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Hypertension clinical trials

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NCT ID: NCT03529838 Recruiting - Hypertension Clinical Trials

Hemodynamic and Salivary Responses of 12 Weeks of Training With Different Anti-hypertensive

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

Different classes of antihypertensives may have different responses when associated with exercise. Thus, this study aims to compare the responses of the association of 12 weeks of aerobic exercise and weightlifting with different classes of medications in 45 postmenopausal hypertensive women.

NCT ID: NCT03524456 Recruiting - Hypertension Clinical Trials

Home Blood Pressure SMS Telemonitoring in the Primary Care Setting

Start date: April 9, 2018
Phase: N/A
Study type: Interventional

Hypertension is a public health problem worldwide, being responsible for 9.4 million deaths worldwide each year, as well as contributing to the burden of coronary, cerebrovascular, renal diseases, among others. The monitoring of blood pressure at home has gained importance in recent years, being related to adherence to treatment, as well as in the prevention of complications and optimization of pressure levels; In the same way, the use of information and communication technologies (ICT) in health has contributed to the improvement of communication systems by providing alternative tele-monitoring in this type of diseases. Objective: To evaluate the impact of tele-monitoring at home through tensiometers with integrated SMS system (text message), for the sending and recording of blood pressure and heart rate data in the primary care setting. Methods: A randomized controlled trial will be conducted, evaluating the intervention with the integrated blood pressure device with SMS capability, comparing it with the standard care. After a follow-up of 1 month, the effect on the values of systolic and diastolic blood pressure will be evaluated, as well as the adherence to treatment and complications related to arterial hypertension. A sample number of 20 participants per group was calculated, with a significance of 95% and a power of 80%, to detect a minimum significant difference of 10 mmHg.

NCT ID: NCT03517709 Recruiting - Hypertension Clinical Trials

Feasibility of Home Telehealth Monitoring for Improvement in Management of Hypertension for Secondary Stroke Prevention

Start date: December 20, 2016
Phase: N/A
Study type: Interventional

This research is being done to determine how home blood pressure monitoring, using a commercially available blood pressure monitor with the capability of transmitting readings to stroke doctors can help manage blood pressure in the optimal range after a stroke. High blood pressure is the leading risk factor for stroke. It is important to control high blood pressure after a stroke to prevent another one from happening. We will use the Withings Smart Blood Pressure Monitor for daily blood pressure measurements. Tracking of blood pressure measurements will be done via iPod Touch equipped with internet connectivity. We hope to learn if this method of managing blood pressure is more effective than the standard way of having patients visit primary care physicians (the control group for this study). We will also get feedback from participants who will receive the Withings Smart Blood Pressure Monitor about the ease of use and overall satisfaction with this blood pressure device. People 18-100 years old who have had a stroke in the past 6 months may join. You will be excluded from the study if you are pregnant or plan on becoming pregnant in the near future.

NCT ID: NCT03511313 Recruiting - Clinical trials for Primary Hypertension

Renal Denervation With Sterile Irrigated Deflectable Ablation Catheter Used in Renal Artery in Primary Hypertension

Start date: April 11, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of renal denervation with sterile irrigated deflectable ablation catheter used in renal artery in primary hypertension in China.

NCT ID: NCT03506724 Recruiting - Preeclampsia Clinical Trials

Response to Anti-hypertensives in Pregnant and Postpartum Patients

Start date: September 11, 2017
Phase: Phase 4
Study type: Interventional

In this study, the investigators will evaluate the blood pressure response to nifedipine and labetalol in pregnant and postpartum patients, who present with hypertensive disease in pregnancy with severe range blood pressure defined as greater than 160/110. These anti-hypertensives are first line therapy for management of severe range blood pressures in pregnancy and postpartum by the American Congress of Obstetricians and Gynecologist (ACOG). In addition at the Mount Sinai West site, the investigators will also analyze the ADRB1 and similar genes involved in beta blockade, genes involved in calcium channel blockade and other genes implicated in blood pressure response among pregnant and postpartum patients receiving labetalol and nifedipine. This analysis will be used to determine if a pharmacogenetic association exists between variant alleles in these receptors in the pregnant and postpartum population.

NCT ID: NCT03503383 Recruiting - Clinical trials for Hypertension With Pregnancy

Evaluation of Psychological Status in Pregnant Women Complaining of Hypertension With Pregnancy

Start date: March 1, 2018
Phase:
Study type: Observational [Patient Registry]

This study is a case controlled study comparing mental health status and some psychological impacts between two groups of patients first group is pregnant women without any other medical disorder during pregnancy,the second group is pregnant women complaining of hypertension with pregnancy.

NCT ID: NCT03502109 Recruiting - Hypertension Clinical Trials

Pharmacist-led Medication Review With Follow-up on Primary Care Cardiovascular Older Adult Patients.

POLARIS
Start date: January 5, 2018
Phase: N/A
Study type: Interventional

Hypothesis: Medication Review with follow-up can improve clinical, health related quality of life and economic outcomes. To prove this hypothesis a cluster randomized controlled trial will be held in primary care centres of the public health system of Chile. Patients of the cardiovascular disease prevention program, older than 60 years and with poly pharmacy (more than 5 drugs) will be recruited. Control group will receive usual care and the intervention arm will have medication review consultations by a pharmacist every 2 months for one year. Clinical interventions will be made with physician authorisation. Participating pharmacist will be trained in cardiovascular prevention pharmacotherapy in the elderly, interview skills and educational techniques. A practice change facilitator will assist the pharmacist in any matters regarding the methodology and will asses barriers and facilitators to the implementation of the medication review with follow-up service. A personalised plan will be developed for every pharmacist. Clinical outcomes (blood pressure, HbA1c, LDL cholesterol, overall cardiovascular risk, among others), number of medications, adherence rate and health related quality of life will be evaluated. A cost-utility analysis will be made through the health ministry of Chile point of view.

NCT ID: NCT03496792 Recruiting - Blood Pressure Clinical Trials

The Venous Distension Reflex and Orthostatic Hypertension

OH
Start date: December 11, 2017
Phase: N/A
Study type: Interventional

This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).

NCT ID: NCT03496623 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Patients With PH Due to COPD

Start date: May 2018
Phase: Phase 3
Study type: Interventional

This is a multicenter, randomized, double-blind, placebo-controlled, 30-week, adaptive cross-over study, with a Treatment Period of approximately 26 weeks under the Original Design or, if applicable, a 17-week parallel study, with a Treatment Period of approximately 14 weeks under the Contingent Design.

NCT ID: NCT03489005 Recruiting - Heart Failure Clinical Trials

Effect of BIA 5 1058 on Cardiac Repolarization

Start date: April 2018
Phase: Phase 1
Study type: Interventional

The purpose is to evaluate the effect of single therapeutic (400 mg) and supratherapeutic (1200 mg) doses of BIA 5-1058 on the time-matched change from baseline in placebo-adjusted interval corrected (QT) for heart rate (HR)