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Coronary Artery Disease clinical trials

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NCT ID: NCT03952351 Not yet recruiting - Clinical trials for Coronary Artery Disease

Troponin in Acute Chest Pain to Risk Stratify and Guide EffecTive Use of Computed Tomography Coronary Angiography

TARGET-CTCA
Start date: August 2019
Phase: N/A
Study type: Interventional

Most patients presenting to hospital with symptoms of a heart attack are sent home without further tests once a heart attack has been ruled out. Current strategies to assess patients with a suspected heart attack involve blood tests to measure troponin, a protein released into the bloodstream when the heart muscle is damaged. Despite having had a heart attack ruled-out, some patients have unrecognised heart disease and are at risk of having a heart attack in the future. However, we do not know what is the best approach to identify and treat these patients. This study will use a heart scan known as computed tomography coronary angiogram (CTCA) to look for unrecognised heart disease in patients who have had a heart attack ruled out. In an earlier study, we performed this scan in patients referred to the outpatient cardiology clinic with stable chest pain and found that this improved the diagnosis of heart disease, leading to improvement in patient care that prevented future heart attacks. Our research has also found that troponin levels below those used to diagnose a heart attack may help to identify those who are at greater risk of having a heart attack in the future. The aim of this study is to find out if patients with these low levels of troponin, where a heart attack has been ruled out, will benefit from CTCA to look for unrecognised coronary heart disease.

NCT ID: NCT03952273 Not yet recruiting - Clinical trials for Coronary Artery Disease

Sort Out XI - Combo Stent Versus BioMatrix Alpha Stent

SORTOUTXI
Start date: May 30, 2019
Phase: N/A
Study type: Interventional

SORT OUT XI Comparison of Combo™ stent and BioMatrix Alpha™ stent in the treatment of unselected patients with ischemic heart disease.

NCT ID: NCT03947229 Not yet recruiting - Clinical trials for Coronary Artery Disease

A Randomized Comparison of CLOpidogrel Monotherapy Versus Extended Dual-antiplatelet Therapy Beyond 12 Months After Implantation of Drug-eluting StEnts in High-risk Lesions or Patients; A-CLOSE Trial

Start date: June 2019
Phase: Phase 4
Study type: Interventional

The investigators hypothesized that clopidogrel mono-therapy will not be inferior to the extended DAPT in terms of the occurrence of both ischemic and bleeding events, for lesions or patients at high risk for either ischemic or bleeding complications 12 months after drug-eluting stent (DES) implantation.

NCT ID: NCT03945968 Not yet recruiting - Stroke Clinical Trials

The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.

STOP RISK
Start date: July 1, 2019
Phase:
Study type: Observational

Study is conducted to assess the prevalence and structure of comorbidity among patients undergoing abdominal surgery and produce the stratification of the risk of postoperative complications by identifying independent predictors for its development.

NCT ID: NCT03945565 Not yet recruiting - Clinical trials for Coronary Artery Disease

FiO2 and Outcomes After OPCAB

Start date: May 2019
Phase: N/A
Study type: Interventional

Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery including off-pump coronary artery bypass grafting (OPCAB). Since the potential adverse effects of hyperoxemia (via reactive oxygen species, vasocontriction, perfusion heterogeneity, myocardiac injury, etc.), various studies on this topic has been performed. However, the results are conflicting and inconsistent, and the consensus about whether the use of additional oxygen supply in cardiac surgery has not been reached among practitioners yet.

NCT ID: NCT03943459 Not yet recruiting - Clinical trials for Coronary Artery Disease Progression

Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease

Start date: June 1, 2019
Phase: Phase 3
Study type: Interventional

Higher consumption of fruits and vegetables promote greater availability of phenolic compounds and these compounds were associated with vascular health. Quercetin, a phenolic compound, is the most abundant natural antioxidant belonging to the group of flavonoids. Quercetin improved lipoprotein metabolism, had antioxidant capacity, produced vasodilating substances in the vascular endothelium and reduced platelet aggregability. Likewise, statins are medications known to reduce cardiovascular events in women with coronary disease by reducing serum LDL-cholesterol. Therefore, a number of metabolic pathways are responsible for vascular health. The serum concentration and gene expression of sirtuin 1 (Sirt1) and RAGE soluble (sRAGE) are directly associated with vascular protection. This study will analyse the influence of atorvastatin and quercetin on serum concentrations and gene expression of Sirt1 and sRAGE in postmenopausal women with stable coronary artery disease.

NCT ID: NCT03939468 Not yet recruiting - Clinical trials for Coronary Artery Disease

Drug-Coated Balloon in Combination With New Generation Drug-Eluting Stent for de Novo Diffuse Disease Treatment

HYPER
Start date: May 1, 2019
Phase:
Study type: Observational [Patient Registry]

A Pilot Observational Study to evaluate safety and efficacy of the hybrid approach DES/DCB in treating de-novo diffuse lesions

NCT ID: NCT03939273 Not yet recruiting - Clinical trials for Coronary Artery Disease

The Effects of Gut Micribiota Disruption on the Immune Response After Open Heart Surgery

REMEDI
Start date: July 2019
Phase: N/A
Study type: Interventional

In this randomized, double-blind, placebo-controlled study, the investigators will assess whether preoperative disruption of the gut microbiota by a course of broad spectrum antibiotics will attenuate the postoperative systemic inflammatory response after on-pump cardiac surgery

NCT ID: NCT03936504 Not yet recruiting - Coronary Disease Clinical Trials

Study on the Effect of the Newly Compiled Tai Chi on Rehabilitation of Patients With Coronary Heart Disease

Start date: May 30, 2019
Phase: N/A
Study type: Interventional

The purposes of this study is to evaluate the improvement of Tai Chi exercise involved cardiac rehabilitation program on the quality of life ,psychological states, and clinical outcomes of patients .

NCT ID: NCT03927560 Not yet recruiting - Clinical trials for Coronary Artery Disease

Robotic-Assisted Percutaneous Coronary Intervention

Start date: June 10, 2019
Phase: N/A
Study type: Interventional

Percutaneous coronary intervention is a safe procedure. However, its execution is manual, fully operator-dependent. The procedure is also associated with radiation exposure to patients and physicians. This study will evaluate the robotic assisted percutaneous coronary intervention as an alternative to manual operation.