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Depression clinical trials

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NCT ID: NCT03736538 Enrolling by invitation - Depression Clinical Trials

Nitrous Oxide- Suicidal Ideation

Start date: October 30, 2018
Phase: Phase 1
Study type: Interventional

Most clinical major depression responds to standard treatments (medication and psychotherapy); however, a significant subset of depressed patients (15-20%) do not respond to these treatments and are referred to as treatment-resistant major depression (TRMD). New treatments for TRMD are needed, and one promising line of research are drugs known as N-methyl-D-aspartate (NMDA) glutamate receptor antagonists. In a recent pilot study, the investigators of this study demonstrated that the NMDA antagonist nitrous oxide is effective in TRMD, reducing depressive symptoms, guilt, and suicidal thinking. To more closely investigate suicidal thinking, this study is designed as a double-blind, randomized, prospective, inpatient trial comparing inhaled nitrous oxide (N2O) plus treatment as usual versus inhaled placebo plus treatment as usual. All unipolar depressed, acutely suicidal inpatients will receive standard treatment for their depression/ suicidal thinking (TAU). Additionally, participants will undergo a maximum of four one hour inhalation sessions as inpatients and 2 booster sessions as outpatients during which they will receive either inhaled nitrous oxide (50% nitrous oxide/50% oxygen = active treatment) or placebo gas (50% nitrogen/50% oxygen). A target total of 50 patients with suicidal ideation and unipolar depression will be enrolled, 25 of whom will be assigned to the TAU control group and 25 of whom will be assigned to the N2O + TAU experimental group.

NCT ID: NCT03716869 Enrolling by invitation - Clinical trials for Major Depressive Disorder

Universal vs. Targeted School Screening for Adolescent Major Depressive Disorder

Start date: July 1, 2018
Phase: N/A
Study type: Interventional

The primary goal of the proposed study is to compare the effectiveness of universal school based screening for adolescent major depressive disorder to the current school process of targeted screening based on concerning behavior.

NCT ID: NCT03686605 Enrolling by invitation - Clinical trials for Screening Tool for Depresion in Cancer Pain Patients

The Edmonton Symptom Assessment System (ESAS) as a Screening Tool for Depression in Cancer Pain Patients

Start date: September 24, 2018
Study type: Observational [Patient Registry]

Compare Thai versions of the Edmonton Symptom Assessment System (ESAS) and the Hospiral Anxiety and Depression Scale (HADS) with Diagnostic and Statistical Manual (DSM-5), as a screening tool for depression in cancer pain patients

NCT ID: NCT03668600 Enrolling by invitation - Clinical trials for Depressive Disorder, Major

Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)

Start date: August 23, 2018
Phase: Phase 3
Study type: Interventional

Multicenter, open-label, long-term extended access treatment protocol in adult patients with a primary diagnosis of MDD.

NCT ID: NCT03647826 Enrolling by invitation - Clinical trials for Mental Health Wellness 1

Mind Power - A CBT Based Program for Adolescents

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to strengthen school achievement and positive mental health, and to prevent and reduce school dropout and mental distress among high school students. The researchers will scale up techniques that have already been proven highly effective in preventing common mental disorders (depression, anxiety) in high risk groups (indicated and selective prevention). The researchers will disseminate these techniques to entire first year classes of high school students irrespective of risk factors (universal prevention). The study will report whether universal delivery in school of "Mind Power" - a Cognitive Behaviour Therapy (CBT) based programme - will strengthen school grades, self-efficacy, self-esteem, self-regulation, mental perceptions and well-being, and prevent and reduce school dropout, and symptoms of anxiety and depression. In addition the researchers will analyse whether such universal delivery prevents more mental distress, and is more cost-effective than when it is delivered only to those at high risk for school failure, dropout, or mental distress.

NCT ID: NCT03610048 Enrolling by invitation - Clinical trials for Refractory Major Depressive Disorder

A Long Term Study of ALKS 5461 in the Treatment of Refractory Major Depressive Disorder (MDD)

Start date: August 9, 2018
Phase: Phase 3
Study type: Interventional

This study will assess the long-term safety and tolerability of ALKS 5461 as an adjunctive treatment for refractory MDD.

NCT ID: NCT03567681 Enrolling by invitation - Bipolar Depression Clinical Trials

Comparison of Two Forms of Oxcarbazepine for the Treatment of Bipolar Depression

Start date: June 13, 2018
Phase: Phase 4
Study type: Interventional

Consenting subjects with Bipolar depression will remain under the care of their local (psychiatric) care provider and be randomized to a six week course of one of two forms of oxcarbazepine (extended release or immediate release. Study outcomes will be assessed based on outcome measures administered to the subject at home by a computer simulated rater. Local care providers will receive "pre-assessment" reports ahead of each clinical visit, rate the Clinical Global Impression for Severity, and evaluate adverse effects. The primary outcome variable is "treatment effectiveness" operationally defined as the response rate X the completion rate.

NCT ID: NCT03560726 Enrolling by invitation - Depression Clinical Trials

Telehealth Cognitive Behavioral Stress Management for Adults With Cystic Fibrosis

Start date: June 4, 2018
Phase: N/A
Study type: Interventional

The purpose of this study to to assess the feasibility, acceptability, and satisfaction of a telehealth cognitive behavioral stress management (CBSM) intervention among adults with cystic fibrosis (CF) who exhibit elevated anxiety and/or depression symptoms.

NCT ID: NCT03555669 Enrolling by invitation - Depression Clinical Trials

Project SOAR-Mental Health Malawi: Depression and HIV Integration

Start date: April 24, 2017
Phase: N/A
Study type: Interventional

Depression is highly prevalent among people living with HIV (PLHIV) in Malawi and elsewhere in sub-Saharan Africa (SSA). Besides its high prevalence, depression likely represents an important barrier to consistent HIV care engagement and long-term viral suppression. However, the potential for depression treatment to improve HIV care outcomes has received little attention in the region, in part because of limited mental health infrastructure. In this study, the investigators will evaluate the impact of a depression treatment program integrated within existing HIV clinics on depression response, retention in HIV care, and viral suppression. It is expected that this evaluation will yield important evidence on the impact of depression treatment integrated with HIV care for improving HIV care and mental health outcomes in Malawi.

NCT ID: NCT03541317 Enrolling by invitation - Depression Clinical Trials

Improving Student Mental Health: Adaptive Implementation of School-based CBT

Start date: July 19, 2018
Phase: N/A
Study type: Interventional

The overarching goal of this study is to improve the delivery of an established, evidence-based intervention (cognitive-behavioral therapy-CBT) in Michigan schools through different implementation strategies designed to better educate school professionals. Specifically, the study will assist the ongoing Transforming Research into Action to Improve the Lives of Students (TRAILS) Program by evaluating different ways to educate school professionals (SPs) to improve their delivery of CBT to high school students and ultimately improve student mental health outcomes in the state of Michigan. The three educational approaches are Replicating Effective Programs (REP), Coaching, and Facilitation.