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Depression clinical trials

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NCT ID: NCT03373981 Recruiting - ALS Clinical Trials

Non-invasive Brain Stimulation for the Treatment of Depression Symptoms in ALS: A Pilot Study

Start date: November 29, 2017
Phase: N/A
Study type: Interventional

This is an open-label clinical trial to determine the safety of rTMS and efficacy in improving depression symptoms, quality of life and cognition deficits among patients with Amyotrophic Lateral Sclerosis (ALS) and other neurodegenerative disorders.

NCT ID: NCT03371810 Recruiting - Obesity Clinical Trials

Prevention of Comorbid Depression and Obesity in Attention-deficit/ Hyperactivity Disorder

PROUD
Start date: March 13, 2017
Phase: Phase 2
Study type: Interventional

Depression and obesity are very common among adolescents and young adults with attention-deficit/ hyperactivity disorder (ADHD). However, intervention programmes to prevent these comorbid disorders rarely exist. In a pilot randomized-controlled study we test two newly developed intervention programmes that do not involve medication: bright light therapy and physical exercise. Both interventions will be supported by a mobile Health application to monitor and feedback intervention success and booster patients' motivation.

NCT ID: NCT03371771 Recruiting - Depression Clinical Trials

Volunteer-Delivery of Behavioral Activation

Start date: September 15, 2017
Phase: N/A
Study type: Interventional

In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, the investigators have simplified a Behavioral Activation intervention to match the skill set of age-matched lay volunteers available to senior centers (Volunteer BA). This R34 proposes developmental work on delivering Volunteer BA in senior centers, so as to arrive to a sustainable intervention with standardized procedures. The investigators follow with a small randomized controlled trial (RCT) testing the comparative impact of Volunteer BA versus MSW-provided BA on increased client activity and reduced depressive symptoms.

NCT ID: NCT03369639 Recruiting - Depression, Anxiety Clinical Trials

Study of Dronabinol Treatment for Depression and/or Anxiety in Older Patients

Start date: November 28, 2017
Phase: N/A
Study type: Observational

This is an observational study evaluating the safety and efficacy of dronabinol for the treatment of anxiety and/or depression in older adults. Participants who are prescribed dronabinol as part of a voluntary inpatient stay in McLean's Division of Geriatric Psychiatry will be interviewed about their mood and cognition on a weekly basis while on dronabinol.

NCT ID: NCT03369418 Recruiting - Depression Clinical Trials

Effectiveness of CES on Emotional and Cellular Wellbeing

Start date: March 2016
Phase: N/A
Study type: Interventional

The investigators aim to use a CES (cranial electrotherapy stimulation) intervention to improve emotional well-being by reducing symptoms of anxiety and depression and to assess for changes in markers of cellular health - specifically, telomere length and telomerase activity

NCT ID: NCT03363750 Recruiting - Depression Clinical Trials

Study of Mind-Body Skills Groups for Adolescents With Depression in Primary Care

Start date: December 2017
Phase: N/A
Study type: Interventional

The Center for Mind -Body Medicine has developed a mind-body skills group program that incorporates meditation, guided imagery, breathing techniques, autogenic training, biofeedback, genograms, and self-expression through words, drawings, and movement. These mind-body skills are designed to increase self-awareness and self-regulation. This program has been shown to significantly improve depression symptoms in children and adolescents with posttraumatic stress disorder in Gaza, but it has not yet been tested in a US adolescent population. The purpose of this study is to determine the feasibility of using mind-body skills groups to reduce depression in adolescents and to investigate the effects of the program on factors such as self-efficacy, mindfulness and rumination which are likely to mediate improvement.

NCT ID: NCT03363529 Recruiting - Depression Clinical Trials

ROOM-LIGHT: Dynamic LED-light as Treatment for Depressed Patients in Inpatient Wards

ROOM-LIGHT
Start date: November 16, 2017
Phase: N/A
Study type: Interventional

Depression is a major health challenge, and despite developments in pharmacotherapy and psychotherapy a substantial part of patients will only recover very slowly and incompletely, and 10-25 % of the patients are resistant to treatment. Therefore, new treatment initiatives are in demand. Chronotherapeutics can regulate diurnal rhythms and sleep, and have shown promising results on antidepressant effects. Among chronotherapeutic treatment modalities, Bright Light Therapy (BLT) has been used in treatment of depression and sleep disorders for several decades with both an antidepressant and a sleep improving effect. BLT has also been shown to augment antidepressant therapy. Objectives. The objective of this trial is to investigate the feasibility of a combination of LED-light armatures aiming to mimic sunlight, when installed in the patient rooms of a psychiatric inpatient Ward. Investigators has opted for using a randomized design that will subsequently be tested in a larger clinical trial with depression severity as the primary outcome. In this feasibility study investigators will register the stability of the system, the influence of the light on patients regarding tolerability, comfort, depression level, and sleep. Investigators also so want to measure and collect specific light-data on the Non-image-forming light (NIF) by using specially designed light sensors to capture the spectral distribution of the light. Finally investigators will test the electronic case report form (eCRF) that has been designed for the trial. Design. The design is a randomised controlled feasibility trial with two arms: an active dynamic light trial arm and a standard light trial arm with blinding of depression outcome assessors (Hamilton depression rating scale), data collection, and data analyses. Randomization will be with a rate for active and standard of 2 to 1.

NCT ID: NCT03358433 Recruiting - Depression Clinical Trials

Effectiveness of Exercise in the Treatment of Depression

DEP-EXERCISE
Start date: June 1, 2016
Phase: N/A
Study type: Interventional

The main objective is to test the non-inferiority of supervised exercise versus antidepressant treatment in reducing depressive symptoms in patients with clinical criteria for depression (according to ICD 10) over a period of 6 months follow-up.

NCT ID: NCT03357796 Recruiting - Clinical trials for Major Depressive Disorder

Relative Bioavailability (RBA) Study of LY03005 vs Pristiq®

Start date: November 27, 2017
Phase: Phase 1
Study type: Interventional

The objective of this study is to evaluate relative bioavailability between 80 mg LY03005 oral tablets and 50 mg Pristiq® oral tablets after a single dose of each drug in a cross-over 2-period design under fasting condition in healthy subjects between 18 and 50 years of age.

NCT ID: NCT03356691 Recruiting - Pain Clinical Trials

The Evaluation Complementary Spirit Therapy

Start date: September 10, 2015
Phase: N/A
Study type: Interventional

Background: Complementary Spiritist Therapy (ECT) based on a range of therapeutic resources including prayer, spiritist "passe", fluidotherapy (fluidic water or magnetized water), spirit education. The aim of this study was to evaluate the effects of ECT in individuals at UFTM Hospital de Clínicas. Methods: Randomized controlled trial, patients were randomly. Patients will then be allocated into groups: - The group submitted to ECT (prayer, spiritual education, spiritist "passe" and fluidized water or prayer or spiritist "passe" or laying on of hands with intent to heal or laying on of hands with intent to heal or fluidized water or no-fluidized water or Control group (CG) will not be submitted to any intervention.