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Depression clinical trials

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NCT ID: NCT03195933 Completed - Depression Clinical Trials

Depression, Adversity, and Stress Hormones (DASH) Study

DASH
Start date: July 31, 2013
Phase: N/A
Study type: Interventional

The stress-related hormone cortisol has been studied in depression for decades. However, relatively little is known about the role of cortisol in psychological features of depression. Basic research shows that cortisol modulates brain processes that are highly relevant to depression (especially the neural substrates of negative biases in learning and memory formation). However, very few studies have directly examined the effects of cortisol on neural circuitry of learning in depressed humans. In addition, the effects of cortisol on the neural substrates of learning differ for males and females. The toll of depression is especially high in women, who are roughly twice as likely as men to suffer from depression. Thus, the primary goal of this project is to investigate the effects of cortisol on the neural circuitry of learning in depressed women. A secondary goal is to investigate whether early life adversity moderates cortisol's effects on the neural circuitry of learning. Animal data suggests that early life adversity causes life-long biases toward learning in threatening conditions associated with elevated cortisol. In addition, new data from humans suggests that alterations in cortisol traditionally ascribed to depression may stem in part from early adversity rather than depression per se. Thus, this study will examine effects of cortisol on the neural circuitry of learning in depressed and healthy women with and without history of early life adversity. The study will use pharmacological manipulation of cortisol levels (compared to placebo) during measurement of brain activity at rest and during memory encoding of emotional and neutral stimuli. The study will also measure whether cortisol alters the negative biases in emotional memory often seen in depression. In doing so, the study will examine the role of cortisol in neural networks associated with emotional learning that are often implicated in depression. Medications that target cortisol receptors in the brain may be beneficial in the treatment of depression. However, this knowledge has yet to inform clinical practice, and mechanisms of action of these medications are not well understood. This project is significant because it provides the prerequisite knowledge (and develops a paradigm) that can be used in the future in the development of more effective targeted intervention strategies.

NCT ID: NCT03194594 Completed - Depressive Symptoms Clinical Trials

Dexamethasone and Ketamine on Change of Postoperative Mood

Start date: May 2, 2017
Phase: Phase 4
Study type: Interventional

Ketamine and dexamethasone have been known to be effective postoperative pain. Many studies also have reported these two drugs might change mood such as depression. This study aimed to investigate the effect of each drug individually with their combination on perioperative change of mood in patients undergoing gynecologic surgery

NCT ID: NCT03191929 Completed - Depression Clinical Trials

Depression Screening in Primary Care: Using HIT for Patients With Limited English

Start date: August 2011
Phase: N/A
Study type: Interventional

This study assessed the potential of Health Information Technology (HIT) to improve the screening, diagnosis, and treatment of depression and post-traumatic stress among LEP Southeast Asians. Should this intervention be found to be effective, the principles of the HIT technology could be easily adapted for screening in other languages to increase the recognition and treatment of depression and PTSD in primary care settings.

NCT ID: NCT03177304 Completed - Depression Clinical Trials

Web Based Therapist Training in Interpersonal Psychotherapy for Depression

Start date: December 1, 2014
Phase: N/A
Study type: Interventional

The National Institutes of Mental Health has identified the use of empirically based mental health treatments (i.e., treatments with research supporting efficacy) as a priority, yet there is a shortage of clinicians trained in these approaches. This study develops an on-line therapist training program for Interpersonal Psychotherapy (IPT), a particularly well-researched yet particularly little disseminated, empirically based treatment, in order to facilitate wider dissemination of this approach.

NCT ID: NCT03165513 Completed - Clinical trials for Depressive Disorder, Major

Dialogue to Empower Traditional and Faith Healers to Deliver mhGAP-IG Adapted Psychosocial Interventions in Kenya

Dialogue
Start date: July 1, 2014
Phase: N/A
Study type: Interventional

The project aimed to create a dialogue between the informal sector (traditional and faith healers) and the formal sector (trained health care workers) in order to increase synergy and communication between the two systems, by minimizing any harmful practices and enhancing complementary practices. The informal sector will also be trained on how to use WHO mhGAP-IG component on depression for routine screening in order to ameliorate functional and social outcomes and refer complicated cases to the formal sector for biological interventions

NCT ID: NCT03157050 Completed - Depression Clinical Trials

Intravenous Iron May Increase Depression Among Hemodialysis Patients

Start date: January 14, 2016
Phase: N/A
Study type: Observational

the aim of this study is to assess whether increased ferritin after intravenous iron therapy will lead to increased prevalence of major depression among treated patients.

NCT ID: NCT03132298 Completed - Depressive Symptoms Clinical Trials

Effects of a Single-session Implicit Theories of Personality Intervention on Early Adolescent Psychopathology

Start date: August 17, 2015
Phase: N/A
Study type: Interventional

The goal of the project is to test whether a single-session intervention teaching incremental theories of personality, or the belief that one's personality is malleable, can strengthen recovery from social stress and reduce the development of anxiety and depression during early adolescence. Results may suggest a scalable, cost-effective approach to improving youths' coping capacities and preventing adverse mental health outcomes over time.

NCT ID: NCT03121573 Completed - Clinical trials for Major Depressive Disorder

Efficacy and Safety of Duloxetine Among Individuals With Depressive Disorder in a 12 Weeks Trial

Start date: December 15, 2014
Phase: N/A
Study type: Interventional

The aim of this study was to investigate the effects of duloxetine on improvement of brain cortical activity in patients suffering from major depressive disorder using near infrared spectroscopy.

NCT ID: NCT03112304 Completed - Depression Clinical Trials

Child STEPS for Youth Mental Health in Maine Sustainability

Start date: September 2011
Phase: N/A
Study type: Interventional

The overarching goal of this project is to study the sustainability of MATCH-ADTC within community mental health clinics, to learn what is needed for evidence-based practices (EBPs) to take root and thrive within a public system.

NCT ID: NCT03109002 Completed - Clinical trials for Depressive Disorder, Treatment-Resistant

An Epidemiology Study of Treatment Resistant Depression in the United States (US)

Start date: January 15, 2017
Phase: N/A
Study type: Observational

The purpose of this study is to describe the epidemiology of Treatment Resistant Depression (TRD) in the US, including the population incidence of TRD, and TRD as a proportion of Pharmacologically Treated Depression (PTD), and stratify the estimates by sex and age group, with separate estimates for the Medicaid population, the Medicare population, and the privately insured population. Anonymized participants data will be used for the analysis.