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Depression clinical trials

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NCT ID: NCT03887312 Not yet recruiting - Depression Clinical Trials

Phone-Delivered Psychological Intervention (t-CETA) for Mental Health Problems in 8-16 Year-Old Syrian Refugee Children

t-CETA
Start date: April 1, 2019
Phase: N/A
Study type: Interventional

This study evaluates the effectiveness of t-CETA, a version of Common Elements Treatment Approach (CETA) adapted to be delivered over the telephone, in treating common mental health problems in 8-16 year old Syrian refugee children living in Lebanon. Children will be randomly assigned to receive either t-CETA or treatment as usual provided by Médecins du Monde, an NGO providing medical and mental health services to Syrian refugees in Lebanon. Symptoms of common mental health problems, including anxiety, depression, PTSD, and behavioural problems, and psychological well-being, will be measured before treatment, immediately after treatment, and three months after treatment is completed. Groups will be compared to determine if t-CETA is at least as effective as standard treatment provided by Médecins du Monde.

NCT ID: NCT03882411 Not yet recruiting - Clinical trials for Coronary Heart Disease

An IT Approach to Implementing Depression Treatment in Cardiac Patients (iHeart DepCare)

Start date: June 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the effect of a brief electronic shared decision making (eSDM) intervention on depressive symptoms in coronary heart disease patients with elevated depressive symptoms.

NCT ID: NCT03881449 Not yet recruiting - Schizophrenia Clinical Trials

DIMES - DIgital MEdicine Study for Adults With Schizophrenia, Bipolar I Disorder, or Major Depression Currently Using Aripiprazole

DIMES
Start date: March 2019
Phase: Phase 4
Study type: Interventional

This is a 12 month, pragmatic trial designed to assess the differences in a digital medicine system (DMS)- ABILIFY MYCITE (Aripiprazole tablets with sensor)- measuring adherence versus treatment as usual (TAU) for adult patients with schizophrenia, bipolar I disorder, and major depression. Outcomes of interest will be adherence as measured by refill rates and all-cause and psychiatric health care use. Each patient will be in the study for a duration of 12 months. All treatment medication decisions will be made by the healthcare professionals (HCPs) and not by protocol. Psychiatrist(s), nurse(s) and/or team manager(s) who will be responsible for subjects' care, will be considered as HCPs in this trial.

NCT ID: NCT03880032 Not yet recruiting - Anxiety Clinical Trials

Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention

HMHB
Start date: April 15, 2019
Phase: N/A
Study type: Interventional

In the proposed study the investigators will develop an early prenatal preventive intervention targeting anxiety and conduct a randomized controlled trial in Pakistan to test its efficacy in reducing generalized anxiety disorder and major depression in mothers in late pregnancy and the postnatal period. Investigators will evaluate the impact of the intervention on fetal and infant growth restriction as well as examine how the impact of the intervention is mediated (to elucidate mechanisms) and/or modified (to help optimize future adaptations of the program) by various social factors. A cost-effectiveness evaluation will shed light on the costs and benefits of intervention components in relation to outcomes, enabling policy-makers and public health planners to scale up this intervention according to resource budgeting requirements.

NCT ID: NCT03879525 Not yet recruiting - Depression Clinical Trials

EMR Outcomes: Anxiety and Depression in Epilepsy

Start date: September 2019
Phase: N/A
Study type: Interventional

The purpose of this research is to find out how people with epilepsy and possible symptoms of anxiety or depression are doing for 6 months after a regular epilepsy clinic visit. Participants in this study will complete questionnaires either by phone or via the patient portal.

NCT ID: NCT03872492 Not yet recruiting - Clinical trials for Depressive Disorder, Major

Major Depressive Disorder: Early Prediction of Non-response to Antidepressant Therapy Via a Mobile Digital Scale

REDRESS
Start date: May 2019
Phase: N/A
Study type: Interventional

Major Depressive Disorder (MDD) is a debilitating disease characterized by a depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleep or appetite. MDD occurs about twice as often in women than it does in men and affects about 6% of the adult population worldwide each year. Standard symptoms scales like the Hamilton Depression Rating Scale or the Montgomery-asberg Depression Rating Scale, the Self-Report 16-item Quick Inventory of Depressive Symptomatology were initially developed for the evaluation of a therapeutic intervention or a pharmacological treatment and are routinely used by clinicians in the assessment of Treatment Resistant Depression (TRD) occurrence. In parallel, patient-reported outcomes have gained increasing importance and are widely recommended by health authorities in the assessment of depression. The same institutions insist on the collection of real-world data to provide clinicians with ecological measurements. It has been demonstrated that an early response to an AntiDepressant (AD) treatment can be seen as early as week 2 and is not related to a placebo-effect. While there is no consensus on the exact cut-off values, several factors emerge as early predictors of a later treatment response, such as: - Improvement in emotional processing of happy facial expressions after 1 week of treatment, - Circa 20% improvement in Hamilton Depression Rating Scale-17 item (HDRS-17) at week 2. The hypothesis is therefore that repeated, systematic and real-time, contextualized and multimodal collection of depressive symptoms from patients at home will establish a threshold score that can predict a subsequent response to their treatment. REDRESS was inspired by several standard depression scales used and recommended by the French Health Authority, augmented with digital active and passive activity monitoring, speech analysis and emotional processing assessment. Another important assumption is that honesty and willingness to disclose personal or embarrassing things will be best achievable via a digital solution. To test this assumption, the overall scores and each subscores on the REDRESS numerical scale will be compared in people with MDD showing adequate response to those showing insufficient response. The response to treatment at week 6 will be studied (end of Phase 1). Non-responders and responders to the first treatment round will be enrolled in a 6-week extension phase (Phase 2). Non-responders will receive another treatment course (Other AD, combination, etc.). Responders will just be followed up and will keep the same treatment. The REDRESS scores will be analysed in this population and will allow us to test the investigator's assumption in people with treatment resistant depression. This study will also allow to assess patients' quality of life at the end of each phase of treatment and to compare results with REDRESS scores.

NCT ID: NCT03870776 Not yet recruiting - Depression Clinical Trials

RESIST : Administration of MAP4343 in Antidepressant Non-Responders Patients Experiencing a Major Depressive Episode

Start date: April 1, 2019
Phase: Phase 2
Study type: Interventional

The study is a phase II, double-blind, randomized, placebo controlled, parallel, multicentric study in 110 patients with drug resistant depression.

NCT ID: NCT03870360 Not yet recruiting - Depression Clinical Trials

Preventing Anxiety and Depression in Older Hispanics

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to look at the best ways to prevent anxiety and depression in older Latino adults who are at risk for developing anxiety and depression. Participants will be randomized to either a health promotion intervention or a healthy lifestyles education program.

NCT ID: NCT03869463 Not yet recruiting - Depressive Symptoms Clinical Trials

Computerized Cognitive Training in Young Adults With Depression

Start date: April 2019
Phase: N/A
Study type: Interventional

The purpose of the study is to examine the benefits and mechanism of action of computerized cognitive training (CCT) on mood, neuropsychological deficits, everyday functioning, and brain activity among young adults with a range of depressive symptoms.

NCT ID: NCT03869424 Not yet recruiting - Depression Clinical Trials

Influence of Expectations on Rumination

Start date: April 20, 2019
Phase: N/A
Study type: Interventional

The study tries to identify whether positive expectations, induced with an active placebo nasal-spray, have effects on rumination.