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Ischemic Stroke clinical trials

View clinical trials related to Ischemic Stroke.

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NCT ID: NCT03745391 Recruiting - Ischemic Stroke Clinical Trials

Multimodal Neuroimaging in the Selection of Acute Ischemic Stroke (AIS) Patients to Endovascular Treatment (EVT)

IMAGECAT
Start date: November 13, 2017
Phase: N/A
Study type: Interventional

To study the feasibility and usefulness of multimodal MR compared to multimodal CT to select patients with acute ischemic stroke and favorable clinical outcome after mechanical thrombectomy. The specific objectives are to compare (1) the door-picture time and door-groin puncture time, (2) the rate of patients with acute stroke selected for endovascular treatment and (3) the safety and clinical response after thrombectomy between the two groups selected according to the imaging modality. Methodology: Single-center, randomized 1:1 and stratified by age and NIHSS study of consecutive patients with acute ischemic stroke. Occlusion site, ischemic volume (core) and perfusion volume will be studied by an automated perfusion system (RAPID software) in both neuroimaging groups. Mechanical thrombectomy criteria will be based on the presence of an Intracranial Carotid Artery (ICA) or Middle Cerebral Artery (MCA)-M1 occlusion and a volume of core lower than 70cc in the Cerebral Blood Flow (CBF) or Diffusion Weighted Image (DWI) sequences. Modified Rankin scale at 90 days and the rate of intracranial hemorrhage and mortality will be considered as variables of response.

NCT ID: NCT03744533 Recruiting - Ischemic Stroke Clinical Trials

Head-down Position for Acute Ischemic Stroke With Large Artery Atherosclerosis

HOPES2
Start date: November 26, 2018
Phase: N/A
Study type: Interventional

Currently, the guideline recommended re-perfusion such as intravenous thrombolysis and mechanical thrombectomy as the most effective treatment for acute ischemic stroke. However, the two methods are restricted by a strict time window, which greatly limits the number of the patients receiving treatment. The abundant studies have suggested that good collateral circulation can provide compensatory blood supply to save the ischemic penumbra and reduces the infarct volume, which improves the prognosis. How to improve collateral circulation in an efficient and safe way is a clinical challenge. Our recent experiment results of the animal and preliminary clinical experiments show that head-down position may significantly increase cerebral perfusion and improve neurological function. Clinically, head-down position is simple and easy to operate, and theoretically may increases brain perfusion and improve collateral circulation. A pilot randomized clinical trial is designed to investigate the effect of head-down position combined with routine rehabilitation in patients with ischemic stroke.The study is designed to explore the efficacy and safety of head-down position in patients with acute ischemic stroke

NCT ID: NCT03738644 Recruiting - Ischemic Stroke Clinical Trials

Monitoring Stroke Patients With Near-infrared Spectroscopy Before, During and After Endovascular Treatment

Start date: November 20, 2018
Phase:
Study type: Observational

The purpose of this study is to examine the hemodynamics of stroke patients with near-infrared spectroscopy before, during and after endovascular treatment and their relations to disabilities and mortality 3 months after treatment.

NCT ID: NCT03733223 Recruiting - Ischemic Stroke Clinical Trials

Clinical Study on the Relationship Between FVIII,t-PA/PAI-1, MMP-9 and Haemorrhagic Adverse Reactions During the Process of Thrombolysis by Alteplase

Start date: October 12, 2018
Phase:
Study type: Observational

The purpose of this study is to investigate whether F VIII, t-PA/PAI-1, and MMP-9 are related factors of intracranial hemorrhage after thrombolysis in patients with cerebral infarction (IS) treated with ateplase thrombolytic therapy.

NCT ID: NCT03728738 Recruiting - Ischemic Stroke Clinical Trials

Zero Degree Head Positioning in Hyperacute Large Artery Ischemic Stroke

ZODIAC
Start date: September 25, 2018
Phase: Phase 3
Study type: Interventional

Placing the head of bed (HOB) at 0-degrees has been shown in small studies to improve blood flow to the brain in patients with ischemic stroke caused by large artery occlusions, thereby reducing stroke symptom worsening. This simple yet potentially impactful intervention has yet to be tested in a large clinical trial in hyperacute large artery ischemic stroke patients, but may provide nurses with a powerful contribution to acute stroke care that is capable of preventing worsening of stroke symptoms and promoting stabilization. Because stroke is the leading cause of preventable long-term disability in adults, this study may show that simple methods such as 0-degree HOB positioning should be considered one of the very first actions taken in the emergent management of acute ischemic stroke patients.

