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Stroke clinical trials

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NCT ID: NCT02081040 Completed - Stroke Clinical Trials

Coughing in Infratentorial Brain Lesion Patients

Start date: September 2013
Phase: N/A
Study type: Observational

To record diaphragm excursion in infratentorial brain lesions patients with dysphagia during coughing and compare them to those with supratentorial brain lesion patients with dysphasia and those with no dysphagia at a university affiliated rehabilitation department.

NCT ID: NCT02080988 Completed - Stroke Clinical Trials

Reflexive Coughing Force in Severe Aspirators

Start date: October 2013
Phase: N/A
Study type: Observational

To assess coughing force during reflex coughing test in those with severe dysphagia and severe aspiration and compare them to than those with stroke patients with no signs of dysphagia/aspiration.

NCT ID: NCT02080910 Completed - Stroke Clinical Trials

A Psychoeducational Intervention for Stroke Family Caregivers

Start date: n/a
Phase: N/A
Study type: Interventional

This is a randomized controlled trial with a 3-month psychoeducational program as intervention, followed by a 3 month observational period. The purpose of this study was to examine whether a psychoeducational program focusing on equipping caregivers with problem-solving skills would improve caregiver's problem-solving abilities, their psychological responses and caregiving resources, and would minimize the use of health and social services among stroke survivors.

NCT ID: NCT02080806 Completed - Stroke Clinical Trials

Pilot Study of Efficacy of Mechanical Insufflation Exsufflation in Stroke

Start date: October 2013
Phase: N/A
Study type: Interventional

Stroke patients with dysphagia have restrictive lung dysfunction and impaired cough response. This pilot study was performed to determine if Mechanical Insufflation Exsufflation (MIE) therapy can help recover impaired cough function.

NCT ID: NCT02080286 Recruiting - Stroke Clinical Trials

Transcranial Stimulation (tDCS) and Prism Adaptation in Spatial Neglect Rehabilitation

Start date: February 2014
Phase: N/A
Study type: Interventional

The present study aims to compare the relative therapeutic efficacy of prism adaptation therapy combined with real versus sham tDCS. The investigators will test the hypothesis that the magnitude and duration of neglect improvement will be increased when prism therapy is combined with real tDCS compared to sham tDCS. A second objective is to test whether individual differences in baseline clinical or brain imaging measures can predict: 1) neglect severity or 2) inter-individual differences in patients' therapeutic response. A third goal is to use brain imaging to characterize the patterns of neural change induced by the intervention to identify brain structures that mediate therapeutic response.

NCT ID: NCT02079779 Completed - Acute Stroke Clinical Trials

Efficacy Study of an Interactive Robot for the Rehabilitation of the Upper Limb in Acute Stroke Patients

Start date: January 9, 2015
Phase: N/A
Study type: Interventional

Stroke is the principal cause of permanent disability within the investigators population. This incapacity justifies an intensive and prolonged multidisciplinary rehabilitation, which can be optimized by robotics. The investigators team has developed a robot designed to rehabilitate the upper limb. This robot allows the patient to perform active, passive, or assisted exercises. The system is also able to assess movement quality and to provide a feedback to the patient and the therapist via a graphical interface. This therapy is designed to improve functional recovery of patients, and then their quality of life. Few quality studies have evaluated the efficacy of robotic assisted therapy in patients at the acute stage of rehabilitation (< 3 months post stroke) when most improvements are observed. Thus, the aim of this study was to objectify the effectiveness of robotic-assisted rehabilitation in the acute stage after stroke by evaluating the 3 fields of the ICF (International Classification of Functioning, Disability and Health) and performing a prospective multicenter randomized controlled single blind trial. In this study, 60 stroke patients will be recruited and randomized into two groups. All patients will receive a similar classical rehabilitation as a basis. Patients of the control and experimental groups will receive a supplement of classical rehabilitation and robotic-assisted therapy, respectively.

NCT ID: NCT02079103 Completed - Stroke Clinical Trials

Virtual Reality Training for Upper Extremity After Stroke

VIRTUES
Start date: March 2014
Phase: Phase 2
Study type: Interventional

Background: High intensity training of challenging tasks with many repetitions is a key factor for regaining motor function after stroke. Novel virtual reality (VR) rehabilitation systems provide the potential to increase intensity and offer challenging and motivating tasks. The efficacy of VR systems has not been demonstrated yet in sufficiently powered studies. Methods: In 5 participating rehabilitation centers patients in the subacute phase after stroke will be randomized to either a group receiving 4 weeks of VR training in addition to conventional arm training or a group receiving dose-matched and therapist attention-matched conventional arm-training. Hypothesis: VR training is more effective in improving arm motor function than conventional arm training in the subacute phase after stroke.

NCT ID: NCT02077582 Recruiting - Cerebral Stroke Clinical Trials

Longitudinal MRI Examinations of Patients With Brain Ischemia and Blood Brain Barrier Permeability

LOBI-BBB
Start date: September 2013
Phase: N/A
Study type: Observational

The objective of this trial is to visualize blood brain barrier function and metabolic changes in the first days after ischemic stroke with new investigational MRI sequences.

NCT ID: NCT02077439 Completed - Stroke Clinical Trials

Interactive Intention-Driven Upper-Limb Training Robotic System

Start date: January 2014
Phase: N/A
Study type: Interventional

The goal of this study is to determine robotic hand system is more effective than conventional physical and occupational therapy at promoting functional recovery of the affected arm in subjects after stroke.

NCT ID: NCT02077023 Completed - Stroke Clinical Trials

An Observational Study of Natural History of Cardiovascular Diseases

Start date: February 2014
Phase:
Study type: Observational

The purpose of the study is to estimate the contemporary prevalence of cardiovascular diseases in the United Kingdom (UK) and to describe the incidence and prevalence of stroke, mini stroke (TIA), Heart Attack (MI), deaths and interventions repairs for carotids and occlusive arterial disease in a large population. This study will also allow us to obtain reliable information on the age- and sex-specific relevance of tobacco and alcohol consumption, obesity, diabetes and blood pressure as risk factors for different cardiovascular diseases. By following up a large group of participants for 5 years, we will be able to estimate the annual risk of stroke and other CVD events associated with asymptomatic carotid artery stenosis and atrial fibrillation.