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Depression clinical trials

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NCT ID: NCT03514810 Completed - Clinical trials for Major Depressive Disorder

Combined Sertraline and Ketoprofen Administration in Major Depressive Disorder

Start date: January 10, 2017
Phase: Phase 1
Study type: Interventional

Among the major depressive disorder (MDD) patients in the follow-up group, 16 were administered with 50 mg of oral sertralin once daily with placebo, whereas 28 were treated with 100 mg of ketoprofen once daily as adjuvant treatment for MDD. Controls do not take any medicine.

NCT ID: NCT03505866 Completed - Depression Clinical Trials

Community Home-based Care Intervention and Its Health Outcome in HIV-positive People

Start date: March 1, 2015
Phase: N/A
Study type: Interventional

An intervention study was designed to examine the impact of impact of community home-based care intervention on mental health and treatment outcome in HIV-positive people. The intervention comprised a home-based counseling on anti-retroviral therapy (ART) adherence, psycho social support, basic health care services at the home of HIV-positive people. The intervention started in March, 2018 and completed in August 2018. The major measurements of the interventions were ART adherence, status of depression, anxiety, and stress levels.

NCT ID: NCT03500250 Completed - Depression Clinical Trials

Feasibility of the Post-Stroke Depression-toolkit

Start date: April 1, 2012
Study type: Observational [Patient Registry]

Rationale: Depression is a frequent complication after a stroke. In stroke guidelines several recommendations focus on early screening, and treatment off depression after stroke. Introducing clinical practice guidelines into routine daily practice however, is a difficult process. In order to make the recommendations applicable to clinical practice a toolkit was developed (the Post Stroke Depression-toolkit), which provides assessment tools for the early detection of depression after stroke, and a set of interventions in case of a positive screening for (risk on) depressive symptoms. Objective: to investigate the feasibility of the Post Stroke Depression-toolkit in daily practice. Study design: An explanatory mixed-methods, before-and-after study design. Study population: Nurses working on the neurological wards of one university hospital and two general hospitals in the Netherlands were included in the study. Additionally, data were obtained from patient charts.

NCT ID: NCT03492619 Completed - Obesity Clinical Trials

Intervention for Women in Costa Rica

Start date: February 1, 2017
Phase: N/A
Study type: Interventional

The study develops, implements, and evaluates an intervention focused on alleviating discouragement, food insecurity, and excess weight in women,targeted at the individual, family, and community levels in the Canton Central of the province of Alajuela, Costa Rica.

NCT ID: NCT03489304 Completed - HIV/AIDS Clinical Trials

Zaleplon in HIV Patients With Depression

Start date: April 3, 2014
Phase: Phase 2
Study type: Interventional

In HIV positive patients with sleep onset insomnia and receiving pharmacologic treatment for comorbid depression, the proposed study aims to evaluate the impact of zaleplon on sleep measures determined by insomnia severity index (ISI) and Epworth sleepiness scale (ESS).

NCT ID: NCT03483896 Completed - Depression Clinical Trials

Pilot Study to Examine Health Effects of Daylight Exposure on Dementia Patients

Start date: January 30, 2017
Phase: N/A
Study type: Interventional

This study is designed to test the hypothesis that an intervention increasing exposure to daylight indoors will reduce depression and other neuropsychiatric symptoms among people living with dementia in long term care facilities.

NCT ID: NCT03470584 Completed - Depression Clinical Trials

Vegetarian Diet and Chronic Degenerative Diseases

Start date: March 1, 2005
Study type: Observational

To investigate the prospective association between a vegetarian diet and chronic degenerative diseases in two cohorts of Taiwanese Buddhists

NCT ID: NCT03468686 Completed - Clinical trials for Major Depressive Disorder

The Study of Effectiveness of rTMS on Anhedonia and Rumination in Patients With MDD

Start date: December 21, 2016
Phase: N/A
Study type: Interventional

This study aims to compare the effectiveness of rTMS on the reduction of anhedonia and rumination and their associated neural networks. In a randomized double-blind trial, 45 patients with major depressive disorder (MDD) in Atieh Clinical Neuroscience Center are assigned to two groups. The first group receives bilateral rTMS for 10 sessions on DLPFC; the second group receives sham rTMS for 10 sessions. In this group, the stimulation parameters are similar to that in the actual rTMS group, except that the coil angel is 90° and perpendicular to the head. Anhedonia symptoms will be measured by the Snaith-Hamilton Pleasure Scale (SHAPS), and rumination symptoms will be measured by the Ruminative Responses Scale (RRS) in the baseline and in the end of 10th session. In order to investigate neural networks associated with Anhedonia and rumination, EEG of patients will be recorded at the first session and at the end of the treatment.

NCT ID: NCT03452384 Completed - Clinical trials for Major Depressive Disorder

Acupuncture in Depression: From the Clinical Trial, Biomarkers to Molecular Biology

Start date: November 6, 2014
Phase: N/A
Study type: Interventional

Major depressive disorder (MDD) is a serious psychiatric illness with a high lifetime prevalence rate and causes major clinical, social and economic burden to patients and their family. Despite more than 40 antidepressants with various mechanisms are available on the market, half of patients fail to achieve remission with optimized medication treatment. Due to unsatisfactory efficacy, frequent intolerability and poor compliance of psychopharmacotherapies, novel and safe alternative therapies are critically in need to improve the treatment of depression. Traditional Chinese medicine (TCM) theory describes a state of health maintained by a balance of energy in the body. If imbalanced, it can be corrected by acupuncture, the insertion of fine needles into different parts of the body. Although there are several clinical trials to demonstrate the antidepressant effects of acupuncture, its biological and physiological mechanisms are still unknown. In addition, clinical depression is frequently accompanied with somatic presentations, which are related to autonomic nervous dysfunction. It would be of interest to know if acupuncture could regulate autonomic nervous system (ANS) and improve the somatic symptoms in depression. The purpose of this study is to assess the effectiveness of acupuncture in the treatment of depression and to determine the influence of acupuncture on the molecular and ANS systems.

NCT ID: NCT03448809 Completed - Anxiety Clinical Trials

Randomized Feasibility Trial of Mind My Mind

Start date: December 8, 2015
Phase: N/A
Study type: Interventional

In this feasibility RCT of the modular and flexible cognitive and behavioural therapy (Mind My Mind, MMM) compared with treatment as usual, the overall research aim was to explore the trial design and the acceptability of the assessments, interventions and outcome measures among children, parents, teachers and therapists, and secondly to provide data to estimate the parameters required to design a definitive RCT.