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Bipolar Disorder clinical trials

View clinical trials related to Bipolar Disorder.

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NCT ID: NCT06313918 Recruiting - Bipolar Disorder Clinical Trials

Exercise Therapy in Mental Disorders-study

Start date: September 27, 2023
Phase: N/A
Study type: Interventional

The study will compare standard high-intensity training with brief high-intensity training in people with schizophrenia-spectrum or bipolar disorder. The overall aim is to determine which of the two is superior in a long-term perspective.

NCT ID: NCT06296784 Completed - Bipolar Disorder Clinical Trials

An E-health Psychoeducation for People With Bipolar Disorders

Start date: May 26, 2021
Phase: N/A
Study type: Interventional

This study aims to present data on the improvement of QoL, biological rhythms, anxiety, depressive symptoms and the correlations between QoL and biorhythms following an e-health psychoeducational intervention for BD during Covid-19 pandemic

NCT ID: NCT06282250 Not yet recruiting - Bipolar Disorder Clinical Trials

Seeing the Light: Early Intervention in People at Risk for Bipolar Disorder

Start date: April 2024
Phase: N/A
Study type: Interventional

In the current study, the feasibility, acceptability and effectivity of a new add-on early intervention program for individuals at risk for the development of bipolar disorder is evaluated. This intervention program entails psycho-education, light and lifestyle therapy in combination with Imagery focused Cognitive Therapy (ImCT). The program aims to contribute to early intervention by focusing on subclinical mood swings, anxiety symptoms, circadian rhythm and lifestyle factors such as activity level. We hypothesize a relationship between this early intervention and a significant improvement in mood symptoms, anxiety, subjective and objective sleep factors and lifestyle variables. Also, the feasibility, acceptability and associations with clinical improvement of symptoms will be studied.

NCT ID: NCT06274567 Not yet recruiting - Bipolar Disorder Clinical Trials

Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The objective of this study protocol is to test whether intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) can strengthen functional connectivity with a key region in emotion regulation (ER) neurocircuitry (anterior insula, AI) and improve performance on ER-related tasks in patients with bipolar disorder. Individual IPL sites for stimulation will be identified through baseline, pre-TMS functional magnetic resonance imaging (fMRI) scans. Patient-specific IPL subregions showing positive functional connectivity with the anterior insula and falling within the patient-specific frontoparietal control network will be used as individualized target sites for TMS stimulation. Patients will be randomized to receive 24 sessions of active versus sham iTBS to patient-specific IPL targets (6 sessions/day, 4 days, 43,200 pulses total). Post-iTBS resting-state and task-based fMRI scans will be acquired 3 days after the final day of iTBS administration (Day 4) following identical procedures as baseline. Effects of iTBS-TMS on ER will be evaluated by comparing pre-TMS versus post-TMS functional connectivity and behavior during performance on ER tasks.

NCT ID: NCT06271304 Not yet recruiting - Bipolar Disorder Clinical Trials

Stabilizing Mood and Sleep With Blue Blocking Eyewear in Bipolar Disorder

BLUES
Start date: March 1, 2024
Phase: N/A
Study type: Interventional

The study investigates whether add-on treatment with eyewear that blocks the short wavelengths of visible light (<500nm) reduces manic symptoms and improves sleep in patients receiving outpatient treatment as usual for bipolar disorder. When in a hypomanic or manic phase, participants will be randomized to receive add-on treatment with either blue blocking or low filtration eyewear from 18 PM to 8 AM daily for 7 days. After this initial intervention phase, the eyewear is used daily for 3 months in either antimanic dose (14 hours) or maintenance dose (2 hours before bedtime).

NCT ID: NCT06235177 Not yet recruiting - Anxiety Clinical Trials

Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairments From Health Issues

PNMD
Start date: January 21, 2024
Phase: Early Phase 1
Study type: Interventional

Psychoneuromentalism Disorder is a disorder arising in the mind; that is related to the mental and emotional state of a person. It is the science of mental life. The body has a natural design to heal itself. This is a mental phenomena that cannot be explained, until now. Psychoneuromentalism Disorder is a new condition resulting from behavioral impairments, neurodiversity, and neurobehavioral dysfunctions that are related to the mental and emotional state of a participant.

NCT ID: NCT06229977 Recruiting - Bipolar Depression Clinical Trials

A Trial of the Fatty Acid Amide Hydrolase Inhibitor Palmitoylethanolamide in Bipolar Depression

Start date: May 17, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to o evaluate the antidepressant efficacy of the PEA in Bipolar Depression and the association between antidepressant response with endogenous cannabinoids and cytokine levels

NCT ID: NCT06229210 Recruiting - Schizophrenia Clinical Trials

Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia or Bipolar Disorder

Start date: January 25, 2024
Phase: Phase 3
Study type: Interventional

This is a multicenter, global, 26-week, open-label study to assess the safety and tolerability of lumateperone in pediatric patients with schizophrenia or bipolar disorder.

NCT ID: NCT06226025 Not yet recruiting - Bipolar Disorder Clinical Trials

Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

Start date: March 2024
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test whether a dietary supplement (low-dose melatonin) commonly used to treat night owls, administered in conjunction with a behavioral sleep intervention, will help to shift the brain clock earlier and improve mood and sleep in bipolar disorder. Eligible participants will be randomized to receive melatonin plus a behavioral sleep intervention or placebo plus a behavioral sleep placebo. The hypotheses for this study include: - Melatonin plus behavioral sleep intervention (compared to placebo plus behavioral sleep placebo) will produce a greater advance of dim light melatonin onset (DLMO), between pre- and post-treatment. - Melatonin (compared to placebo) will produce a greater reduction in Patient Health Questionnaire-9 score between pre- and post-treatment.

NCT ID: NCT06221852 Recruiting - Clinical trials for Schizoaffective Disorder

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

Start date: March 5, 2024
Phase: N/A
Study type: Interventional

This is a randomized, controlled clinical trial to assess the effects of the ketogenic diet in combination with treatment as usual on brain energy metabolism and psychiatric symptoms in individuals with first episode bipolar disorder and schizoaffective disorder.