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Coronary Artery Disease clinical trials

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NCT ID: NCT03739073 Recruiting - Clinical trials for Coronary Artery Disease

Can we Predict COronary Resistance By EYE Examination ? (COREYE)

COREYE
Start date: October 4, 2018
Phase: N/A
Study type: Interventional

Prospective interventional study, open, non-comparative and non-randomized. The research concerns physiological parameters of the coronary and ocular blood circulation. At the coronary level, the curves of pressure and Doppler flow will be extracted from ComboMap® (Philips). The coronary microvascular resistances, basal and hyperemic, will be determined by the average ratio of the distal pressure and flow. At the ocular level, a fundus oculi and an OCTA (angiography by tomography in optical coherence) examination will be performed. The measures of the FFR and the coronary microvascular resistance will be determined by a specific guidewire allowing simultaneous measures of pressure and Doppler flow (ComboWire®, Philips), in 200 patients with intermediate stenosis of the left anterior descending artery (LDA). Topological parameters characterizing the retinal area and choriocapillaires will be determined by statistical approaches and mathematical morphology. To establish a predictor of the coronary microvascular resistance from the eye vascular parameters, we shall use a non-linear regression by supervised machine learning. The main cardiovascular risk factors (hypertension, diabetes, dyslipidemia, age, sex) will be part of predetermined input features for the machine learning.

NCT ID: NCT03732066 Recruiting - Coronary Disease Clinical Trials

Web basEd soCial Media tecHnology to Improvement in Adherence to Dual anTiplatelet Therapy Following Drug-Eluting Stent Implantation

WeChat
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Few studies have attempt to improve DAPT adherence through social media. The investigators will explore the prevalence of DAPT discontinuation and prove the hypothesis that using social media will improve DAPT adherence among patients requiring DAPT following DES implantation.

NCT ID: NCT03731936 Recruiting - Clinical trials for Coronary Artery Disease

Artificial Intelligence to Assess the Association Between Facial Characteristics and Coronary Artery Diseases

Start date: July 10, 2017
Phase:
Study type: Observational

The purposes of this study are 1) to explore the association between facial characteristics and the increased risk of coronary artery diseases; 2) to evaluate the diagnostic efficacy of appearance factors for coronary artery diseases.

NCT ID: NCT03729531 Recruiting - Clinical trials for Coronary Artery Disease

Clinical Effect of No-touch Harvesting Technique in OPCABG

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

This study aims to investigate the clinical effect of the new saphenous vein harvesting technique "No-touch" in off-pump coronary artery bypass grafting(OPCABG), comparing to the conventional technique. Adopting CTA to evaluate the 3 months patency of the graft, we will compare veins harvested using No-touch technique to saphenous veins using conventional open technique.

NCT ID: NCT03712644 Recruiting - Clinical trials for Obstructive Coronary Artery Disease

Coronary Revascularization Versus Conservative Therapy in Patients With Treated Critical Limb Ischemia

INCORPORATE
Start date: July 11, 2018
Phase: N/A
Study type: Interventional

The objective of the INCORPORATE trial is to evaluate whether an intentional invasive strategy with ischemia targeted, reasonably complete coronary revascularization and optimal medical therapy is superior as compared to a primary conservative approach and optimal medical therapy alone in terms of spontaneous myocardial infarct-free and overall survival in patients with severe peripheral artery disease, underwent peripheral artery revascularization due to critical limb ischemia. The INCORPORATE trial is designed to be non-blinded, open-label, prospective 1:1 randomized controlled multicentric trial.

NCT ID: NCT03711539 Recruiting - Clinical trials for Coronary Artery Disease

Lifetime Endurance Exercise to Prevent Coronary Artery Disease

MASTER@HEART
Start date: October 18, 2018
Phase:
Study type: Observational

The primary objective of the Master@Heart Trial is to investigate whether lifelong endurance exercise reduces the incidence of non-calcified plaques (both mixed and soft plaques) as compared to late-onset endurance exercise and a non-athletic lifestyle.

