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Depression clinical trials

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NCT ID: NCT03196544 Not yet recruiting - Depression Clinical Trials

Novel Behavioral Intervention to Enhance Social Connections in Anxiety and Depression

Start date: September 2017
Phase: N/A
Study type: Interventional

The overall goal of this project is to develop a novel transdiagnostic behavioral treatment -- social approach training -- intended to enhance positive social connections in individuals with elevated anxiety and/or depression. Social relationship impairments are pervasive and debilitating consequences of anxiety and depression. Existing treatments have some beneficial impact on social functioning; however, many people continue to have few and/or poor quality relationships following treatment, even after experiencing symptom relief. This study will evaluate the effects of social approach training on the brain systems that have been shown to be important for establishing positive connections with others. Approximately 60 individuals (ages 18-55) seeking treatment for anxiety or depression will participate in this study. Participants will be randomly assigned with equal probability to one of two versions of social approach training (5 or 10 sessions) or a waitlist (assessment only) control group. Participants will be assessed at baseline and post-treatment and compared on measures assessing brain responses to social reward (primary outcome), as well as physiological, behavioral, and emotional responses to social reward (secondary outcomes). It is hypothesized that participants assigned to social approach training will display greater increases from pre- to post-treatment in activity in brain systems that regulate the processing of social reward (e.g., striatum) relative to participants in the control group. This study will also determine whether the 5- vs. 10-session versions of the treatment program result in meaningful differences, compared to each other, in how the brain responds to social reward.

NCT ID: NCT03195231 Not yet recruiting - Clinical trials for Antidepressive Agents

Wuling Powder for the Treatment and Underlying Mechanism of Depressive Symptoms in Patients With Parkinson's Disease

Start date: June 25, 2017
Phase: Phase 4
Study type: Interventional

Depression is one of the most important nonmotor features of idiopathic PD(Parkinson's disease )which may not just interfere with the motor symptoms of PD but can also cause immense personal suffering as well as decreased quality of life with increased disability and caregiver burden. However,there is little hard evidence to guide clinical treatment. Although some newer dopamine agonists also have antidepressive effect, the use of tricyclic or nontricyclic antidepressants is frequently required.However, the side-effects of these agents may also worsen some preexisting nonmotor problems in PD. Wuling powder is a Chinese medicine which is made by cultivating Xylariasp mycelium using submerged fermentation technology. Xylariasp is the fungus sclerotia which grow in termite nests. Wuling powder is mainly used to soothe nerves and anti-insomnia in clinical. The antidepressant effect of Wuling powder has been confirmed in clinical, but not in the patients of Parkinson`s disease. Therefore, the investigators design a randomized, double-blind, placebo-controlled study to evaluate the antidepressant effect of Wuling powder in PD patients and its underlying mechanism.

NCT ID: NCT03194997 Not yet recruiting - Breast Cancer Clinical Trials

Pilates and Dance to Breast Cancer Patients Undergoing Treatment

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

Breast cancer is one of the most common types of cancer in Brazil, and its treatment, namely surgery, chemotherapy, radiotherapy or hormone therapy, has consequences and side effects that significantly affect the quality of life and associated physical and psychological factors. The practice of physical activity, in turn, may play a beneficial role in these factors, and help the recovery of the patient in relation to the consequences of the treatments. Two types of physical activity can be addressed in the context of breast cancer; Dance and the Pilates method. Thus, the objective of the present study will be to analyze the impact of Pilates practice and dance on quality of life and on psychological and physical factors in patients undergoing adjuvant treatment of breast cancer. Patients older than 18 years who are in adjuvant treatment, namely, chemotherapy, radiotherapy and / or hormone therapy at the Oncology Research Center - CEPON, will be invited to be part of the study. With a randomized clinical trial of three arms, the patients will be submitted to 16 weeks of intervention, and randomized in 3 groups: (A) belly dance protocol group; (B) Pilates method protocol group, and (C) control group who will continue with their routine activities. Sample randomization will be conducted in confidence by one of the researchers in a specific computer program. Information about personal and clinical characteristics, quality of life, psychological factors (depressive symptoms, body image, self-esteem, optimism, perceived stress, fatigue, pain, sexual function and sleep quality) and physical factors (cardiorespiratory fitness, balance , Posture, upper limb functionality and presence of lymphedema). All information will be collected before and after the intervention period. Statistical analysis will use the statistical package SPSS - IBM, version 20.0. Firstly, descriptive statistics (mean, standard deviation and percentage) will be used in order to know the data, and then the Anova two way test with repeated measurements and Sydak Comparison Test, in order to analyze the data. Groups of the Pilates method, of the dance and control group. Significance level of 5%.

