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Depression clinical trials

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NCT ID: NCT03468686 Recruiting - Clinical trials for Major Depressive Disorder

The Comparison of Effectiveness of CBT and rTMS on Anhedonia and Rumination in Patients With MDD

Start date: December 21, 2016
Phase: N/A
Study type: Interventional

This study aims to compare the effectiveness of rTMS, classical cognitive-behavioral therapy and religious cognitive-behavioral therapy on the reduction of Anhedonia and rumination and their associated neural networks. In a randomized double-blind trial, 60 patients with major depressive disorder (MDD) in Atieh Clinical Neuroscience Center are assigned to four groups. The first group receives bilateral rTMS for 10 sessions on DLPFC; the second group receives sham rTMS for 10 sessions. In this group, the stimulation parameters are similar to that in the actual rTMS group, except that the coil angel is 90° and perpendicular to the head. In the third group, patients receive classical cognitive-behavioral therapy for 10 sessions. In the fourth group, patients receive religious cognitive-behavioral therapy for 10 sessions. Anhedonia symptoms will be measured by the Snaith-Hamilton Pleasure Scale (SHAPS), and rumination symptoms will be measured by the Ruminative Responses Scale (RRS) in the baseline and in the end of 10th session. In order to investigate neural networks associated with Anhedonia and rumination, EEG of patients will be recorded at the first session and at the end of the treatment.

NCT ID: NCT03465813 Recruiting - Breast Cancer Clinical Trials

Reducing Distress and Depressive-symptoms in Rural Women

Start date: July 19, 2017
Phase: N/A
Study type: Interventional

Of the 3.1 million U.S. breast cancer survivors, approximately 30% experience significant cancer-related distress ranging from sub-threshold to diagnosable adjustment disorders, depression-symptoms and major depression up to 20 years after diagnosis. Rural cancer survivors report poorer mental health than urban survivors. Lack of access to care, support and stigma associated with cancer and mental health, challenge rural women's ability to prevent cancer-related distress and its deleterious outcomes. These barriers may be overcome by a new Internet-based, psychoeducational program designed for newly diagnosed women; CaringGuidance™- After Breast Cancer Diagnosis. This self-guided program provides information, cognitive-behavioral and supportive coping strategies in a text/audio/visual format accessed via Internet/mobile devices to increase understanding, and provide supportive tools to prevent/manage distress and depressive-symptoms. The aims of this pilot study are to determine preliminary efficacy of the CaringGuidance™ program on distress and depressive-symptoms monthly and over 3 months, for rural women newly diagnosed with breast cancer, and trial measures and methods, prior to a fully powered RCT. Sixty rural women, will be randomized to 3 months of self-guided CaringGuidance™ program access with usual care or usual care alone. Both groups complete monthly standard psychosocial measures, daily activity/symptom logs and receive a monthly call. Program engagement/dose will be measured by the CaringGuidance™ internal data system. Descriptive and inferential statistics will characterize the sample and determine differences between groups at monthly intervals and overall. Variability of outcome variables will also be assessed to determine usefulness.

NCT ID: NCT03464630 Recruiting - Clinical trials for Depression, Postpartum

Reducing Maternal Depression and Promoting Infant Social-Emotional Health & Development

Start date: February 15, 2018
Phase: N/A
Study type: Interventional

A mobile remote coaching program study to improve maternal mood and increase parenting practices that lead to better infant social-emotional and communication outcomes

NCT ID: NCT03460756 Recruiting - Depression Clinical Trials

A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression

Start date: December 28, 2017
Phase: Phase 2
Study type: Interventional

A clinical study to evaluate safety, tolerability and efficacy of oral administration of ganaxolone in women with postpartum depression

NCT ID: NCT03460574 Recruiting - Clinical trials for Major Depressive Disorder

Targeting Cognitive Immunization in Depression

Start date: October 14, 2017
Phase: N/A
Study type: Interventional

Research has shown that people suffering from MDD tend to maintain dysfunctional expectations despite experiences that disconfirm expectations. Recently, it has been shown that this persistence of expectations is due to maladaptive information processing involving "cognitive immunization". This experimental study aims at testing three different strategies to inhibit cognitive immunization, in order to enhance expectation change.

