Obesity Clinical Trial
To conduct a longitudinal study of central obesity and related risk factors found to be associated with hypertension and atherosclerotic cardiovascular disease (ASCVD) in a previously-examined cross-sectional cohort of second-generation Japanese Americans and in a newly-recruited cohort of third generation Japanese Americans.
BACKGROUND:
The study was conducted in response to a program announcment issued in 1991 on obesity and
tests the hypothesis that atherosclerotic cardiovascular disease (ASCVD), hypertension,
and/or non-insulin dependent diabetes mellitus (NIDDM) develop in Japanese Americans when
there is a truncal pattern of weight gain (central adiposity), which is in turn accompanied
by insulin resistance, hyperinsulinemia, and lipid abnormalities. This cluster of
abnormalities has been called 'Syndrome X'. It is postulated that 'Syndrome X' develops in
Japanese Americans in response to environmental (behavioral) factors, many of which reflect
'westernization' in this ethnic group. The research plan focuses upon the relationship
between central obesity and metabolic changes and disease outcomes associated with 'Syndrome
X' along with the behavioral variables that potential risk factors for the development of
this cluster of abnormalities.
DESIGN NARRATIVE:
The cohort was re-examined for diabetes, hypertension, coronary heart, disease, peripheral
vascular disease, and a number of potential coronary heart disease risk factors including
medical history, health practice, social history, diet, glycosylated hemoglobin, insulin,
proinsulin, c-peptide, glucose, anthrometric measurements, lipids, and computed tomography
on the thorax, abdomen, and thigh.
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N/A
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