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Heart Diseases clinical trials

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NCT ID: NCT03404024 Recruiting - Clinical trials for Acute Myocardial Infarction

Safety and Efficacy Study of Gene Therapy for Acute Myocardial Infarction in Korea

Start date: December 5, 2017
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and clinical efficacy of VM202RY injected via transendocardial route using C-Cathez® catheter (Celyad, S.A., Belgium) in subjects with AMI. - Stage 1: Evaluation of safety and tolerability of VM202 injection - Stage 2: Evaluation of safety and efficacy of VM202 injection

NCT ID: NCT03401216 Recruiting - Clinical trials for Coronary Artery Disease

StEnt Coverage and Neointimal Tissue Characterization After eXtra Long evErolimus - Eluting Stent imPlantation

Start date: March 20, 2017
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate the rate of SYNERGY 48 mm stent strut coverage and assess neointimal progression via OCT measurement in patients who underwent PCI.

NCT ID: NCT03399162 Not yet recruiting - Clinical trials for Coronary Artery Disease

PRehabilitiation in Elective Frail and Elderly Cardiac Surgery PaTients

PREFECT
Start date: February 2018
Phase: N/A
Study type: Interventional

Older and more frail adults are more often being referred for cardiac surgery. These patients are often in suboptimal health, and may be physically frail, malnourished, and have other conditions, such as diabetes, that complicate their recovery. Research suggests that a rehabilitation program prior to surgery may help improve participants' health and improve their fitness for surgery. Currently, a pre-operative rehabilitation workshop is offered at the University of Ottawa Heart Institute, but this interventional, randomized study will investigate whether a more comprehensive pre-operative regime, including structured weekly exercise program, is more effective at improving health prior to surgery. Patients will be randomized to either the control group (pre-operative rehabilitation workshop ONLY) or the treatment group (pre-operative rehabilitation workshop plus exercise regime). This regime will attempt to improve patients' overall health, including their physical fitness and nutritional status. The effectiveness of this regime will be evaluated by comparing patients' physical function, questionnaires (diet, quality of life, stress) and serum biomarkers from baseline to pre-surgery to post-surgery. The Investigators hypothesize that patients that complete the pre-operative rehabilitation program will improve their health prior to surgery, and that this may result in shorter length of hospitalization and fewer complications after surgery. The study will take place over two years, with each patient's participation lasting about 3 months.

NCT ID: NCT03398733 Recruiting - Clinical trials for Obstructive Sleep Apnea

CPAP Treatment and Postoperative Outcomes in Patients With Rheumatic Valvular Heart Disease

CPAP
Start date: December 1, 2017
Phase: N/A
Study type: Interventional

The prevalence of OSA (Obstructive sleep apneaļ¼ŒOSA) is 2%-4% in general population and 16%-47% in surgical-heart failure patients. Our previous study found that OSA was associated with the increasing incidence of perioperative adverse events.The continuous positive airway pressure (CPAP), as the standard treatment for OSA, is extensively applied clinically. The previous study reported that postoperative AHI was reduced and SPO2 was increased by CPAP treatment. However, whether CPAP treatment can improve OSA postoperative and related adverse events or not in patients with rheumatic valvular heart diseases (RVHD) were not reported.The purpose of this study is to observe the effective of preoperative CPAP on postoperative sleep parameters and adverse events, such as AHI changes, duration of ICU stay and duration of mechanical ventilation.

NCT ID: NCT03398187 Not yet recruiting - Cardiac Disease Clinical Trials

Cardiac Catheterization in the Management of Pediatric Cardiac Patients at A.U.C.H.

Start date: January 2018
Phase: N/A
Study type: Observational

The aim of this study is to find out and record the indications for diagnostic catheterization as well as for interventional cardiac catheterization in A.U.C.H , and record the outcome in these cases.

NCT ID: NCT03395951 Completed - Heart Failure Clinical Trials

Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients

Start date: October 1, 2014
Phase: N/A
Study type: Observational

Within clinical settings observation of hemodynamic changes (e.g. mean systemic filling pressure, cardiac output) in critically ill patients with a clinical indication for deresuscitation with intravenous diuretic therapy.

NCT ID: NCT03395639 Not yet recruiting - Cardiac Disease Clinical Trials

Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombolytic Events) in Children at Risk Because of Cardiac Disease

Start date: February 2018
Phase: Phase 3
Study type: Interventional

A committee will judge the safety and effectiveness of edoxaban and the regular treatment (standard of care). All children in the study will receive free treatment. They will have a 2 in 3 chance to receive edoxaban, and a 1 in 3 chance to receive the standard of care for preventing blood clots. The study will find out if edoxaban is safer and more effective than the standard of care.

NCT ID: NCT03394859 Enrolling by invitation - Diabetes Clinical Trials

Electronic Medical Records and Genomics (eMERGE) Phase III

eMERGE
Start date: September 1, 2015
Phase: N/A
Study type: Observational

The Electronic Medical Records and Genomics (eMERGE) Network is in its third phase and during this time is enrolling and sequencing 25,000 individuals on a custom sequencing panel of clinically relevant, actionable genes. The genetic results will be returned to participants and outcomes tracked through the electronic health records.

NCT ID: NCT03394339 Active, not recruiting - Stroke Clinical Trials

Meta-analysis of Fruit and Vegetable Sources and Cardiovascular Outcomes

Start date: April 1, 2017
Phase: N/A
Study type: Observational

Fruit and vegetables are a cornerstone of healthy dietary patterns and dietary guidelines worldwide. The supporting evidence, however, is largely derived from observational studies of protective associations with cardiovascular disease (CVD) in health-conscious populations or from randomized trials of the effect of specific fruit or vegetable derived nutrients on CVD risk factors. A growing body of literature has influenced a shift away from a focus on single nutrients to a focus on whole foods and dietary patterns. To what extent fruit and vegetables should contribute to dietary patterns for cardiovascular health and whether specific types of fruit or vegetables should be recommended is unclear. Although previous systematic reviews and meta-analyses have elucidated the association between the intake of total and some specific fruit and vegetables with cardiovascular outcomes, a comprehensive synthesis comparing the certainty of the evidence for the different types of fruit and vegetables in relation to a range of cardiovascular outcomes has yet to be completed. We propose to conduct a systematic review and meta-analysis of the available prospective cohort studies using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the association between different types of fruit and vegetables and different cardiovascular outcomes that include CVD, coronary heart disease [CHD], and stroke incidence and mortality.

NCT ID: NCT03391622 Not yet recruiting - Clinical trials for Ischemic Heart Disease

Thrombin Generation Values and Percutaneous Coronary Intervention Results.

Start date: February 1, 2018
Phase: N/A
Study type: Observational

Cardiovascular diseases are the most common cause of death in the western world. Myocardial infarction pathogenesis usually involves the development of an atherosclerotic plaque and thrombus. Past research has shown a correlation between thrombin generation values and ischemic heart disease, however, to our knowledge no investigation has been done into the correlation of thrombin generation and cardiac catheterization results in ischemic heart disease patients. In the current research the investigator will investigate the correlation of thrombin generation values using calibrated automated thrombogram and cardiac catheterization results in active ischemic heart disease patients.