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Stroke clinical trials

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NCT ID: NCT04651322 Recruiting - Stroke Clinical Trials

Quantified Analysis of Neuronal Recovery Using Myelin Imaging After Robot Assisted Upper Arm Training in Subacute Stroke Patients

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

- Quantitative assessment method developed for brain plasticity through disability rehabilitation using a brain imaging technique. - Development of brain imaging technology to improve understanding of brain plasticity during rehabilitation and to improve the efficiency of rehabilitation treatment for people with brain injury. ○ Development of the latest brain function image analysis algorithm and data processing technology - Development of new technology for imaging brain plasticity in addition to existing functional imaging technology and diffuse imaging technology (Example: Myelinated brain imaging technology, susceptibility imaging (SWI) technology) - Development of image reconstruction software technology using new image technology - Multi-image and repeated shot data processing technology, wheat analysis technology development (Example: 3D registration technology, automated segmentation technology) - Conducted clinical research on clinical quantitative evaluation of brain plasticity due to rehabilitation treatment - Recruitment of a group of patients for pursuing plasticity through rehabilitation among stroke patients (estimating the number of sample patients by setting a specific patient group and analyzing statistical power) - Image-based brain change analysis through patient rehabilitation and before and after imaging - Comparative analysis through securing a control group and activating the control group. Derivation of clinical relevance through comparison with rehabilitation process

NCT ID: NCT04650802 Completed - Stroke Clinical Trials

Improving Propulsion of the Paretic Leg In Chronic Stroke

I-PICS
Start date: March 4, 2019
Phase: N/A
Study type: Interventional

Stroke survivors may have a latent, propulsive capacity of the paretic leg, that can be elicited during short, intensive gait training interventions. The aim of this study was therefor to investigate the effect of a five-week gait training on paretic propulsion, propulsion symmetry, gait capacity, and daily-life mobility and physical activity in chronic stroke survivors.

NCT ID: NCT04650425 Recruiting - Stroke Clinical Trials

Causal Evidence for Task Regulation by Anterior Cingulate Cortex

Start date: April 29, 2021
Phase: N/A
Study type: Interventional

The exact function of the anterior cingulate cortex (ACC) is one of the largest riddles in cognitive neuroscience and a major challenge in mental health research. ACC dysfunction contributes to a broad spectrum of neurological and psychiatric disorders, such as depression, ADHD, Parkinson's disease, OCD and many others, but nobody knows what it actually does. Recently a new theory has been developed about ACC function; the HRL-ACC (Hierarchical Reinforcement Learning Theory of ACC). This theory proposes that the ACC selects and motivates high-level tasks based on the principles of hierarchical reinforcement learning. The ACC associates values with tasks (these values are based on the reward positivity produced by the midbrain dopamine system), selects the correct tasks and applies control over other neural networks (such as the dorsolateral prefrontal cortex and basal ganglia), which execute the tasks. The goal of this study is to investigate the consequences of ACC damage (and other areas of the frontal lobe) on task regulation within a group of patients who have suffered a stroke in the frontal lobe. Furthermore, the correlation between ACC damage and mood disorders such as depression and apathy is going to be investigated.

NCT ID: NCT04650022 Completed - Ischemic Stroke Clinical Trials

Total Posterior-circulation Infarct Volume in Basilar Artery Stroke

TPCIV-ABAO
Start date: January 30, 2011
Phase:
Study type: Observational

Preprocedural predictors of outcome in patients with acute basilar artery occlusion (ABAO) who underwent endovascular treatment (EVT) remain controversial. The Investigators aimed to analyse, in patients with ABAO treated by EVT, if pre-EVT DWI total posterior-circulation infarct volume (TPIV) was a predictor of 90-days outcomes

NCT ID: NCT04649034 Recruiting - Stroke Clinical Trials

Intraventricular Stasis In Cardiovascular Disease

ISBIFLOW
Start date: November 24, 2020
Phase:
Study type: Observational

This study is designed to quantify the ventricular stasis in patients with different forms of cardiomyopathy and at risk of stroke (ischemic, non-ischemic dilated cardiomyopathy and hypertrophic cardiomyopathy) by post-processing of 2D color Doppler echocardiography and phase contrast-magnetic resonance images in order to establish the relationship between quantitative variables of intraventricular stasis and the prevalence of silent embolic events and/or intraventricular mural thrombosis.

NCT ID: NCT04648878 Recruiting - Stroke Clinical Trials

A Comparison of Conventional Physical Therapy, Powered Exoskeleton, and Hybrid Physical Therapy With Exoskeleton

Start date: February 14, 2021
Phase: N/A
Study type: Interventional

The purpose of this investigator-initiated study is to establish if powered exoskeleton therapy as a part of a rehabilitation program can be used as a standard of care in stroke rehabilitation.

NCT ID: NCT04648449 Active, not recruiting - Stroke, Acute Clinical Trials

Artificial Intelligence (AI) Support in Medical Emergency Calls

AISMEC
Start date: September 1, 2020
Phase:
Study type: Observational

More than 12.000 patients suffer acute stroke in Norway every year, but less than half of them reach hospital within the current treatment window for thrombolysis. Stroke is the third-highest cause of death and the number one cause of severe disability requiring long time care at institutions. Consequently this has a high impact on society, patients and relatives, in addition to high costs related to care estimated to approximately 10 billion NOK per year. Although there are few studies on emergency medical communication centres (EMCC) in Norway, some have shown that the performance of the emergency medical communication centres can be improved. This project will seek to amend EMCC´s handling of acute stroke inquiries using artificial intelligence (AI), thus contributing to getting the patient to hospital in time for optimal treatments.

NCT ID: NCT04648098 Completed - Stroke Clinical Trials

Effect of Post-stroke Discharge Training

Start date: March 4, 2017
Phase: N/A
Study type: Interventional

The aim of this study was to determine the effect of post-stroke discharge training and telephone counseling service on patients' functional status and caregiver burden. The study was conducted with 69 stroke patients (34 in the intervention group and 35 in the control group) and their caregivers. In the study, data were collected before discharge and three months after discharge. Discharge training and telephone counseling (one week after discharge and once a month for three months) were given to the caregivers of the patients in the intervention group.

NCT ID: NCT04647812 Recruiting - Stroke Clinical Trials

Technology-assisted Rehabilitation After Acute Stroke

Start date: January 4, 2021
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the effects and costs of an intensified rehabilitation for stroke patients. Using novel technologies the patients will receive an augmented exercise therapy during the first weeks after stroke. The effects on restoration of functions as well as on the costs incurred from social and health care services will be assessed and compared to the conventional rehabilitation over 6 month follow-up.

NCT ID: NCT04647292 Recruiting - Ischemic Stroke Clinical Trials

European Blood Pressure Intensive Control After Stroke

EPICS-Pilot
Start date: May 2, 2024
Phase: Phase 2
Study type: Interventional

Stroke is the third most common cause of death worldwide and the leading cause of disability. High blood pressure is an important risk factor for stroke. Lowering a person's blood pressure reduces the risk of future stroke or heart attack, and current guidelines recommend treatment to a target of <130mmHg for secondary prevention. Home blood pressure measurement and telemonitoring are acceptable to patients, but there is uncertainty over the use of out of office blood pressure measurements in stroke patients in guidelines. This is a study designed to establish the feasibility of a larger clinical trial, comparing home blood pressure monitoring, telemonitoring and medication titration with standard care. The study hypothesis is that home BP measurement and telemonitoring with medication titration may lead to improved BP control compared to standard of care clinical practice.