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Hypertension clinical trials

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NCT ID: NCT03753204 Not yet recruiting - Inflammation Clinical Trials

Salt-Sensitivity and Immunity Cell Activation

Start date: March 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

Salt-sensitive hypertension affects nearly 50% of the hypertensive and 25% of the normotensive population, and strong evidence indicates that reducing salt intake decreases blood pressure and cardiovascular events. The precise mechanisms of how dietary salt contributes to blood pressure elevation, renal injury, and cardiovascular disease remains unclear. Our data indicated that monocytes exhibit salt sensitivity, and the investigators hypothesize that of salt sensitivity of these and similar immune cells correlate with the hypertensive response to salt intake. Currently, the research tools for diagnosing salt-sensitivity are costly, time consuming and laborious. In this study the investigators will identify monocyte salt-sensitivity as a marker of salt-sensitive hypertension.

NCT ID: NCT03749902 Not yet recruiting - Induction of Labor Clinical Trials

A Randomized Trial Comparing Oral Misoprostol Alone With Oral Misoprostol Followed by Oxytocin in Women Induced for Hypertension of Pregnancy

Start date: June 2019
Phase: Phase 4
Study type: Interventional

The primary objective of the trial is to assess the following: In women who have undergone cervical preparation with oral misoprostol as part of labour induction for hypertensive disease in India, is augmentation using oral misoprostol superior to the standard protocol of intravenous oxytocin?

NCT ID: NCT03749746 Not yet recruiting - Obesity Clinical Trials

Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia

Start date: December 2018
Phase: N/A
Study type: Interventional

Preeclampsia causes devastating maternal and neonatal morbidity and mortality with a high recurrence risk and a rapid, occult progression to cardiovascular disease after delivery. There is a critical need for effective interventions to reduce these risks. This is a pilot randomized controlled trial of a novel postpartum lifestyle intervention compared to women who take home blood pressure measurements and women with usual care who are overweight and obese in the first year after preeclampsia. The investigators hypothesize that the intervention will lead to improved weight loss and blood pressure in the first year postpartum, which has broad implications for future pregnancy and long-term cardiovascular health.

NCT ID: NCT03749499 Not yet recruiting - Hypertension Clinical Trials

Targeting of UnControlled Hypertension in Emergency Department

Start date: December 2018
Phase: N/A
Study type: Interventional

The proposed project underscores the following: 1) The prevalence of uncontrolled/undiagnosed hypertension (HTN) in underrepresented groups presenting to the ED is alarmingly high, and 2) ED engagement and early risk assessment/stratification is a cost-effective, feasible innovation to help close health disparity gaps in HTN. This proposal involves a two-arm randomized controlled trial of up to 770 patients from the Emergency Department at University of Illinois Hospital with elevated blood pressure (BP). The primary objective is to determine the effectiveness of an emergency department-initiated Educational and Empowerment (E2) intervention with a Post Acute Care Hypertension Consultation (PACHT-c) intervention (arm 2) on the primary outcome of mean systolic blood pressure (SBP) differences between the two trial arms at 6-months post intervention. Secondary objectives include evaluating the effectiveness of this ED education and empowerment intervention on mean SBP and diastolic blood pressure (DBP) differences at 3-months, and mean DBP differences at 6-months. Additionally improvement in cardiovascular risk score (as measured by the Atherosclerotic Cardiovascular Disease (ASCVD) Risk Score), medication adherence (as measured by the Modified Morisky Scale), primary care engagement (measured by compliance with outpatient follow-up appointments), HTN knowledge improvement (as measured by a validated HTN knowledge survey), and overall patient motivation (as measured by the Patient Activation Measures (PAM) will also be assessed as part of this study.

NCT ID: NCT03748563 Not yet recruiting - Portal Hypertension Clinical Trials

DS-MCE vs EGD for Diagnosing Gastroesophageal Varices

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

The aim of this study is to assess the accuracy of the detachable string magnetically controlled capsule endoscopy (DS-MCE) in identifying and grading gastroesophageal varices in patients undergoing screening or surveillance for gastroesophageal varices using EGD as the golden standard.

NCT ID: NCT03748420 Not yet recruiting - Hypertension Clinical Trials

Medication Adherence Clinical Decision Support

Start date: November 2019
Phase: N/A
Study type: Interventional

The study team will implement and evaluate a team-based, informatics-driven intervention that integrates primary care clinical decision support with active outreach from pharmacists. The intervention will proactively (1) identify and address nonadherence for adults with chronic diseases; (2) improve management of previously uncontrolled blood pressure, blood sugar, and lipid disorders; (3) increase patient involvement in medication decision making; and (4) develop informatics systems that integrate retail pharmacists within the primary care team.

NCT ID: NCT03748212 Recruiting - Hypertension Clinical Trials

Clinical Trial to Evaluate Pharmacokinetic Profiles and Safety Between CKD-385 and D935 in Healthy Volunteers

Start date: October 24, 2018
Phase: Phase 1
Study type: Interventional

A randomized, open-label, fed, single dose, crossover study to evaluate the pharmacokinetic profiles and safety of CKD-385 in healthy volunteers

NCT ID: NCT03747978 Completed - Hypertension Clinical Trials

Short-term Effects of Perindopril-amlodipine Versus Perindopril-indapamide in Type 2 Diabetes

Start date: October 1, 2016
Phase: Phase 4
Study type: Interventional

This was a double-blinded randomized controlled trial of 24-hour blood pressure control in sub Saharan type 2 diabetes patients, newly diagnosed for hypertension. They were allocated to receive either a fixed combination of perindopril + amlodipine or perindopril + indapamide for 42 days.

NCT ID: NCT03744637 Not yet recruiting - Clinical trials for Pulmonary Arterial Hypertension

A Study of Single Doses of MK -5475 on Pulmonary Vascular Resistance (MK-5475-002)

Start date: December 10, 2018
Phase: Phase 1
Study type: Interventional

This is a 2-part, 2-panel study of MK-5475 in participants with Group 1 pulmonary arterial hypertension (PAH). Part 1 is a double-blind, randomized, single-ascending dose assessment of the safety, tolerability and pharmacokinetics (PK) of inhaled MK-5475. Part 2 of this study is an open-label study and will assess the safety, tolerability, PK and pharmacodynamics of inhaled MK-5475 at dose determined by results of Part 1 of the study. There is no formal hypothesis to be tested.

NCT ID: NCT03742544 Enrolling by invitation - Hypertension Clinical Trials

Post Marketing Surveillance of Telostop TAB (Telmisartan/Rosuvastatin) for Evaluating the Safety and Efficacy

Start date: June 23, 2015
Study type: Observational

Post-marketing surveillance of Telostop TAB (Telmisartan/Rosuvastatin)