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Heart Diseases clinical trials

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NCT ID: NCT03629574 Not yet recruiting - Clinical trials for Congenital Heart Disease

Mechanical Ventilation During Cardiopulmonary Bypass

VENICE
Start date: August 20, 2018
Phase: N/A
Study type: Interventional

The study is about a protocol of protective mechanical ventilation during cardiopulmonary bypass used during cardiosurgery for the correction of congenital heart diseases, to evaluate what's the best for the lungs

NCT ID: NCT03629158 Not yet recruiting - Clinical trials for Coronary Artery Disease

Brief Behavioral Health Intervention Program for Patients With Stable Coronary Artery Disease

Start date: August 15, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the effectiveness of a lifestyle intervention for patients living with stable coronary artery disease (CAD). One group will receive the the intervention, and the other will receive treatment as usual (TAU). The investigators hypothesize that, compared to the TAU group, participants receiving the intervention will 1) experience greater confidence in managing their cardiac disease, as indicated by perceived self-efficacy and illness perceptions; 2) experience greater psychological adjustment as indicated by depressive, anxious, and demoralization symptoms; 3) experience greater engagement in health behaviors including healthy eating and physical activity.

NCT ID: NCT03628534 Not yet recruiting - Clinical trials for Cardiovascular Diseases

The Purpose of This Study is to Demonstrate the Safety and Technical Feasibility of the SERF Catheter and SERF Cardiac Ablation System to Eliminate or Control Ventricular Tachycardia (VT)

SERF VT EFS
Start date: September 2018
Phase: N/A
Study type: Interventional

The primary objective is to demonstrate safety and feasibility of the Thermedical Ablation System and Durablate needle catheter in subjects with recurrent, monomorphic ventricular tachycardia (VT) who have failed conventional treatment.

NCT ID: NCT03626480 Not yet recruiting - Clinical trials for Congenital Heart Disease

Peri-operative Nutrition in Infants With Congenital Heart Disease

Start date: September 1, 2018
Phase:
Study type: Observational

The purpose of our multi-center cohort study is to build a large platform to follow up the peri-operative nutrition of children with congenital heart disease. And data will be collected pre and 1, 3, 6, 12 months post surgery including physical, laboratory, imaging examination and questionnaire. The primary outcome is nutrition status (measured as WAZ, WHZ and HAZ) and secondary outcomes were the biochemical index and quality of life.

NCT ID: NCT03620539 Not yet recruiting - Clinical trials for Coronary Artery Disease

Sauna Bathing to Improve Vascular Health of Adults With Heart Disease

Start date: September 2018
Phase: N/A
Study type: Interventional

This study is a clinical trial that will determine if sauna bathing improves blood vessel health in adults aged 50-70 years with heart disease.

NCT ID: NCT03620071 Not yet recruiting - Cerebral Palsy Clinical Trials

GoalKeeper: Intelligent Information Sharing for Children With Medical Complexity

GoalKeeper
Start date: September 2018
Phase: N/A
Study type: Interventional

This proposal addresses the major challenge of improving health outcomes for children with cancer and other complex conditions, for whom the effectiveness of outpatient care depends on care coordination across a diverse group of caregivers that includes parents, community support organizations and pediatric care providers. The investigators have developed GoalKeeper, a prototype system for supporting care coordination across multiple care providers. The primary aim of the clinical trial is to assess the potential for this new system, GoalKeeper, to improve meaningful use of goal-centered care plans in the care of children with cancer and other complex chronic conditions.

NCT ID: NCT03619395 Not yet recruiting - Clinical trials for Acute Coronary Syndrome

Risc Optimisation- Acute cor5onary Syndrome

RiskOp-ACS
Start date: September 1, 2018
Phase:
Study type: Observational [Patient Registry]

This study evaluates the percentage of patients that reach the objective levels of LDL cholesterol, glycosylated hemoglobin and blood pressure recommended by clinical guidelines after an acute coronary syndrome, following strategies of pharmacological optimization based on algorithms. The investigators hypothesize that the use of algorithms designed and protocolized within a cardiac rehabilitation program after an ACS to optimize pharmacological treatment is effective and safe to improve the control of risk factors in patients with high cardiovascular risk.