NCT ID: NCT03709836 Recruiting - Clinical trials for Coronary Artery Disease

Computed Tomography Angiography Prediction Score for Side Branch Occlusion

CT-PRECISION
Start date: September 25, 2018
Phase:
Study type: Observational

Lesions involving coronary bifurcations account for approximately 20% of all percutaneous coronary interventions (PCI). Revascularization within bifurcation sites remains technically challenging. While the most optimal interventional treatment strategy for bifurcation lesions is still debatable, side branch (SB) occlusion is one of the most serious procedural complications with prevalence rates over 7%. Numerous mechanisms of the SB occlusion (e.g. plaque or carina shift, coronary artery dissection, thromboembolism, coronary artery spasm, etc) have been postulated. Regardless of the cause, loss of the SB is associated with increased risk of periprocedural mortality and myocardial infarction. Therefore, PCI involving coronary bifurcation mandates consideration of the risk of SB compromise. The CT-PRECISION (Computed Tomography angiography PREdiCtIon score for SIde branch Occlusion in coronary bifurcation interventioN) registry was designed to evaluate the application of coronary computed tomography angiography (coronary CTA) for the prediction of SB occlusion during percutaneous revascularization of bifurcation lesions. The main purpose of this single-center study is to develop a noninvasive CTA-based prediction tool to determine the procedural outcome of PCI in bifurcation lesions.

NCT ID: NCT03707626 Recruiting - Clinical trials for Coronary Artery Disease

Collateral Circulation to LAD and Wellens Sign

Start date: September 26, 2018
Phase:
Study type: Observational

Overall Aim Coronary artery disease significantly contributes to morbidity and mortality in the United States. Atherosclerotic disease can lead to stenosis of the coronary arteries and subsequent cardiac hypoperfusion. Patients with a critical stenosis of the LAD, potentially leading to acute anterior wall myocardial infarction, may be asymptomatic at presentation with subtle EKG changes as its only manifestation. It is imperative for physicians to recognize patients with new T wave inversions in leads V2-V3 as the standard course of management may lead to poor prognosis. The purpose of this study is to determine if collateral circulation to the left anterior descending (LAD) artery will mask the presence of a Wellens sign and therefore diminish its diagnostic utility. The conclusion of this study would raise awareness for physicians in light of an absent Wellens sign. Hypothesis The presence of coronary collateral circulation to the LAD masks the presence of a Wellens sign (both Type 1 and Type 2) in precordial leads V2-V4.

NCT ID: NCT03693261 Recruiting - Clinical trials for Coronary Artery Disease

Epicardial Fat in Cardiovascular Diseases

Start date: September 1, 2018
Phase:
Study type: Observational

Epicardial adipose tissue (EAT) is the visceral fat depot of the heart. EAT transcriptome is unique when compared to subcutaneous fat. EAT is a highly inflammatory tissue enriched with genes involved in inflammation, endothelial function, immune signaling and thermoregulation. EAT has been correlated with coronary artery disease (CAD) and atrial fibrillation (AF), although the mechanisms of the interplay of EAT with these two major cardiovascular diseases have not been fully understood. Whether EAT may act as brown fat and whether this may be affected by the presence of CAD is currently unknown. Whether the postulated thermoregulatory function of the EAT is correlated to the presence and severity of CAD is unknown EAT is though to play a role in the development and recurrence of AF. Recent studies showed that EAT has a unique transcriptome with genes encoding for pro-arrhythmogenic proteins. EAT is located in different areas of the heart. Whether regional EAT depots may have different genetic profile and functions is unknown. Whether peri-atrial EAT may have unique effects on cardiac muscle activity distinct from other EAT sub-depots is unknown. Peri left atrial EAT and pericoronary EAT will be collected from patients who are undergoing elective cardiac surgery as standard care. EAT transcriptome will be analysed with RNA- sequencing analysis (RNA-seq) and quantitative real time polymerase chain reaction (qRT-PCR) . Immunofluorescence and immunoblot will be also performed on fat samples.

NCT ID: NCT03679091 Recruiting - Platelet Reactivity Clinical Trials

Low-dose of Ticagrelor and Standard-dose Clopidogrel on Platelet Effects in Chinese Patients With Stable CAD.

Start date: August 29, 2018
Phase: Phase 4
Study type: Interventional

Ticagrelor has been demonstrated to provide a more rapid and more powerful inhibition of platelet aggregation compared with clopidogrel in coronary artery disease (CAD) patients. However, current guidelines recommend ticagrelor 90 mg twice daily might not be suitable for patients of Chinese. Therefore, the investigators performed this study to observe the efficacy of 60-mg ticagrelor in comparison to 75-mg clopidogrel in Chinese patients with stable CAD.