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Coronary Artery Disease clinical trials

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NCT ID: NCT03577652 Completed - Clinical trials for Coronary Artery Disease

The Optimal Strategy of Switching From Clopidogrel to Ticagrelor in Patients With Complexity of Coronary Artery Disease

Start date: July 10, 2017
Phase: N/A
Study type: Interventional

The study is to further exploring the optimal switching strategy by evaluating the pharmacodynamic responses as well as adverse events in patients with complexity of coronary artery disease managed by percutaneous coronary intervention (PCI). All participants will be divided into three groups and recieving ticagrelor 90mg plus aspirin 100mg at 12 hours after the last dose of clopidogrel; recieving ticagrelor 90mg plus aspirin 100mg at 24 hours after the last dose of clopidogrel; recieving ticagrelor 180mg plus aspirin 100mg at 24 hours after the last dose of clopidogrel.

NCT ID: NCT03573388 Completed - Coronary Disease Clinical Trials

OCT Measures Predicting FFR

OMEF
Start date: October 16, 2017
Phase:
Study type: Observational

Background: the decision-making process of patients with angiographically-intermediate coronary lesions (ICL) is clinically challenging and may benefit from adjunctive invasive techniques. Fractional-flow-reserve (FFR) represents the gold standard to evaluate ICL but optical-coherence-tomography (OCT) is a novel, promising, high resolution coronary imaging technique. Objectives: 1. Investigate the relation between OCT and FFR parameters in ICL and understand if OCT measures may predict FFR. 2. Understand if OCT parameters may predict clinical outcome of patients with ICL not underwent revascularization on the bases of negative FFR. Study design: multicentre, international, individual patient's level data pooled analysis.

NCT ID: NCT03570762 Completed - Clinical trials for Coronary Artery Disease

Long Term Outcomes Of Hybrid Percutaneous Approach

Start date: February 1, 2015
Phase:
Study type: Observational

Bioresorbable vascular scaffolds (BVS) are considered as a new revolution in coronary intervention due to their potential advantages for long term follow up. However, current generation BVS have also some drawbacks that restrict the use for complex lesions. Using BVS and drug eluting stents (DES) together -implanting DES for BVS inappropriate segments -may be a feasible option to avoid the disadvantages of permanent foreign body and to reduce very late adverse events. In this context, we investigated the clinical outcomes following treatment with hybrid strategy with concomitant use of BVS and DES for complex lesions. A single center retrospective cohort was performed enrolling 40 patients with complex lesions treated with hybrid approach from February 2015 up to April 2017. Lesion segments with a large plaque burden and/or severe calcification, aorto-ostial and bifurcation lesions that may be unfavorable for BVS, treated with DES. BVS and DES were implanted with minimal overlap of DES and BVS struts. The primary end-point was target lesion failure (TLF) which was a composite of cardiac death, target vessel myocardial infarction and target lesion revascularization (TLR). During follow-up, coronary angiography was performed when patients had ischemic symptoms.

NCT ID: NCT03544294 Completed - Stent Thrombosis Clinical Trials

veRy Thin Stents for Patients With Left mAIn or bifurcatioN in Real Life: the RAIN a Multicenter Study

RAIN
Start date: June 1, 2017
Phase:
Study type: Observational [Patient Registry]

For permanent coronary stents, reduction of thickness of struts have become one of the most important innovation, being related to easier manipulation, reduced risk of stent thrombosis and low rate of revascularization. Consequently the investigators performed a multicenter registry enrolling all consecutive patients treated with very thin stents for ULM or bifurcation.

NCT ID: NCT03540381 Completed - Clinical trials for Coronary Artery Disease Progression

Relation Among HDL Functionality, Neoatherosclerosis and Target Lesion Revascularization

Start date: May 1, 2011
Phase:
Study type: Observational

The aim of this study is to evaluate the relation among cholesterol uptake capacity which measure HDL functionality, neoathrosclerosis and target-lesion revascularization.

NCT ID: NCT03527381 Completed - Clinical trials for Coronary Artery Disease

Nitric Oxide in CPB for Renal Protection in Cardiac Surgery

NephroNO
Start date: September 1, 2015
Phase: Phase 1/Phase 2
Study type: Interventional

This prospective randomized study evaluates the nephroprotective effects of exogenous nitric oxide delivered to the extracorporeal circulation circuit during cardiac surgery with cardiopulmonary bypass.

NCT ID: NCT03518645 Completed - Clinical trials for Coronary Artery Disease

Optimal Lesion Preparation With Non-compliant Balloons Before Implantation Of Bioresorbable Scaffolds

OPreNBiS
Start date: March 2015
Phase: N/A
Study type: Interventional

Study aim : To compare a novel strategy of lesion preparation with noncompliant balloons before implantation of BVS. Hypothesis: Predilatation with non-compliant balloons could facilitate optimal deployment of BVS. By achieving good scaffold apposition a need for post-dilatation could be significantly reduced. This is expected to result in better short- and long-term outcomes.

NCT ID: NCT03507205 Completed - Clinical trials for Coronary Artery Disease

Korean Nationwide Multicenter Pooled Registry of Drug-Eluting Stents

Grand-DES
Start date: April 1, 2008
Phase:
Study type: Observational [Patient Registry]

The objective of this study is to evaluate the long-term efficacy and safety of coronary stenting with the various types of drug-eluting stents (DES) and to determine clinical device and procedural success during commercial use of DES in the real world. The investigators will compare EES (Xience V/Promus and Xience Prime), SES (Cypher), ZES (Resolute Integrity, Endeavor Resolute, Endeavor), and BES (Biomatrix, Biomatrix Flex, and Nobori).

NCT ID: NCT03500783 Completed - Clinical trials for Coronary Artery Disease

Nitric Oxide-mediated Cardioprotection During Cardiac Surgery With Cardiopulmonary Bypass

NOinCPB
Start date: May 15, 2015
Phase: Phase 1/Phase 2
Study type: Interventional

This prospective randomized study elucidates the effects of exogenous nitric oxide delivered to the extracorporeal circulation circuit for cardioprotection against ischemia-reperfusion injury during coronary artery bypass graft surgery with cardiopulmonary bypass.

NCT ID: NCT03479840 Completed - Clinical trials for Coronary Artery Disease

Age-Dependent Impact of the SYNTAX-score on Mortality

Start date: January 1, 2013
Phase:
Study type: Observational

The SYNTAX-score has been proposed as a tool for risk stratification and guiding revascularization therapy in patients with complex coronary artery disease. There are limited data on the prognostic value of the SYNTAX-score among elderly patients. Aim of this study was to investigate whether age modifies the impact of the SYNTAX-score on all-cause mortality at 2 years after percutaneous coronary intervention (PCI).