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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT03947229 Not yet recruiting - Clinical trials for Coronary Artery Disease

A Randomized Comparison of CLOpidogrel Monotherapy Versus Extended Dual-antiplatelet Therapy Beyond 12 Months After Implantation of Drug-eluting StEnts in High-risk Lesions or Patients; A-CLOSE Trial

Start date: June 2019
Phase: Phase 4
Study type: Interventional

The investigators hypothesized that clopidogrel mono-therapy will not be inferior to the extended DAPT in terms of the occurrence of both ischemic and bleeding events, for lesions or patients at high risk for either ischemic or bleeding complications 12 months after drug-eluting stent (DES) implantation.

NCT ID: NCT03945968 Not yet recruiting - Stroke Clinical Trials

The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.

Start date: July 1, 2019
Study type: Observational

Study is conducted to assess the prevalence and structure of comorbidity among patients undergoing abdominal surgery and produce the stratification of the risk of postoperative complications by identifying independent predictors for its development.

NCT ID: NCT03945565 Not yet recruiting - Clinical trials for Coronary Artery Disease

FiO2 and Outcomes After OPCAB

Start date: May 2019
Phase: N/A
Study type: Interventional

Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery including off-pump coronary artery bypass grafting (OPCAB). Since the potential adverse effects of hyperoxemia (via reactive oxygen species, vasocontriction, perfusion heterogeneity, myocardiac injury, etc.), various studies on this topic has been performed. However, the results are conflicting and inconsistent, and the consensus about whether the use of additional oxygen supply in cardiac surgery has not been reached among practitioners yet.

NCT ID: NCT03943459 Not yet recruiting - Clinical trials for Coronary Artery Disease Progression

Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease

Start date: June 1, 2019
Phase: Phase 3
Study type: Interventional

Higher consumption of fruits and vegetables promote greater availability of phenolic compounds and these compounds were associated with vascular health. Quercetin, a phenolic compound, is the most abundant natural antioxidant belonging to the group of flavonoids. Quercetin improved lipoprotein metabolism, had antioxidant capacity, produced vasodilating substances in the vascular endothelium and reduced platelet aggregability. Likewise, statins are medications known to reduce cardiovascular events in women with coronary disease by reducing serum LDL-cholesterol. Therefore, a number of metabolic pathways are responsible for vascular health. The serum concentration and gene expression of sirtuin 1 (Sirt1) and RAGE soluble (sRAGE) are directly associated with vascular protection. This study will analyse the influence of atorvastatin and quercetin on serum concentrations and gene expression of Sirt1 and sRAGE in postmenopausal women with stable coronary artery disease.

NCT ID: NCT03939923 Active, not recruiting - Clinical trials for Coronary Artery Disease

Role of Sugammadex as Reversal Agent in Patients Extubated Immediately After Isolated Coronary Artery Bypass Grafting Surgery

Start date: May 1, 2019
Phase: Phase 4
Study type: Interventional

The purpose of this study is to examine whether the use of Sugammadex will reduce time from reversal to extubation and improve other post extubation outcomes in Coronary artery bypass grafting patients. This study is a prospective, clinical interventional, randomized single blinded single-center design. The nurses in the cardiac intensive care unit will be blinded to treatment allocation (Group 1 or 2).

NCT ID: NCT03939468 Not yet recruiting - Clinical trials for Coronary Artery Disease

Drug-Coated Balloon in Combination With New Generation Drug-Eluting Stent for de Novo Diffuse Disease Treatment

Start date: May 1, 2019
Study type: Observational [Patient Registry]

A Pilot Observational Study to evaluate safety and efficacy of the hybrid approach DES/DCB in treating de-novo diffuse lesions

NCT ID: NCT03939273 Not yet recruiting - Clinical trials for Coronary Artery Disease

The Effects of Gut Micribiota Disruption on the Immune Response After Open Heart Surgery

Start date: July 2019
Phase: N/A
Study type: Interventional

In this randomized, double-blind, placebo-controlled study, the investigators will assess whether preoperative disruption of the gut microbiota by a course of broad spectrum antibiotics will attenuate the postoperative systemic inflammatory response after on-pump cardiac surgery

NCT ID: NCT03936504 Not yet recruiting - Coronary Disease Clinical Trials

Study on the Effect of the Newly Compiled Tai Chi on Rehabilitation of Patients With Coronary Heart Disease

Start date: May 30, 2019
Phase: N/A
Study type: Interventional

The purposes of this study is to evaluate the improvement of Tai Chi exercise involved cardiac rehabilitation program on the quality of life ´╝îpsychological states, and clinical outcomes of patients .

NCT ID: NCT03934957 Recruiting - Obesity Clinical Trials

Hamburg City Health Study - a German Cohort Study

Start date: February 8, 2016
Study type: Observational

The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several risk and prognostic factors in major chronic diseases.

NCT ID: NCT03931434 Completed - Clinical trials for Type 2 Diabetes Mellitus

Effect of Aged Garlic Extract (AGE) on Improving Coronary Atherosclerosis in People With Type 2 Diabetes Mellitus

Start date: February 23, 2016
Phase: N/A
Study type: Interventional

The purpose of this research study is to see the effect of taking Aged Garlic Extract (AGE) on the progression of coronary plaque, a condition called atherosclerosis, in people diagnosed with Diabetes.