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Diabetes clinical trials

View clinical trials related to Diabetes.

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NCT ID: NCT03254446 Not yet recruiting - Hypertension Clinical Trials

Phase III Study of TRC150094 in Improving CV Risk in Subjects With Diabetes, Dyslipidemia and Hypertension

CAMRRI
Start date: December 2017
Phase: Phase 3
Study type: Interventional

The phase III trial is designed with an aim of determining the efficacy of Investigational Product TRC150094 in concurrently reducing non-traditional risk factors for CV risk i.e., HbA1c, MAP and non-HDL cholesterol. This study will be a randomized, double blind, parallel group, placebo controlled, multi-centre, multinational study in 1250 subjects. All the study subjects will receive once daily dose of TRC150094 45 mg or placebo tablets in addition to their standard of care, for 24 weeks followed by roll over to a safety extension phase of 26 weeks.

NCT ID: NCT03254095 Active, not recruiting - Diabetes Clinical Trials

Predictors of Skin Temperature, Plantar Pressure and Ulceration in Diabetic Foot Patients.

Start date: September 1, 2016
Phase: N/A
Study type: Observational [Patient Registry]

Diabetes is a chronic disease with increasing prevalence worldwide with a high burden to individuals and the society and it is expected to be the 7th leading cause of death in 2030. Diabetes related complications manifest in many body parts, often in the foot, due to reduced blood flow and nerve damage, increasing the risk of ulcers and amputation. High plantar pressures during walking contribute to the development of foot ulcers and foot ulcer recurrence. Emerging studies also point skin temperature as another predictor of foot ulceration. However, the number of studies including prediction models of plantar pressure and skin temperature are scarce, especially in patients with confirmed diagnosis of diabetic foot and a history of foot ulcer. Factors like mobility, hardness of plantar soft tissue, foot deformities and other diabetes related characteristics have been related to plantar pressure measurements but not to foot skin temperature measurements, and the relation between skin temperature and plantar pressure has not been much explored in the literature. The role of these variables in the development of foot ulceration needs further attention, especially in patients with history of foot ulcers has they are at the highest risk to develop a foot ulcer. Therefore, the goal of this research is to determine which variables can be used to predict plantar pressure and skin temperature and which factors are associated with the development of foot ulcers in patients with established diagnosis of diabetic foot. The associations between skin temperature and plantar pressure will also be addressed.

NCT ID: NCT03249077 Active, not recruiting - Diabetes Clinical Trials

Evaluating the Implementation of the Diabetes Prevention Program in an Integrated Health System

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

In preparation for the rollout of Medicare Diabetes Prevention Program (DPP) in 2018, Kaiser Permanente Northwest (KPNW), a large, integrated health care system, plans to pilot the implementation of Medicare DPP starting in April 2017. The Health Engagement and Wellness Services at KPNW will randomize Medicare patients 65 and older to one of two treatment arms: 1) patient choice between DPP in-person or online; or 2) Usual care. Researchers at the KPNW Center for Health Research will plan to augment the limited analysis planned by KPNW with a pragmatic, rigorous quantitative and qualitative evaluation to better inform future implementation efforts of Medicare DPP within and outside of KPNW.

NCT ID: NCT03248271 Not yet recruiting - Diabetes Clinical Trials

Effects of Insulin on Hypotension and Sarcopenia

Start date: October 2017
Phase: N/A
Study type: Observational

In this study investigator's aim to determine the impact of insulin therapy on hypotension and sarcopenia

NCT ID: NCT03246997 Recruiting - Obesity Clinical Trials

Project Powerfood: Promoting Food Security, Equity, and Health

Start date: June 21, 2017
Phase: N/A
Study type: Interventional

Project Powerfood is a pilot program aimed at addressing food insecurity and food access in primary care through the implementation of a food prescription program in collaboration with a number of community partners. The objectives of this project are: 1. Implement screening for food insecurity in adult and pediatric primary care practices at Mount Sinai. 2. Provide fresh fruit and vegetable "prescriptions" to be redeemed for farm shares from local partner, the Corbin Hill Food Project. Prescriptions will provide 50% off of a fruit and vegetable box. Participants will have the option to purchase 2 boxes per month for 6 months. 3. Pilot prescriptions with 50 adult patients with poorly-controlled diabetes and 50 obese children who are food insecure and/or receive SNAP and/or WIC benefits. Examine/evaluate: 1. Feasibility of program in a busy primary care practice 2. Outcomes before and after the intervention (at baseline, 6 and 12 months), including diet, diabetes control, and body mass index (BMI) 3. Outcomes in a comparison group (that will receive the food prescriptions beginning at 6 months)

