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Depression clinical trials

View clinical trials related to Depression.

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NCT ID: NCT02546024 Suspended - Clinical trials for Depressive Disorder, Major

Predictors of Treatment Response in Late-onset Major Depressive Disorder

Start date: September 2015
Phase: N/A
Study type: Observational

Depression is a common disorder, especially in old age, where it is associated with significant morbidity and mortality. This study will investigate whether there are features of individual patients with major depression that may predict positive treatment response. The study will invite 40 patients who have been diagnosed with major depressive disorder with onset after the age of 60 years to participate. Participants will be recruited from the Mental Health of Older Adults services at the South London and Maudsley NHS Mental Health Foundation Trust. Participants will receive usual treatment as set out in standard Care Pathways, used by the clinical care team. As part of the study, they will undergo a short battery of neuropsychological tests and a standard MRI brain imaging protocol. The neuropsychological tests and assessment of depression severity will be carried out twice (at Baseline and Week 12). Data will be analysed to investigate whether there are features specific to those patients who show a good response to antidepressant treatment after 12 weeks. Identification of such predictors may help to stratify treatment approaches in the future and lead to the early identification of individual patients who may require alternative treatment approaches to standard antidepressants.

NCT ID: NCT02498392 Suspended - Anxiety Clinical Trials

An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress

Start date: October 7, 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety and tolerability of JNJ-42165279 in participants with major depressive disorder (MDD) with anxiety symptoms who have had inadequate response to treatment with a selective serotonin reuptake inhibitor (SSRI) or serotonergic/noradrenergic reuptake inhibitor (SNRI).

NCT ID: NCT02408081 Suspended - Depression Clinical Trials

Family Focused Nursing for Elderly Medical Patients

Start date: April 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether Family Focused Nursing are effective in the treatment of elderly medical patients with respect to prevalence of depression

NCT ID: NCT02176824 Suspended - Clinical trials for Major Depressive Disorder

Chronotherapy Randomized Controlled Trial

Start date: June 1, 2014
Phase: N/A
Study type: Interventional

Chronotherapy is a term that describes therapeutic alterations of sleep wake cycles. Different variations of sleep deprivation, set sleep wake schedules, and types of light therapy have demonstrated efficacy in rapidly treating depression, and suicidal thinking. This study seeks to explore the effect of two different chronotherapuetic protocols on acutely depressed and suicidal inpatients admitted to the Medical University of South Carolina

NCT ID: NCT01772498 Suspended - Depression Clinical Trials

HRV Biofeedback for Brain Tumour Survivors

Start date: January 2013
Phase: N/A
Study type: Interventional

This study is designed to take a first step toward testing the efficacy and acceptability of heart rate variability biofeedback (HRVB) as a means of ameliorating psychological distress in survivors of Primary Brain Tumour (PBT). HRVB is a biofeedback approach that provides clients with real time feedback about their heart rate variability (HRV) as a means of teaching them how to breathe in a specific, therapeutic manner. More specifically, this study has been designed to test several hypothesises. Each hypothesis is based on the prediction that, in a sample of psychologically distressed PBT survivors, a course of 8 HRVB sessions will demonstrate: - statistically significant reductions in levels of depression - statistically significant reductions in levels of anxiety - statistically significant increases in resting HRV - that reductions in anxiety and depression will be significantly, negatively correlated with increases in resting HRV - that the HRVB will be viewed as an acceptable intervention by the participants In addition to the hypothesises stated above, the study will also investigate in a discovery oriented manner if the HRVB intervention will have positive impacts on the participants: - levels of sleep impairment - levels of pain

NCT ID: NCT01557192 Suspended - Bipolar Depression Clinical Trials

Low Field Magnetic Stimulation (LFMS) in Mood Disorders: 6 Treatments

LFMS6tx
Start date: May 2010
Phase: Phase 1
Study type: Interventional

To demonstrate the efficacy of multiple applications of Low Field Magnetic Stimulation (LFMS) as an antidepressant treatment in subjects with mood disorders.

NCT ID: NCT01162382 Suspended - Clinical trials for Major Depressive Disorder

Repetitive Transcranial Magnetic Stimulation for Treating Depression: A Functional Magnetic Resonance Imaging Study

Start date: January 2010
Phase: N/A
Study type: Interventional

This protocol, "Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Major Depressive Disorder (MDD): A Functional Connectivity Magnetic Resonance Imaging (fcMRI) Study," is an open-label pilot treatment study. The purpose of the present protocol is to treat participants with a diagnosis of Major Depressive Disorder with 4 weeks of rTMS, performing fcMRI and EEG studies prior to and following treatment to determine if treatment response is related to changes in fcMRI and/or EEG results. The investigators hypothesize that patients who respond to treatment will display changes in functional connectivity patterns thought to be related to the occurrence of depressive symptoms.

NCT ID: NCT00750906 Suspended - Depression Clinical Trials

ECT/Succinylcholine: Biochemical, Serum and Cardiovascular Changes

Start date: October 2008
Phase: N/A
Study type: Observational

This study will be conducted to determine the pharmacodynamics, cardiovascular and biochemical effects of succinylcholine when given during electroconvulsive therapy. (ECT). This is a single center, prospective, study in patients who will be receiving ECT as indicated and prescribed by their psychiatrist. The study will be performed twice on each patient, 48-72 hours apart during consecutively scheduled ECT procedures.

NCT ID: NCT00470639 Suspended - Bipolar Depression Clinical Trials

Transcranial Magnetic Stimulation for Bipolar Depression

Start date: April 2007
Phase: Phase 1/Phase 2
Study type: Interventional

This is a study to assess the effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a treatment for depressed adults with bipolar disorder. In rTMS high-intensity, fluctuating magnetic fields non-invasively stimulate the cortex of the brain depolarising neurons. No anaesthetic is required and the treatment in subconvulsive. Recent studies suggest that rTMS can be an effective treatment for depressive illness in adults (Loo and Mitchell et al, 2005) and appears to be quite safe. Most of the published studies to date have focused on unipolar depression. There is limited data of TMS use in bipolar depression. Eg. Pilot study by Nahas Z, Kozel FA, Li X, Anderson B, George MS.in 2003, which was negative. The investigators wish to assess this in a sham-controlled study of adults. The investigators hypothesise that both left and right sided rTMS will have an antidepressant effect superior to sham in this population.

NCT ID: NCT00200902 Suspended - Depression Clinical Trials

Evaluation of Depression Symptoms and Brain Activity Associated With Response to Treatment of Depression

Start date: August 2005
Phase: Phase 4
Study type: Interventional

This study will use measurements of depression symptoms and brain activity to determine what factors may influence an individual's response to treatment for depression.