Clinical Trials Logo

Depression clinical trials

View clinical trials related to Depression.

Filter by:
  • Completed  
  • Page 1 ·  Next »

NCT ID: NCT03658330 Completed - Clinical trials for Major Depressive Disorder

Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

Start date: May 2016
Phase: Phase 2
Study type: Interventional

To evaluate if naltrexone plus ketamine is effective in reducing depression and alcohol consumption.

NCT ID: NCT03656900 Completed - Clinical trials for Patients With Resistant Depressive Disorders

Monocentric Pilot Study, for a Randomized, Crossover, Blinded Trial: Comparison of the Therapeutic Efficacy of Low Frequency Repeated Transcranial Magnetic Stimulation on Cortical Area 9 Compared to Brodmann Area 46 in the Treatment of Depressive Disorders.

rTMS
Start date: February 2010
Phase: Phase 2
Study type: Interventional

Repetitive transcranial magnetic stimulation (rTMS) is a new therapeutic tool used in psychiatry. Non-invasive, well tolerated and requiring no premedication, it is performed on an outpatient basis. The principle of this technique is to stimulate the cerebral cortex from an electromagnetic coil placed on the scalp. Unlike electroconvulsive therapy, rTMS induces an electrical current on a well-defined region of the cerebral cortex. In psychiatry, this technique is mainly considered in the treatment of depressive disorders resistant to antidepressant medication. The brain target, obtained from brain imaging data in depressed patients, is the dorsolateral prefrontal cortex (DLPFC). The Food and Drug Administration (FDA) has recognized the interest of rTMS for treating depressive disorders (October 7, 2008). However, some stimulation parameters still need to be optimized before rTMS can be considered a therapeutic method in its own right and used routinely. Indeed, its effectiveness over time has not yet been evaluated, and rTMS has shown a lack of reproducibility between subjects [Foucher, 2007]. Finally, the therapeutic results of rTMS are very modest whatever the study [Daskalakis, 2008]. Additional studies are therefore needed to optimize stimulation parameters.

NCT ID: NCT03656770 Completed - Depression Clinical Trials

Measuring Beliefs and Norms About Persons With Mental Illness

Start date: December 13, 2016
Phase: N/A
Study type: Interventional

Survey experiment to estimate drivers of mental illness stigma

NCT ID: NCT03605784 Completed - Clinical trials for Major Depressive Disorder

Safety and Efficacy of Cariprazine As Adjunctive Therapy In Major Depressive Disorder

Start date: June 30, 2009
Phase: Phase 2
Study type: Interventional

This is an outpatient study to evaluate the safety, and efficacy of RGH-188 as an add-on therapy to standard antidepressants in patients who did not respond to previous antidepressant therapy.

NCT ID: NCT03591211 Completed - Chronic Disease Clinical Trials

Bio-psycho-social Pathways Underlying the Effects of Qigong Among Comorbid Depressed Elderly With Chronic Conditions

Start date: August 1, 2017
Phase: N/A
Study type: Interventional

Depression and chronic medical conditions are common in older adults. Qigong is increasingly documented to have anti-depressive effects for older adults. Nevertheless, the scientific concepts behind qigong remain a mystery. To fill the knowledge gap, the neurobiological mechanism of the effects of qigong was explored. In addition, the benefits of qigong on subjective well-being, functional independence, sleep quality, mobility, and muscle strength were also tested. After random assignment, intervention group (n = 14) went through individual qigong exercise twice a week and for 12 weeks,whereas control group (n = 16) was involved in cognitive training activities with mobilization elements. The psychosocial, physical, and neurobiological outcomes of the two groups were compared.

NCT ID: NCT03591198 Completed - Chronic Disease Clinical Trials

Improving Health and Reducing Disability of Depressed Elderly With Chronic Conditions Through Qigong Exercise

Start date: October 1, 2015
Phase: N/A
Study type: Interventional

Qigong exercise is beneficial for older adults with co-occurring chronic physical illness and depression in terms of psychological and physical outcomes. However, the effects on functional independence, sleep quality, and mobility of depressive older adults remain unclear. It is also important to replicate its benefits for subjective well-being and muscle strength. A randomized clinical trial was conducted among older adults who were aged 60 or above and with chronic medical conditions for one year. After random assignment, intervention group (n = 25) went through qigong exercise twice a week and for 12 weeks,whereas control group (n = 22) was involved in cognitive training activities with mobilization elements. The psychosocial and physical outcomes of the two groups were compared.

NCT ID: NCT03586921 Completed - Depression Clinical Trials

Primary Care Group Therapy for Depression/Anxiety for Women in Petropolis

Start date: May 19, 2006
Phase: Phase 3
Study type: Interventional

This is a randomized controlled trial comparing two groups: 1) Enhanced usual care and 2) Enhanced usual care plus group psychological intervention. In both groups a "stepped care" approach was used to the management of anxiety and depression among women seen in primary care.

NCT ID: NCT03571412 Completed - Clinical trials for Major Depressive Disorder

Antidepressive Effect on 5 Herz (Hz) rTMS Over Dorsomedial Prefrontal Cortex and Left Dorsolateral Prefrontal Cortex

Start date: August 8, 2016
Phase: N/A
Study type: Interventional

This study evaluates the efficacy of 5Hz repetitive Transcranial Magnetic Stimulation (rTMS) over Left Dorsolateral Prefrontal Cortex and Dorsomedial Prefrontal Cortex on Major Depressive Disorder (MDD).

NCT ID: NCT03556735 Completed - Clinical trials for Depression, Unipolar

Pulsed Electro Magnetic Fields (PEMF) in Depression

PEMF
Start date: September 2016
Phase: N/A
Study type: Interventional

PEMF (Pulsed Electro Magnetic Fields) therapy has been used to stimulate bone repair in non-union since the 1970s. This is an accepted use, which has been approved by the Food and Drug Administration in the US. The mode of action of PEMF is based on creating small electrical fields in tissue and thereby promoting healing. Besides it has been shown that PEMF enhance regeneration of nerve fibers exposed to a lesion For treatment of depression the PEMF equipment, which are provided by the company Re5 A/S, consists of a 220 V impulse generator that creates electrical impulses and an applicator which consists of an electrical cable connected to a helmet on which there are 7 electrical coils on the inside. In comparison with the rTMS (Transcranial Magnetic Stimulation) equipment, which uses stimuli approaching neuronal firing level, the PEMF fields in human is very much lower.

NCT ID: NCT03551288 Completed - Clinical trials for Major Depressive Disorder

Effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-911 in Healthy Subjects

SUVN-911
Start date: May 22, 2018
Phase: Phase 1
Study type: Interventional

The purpose of the study is to investigate the effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-911 in Healthy Subjects