NCT ID: NCT03243903 Recruiting - Diabetes Clinical Trials

Comparison of Safety and Efficacy of QS-M Needle- Free Injector and Insulin Pen in Controlling T2DM Patient's Glucose

Start date: May 19, 2017
Phase: N/A
Study type: Interventional

In this study, QS-M needle-free injector and needle-insulin pen were used as a drug carrier to control blood glucose in type 2 diabetic patients.The efficacy and safety of QS-M needle-free injector and needle-insulin pen were evaluated and compared.This is a needle-insulin pen as control group, using a prospective, multicenter, randomized, open, parallel grouping study.

NCT ID: NCT03243058 Not yet recruiting - Diabetes Clinical Trials

Administration of Low-dose IL-2 in Established T1D

IL-2
Start date: January 2018
Phase: Phase 1/Phase 2
Study type: Interventional

Randomized, controlled, double blinded, multicenter, phase I/II clinical trial to evaluate the safety of low-dose IL-2 and to test whether low-dose IL-2 can prevent further loss of beta-cell function in patients with established T1D, or even potentially improve ß-cell function in such individuals, when IL-2 is given for one year (primary outcome). Equally important, the study will carefully examine various effects of low-dose IL-2 on the immune system in patients with T1D, including effects on Treg and other cell subsets, and disease-specific autoimmune responses.

NCT ID: NCT03242109 Completed - Diabetes Clinical Trials

The Moli-sani Study

Start date: March 1, 2005
Phase: N/A
Study type: Observational

Cardiovascular disease and malignancies account for more than 70% of all causes of mortality and morbidity in Italy. There is a subtle balance between genetic determinants and lifestyle, that often defines the line between health and sickness. So far studies aiming at identifying risk factors have mainly come from Northern Europe and the USA. It was to understand this balance between genetics and environmental determinants better, and to tailor appropriate preventive strategies for Italian and other Southern European populations, that the Moli-sani study was launched, transforming a small Italian region into a large scientific laboratory: the "Molise lab". Each participant received a thorough medical check-up at no cost to either him/her or the national health service, resulting in thousands of hours of free public health care. With a completely computerized system, Moli-sani is a "paperless" study, in which researchers and participants communicate using recently developed technologies such as mobile phone text messages (SMS). The biological data bank (the "MoliBank") is one of the largest in Europe. Paying particular attention towards innovation and new technologies, the Moli-sani study has placed itself at the cutting edge of a new paradigm crossing research and prevention

NCT ID: NCT03239717 Recruiting - Obesity Clinical Trials

SOAR: Can we Stop Obesity and Diabetes by Amino Acid Reduction?

SOAR
Start date: July 28, 2017
Phase: N/A
Study type: Interventional

Branched-chain amino acids (BCAAs) are essential nutrients that the body obtains from proteins found in food, especially meat, diary products, and legumes. Data from rodent studies suggest that reduction of dietary BCAAs will promote fat mass loss and improved control of blood glucose. The purpose of this study is to test if reduction of dietary BCAAs without reducing calorie intake will lead to similar metabolic benefits in humans. Here the investigators test the feasibility of reducing dietary BCAAs using BCAA-free meal replacement beverages for two months.

NCT ID: NCT03238547 Not yet recruiting - Diabetes Clinical Trials

Screening of Microalbuminuria Using a Semi-quantitative UACR Test

Start date: August 2017
Phase: N/A
Study type: Observational [Patient Registry]

Microalbuminuria is an important biomarker for the development of diabetic nephropathy and cardiovascular complications. Since microalbuminuria is not easily detected on routine urinalysis, current guidelines recommend measuring spot urine albumin-to-creatinine ratio (uACR) annually in a patient with diabetes mellitus. While the standard method is quantitative measurement using turbidimetric immunoassay, it requires high cost and special laboratory equipment. This may be a hurdle that prevents screening for microalbuminuria in many patients with diabetes. Therefore, a semi-quantitative uACR test, which is rapid and inexpensive, could be used as a substitute to the current standard quantitative measurement. The investigators aimed to assess the diagnostic accuracy of a semi-quantitative urine albumin-to-creatinine ratio test, URiSCAN 2ACR, as a screening tool for microalbuminuria in patients with diabetes.