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Atherosclerosis clinical trials

View clinical trials related to Atherosclerosis.

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NCT ID: NCT03504956 Not yet recruiting - Clinical trials for Coronary Atherosclerosis

Coronary Atherosclerosis T1-Weighted Characterization (CATCH)

CATCH
Start date: April 30, 2018
Phase: N/A
Study type: Interventional

This study proposes to develop an MRI technique named Coronary Atherosclerosis T1-weighed Characterization (CATCH) that will improve the quality and reliability of coronary atherosclerosis evaluation, as well as simplify the scanning process and significantly shorten imaging time compared with conventional imaging methods.

NCT ID: NCT03499496 Completed - Clinical trials for Atherosclerosis of Artery

Screening for Atherotic Plaques by Ultrasound for Assessing Cardiovascular Risk

Start date: January 15, 2016
Phase:
Study type: Observational

Cardiovascular disease is a common diagnosed and treated condition in private practices of primary health care. There is growing evidence that atherosclerotic plaques as predictors for stroke and heart attack are more prevalent than expected based on the clinical score in people with low risk for stroke and heart attack . Diagnosing atherosclerotic plaques can help to decide if a lipid lowering therapy should be prescribed even if the clinical risk score is low or on the other hand if they can be observed even in high lipid levels.

NCT ID: NCT03496948 Not yet recruiting - Clinical trials for Cardiovascular Diseases

Telephone Health Coaching and Remote Exercise Monitoring for Peripheral Artery Disease

TeGeCoach
Start date: April 23, 2018
Phase: N/A
Study type: Interventional

Peripheral artery disease (PAD) is the third most prevalent cardiovascular disease worldwide, with over 200 million people affected. Most prominent symptom is leg pain while walking known as intermittent claudication. Based on the currently existing gaps in the management of intermittent claudication, the objective of the this study is to explore the clinical effectiveness and cost advantage of TeGeCoach, a 12-month long home-based exercise program, compared to usual care. TeGeCoach consists of telephone health coaching, remote walking exercise monitoring based on wearable activity monitors and intensified primary care. It is hypothesized that TeGeCoach will improve functional outcomes and will reduce total health care costs.

NCT ID: NCT03494270 Not yet recruiting - ASCVD Clinical Trials

High-intensity Rosuvastatin and Moderate-intensity Rosuvastatin/Ezetimibe in ASCVD Patients

Start date: April 2018
Phase: Phase 4
Study type: Interventional

This study will evaluate the efficacy and safety of high-intensity rosuvastatin and moderate-intensity rosuvastatin/ezetimibe in ASCVD patients.

NCT ID: NCT03490903 Not yet recruiting - Clinical trials for Coronary Artery Disease

Coronary Angiography THerapeutic Virtual Reality

CATH-VR
Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The CATH-VR study will investigate the effect of virtual reality (VR) on patient pain, anxiety, and radial artery vasospasm during coronary angiography. Our hypothesis is that the use of VR will decrease patient anxiety and pain via validated scoring systems, as well as show a low rate of vasospasm of the radial artery. In addition, we hypothesize that the amount of opioid and benzodiazepine medications utilized for procedural sedation will be lower in the intervention arm. VR has gained recent attraction as an alternative or adjunctive treatment option for pain, but its effect on reducing procedural sedation has not been studied. We propose a single center, randomized control pilot study to further investigate. The patient population will include adults older than 18 years who present for outpatient diagnostic coronary angiography.

NCT ID: NCT03485495 Not yet recruiting - Clinical trials for Cerebral Atherosclerosis

Clinical Trial of Efficacy and Safety of Divaza in the Management of Oxidative Disturbances in Cerebral Atherosclerosis

Start date: April 2018
Phase: Phase 4
Study type: Interventional

The purpose of this study is to obtain further data on the efficacy and safety of Divaza therapy for oxidative impairment elimination in patients with cerebral atherosclerosis. It is assumed that the inclusion of the drug Divaza in the basic therapy will help reduce the severity of cognitive disorders, other clinical symptoms of cerebral atherosclerosis, reduce the impact of the disease on the quality of life of the patient. Participate in the study may be patients with a diagnosis of "cerebral atherosclerosis", which, against the backdrop of basic therapy with constant doses of drugs (within the last 4 weeks), to achieve a stable course of cerebral atherosclerosis, cognitive disorders without significant disability are detected.

NCT ID: NCT03481712 Recruiting - Clinical trials for Coronary Artery Disease

Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease 2

Dan-NICAD 2
Start date: January 24, 2018
Phase:
Study type: Observational

In a cohort of symptomatic patients referred to coronary computed tomography angiography (CCTA), the investigators aim: 1. To investigate and compare the diagnostic precision of Rubidium Positron Emission Tomography (Rb PET) and 3 Tesla Cardiac Magnetic Resonance imaging (3T CMRI) in patients where CCTA does not exclude significant coronary artery disease (CAD) using invasive coronary angiography with fractional flow reserve (ICA-FFR) as reference standard. 2. To evaluate the diagnostic precision of quantitative flow ratio (QFR) and ICA-FFR in patients where CCTA does not exclude significant CAD using Rb PET and 3T CMRI as reference standard. 3. To show superiority for the CADScor®System compared to the Diamond-Forrester score in detection of CAD with CCTA and ICA quantitative coronary angiography (ICA-QCA) as reference standard. 4. To study the diagnostic accuracy of computed tomography fractional flow reserve (CT-FFR) in patients where CCTA does not exclude significant CAD with ICA-FFR as reference standard. 5. To identify and characterize genetic risk variants´ and circulating biomarkers´ importance in developing CAD. 6. To evaluate the bone mineral density in the hip and spine and correlate this to the degree of vascular calcification.

NCT ID: NCT03474562 Not yet recruiting - Hypertension Clinical Trials

High-Dose Statin Combined With Telmisartan vs Amlodipine on Glucose Metabolism in ASCVD Patients With IFG and Hypertension

Start date: April 2018
Phase: Phase 4
Study type: Interventional

This study will evaluate the effect of high-dose rosuvastatin combined with telmisartan or amlodipine on glucose metabolism in ASCVD patients with impaired fasting glucose and hypertension.

NCT ID: NCT03471611 Not yet recruiting - Clinical trials for Atherosclerosis, Coronary

Study of Intracoronary CD34+ Cell Administration in Patients With Early Coronary Atherosclerosis

Start date: May 1, 2018
Phase: Phase 1
Study type: Interventional

How safe and effective are CD34+ cell intracoronary injections for treating coronary endothelial dysfunction (CED)?

NCT ID: NCT03470376 Completed - Atherosclerosis Clinical Trials

NUtraceutical TReatment for hYpercholesterolemia in HIV-infected Patients

NU-TRY(HIV)
Start date: January 15, 2017
Phase: Phase 4
Study type: Interventional

The effects of a nutraceutical combination (NC) containing low-dose monacolin K and berberine on lipid profile, proprotein convertase subtilisin/kexin type 9 (PCSK9), subclinical inflammation and arterial stiffness were investigated in human immunodeficiency virus (HIV)-infected patients receiving stable antiretroviral therapy (ART).