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Ischemic Stroke clinical trials

View clinical trials related to Ischemic Stroke.

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NCT ID: NCT03496545 Not yet recruiting - Clinical trials for Traumatic Brain Injury

Efficacy of Bromocriptine on Febrile Adults With Acute Neurologic Diseases

Start date: July 1, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to evaluate the antipyretic effect of bromocriptine in critically-ill patients with acute neurologic injury and fever from infectious and non-infectious etiologies.

NCT ID: NCT03496064 Enrolling by invitation - Ischemic Stroke Clinical Trials

Registry for Evaluating Outcome of Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy.

BEYOND-SWIFT
Start date: November 1, 2017
Phase:
Study type: Observational

The Bernese-European RegistrY for ischemic stroke patients treated Outside current guidelines with Neurothrombectomy Devices using the SOLITAIRE™ FR With the Intention For Thrombectomy (BEYOND-SWIFT) is a retrospective, multi-center, non-randomized observational study aims to investigate the safety and efficacy of a Medtronic market-released neurothrombectomy device (applied as initial devices used for intervention) in acute ischemic stroke patients who do not fulfill treatment eligibility according to current guidelines. Patients will be treated or were treated at the discretion of the investigator, independent of participation in this registry. Primary Analysis is the Impact of successful reperfusion on functional outcome at day 90 in patients presenting with large infarct cores (ASPECTS<6) or minor symptoms (NIHSS<8).

NCT ID: NCT03494920 Not yet recruiting - Ischemic Stroke Clinical Trials

DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval

Start date: April 2018
Phase: Phase 3
Study type: Interventional

The study will be a multicentre, prospective, randomized, open label, blinded endpoint (PROBE) phase 3 trial (2 arm with 1:1 randomization) in ischemic stroke patients within 4.5 hours of stroke onset. Randomised patients will be stratified for site of baseline arterial occlusion into one of three groups: 1. internal carotid artery (ICA) 2. middle cerebral artery (MCA) 3. basilar artery (BA). Patients will be randomised to either bridging intravenous thrombolysis with endovascular clot retrieval (ECR), or direct endovascular clot retrieval.

NCT ID: NCT03494530 Not yet recruiting - Ischemic Stroke Clinical Trials

Lixiana Acute Stroke Evaluation Registry

LASER
Start date: April 15, 2018
Phase:
Study type: Observational

Edoxaban (also referred to as Lixiana) is an anti-clotting drug, approved by Health Canada for the prevention of stroke in patients with atrial fibrillation (abnormal heart rhythm). We are doing this study to try to determine the best time to start apixaban treatment after an ischemic stroke has occurred. The purpose of the LASER study is to determine the safety of early edoxaban use after TIA/ischemic stroke in patients with atrial fibrillation using advanced MR imaging. This study will also gather information about participant general well being, mental status, and the effects of the TIA/stroke on daily living, as well as CT and MRI of the brain.

NCT ID: NCT03485820 Recruiting - Ischemic Stroke Clinical Trials

A Novel Transition Program to Reduce Disability After Stroke

COMPASS
Start date: January 18, 2018
Phase: N/A
Study type: Interventional

This study evaluates a program designed to help individuals transition home from inpatient rehabilitation following and ischemic stroke. Half of the participants will receive a stroke education program while the other half will receive an environmental modifications program.

NCT ID: NCT03481777 Recruiting - Ischemic Stroke Clinical Trials

Remote Ischemic Conditioning in Patients With Acute Stroke (RESIST)

RESIST
Start date: April 3, 2018
Phase: N/A
Study type: Interventional

Our primary aim is to investigate whether remote ischemic conditioning (RIC) as an adjunctive treatment reduce neurological impairment at 24 hours and improve long-term recovery in acute stroke patients as an adjunct to standard treatment.

NCT ID: NCT03474549 Not yet recruiting - Ischemic Stroke Clinical Trials

Treatment With Intent to Generate Endovascular Reperfusion

TIGER
Start date: April 2018
Phase: N/A
Study type: Interventional

Tigertriever is a CE marked mechanical revascularization device indicated to restore blood flow by removing thrombus from a large intracranial vessel in patients experiencing ischemic stroke within 8 hours of symptom onset. Patients who are ineligible for IV t-PA or who fail IV t-PA therapy are candidates for treatment. The objective of the TIGER Study is to evaluate the safety and effectiveness of the Tigertriever device in restoring blood flow in the neurovasculature by removing thrombus in patients experiencing ischemic stroke due to a large vessel occlusion (LVO). This study is designed to support substantial equivalence to approved and marketed products such as the Solitaire or Trevo Retriever.

NCT ID: NCT03470506 Active, not recruiting - Ischemic Stroke Clinical Trials

A Study of the Relationship of Gut Microbial Composition and Stroke Outcome

GEMSTONE
Start date: December 6, 2017
Phase:
Study type: Observational

The purpose of this pilot study is to investigate the relationship between gut microbial composition and stroke outcome. If we can establish a relationship between gastrointestinal microbial community composition and convalescent ischemic stroke outcomes in a U.S. sample, such results would prompt further mechanistic studies, and ultimately provide a rationale for trials to determine whether modulating intestinal immune responses (e.g. via prebiotic, probiotic, or fecal transfer methods) would be beneficial.

NCT ID: NCT03463421 Recruiting - Ischemic Stroke Clinical Trials

Αdherence and Persistence to Oral Anticoagulation in ΑF Patients With Previous Ischemic Stroke

ADHERE-OAC
Start date: June 2018
Phase: N/A
Study type: Observational [Patient Registry]

The aims of this project are to: 1. investigate the adherence and persistence to anticoagulation (and in specific, to VKAs and NOACs) in AF patients with previous ischemic stroke; 2. identify predictors of poor adherence and persistence and 3. assess whether the SAMe-TT2R2 score predicts adherence and persistence to anticoagulation

NCT ID: NCT03425305 Active, not recruiting - Heart Failure Clinical Trials

Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study

Start date: January 1998
Phase: N/A
Study type: Observational

Serum uric acid level is a commonly measured biomarker. The association between serum uric acid level and the risk of developing cardiovascular diseases has been observed in some studies, while others showed controversial results. Estimation of this association may help to predict cardiovascular outcomes and may guide new treatment strategies. The hypothesis is that increased serum uric acid level is associated with a range of cardiovascular diseases.