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Atrial Fibrillation clinical trials

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NCT ID: NCT03838341 Recruiting - Atrial Fibrillation Clinical Trials

Stand-alone Totally Thoracoscopic AtriClip® Left Atrial Appendage Occlusion in Non-valvular Atrial Fibrillation.

THORACS-LAAO
Start date: June 8, 2015
Phase:
Study type: Observational [Patient Registry]

Polish multicenter registry to assess safety and durability of totally thoracoscopic left atrial appendage occlusion for stroke prevention in atrial fibrillation.

NCT ID: NCT03836339 Active, not recruiting - Atrial Fibrillation Clinical Trials

Assessment of Atrial Fibrillation in Emergency Department

ACFA
Start date: October 1, 2018
Phase:
Study type: Observational [Patient Registry]

Atrial Fibrillation (AF) is the most common disorder of the rhythm disturbance, especially in older adults. The incidence and prevalence of AF increases significantly with age: less than one new case per 1000/year before age 40 to 20/1000 per year after the age of eighty. AF represents 1% of emergency department (ED) visits a third of which are inaugural or recurrent. The causes are varied from cardiac (ischemic cardiac disease, valvular, high blood pressure, heart failure, pericarditis, myocarditis) to extra cardiac etiologies (pulmonary embolism, thyroid disorders, thyrotoxicosis, alcohol, shock, chest trauma, electrolyte disorders, dehydration). While the diagnosis is given quickly by reading the electrocardiogram (ECG), its management both in terms of therapeutic strategy that of choice of care pathway is complex as evidenced by the diversity of possibilities and the difference in practice. Specific recommendations have been published by the French Society of Emergency Medicine in 2015. Our study aims to investigate guidelines implementation in French ED, especially the contribution of diagnostic tests and initiated treatments. Therapeutic strategies are evaluated with a follow up at 3 months, 6 months and 1 year, reporting cardiovascular events and long-term treatment.

NCT ID: NCT03836092 Recruiting - Atrial Fibrillation Clinical Trials

ECGI in Patients With Persistent Atrial Fibrillation

Start date: February 23, 2018
Phase:
Study type: Observational

To determine the values and limitations of ECGI in guiding ablation and risk stratification in patients with persistent atrial fibrillation.

NCT ID: NCT03835429 Recruiting - Atrial Fibrillation Clinical Trials

Effect of Oral Appliance Therapy on Atrial Fibrillation

Start date: January 15, 2019
Phase: N/A
Study type: Interventional

This pilot study is expected to determine the efficacy of using the midline traction designed MyTAP plus mouth shield (MyTAP + MS) oral appliance combination in decreasing the number of Atrial Fibrillation events. The MS is a patient comfort accessory to the MyTAP.

NCT ID: NCT03835338 Not yet recruiting - Clinical trials for Persistent Atrial Fibrillation

WATCHMAN for Concomitant Left Atrial Appendage Electrical Isolation and Occlusion to Treat Persistent Atrial Fibrillation Rhythm

WATCH-Rhythm
Start date: June 2019
Phase: N/A
Study type: Interventional

WATCH-Rhythm is a prospective, randomized, multi-center, investigation to collect safety and effectiveness data on combining conventional AF ablation with LAA electric isolation and closure within a single procedure.

NCT ID: NCT03833089 Not yet recruiting - Atrial Fibrillation Clinical Trials

Targeted Potassium Levels for Prevention of ICD Therapy

Start date: February 5, 2019
Phase: Phase 4
Study type: Interventional

This study evaluates whether a rigorously controlled high-normal level of serum-potassium (4.5-5.0 mEq/L) using dietary recommendations, potassium supplements and mineralocorticoid receptor antagonists will results in a lower incidence of cardiac arrhythmias in patients with an ICD. Patients will be randomized to this treatment or a control arm, where patients will receive usual guideline recommended follow-up.

NCT ID: NCT03832959 Not yet recruiting - Atrial Fibrillation Clinical Trials

Esophageal Damage Protection During Pulmonary Vein Ablation. Pilot Study.

Start date: February 2019
Phase: N/A
Study type: Interventional

Catheter ablation of atrial fibrillation with electrical isolation of the pulmonary veins in the left atrium carries risk of esophagus thermal lesion. EnsoETM is a device . This study evaluates the benefit of using the EnsoETM, a device device for esophageal temperature adjustments, during catheter ablation of atrial fibrillation. Half of participants will undergo esophageal temperature adjustment during pulmonary vein catheter ablation, while the other half will undergo catheter ablation with no esophageal temperature adjustment.

NCT ID: NCT03830320 Recruiting - Atrial Fibrillation Clinical Trials

Imaging of LAA Thrombosis

Start date: August 1, 2016
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate a new radiotracer called 64Cu-FBP8 for PET-MR imaging of thrombosis. The tracer has the potential of detecting thrombosis in the left atrial appendage of patients with atrial fibrillation, thereby may provide a non-invasive alternative to the current standard-of-care, transesophageal echocardiography.

NCT ID: NCT03828162 Completed - Atrial Fibrillation Clinical Trials

Atrial Fibrillation: Risk and Benefits of Anti-coagulation in the Elderly

Carebbean-e
Start date: November 1, 2010
Phase:
Study type: Observational

This study was designed to assess the effectiveness of oral anticoagulants in elderly patients (>=75 years) with atrial fibrillation. All patients discharged from one large hospital in Stockholm, Danderyds Hospital, between november 1st 2010 and december 31st 2017 with atrial fibrillation as main diagnosis have been included (n=2943). Adverse events (cardiovascular death, fatal/non fatal ischemic stroke, peripheral thromboembolism, fatal/non fatal intracerebral hemorrhage and extracranial bleeding) are recorded through linkage to mandatory and qualitative national registries and review of the medical records until december 31 2018.

NCT ID: NCT03827915 Recruiting - Atrial Fibrillation Clinical Trials

Double Sequential External Defibrillation in Patients With Atrial Fibrillation Refractory to DC Cardioversion

Start date: January 21, 2019
Phase: N/A
Study type: Interventional

Atrial fibrillation (AF) is a common cardiac arrhythmia that leads to increased risk of heart failure, hospitalization, thromboembolic events, and death. Restoration of normal heart rhythm is performed in many patients with AF to improve symptoms. In this study, the investigators will consider patients who fail 2 or more trials of DC cardioversion as having refractory AF. The aim of this study is to assess whether the use of double sequential defibrillation in patients with refractory AF has a higher success rate in reverting them to a normal heart rhythm than a third cardioversion. This is a phase III, randomized controlled, single-centered, superiority trial. All patients with AF admitted to the coronary care unit (CCU) for DC cardioversion, and refractory to at least two trials of DC cardioversion will be enrolled. Patients are randomized into two arms: the first will receive a third trial of DC cardioversion (standard of care) and the second will receive double sequential external defibrillation. The resolution of AF by reverting back to normal sinus rhythm is the primary outcome of the investigators. This will be determined using EKG (electrocardiogram) immediately after DC cardioversion or double sequential defibrillation.