NCT ID: NCT03710902 Recruiting - Hypertension Clinical Trials

Empowerment and Mobile Technology in the Control of Cardiovascular Risk Factors in Patients With Ischemic Stroke

CARDIOSTROKE
Start date: October 17, 2018
Phase: N/A
Study type: Interventional

The CARDIOSTROKE is a randomized trial comparing mobile-device assisted control of hypertension together with screening of occult atrial fibrillation to standard care in patients with recent ischemic stroke or transient ischemic attack.

NCT ID: NCT03685006 Recruiting - Inflammation Clinical Trials

Atherosclerosis and Acute Ischemic Stroke Study

Start date: January 1, 2009
Phase:
Study type: Observational [Patient Registry]

A significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaque at the carotid bifurcation. It is now wellknown that inflammation plays a key role in atherogenesis and plaque destabilization. However the identification and characterization of the different inflammatory factors, as well as their relative importance, have not been clarified. This main aim of this study is to identify new risk markers for atherosclerosis and to characterize more precise methods for detection of the unstable carotid plaque with increased stroke-risk.

NCT ID: NCT03673241 Not yet recruiting - Ischemic Stroke Clinical Trials

Study of the Guardian System on Motor Recovery and Impact on Length of Stay in Ischemic Stroke Patients

Start date: October 30, 2018
Phase: N/A
Study type: Interventional

This is a non-blinded randomized study that will investigate whether the use of a novel, non-invasive perfusion enhancement system (The Guardian System) impacts motor recovery and hospital length of stay in acute ischemic stroke patients.

NCT ID: NCT03668132 Completed - Ischemic Stroke Clinical Trials

Language Functional Reorganization in Subcortical Infarction Patients

Start date: January 19, 2016
Phase:
Study type: Observational

Post stroke aphasia (PSA) is one of the most frequently happened deficiency of stoke, affecting speaking,comprehension, writing and reading of language. Generally, PSA is commonly seen in cortical damage, but in recent years it has been found that subcortical injury is also an important cause of PSA, which is called subcortical aphasia. Using fMRI technology, the investigators aim to investigate the language function of patients with subcortical cerebral infarction at different stages of recovery , and explored the mechanism of post-injury language reorganization in the brain. The investigators recruited 60 first-episode acute cerebral infarction patients with one-side lesion in subcortical white matter (40 with left injury and 20with right injury) and 20 health volunteers. All participants are right-handed, and screened with MMSE, HAMD and HAMA to exclude cases of psychosis, post-stroke dementia and depression. Each participant was arranged to have three test sessions at different stages after the infarction (T1:within 3 days after onset of the stroke ; T2:28 ±3days after onset; T3: 90±3days after onset), with fMRI and Western aphasia battery (WAB) in each session. The purpose of this study is to explore the pathogenesis of subcortical aphasia, and to understand the dynamic reorganization of language network during the recovery of language function.

NCT ID: NCT03653312 Recruiting - Ischemic Stroke Clinical Trials

Neuromuscular Electrical Stimulation in Acute Ischemic Stroke

NESA
Start date: August 27, 2018
Phase: N/A
Study type: Interventional

The purpose of the study is to examine the added effect of NeuroMuscular Electric Stimulation (NMES) as an exercise therapy tool in the acute phase of ischemic stroke in order to increase the patient's functionality. Further, to induce and measure neuroplasticity in the central nervous system during rehabilitation training. This randomized controlled trial includes 50 patients allocated to either control or intervention. The inclusion, test, training and re-test will be provided during the first 14 days after ictus, starting day 1 after ictus and a follow-up at day 90. The exercise training with external NMES is done with the patient every weekday for 27 minutes. The neural plasticity test will be performed using Transcranial Magnetic Stimulation (TMS).