NCT ID: NCT03191058 Not yet recruiting - Depression Clinical Trials

Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression

CREST-MST
Start date: July 2017
Phase: N/A
Study type: Interventional

The study will involve a randomized, double blind, non-inferiority clinical trial with two treatment arms conducted in two international academic medical centers (CAMH and UT Southwestern). The investigators are pursuing a non-inferiority clinical trial in an effort to compare MST - a new treatment in TRD - to RUL-UB-ECT with the primary aim of demonstrating that MST is non-inferior to RUL-UB-ECT vis à vis remission of suicidal ideation. Treatment will be administered three days per week. Suicidal ideation will be assessed using the SSI. Depressive symptoms will be assessed with the HRSD-24 to ensure comparability with previous NIMH supported brain stimulation treatment studies. Remission will be defined as a SSI=0 and HRSD-24 < 10 and > 60% decrease from baseline over 2 consecutive ratings. Therefore, there will be no specific minimum number of treatments that patients must receive to be classified as remitters. Patients who do not meet remission criteria after 21 treatment sessions will be considered non-remitters. This maximum treatment number was chosen considering the possibility that MST and RUL-UB-ECT may require more treatment sessions to achieve remission. Also, the pilot data from the CAMH study site demonstrated that the mean number of MST treatments needed to achieve remission was 14.67 + 6.35 treatments. Upon completion of the study, remitters and non-remitters will be referred back to their referring clinician for treatment as usual, which may include MST, ECT, ECT plus pharmacotherapy or psychotherapy, depending on provider recommendation and patient preference. The subject blind will be maintained until the completion of the entire study.

NCT ID: NCT03190772 Not yet recruiting - Clinical trials for Major Depressive Episode

The Role of Expectations in the Pharmacological Treatment of Depression - An Experimental Investigation

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

The study aimes at identifying whether positive expectations have an impact on the way depressive participants experience emotions in the form of sadness.

NCT ID: NCT03188575 Not yet recruiting - Depression Clinical Trials

Effectiveness & Cost-effectiveness of Internet-delivered Interventions for Depression and Anxiety Disorders in IAPT

D-IAPT
Start date: July 25, 2017
Phase: N/A
Study type: Interventional

Depression and anxiety are common mental health problems. There are effective treatments for depression and anxiety and one of these is talking therapies using cognitive behaviour therapy (CBT). In recent years CBT has been transferred to online delivery methods and these interventions have proven successful for people being treated with symptoms of depression and anxiety. The current study will utilise a randomised controlled trial design, where the majority (n=240) of participants will be allocated to the immediate treatment (internet-delivered CBT for either depression or anxiety), and a smaller number (n=120) will be allocated to a waiting list. The waiting list group will receive treatment after an eight week wait. This design helps us to understand that any changes in symptoms in the treatment group will be likely due to the treatment they received compared to the waiting list. A sample size of 360 participants is proposed and has been adjusted to ameliorate against patient dropout. Follow-up and maintenance of any positive changes in symptoms is very important in CBT for depression and anxiety, simply because some people can have a relapse of symptoms. We will therefore follow-up the treatment group for 3, 6, 9 and 12 months to assess maintenance of positive gains from treatment. The study also seeks to investigate the cost effectiveness of the treatments.

NCT ID: NCT03185819 Not yet recruiting - Clinical trials for Depressive Disorder, Major

Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for Suicide

Start date: August 14, 2017
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the efficacy of a single (first) dose of 3 fixed doses of intranasal esketamine {28 milligram (mg), 56 mg, and 84 mg} compared with psychoactive placebo (oral midazolam) in rapidly reducing the symptoms of major depressive disorder (MDD) including suicidal ideation in participants 12 to less than 18 years of age who are assessed to be at imminent risk for suicide.

NCT ID: NCT03183947 Not yet recruiting - Depression Clinical Trials

Symptom Based Treatment Affects Brain Plasticity - Cognitive Training in Patients With Affective Symptoms

APIC-II
Start date: June 2017
Phase: N/A
Study type: Interventional

The aim of the study is the examination of brain plasticity on on affective symptoms after neuromodulation with fMRI (functional magnetic resonance imaging) neurofeedback. During the fMRI neurofeedback training, patients with depression as well as patients with schizophrenia are trained to consciously regulate the activity of areas which are associated with the cognitive reappraisal of emotional stimuli.The aim is to improve the patients' subjective emotional processing and perception in everyday life as well as to investigate the impact of neurofeedback on resting-state networks in the brain. Healthy participants will be investigated as control group.

NCT ID: NCT03183505 Not yet recruiting - Clinical trials for Major Depressive Disorder

Comparison of Anyu Peibo With Placebo in Treatment of MDD,Ⅱb

Start date: June 2017
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of Anyu Peibo Capsule comparing with placebo in the treatment of Chinese Patients with Depression. And to provide some scientific evidence for protocol designing in following phase Ⅲ clinical trial.

NCT ID: NCT03181529 Not yet recruiting - Clinical trials for Major Depressive Disorder

Effects of Psilocybin in Major Depressive Disorder

Start date: June 2017
Phase: Phase 2
Study type: Interventional

The proposed pilot study will assess whether people with major depressive disorder experience psychological and behavioral benefits and/or harms from psilocybin. This study will investigate acute and persisting effects of psilocybin on depressive symptoms and other moods, attitudes, and behaviors. Our primary hypothesis is that psilocybin will lead to rapid and sustained antidepressant response, as measured with standard depression rating scales.