NCT ID: NCT03618303 Recruiting - Clinical trials for Heart Diseases, Ischemic

PET-MR Imaging of Coronary Atherothrombosis

Start date: July 16, 2018
Phase: N/A
Study type: Interventional

Heart attacks remain a common cause of death in the United Kingdom and throughout the world. The most common initiating event is the formation of a blood clot (thrombus) within the coronary arteries occluding blood supply to the heart. However, we know that thrombus often occurs within the coronary arteries without causing any symptoms, and may be found in patients with stable angina. We wish to investigate whether thrombus within the coronary arteries can be detected in patients who have had a heart attack and in patients with stable angina using combined positron emission tomography and magnetic resonance (PET-MR) imaging. If possible, this may provide a safe and noninvasive means of identifying patients at higher risk of heart attacks. The study will be conducted in Edinburgh Heart Centre and participants will be recruited from the cardiology wards, outpatient clinics and day case unit. Participants will be asked to undergo a single PET-MRI scan and will subsequently undergo invasive angiography as part of standard care (non-research procedure). During the invasive angiogram procedure, an additional imaging test will be performed called Optical Coherence Tomography to provide images from within the heart blood vessels. A total of 40 participants will be recruited to this study.

NCT ID: NCT03618108 Recruiting - Clinical trials for Coronary Heart Disease

Anti-chlamydophila Antibiotic Combination Therapy in the Treatment of Patients With Coronary Heart Disease

ACAC-CHD
Start date: April 4, 2018
Phase: Phase 2
Study type: Interventional

The purpose of the study is to see whether the antibiotic combination of 100mg doxycycline, 500mg azithromycin and 300mg rifabutin is a safe and effective treatment for coronary artery disease which has not responded to 'standard treatment'. Coronary artery disease is the process of plaque build up within the walls of the arteries responsible for supplying the heart with oxygen and nutrients. plaque is usually made up of fatty deposits, minerals and various amounts of tissue and white cells which eventually narrows the artery, reducing blood flow to the heart. The resulting damage and build up of fat leads to inflammation of the arterial wall and eventually the arteries narrow. The researchers involved in this study consider that a pathogen called Chlamydophila pneumoniae, which can live inside cells may cause this inflammation of the arterial wall. The purpose of this study is to see if treatment with this antibiotic combination in patients with CHD is safe and effective in reducing disease severity measured at coronary angiography and improving quality of life. Approximately 60 patients will be involved in this trial. the treatment period is 90 days with a further 90 day follow up period.

NCT ID: NCT03616730 Not yet recruiting - Clinical trials for Congenital Heart Disease in Pregnancy

NICOM in Pregnant Women With Heart Disease

Start date: August 1, 2018
Phase:
Study type: Observational

An accepted "gold standard" for hemodynamic monitoring in women with both healthy and diseased hearts is not currently available. Pregnancy is associated with significant hemodynamic changes, both during and following delivery, which can be even more profound in the structurally-abnormal heart. Clinical management of these women is based on surrogate markers of cardiac indices such as peripheral blood pressure, heart rate and oxygen saturation, rather than the use of invasive testing due to its associated complications. Echocardiography has largely replaced PAC in the obstetric population to measure cardiac output due to its non-invasive nature and good correlation with PAC18. However, its use is limited in the intrapartum period due to the need for clinical expertise in obtaining and interpreting the images. The proposed study has the potential to validate bio-reactance cardiac output monitoring using the NICOM against echocardiography for use in structurally normal and abnormal pregnant hearts in order to better drive goal-directed (specifically delivery mode) therapy through continuous hemodynamic monitoring during the second and third stages of labor, and 24 hours postpartum.