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Depression clinical trials

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NCT ID: NCT03733574 Completed - Clinical trials for Major Depressive Disorder

A Study of LY03005 vs Pristiq

Start date: June 19, 2018
Phase: Phase 1
Study type: Interventional

The objective of this study is to evaluate relative bioavailability between 80 mg LY03005 oral tablets and 50 mg Pristiq® oral tablets after a single dose of each drug in a cross-over 2-period design under fasting condition in healthy subjects between 18 and 50 years of age.

NCT ID: NCT03732378 Completed - Clinical trials for Role of Omega-3 Polyunsaturated Fatty Acid in the Management of Major Depressive Disorder: A Randomized Controlled Trial

Role of Omega-3 Polyunsaturated Fatty Acid in the Management of Major Depressive Disorder.

Start date: April 27, 2017
Phase: N/A
Study type: Interventional

Background: Patients with major depressive disorder have prominently been reported to be related with subnormal polyunsaturated omega-3 fatty acids levels, importantly low docosahexaenoic acid and eicosapentaenoic acid in plasma and dietary intake. However, more randomized controlled trials are needed to support its importance in management of depression. Objective: To explore polyunsaturated omega-3 fatty acid role in major depressive disorder management. Materials & Methods: Seventy patients 20 to 40 yeas, who were already diagnosed with depression and taking antidepressant treatment, were selected at department of psychiatry and behavioral sciences Kind Edward Medical University Lahore, and assigned into 2 groups, i.e. Intervention and control, by simple random lottery method. For twelve weeks, intervention group advised to take one omega-3 (300mg EPA, eicosapentaenoic acid and 200mg DHA docosahexaenoic acid), or placebo (500 mg corn oil) capsules once daily with meal. Beck Depression Inventory (BDI) scale was used to assess the depression. Demographic information was collected by using a structured questionnaire.

NCT ID: NCT03731481 Completed - Obesity Clinical Trials

Virtual Lifestyle Medicine Comparative Effectiveness Research

Start date: May 31, 2017
Phase: N/A
Study type: Interventional

This study evaluates the effectiveness of two online Lifestyle Medicine programs. Participants will be randomized by residence, urban vs. rural, into one of two Lifestyle Medicine programs.

NCT ID: NCT03721588 Completed - Clinical trials for Depressive Disorder, Major

Clinical and Suicidal Features of Urban, Turkish Middle Age Depressive Patients With Comorbid ADHD

Start date: September 1, 2015
Phase:
Study type: Observational

In the presence of attention deficit hyperactivity disorder (ADHD) together with additional psychiatric diseases, the treatment process and prognosis of both ADHD and psychiatric comorbidity are adversely affected. The aim of this study is to compare the characteristics concerning the suicidal behavior of the patients with major depressive disorder (MDD) who have (ADHD+) or do not have (ADHD-) adult ADHD comorbidity and their responses to depression treatment. 96 inpatients were included in the study. Socio-demographic data form, Hamilton Depression Scale (HDRS), Wender Utah Rating Scale (WURS), Adult ADD/ADHD DSM IV- Based Diagnostic Screening and Rating Scale (A-ADHD), Personal and Social Performance Scale (PSP) were applied to the cases. In the study, depression starts at an early age in individuals with comorbid ADHD and the depression treatment progress changes negatively. This group of patients is at greater risk in terms of suicidal behavior. For these reasons, clinicians should be careful during ADHD and depression management in adults.

NCT ID: NCT03714204 Completed - Depression Clinical Trials

Academic Physician Burnout and Transcendental Meditation

Start date: August 1, 2015
Phase: N/A
Study type: Interventional

This research study will examine the effects of the Transcendental Meditation (TM) technique on academic physician burnout, depression, insomnia, perceived stress, and resilience through a mixed methods approach.

NCT ID: NCT03699488 Completed - Anxiety Disorders Clinical Trials

Messaging Therapy for Depression and Anxiety: 2 Longitudinal Effectiveness Studies

Start date: February 12, 2015
Phase:
Study type: Observational

Therapies delivered via technology have been developed to improve accessibility, however, there is limited research regarding messaging therapy in particular, and none that we know of utilizing a longitudinal effectiveness design. The aim of two studies was to investigate the overall effectiveness of messaging therapy, identify any contributors to its effectiveness, and to evaluate a dosage effect for this type of treatment.

NCT ID: NCT03696667 Completed - Emotion Regulation Clinical Trials

Affect Regulation Based on Brain-computer Interface Towards Treatment for Depression

Start date: March 8, 2018
Phase: N/A
Study type: Interventional

The primary objective is to examine the feasibility and efficacy of a locally developed brain-computer interface (BCI) based system training for regulating mood in healthy elderly. The investigators hypothesize that elderly who complete the training program will be better at regulating emotions as compared to controls, based on their ratings of the primary outcome measures.

NCT ID: NCT03674580 Completed - Suicide Clinical Trials

Impairment of the Cognitive Flow in the Development of a Depressive Disorder and Suicidal Ideas

AQUARIUM
Start date: May 2015
Phase:
Study type: Observational

The study consists in estimating the mental load (cognitive saturation) and the production of driving cognition to suicidal patients.

NCT ID: NCT03658330 Completed - Clinical trials for Major Depressive Disorder

Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

Start date: May 2016
Phase: Phase 2
Study type: Interventional

To evaluate if naltrexone plus ketamine is effective in reducing depression and alcohol consumption.

NCT ID: NCT03656900 Completed - Clinical trials for Patients With Resistant Depressive Disorders

Monocentric Pilot Study, for a Randomized, Crossover, Blinded Trial: Comparison of the Therapeutic Efficacy of Low Frequency Repeated Transcranial Magnetic Stimulation on Cortical Area 9 Compared to Brodmann Area 46 in the Treatment of Depressive Disorders.

rTMS
Start date: February 2010
Phase: Phase 2
Study type: Interventional

Repetitive transcranial magnetic stimulation (rTMS) is a new therapeutic tool used in psychiatry. Non-invasive, well tolerated and requiring no premedication, it is performed on an outpatient basis. The principle of this technique is to stimulate the cerebral cortex from an electromagnetic coil placed on the scalp. Unlike electroconvulsive therapy, rTMS induces an electrical current on a well-defined region of the cerebral cortex. In psychiatry, this technique is mainly considered in the treatment of depressive disorders resistant to antidepressant medication. The brain target, obtained from brain imaging data in depressed patients, is the dorsolateral prefrontal cortex (DLPFC). The Food and Drug Administration (FDA) has recognized the interest of rTMS for treating depressive disorders (October 7, 2008). However, some stimulation parameters still need to be optimized before rTMS can be considered a therapeutic method in its own right and used routinely. Indeed, its effectiveness over time has not yet been evaluated, and rTMS has shown a lack of reproducibility between subjects [Foucher, 2007]. Finally, the therapeutic results of rTMS are very modest whatever the study [Daskalakis, 2008]. Additional studies are therefore needed to optimize stimulation parameters.