBS on functional connectivity networks and simultaneous measurements of the depressive symptoms it will be possible to assess the time course of changes in connectivity across different networks, and to assess the overall relationship between the network modulation and the antidepressant effects of the treatment over time.

NCT ID: NCT03942627 Not yet recruiting - Anxiety Clinical Trials

Promoting Maternal Mental Health and Wellbeing in Neonatal Intensive Care

Start date: May 2019
Phase: N/A
Study type: Interventional

This small randomized pilot study will evaluate feasibility and preliminary outcomes of an audio-delivered mindfulness program to reduce psychological distress for mothers with an infant in neonatal intensive care, as compared with an active control condition.

NCT ID: NCT03941301 Not yet recruiting - Depressive Disorder Clinical Trials

Light Therapy on Major Depression Disorder

Start date: May 2019
Phase: N/A
Study type: Interventional

Background: Major depression disorder is a common psychological disease. It is the second-ranked cause of disability worldwide. The pathophysiology is not yet understood. The main theory is monoaminergic theory based on the effect of monoaminergic drugs. Current treatment includes psychotherapy, medication and electroconvulsive therapy. The onset of action for antidepressant is often slow, therefore strategies to improve the outcome are important. Bright light therapy has been found to be effective in reducing the severity of depression not only in seasonal affective disorder but also in other affective disorder. Previous meta-analyses of light therapy for non-seasonal major depression, however, has yielded conflicting evidence for efficacy. Purpose: 1. To investigate possible imaging biomarkers of major depression disorder 2. To evaluate the effect of light therapy on depression Materials and Methods: This prospective study will recruit 100 patients, randomized into 2 study groups: (1) antidepressant plus treatment light, and (2) antidepressant plus placebo light. All patients will accept a thorough psychological evaluation (including Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale, Clinical Global Impression-Severity and Patient Health Questionnaire-9 items) at baseline and at the 2nd, 4th, 8th week during the 8-week experiment intervention, by a blind assessor. Mini-International Neuropsychiatric Interview (MINI) and Morningness- Eveningness Questionnaire-Self-Assessment Version (MEQ-SA) were only evaluated at baseline. Adverse events were evaluated at baseline, 2nd,4th,8th weeks. MRI study will be arranged at baseline and in 4-week experiment. Predicted Results and Influence: 1. To evaluate the additional effect of the treatment light on depression disorder 2. To compare the difference of functional magnetic resonance imaging(fMRI), structural MRI among the two groups and between the patients with and without treatment effect in order to detect imaging biomarkers.