Clinical Trials Logo

Depression clinical trials

View clinical trials related to Depression.

Filter by:
  • Recruiting  
  • Page 1 ·  Next »

NCT ID: NCT03198754 Recruiting - Depression Clinical Trials

Systematic Programmed Illumination (sPI) of Hospital Rooms to Prevent/Reduce Cancer-Related Fatigue

Start date: July 22, 2016
Phase: N/A
Study type: Interventional

A sample of 24 patients scheduled for HSCT in the treatment of MM will be recruited in the weeks to months prior to their hospitalization. Light therapy incorporating ambient systematic programmed light illumination (sPI) will be used in patient hospital rooms (during scheduled transplant) to control cancer-related fatigue (CRF). The FDA has certified that light therapy, like that used in this study, is a low-risk intervention. After initial assessment of CRF, depression, and sleep quality/quantity (baseline assessments), participants will be randomized to one of two treatment conditions: one with an active intervention, and one with a non-active comparison. During inpatient hospitalization, the sPI active intervention will consist of the following regimen: high intensity bright-white light (1300 lux at the eyes) during morning hours (7AM to 10AM). The non-active comparison condition will receive half the intensity dim-white light of the active group (i.e., 90 lux at the eyes) during 7AM-10AM. These differences in lux intensity are not easily discernable. Following baseline, assessment of fatigue, sleep activity, depression, circadian rhythms, and quality of life will continue through the course of hospitalization (14-21 days of treatment, to determine immediate impact of sPI), then repeat at one month and three months post-discharge follow-ups (to determine lasting effects). Outcomes will be assessed through standardized scales (e.g., FACIT-Fatigue Scale) and objective measures (e.g., actigraphy, daysimeter for light monitoring, melatonin from urine collection, blood inflammatory markers, all explained below). This trial will: 1) be the first randomized clinical trial (RCT) to investigate the effects of sPI to prevent CRF and other biopsychosocial side effects of transplant; 2) focus on a distinct, relatively homogenous patient population (MM-HSCT patients) with high prevalence of CRF; and 3) explore possible circadian rhythm mediation via melatonin analysis and blood analysis. This investigation will have major public health relevance as it will determine if an inexpensive and low patient burden intervention (sPI) is able to control fatigue associated with medical illnesses and related problems.

NCT ID: NCT03196726 Recruiting - Clinical trials for Postnatal Depression

Behavioural Interventions for Postnatal Depression: a RCT Study

Start date: March 2, 2017
Phase: N/A
Study type: Interventional

Randomized-controlled trial on the effectiveness of managing postnatal depression mothers at primary care clinics using Cognitive-behavioural therapy treatment by nurses as adjunct to management by Medical Officer as compared to Medical Officer alone

NCT ID: NCT03193398 Recruiting - Clinical trials for Major Depressive Disorder

BTRX-246040 Administered Once Daily to Patients With Major Depressive Disorder

Start date: June 12, 2017
Phase: Phase 2
Study type: Interventional

This study will determine the efficacy, safety, and tolerability of a once-daily (QD) dose of up to 80 mg of BTRX-246040 for 8 weeks in participants with MDD.

NCT ID: NCT03193112 Recruiting - Depressive Disorder Clinical Trials

Melatonin Decreases Eye Pressure in Normotensive Patients

Start date: June 16, 2017
Phase: N/A
Study type: Observational

Agomelatine is a melatonin drug used to treat depressive disorder. Agomelatine may also some effects on ocular pressures. In this study, we aimed to demonstrate that melatonin decreases intraocular pressures when given depressive patients.

NCT ID: NCT03191994 Recruiting - Clinical trials for Major Depressive Disorder

Impact of an Eight Week Exercise Intervention in Treating Major Depressive Disorder

Start date: January 2, 2014
Phase: N/A
Study type: Interventional

To investigate the impact of a structured eight week exercise intervention as an add-on therapy in treating Major Depressive Disorder. Using behavioural techniques and neuroimaging to measure changes in brain function following an exercise intervention in people with clinical depression. By correlating changes in the hippocampus with changes in HPA axis hormones, inflammatory cytokines and growth factors it is possible to determine which of the biochemical markers is most predictive of improved neural function.

NCT ID: NCT03188861 Recruiting - Depression Clinical Trials

Systematic Screening for Comorbid Psychological Conditions in Cardiac ACSC Patients With Multimorbidity in the ED

EMASPOT
Start date: June 1, 2017
Phase: N/A
Study type: Observational

EMASPOT assesses the prevalence and impact of mental health conditions in multimorbid emergency patients with cardiac ACSC on transsectoral utilisation of health care services.

NCT ID: NCT03188185 Recruiting - Clinical trials for Major Depressive Disorder

A Study of ALKS 5461 for Treatment Refractory Major Depressive Disorder (MDD)

Start date: June 12, 2017
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy, safety, and tolerability of adjunctive ALKS 5461 in adults who have treatment refractory MDD.

NCT ID: NCT03187249 Recruiting - Depression Clinical Trials

Intervention Strategy in Chronic Obstructive Pulmonary Disease With Anxiety and Depression

Start date: June 15, 2017
Phase: N/A
Study type: Interventional

Anxiety and depression have negative effect on outcomes of chronic obstructive pulmonary disease (COPD). Intervention strategy including behavioral-cognitive therapy and pulmonary rehabilitation are promising in improving life quality, disease symptom and outcomes. But there's not standard algorithm in China so far. The study aims to compare the effectiveness of these interventions and develop an intervention algorithm of anxiety and depression in COPD.

NCT ID: NCT03187236 Recruiting - Depression Clinical Trials

Registry for Chronic Obstructive Pulmonary Disease With Anxiety and Depression in China

Start date: June 15, 2017
Phase: N/A
Study type: Observational [Patient Registry]

Anxiety and depression are common comorbidities of chronic obstructive pulmonary disease (COPD). However, the exact prevalence is not known in China. COPD patients with anxiety and depression tend to have more severe symptoms and worse prognosis, but the related evidences are not strong enough. The study aim to investigate the prevalence and long-term outcome of anxiety and depression in COPD.

NCT ID: NCT03187093 Recruiting - Clinical trials for Major Depressive Disorder

Cognitive Dysfunction in MDD Patients

Start date: October 2016
Phase: Phase 4
Study type: Interventional

Major Depressive Disorder (MDD) is one of the most prevalent mental diagnosis within the worldwide population. Although there is evidence about relationship between MDD and cognitive dysfunction, still the correlations between biomarkers and the severity of the disorder or the level of cognitive dysfunction need further research. Therefore, the aim of the study is to determine such relationships in Ukrainian population.