NCT ID: NCT03459677 Recruiting - Depressive Symptoms Clinical Trials

Back2School - CBT Intervention for School Absenteeism

Start date: August 25, 2017
Phase: N/A
Study type: Interventional

The main objective of this study is to examine the efficacy of a new psychological intervention, called Back2School, in helping youths with problematic school absenteeism to return to school. Furthermore, the study will examine how well this program fares against the treatment or interventions that are usually given to youths with school absenteeism (treatment as usual or TAU). Based on previous studies we hypothesize that the Back2School intervention will be better at improving levels of school attendance as compared with treatment as usual (TAU).

NCT ID: NCT03458143 Recruiting - Clinical trials for Ventilatory Depression

Respiratory Depression During an Analgosedation Combining Remifentanil and Ketamine in TCI for Oocyte Retrieval

Start date: February 12, 2018
Phase: N/A
Study type: Observational

This study evaluates the effect of the addition of ketamine to a conscious sedation protocol including remifentanil during oocyte retrieval. The investigators will have 2 groups with different target effect site concentrations, namely 150 ng/ml and 200 ng/ml.

NCT ID: NCT03457714 Recruiting - Depression Clinical Trials

Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial

Start date: September 7, 2017
Phase: N/A
Study type: Observational

In Canada the prevalence of spinal cord injury (SCI) is approximately 85,556, with incidence rates of traumatic and non-traumatic SCI at 1,785 and 2,286 cases per year, respectively. Common secondary health conditions experienced by individuals with SCI include psychological distress and pain. Appropriate management of these secondary conditions, through a multidisciplinary approach, is imperative as they have been shown to contribute to slower recovery, increased negative outcomes, and greater rates of rehospitalizations and health care utilization. However, resource limitations can restrict the ability of service providers to deliver these integrative biopsychosocial approaches in the community. In Canada over 37% of individuals with SCI expressed a need for emotional counselling; of these, only 43% felt that these needs were met. Transportation can also be a significant issue for persons with SCI, with 87% and 73% respectively expressing a need for short- and long-distance transportation. Guided internet delivered cognitive behavioural therapy (ICBT) program offers an alternative approach for psychosocial service delivery in the community. The program provides online structured self-help modules based on the principles of cognitive behavioural therapy (CBT) in combination with guidance from a coach through weekly emails and telephone calls. ICBT has shown to have a greater reduction in levels of anxiety and depression post treatment compared to a waitlist control group, and these levels were maintained at both 3 and 12 month follow-ups. ICBT was shown to have similar effects to face-to-face CBT. These studies demonstrate that guided ICBT is a safe and effective alternative to face-to-face interventions and it may be beneficial for under serviced populations. Hence, examination of its effectiveness is warranted in the SCI population which faces various psychological and somatic secondary issues. Participants with SCI will receive a 8 week guided ICBT program called the Chronic Conditions Course for persons with SCI. The program is completed over 8 weeks with once a week guidance from a coach. The guided course consists of five lessons, "Do It Yourself" activities, and case vignettes adapted from persons with SCI. The course also provides guidance and resources on other essential skills for persons with SCI, including communicating with health care professional, managing chronic pain, and sleep hygiene. Psychosocial outcomes will be assessed at baseline, 8 weeks, and at 3 months. Data on intervention usage and satisfaction measures will also be examined through a qualitative interview. Caregivers of participants will be asked to complete self-report measures and a qualitative interview regarding their caregiver burden.

NCT ID: NCT03456388 Recruiting - Depression Clinical Trials

Study of Ammoxetine Hydrochloride Enteric-coated Tablets in Healthy Subjects

Start date: October 30, 2017
Phase: Phase 1
Study type: Interventional

This study evaluates the safety, tolerability and pharmacokinetics of Ammoxetine Hydrochloride Enteric-coated Tablets in Chinese heathy subjects. Part of the participants will receive Ammoxetine Hydrochloride Enteric-coated Tablets, while the other part will receive placebo.

NCT ID: NCT03453437 Recruiting - Depression Clinical Trials

Mindful Self-compassion and Perfectionism

Start date: February 3, 2018
Phase: N/A
Study type: Interventional

The study is a randomized controlled study. A total of 200 students will be invited to participate in a 5-session mindful self-compassion course aimed at increasing self-compassion and reducing maladaptive perfectionism, anxiety, depression, and unhealthy body image. Self-compassion is the ability to show oneself kindness in instances of perceived inadequacy, failure, and suffering by attending to distressing experiences with kindness, mindfulness, and the ability to recognize these as a part of a shared humanity. Twelve participants will be randomly selected for pre- and post interviews to qualitatively evaluate outcome. Ten participants with high perfectionistic tendencies will be selected to participate in a narrative life story interview.