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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT03760705 Active, not recruiting - Clinical trials for Coronary Artery Disease

Singapore Cardiac Longitudinal Outcomes Database

SingCLOUD
Start date: July 5, 2013
Phase:
Study type: Observational [Patient Registry]

The research project aims to perform data extraction, integration and analysis across multiple clinical, administrative, financial and pharmacy databases in the participating institutions. The key data components will include clinical cardiovascular specific data, procedural data, financial and administrative data (e.g. cost of medications and supplies, length of stay, diagnosis codes etc.), short-to-long term clinical outcomes (including hospital re-admissions, cardiovascular events, death), and quality-of-care indices (e.g. compliance to guideline-recommended therapy and medications). The research project will involve all patients proven and/or suspected with coronary artery disease (CAD), congestive heart failure (CHF) and atrial fibrillation (AF) admitted to National Heart Centre Singapore (NHCS) and NUH.

NCT ID: NCT03753022 Active, not recruiting - Clinical trials for Coronary Artery Disease

Effects of PEEP on Parameters of Tissue Perfusion in Patients Post Cardiac Surgery

Start date: January 2012
Phase: N/A
Study type: Interventional

Pulmonary dysfunction is a condition inherent in cardiac surgery because of various interventions, such as general anesthesia, a median sternotomy, cardiopulmonary bypass and establishment of internal thoracic artery dissection. In situations when there is a deterioration in oxygenation, increased positive pressure on the airways end pressure (PEEP) can be used as therapeutic mode by reversing severe hypoxemia resulting pulmonary shunt. But the use of PEEP has been associated to reduced cardiac output, due mainly to decrease systemic venous return consequent to increased intrathoracic pressure, and thus might reduce tissue oxygenation. Moreover, the increased transpulmonary gradient may also impair right ventricular ejection exacerbating the hemodynamic consequences in some patients, which in clinical practice this diagnosis may be difficult to perform. In hypovolemic patients or those with cardiac changes may become even more pronounced, resulting in accentuation of low flow and systemic hypotension entailing changes in markers of tissue perfusion commonly measured by venous saturation central difference venoarterial carbon dioxide and lactate. The hypothesis of the investigators is that PEEP of 10 cmH2O and 15 cmH2O can be applied to reverse lung damage in patients in the immediate postoperative myocardial revascularization without repercussion tissue importantly in markers of tissue perfusion. The objective is to evaluate the effects of different optimization levels of PEEP on gas exchange and influences the tissue perfusion after coronary artery bypass graft surgery.

NCT ID: NCT03738631 Active, not recruiting - Clinical trials for Coronary Artery Disease

Cardiac Biomarkers After Marathon Running and Coronary Atherosclerosis

MaraCat
Start date: August 17, 2018
Phase:
Study type: Observational

This study evaluates cardiac biomarkers and their association to coronary artery disease in marathon runners.

NCT ID: NCT03712020 Active, not recruiting - Chest Pain Clinical Trials

Investigating the Role of Active Versus Chronic Coronary Artery Calcification on Acute Myocardial Infarct

Active-AMI
Start date: February 2015
Phase:
Study type: Observational

The investigator aims to determine the feasibility of understanding the process of active versus chronic calcification using Na-F PET scan and contrast CT scan of the heart. The patient cohort will consist of patients diagnosed to have either acute coronary syndrome (ACS) (comprising of either unstable angina pectoris or acute myocardial infarction) or suspected coronary artery disease (CAD). The PET images will be compared to images obtained from standard contrast CT of the coronaries. This study will provide additional insights about active versus non-active calcification amongst patients with ACS or suspected CAD.

NCT ID: NCT03693560 Active, not recruiting - Clinical trials for Coronary Artery Disease

Effect of Adding Vildagliptin vs Glimepiride to Metformin on Inflammation's Markers in Type-2 Diabetic Patients With CAD

Start date: October 8, 2018
Phase: Phase 4
Study type: Interventional

The aim of this study is to evaluate the effect of adding Vildagliptin versus Glimepiride to Metformin on markers of inflammation, thrombosis, and atherosclerosis in diabetic patients with symptomatic Coronary artery diseases. The pre-specified established biological markers of inflammation, thrombosis, and atherosclerosis will include: Interleukin 1 beta (IL-1 beta)), hs-CRP, Atherogenic index and coronary risk index, Lipid profile. and adiponectin levels..

NCT ID: NCT03683836 Active, not recruiting - Atrial Fibrillation Clinical Trials

Minor Troponin Elevations in Patients With Atrial Fibrillation

Tropo-AF
Start date: June 1, 2016
Phase:
Study type: Observational

This study aims at identifying the etiology of troponin-T elevations in patients with atrial fibrillation visiting the emergency department.

NCT ID: NCT03651180 Active, not recruiting - Clinical trials for Coronary Artery Disease

Efficacy and Safety of Coronary Amphilimus-ELuting Stent in diAbeTic patiEnts

ESCALATE
Start date: August 1, 2018
Phase:
Study type: Observational [Patient Registry]

More recently a polymer-free drug eluting stent (Amphilimus eluting stent) has shown to have a superiority in terms of efficacy and safety if compared with stable polymer drug eluting stent when used in diabetic patients. However, to date there are no direct comparisons of these two type of drug eluting stents.

NCT ID: NCT03646097 Active, not recruiting - Clinical trials for Ischaemic Heart Disease

Impact of Real-time Angiographic Co-registered OCT on PCI Results - the OPTICO-integration II Study

Integration-II
Start date: August 21, 2018
Phase: N/A
Study type: Interventional

Intracoronary optical coherence tomography (OCT) imaging allows for high-resolution characterization of coronary lesions. Difficulties in matching cross-sectional OCT-images with angiographic lesion localization, however, may limit its clinical utilization. The investigators sought to prospectively assess the impact of a novel system of real-time OCT-coregistration with angiography (ACR) compared to OCT alone and to the clinical standard proceeding (angiographic guided-PCI) all used for coronary lesion evaluation before percutaneous coronary interventions (PCI). The investigators hypothesize that the use of ACR will lead to less incidence of insufficient covered coronary lesions (geographical mismatch) and/or a less rate of edge dissections after PCI (combined primary study endpoint)

NCT ID: NCT03610828 Active, not recruiting - Stroke Clinical Trials

Meta-analysis of Vegetarian Diets and Incident Cardiovascular Outcomes

Start date: October 1, 2017
Phase:
Study type: Observational

Vegetarian and vegan diets have been shown to reduce cardiometabolic risk factors for chronic diseases, such as cardiovascular disease and diabetes, and have been associated with decreased risk of these chronic diseases. The role of vegetarian and/or vegan dietary patterns and incident cardiovascular outcomes still remains unclear. To address these uncertainties, the investigators propose to conduct a systematic review and meta-analysis of the totality of evidence from prospective cohort studies to distinguish the association of vegetarian and/or vegan dietary patterns on the prevention and management of cardiovascular diseases. This proposed knowledge synthesis was commissioned by the Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD) and will be used to inform clinical practice and dietary guidelines, help improve health outcomes, and guide future research design.

NCT ID: NCT03603210 Active, not recruiting - Clinical trials for Ischaemic Heart Disease

Outcomes of Drug Coated Balloon Angioplasty, A UK Real Life Experience From 2009 to 2015

DCBNORWICH
Start date: September 11, 2017
Phase:
Study type: Observational

This is a single center, retrospective, observational cohort study to assess the safety and efficacy of drug coated balloon (DCB) angioplasty in all forms of coronary artery disease. The Investigators intend to report outcomes of all patients who received DCB angioplasty at their center during the above mentioned period for up to 10 years.