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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT03588962 Not yet recruiting - Clinical trials for Coronary Artery Disease

Metal Allergy In-Stent Restenosis Study

RESTALL
Start date: October 1, 2018
Phase: N/A
Study type: Interventional

In-stent restenosis remains one of the most challenging problems in patients after coronary artery angioplasty. Angiographically, it is discovered in 10% of the patients after drug-eluting stent (DES) implantation. There are multiple factors causing restenosis, which can be divided into two major groups: first vessel-dependent (based on the vessel's tortuosity, dimensions and lesion's calcification, all leading to suboptimal stent expansion), and second dependent on the inflammatory processes caused by the intervention. Study objectives is the analysis of the possible correlation between allergy to metals utilised during the stent manufacturing (nickel, cobalt, chromium, molybdenum, tungsten) and in-stent restenosis occurence. The angiographic results of stent implantation, and in-stent restenosis will be assessed independently by two skilled interventional cardiologists, and in case of their discrepant opinions, the decision will be made on the basis of the third cardiologist. The tests will be applicated during the hospitalisation, then read after 48 hours and 72 hours, and subsequently interpreted by the skilled dermatologist, during the hospital stay or afterwards.

NCT ID: NCT03588481 Not yet recruiting - Coronary Disease Clinical Trials

IRIS- DESyne X2 in the IRIS-DES Registry

IRIS DESyne X2
Start date: August 30, 2018
Phase:
Study type: Observational

This study evaluates effectiveness and safety of DESyne X2 in Routine Clinical Practice.

NCT ID: NCT03586492 Not yet recruiting - Clinical trials for Ischemic Heart Disease

Coronary Flow Reserve (CFR) in Cardiovascular Risk Stratification

CFR-OR
Start date: October 1, 2018
Phase: N/A
Study type: Interventional

CFR has been studied for few years using 82 Rubidium PET (positron emission tomography) /CT. CFR has shown to be correlated with cardiovascular events occurring in the 10 following years. CFR also helps to identify multivessel coronary disease. Few studies have shown the possibility to calculate CFR during myocardial perfusion SPECT on new ultrafast CZT cameras.

NCT ID: NCT03577821 Not yet recruiting - Clinical trials for Ischemic Heart Disease

Early Outcome of Total Arterial Revasclarization in IHD

Start date: July 1, 2018
Phase:
Study type: Observational

Complete arterial coronary artery bypass grafting (CABG) is a surgical option to improve long-term results in the treatment of coronary artery disease (CAD). The goal of coronary artery bypass operations is complete revascularization and there is an increasing interest toward complete arterial revascularization to achieve this goal because of high late failure of saphenous vein graft

NCT ID: NCT03574311 Not yet recruiting - Clinical trials for Coronary Artery Disease

Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Elective Coronary Artery Bypass Grafting

PREFER-CABG
Start date: July 2018
Phase: Phase 4
Study type: Interventional

This study evaluates the efficacy and safety of single dose preoperative ferric carboxymaltose in the prevention of postoperative infections and blood transfusions in patients scheduled for isolated coronary artery bypass grafting. Half of the patients will receive ferric carboxymaltose and half of the patients physiological saline solution as placebo.

NCT ID: NCT03570697 Not yet recruiting - Clinical trials for Coronary Artery Disease (CAD)

Imaging of Coronary Plaques in Subjects Treated With Evolocumab

Start date: October 22, 2018
Phase: Phase 3
Study type: Interventional

To evaluate the effect of evolocumab on fibrous cap thickness (FCT) in subjects with non-ST-elevation acute coronary syndrome (NSTE-ACS) who are taking maximally tolerated statin therapy.

NCT ID: NCT03567733 Not yet recruiting - Clinical trials for Coronary Artery Disease

Prospective Registry of Patients Over 75 Years Old Treated With Xience Sierra Stents. Sierra 75 Study

SIERRA 75
Start date: June 30, 2018
Phase:
Study type: Observational [Patient Registry]

This prospective registry is intended to evaluate the safety and efficacy of the XIENCE Sierra stent.

NCT ID: NCT03567408 Not yet recruiting - Clinical trials for Coronary Heart Disease

Clinical Study of Bivalirudin for Percutaneous Coronary Intervention (PCI)

Start date: July 30, 2018
Phase: Phase 2
Study type: Interventional

Bivalirudin is widely used as an anticoagulant to reduce the risk of bleeding in PCI perioperative period. Additionally, 15.7%-32.7% patients have diabetes mellitus who undergo percutaneous coronary interventions (PCI), so bivalirudin was used to anticoagulate in these patients to evaluate its safety and efficacy.

NCT ID: NCT03564080 Not yet recruiting - Clinical trials for Coronary Artery Disease

Assessing the Feasibility of Including Patients With Peripheral Artery Disease in to an Established Cardiac Rehabilitation Service.

Start date: July 18, 2018
Phase: N/A
Study type: Interventional

This study will investigate if patients with peripheral artery disease (PAD) can be successfully incorporated into an already existing Cardiac Rehabilitation programme. One group of PAD patients will exercise as a group, and the other group will exercise alongside patients with coronary artery disease (CAD).

NCT ID: NCT03563989 Not yet recruiting - Clinical trials for Coronary Artery Disease

STENTYS Xposition S in the Treatment of Chronic Total Artery Occlusion

SXS-CTO
Start date: June 2018
Phase: N/A
Study type: Interventional

Intro: Chronic total occlusions (CTO) are the most severe coronary lesions. Negative distal vessel remodeling occurs in these lesions, leading to reduction of artery diameter. Treatment of CTO with percutaneous coronary intervention (PCI) is associated with good clinical outcomes. However, QCA and IVUS studies showed a notable lumen and vessel enlargement distal to recanalized CTO. In addition, optical tomography (OCT) studies showed high rates of stent strut malapposition and incomplete stent strut coverage after CTO PCI. The Stentys Xposition S is a self-apposing stent device which lowers stent strut malapposition rates. Its safety and effectiveness has been demonstrated in STEMI and stable coronary patients but never investigated in CTO lesions. Hypothesis/Objective To investigate whether self-expanding stents are more effective than balloon-expandable stents for reducing stent malapposition at 6 months after implantation in patients with CTO undergoing percutaneous coronary intervention. Method Pilot randomized study. Patients are randomized to receive either self-expandable stent or balloon expandable stent to perform CTO-PCI. Follow-up coronary angiography is performed at 6 months post-PCI. Stent malapposition is evaluated by OCT.