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Major Depressive Disorder clinical trials

View clinical trials related to Major Depressive Disorder.

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NCT ID: NCT03404466 Not yet recruiting - Clinical trials for Major Depressive Disorder

To Explore the Safety and Efficacy of Hypidone Hydrochloride Tablets in Treatment of Patients With MDD

Start date: January 20, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The objective of this study is to evaluate the safety and efficacy of Hypidone Hydrochloride tablets in treatment of patients with major depressive disorder (MDD) by evaluating the change of MADRS total score from baseline to week 6.

NCT ID: NCT03403881 Recruiting - Clinical trials for Major Depressive Disorder

Movement for Depression - An RCT Assessing Physical Activity Promotion for People With MDD

MOVEDEP
Start date: March 2016
Phase: N/A
Study type: Interventional

Randomized clinical trial that aims to increase physical activity levels in people with depression and to evaluate if the increase on PA levels has impact on clinical and biological measures.

NCT ID: NCT03401164 Not yet recruiting - Clinical trials for Major Depressive Disorder

Target Engagement of D-cycloserine (DCS)

Start date: March 2018
Phase: Phase 2
Study type: Interventional

Assess the mechanism of action of d-cycloserine (DCS) to guide development of other medications working via similar molecular targets.

NCT ID: NCT03388177 Recruiting - Clinical trials for Major Depressive Disorder

Yoga for Young Women With Depression

Start date: December 16, 2016
Phase: N/A
Study type: Interventional

We examine whether adding yoga-based therapy (YBT) to treatment as usual (TAU) for young adult women (age 18-34 years) with a primary diagnosis of MDD. leads to (1) greater reductions in symptoms and (2) greater cost-effectiveness in that the economic benefits of adding YBT to TAU outweigh the costs.

NCT ID: NCT03378570 Not yet recruiting - Depression Clinical Trials

rTMS for MDD: 5.5cm Rule vs. F3 Targeting

Start date: January 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the effects of different treatment locations using repetitive transcranial magnetic stimulation (rTMS) to treat major depressive disorder.

NCT ID: NCT03357796 Completed - Clinical trials for Major Depressive Disorder

Relative Bioavailability (RBA) Study of LY03005 vs Pristiq®

Start date: November 27, 2017
Phase: Phase 1
Study type: Interventional

The objective of this study is to evaluate relative bioavailability between 80 mg LY03005 oral tablets and 50 mg Pristiq® oral tablets after a single dose of each drug in a cross-over 2-period design under fasting condition in healthy subjects between 18 and 50 years of age.

NCT ID: NCT03329287 Recruiting - Clinical trials for Major Depressive Disorder

Simplified Cognitive Behavioral Therapy for Generalized Anxiety Disorder and Depression

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

This trial attempts to evaluate the treatment efficacy of Simplified Cognitive Behavioral Therapy (SCBT) and its safety among schizophrenia patients. Half of participants will be randomized to accept SCBT.

NCT ID: NCT03327129 Not yet recruiting - Clinical trials for Major Depressive Disorder

Identifying the Neural Basis of Suicide Risk: Capability for Suicide and the Opioid System

Start date: January 2018
Phase: N/A
Study type: Observational

Since capability for suicide involves overriding potential pain, and the opioid system plays a strong role in controlling pain perception, it follows that capability for suicide may be impacted by the opioid system. The goal of the proposed research is to identify the neural opioid network underlying capability for suicide in order to determine if it can be a target for identifying high-risk individuals and for intervention.

NCT ID: NCT03313674 Recruiting - Clinical trials for Major Depressive Disorder

Investigation of Seasonal Variations of Brain Structure and Connectivity in SAD

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

Seasonal Affective Disorder (SAD) is a subtype of Major Depressive Disorder, characterized by a recurrent temporal relationship between the season of year, the onset and the remission of a major depressive episode. Estimates of the annual prevalence state that 1-6% of the population will develop SAD with the larger prevalences found at greater extremes in latitude. SAD is most likely triggered by the shortening photoperiod experienced in the winter months leading to a deterioration of mood. Recent cross-sectional neuroimaging studies have found cellular and neurotransmitter changes in response to seasonality, ultimately having an impact on the affect of patients. Conversly, this study aims to investigate the changes in neurocircuitry related to depression and euthymic states. Patients with SAD offer a unique ability to study these changes since they have predictable triggers for the onset of depression (i.e. the winter months) and remission (i.e. the summer months).

NCT ID: NCT03310281 Recruiting - Clinical trials for Major Depressive Disorder

Software Treatments for Actively Reducing Severity of Cognitive Deficits in MDD (STARS-MDD)

Start date: December 4, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effects of videogame-like digital therapies as adjunct therapy to antidepressant medications on cognitive deficits associated with major depressive disorder.