Coronary Artery Disease Clinical Trial
Official title:
The Impact of Novel Strategies to Improve Cardiometabolic Status and Adherence to Exercise Regimens in Patients at High Risk for Cardiovascular Disease
This is a 2x2 study examining the impacts of a novel exercise regimen and daily text message reminders in patients at high risk for cardiovascular disease. Patients participating in cardiac rehabilitation will be randomized to either moderate intensity continuous training (MICT) or a novel exercise regimen consisting of three periods of high intensity exercise, called BURST exercise. Additionally, half of the patients in each exercise group will be randomized to receive daily text message reminders to improve adherence to the prescribed exercise regimen.
Numerous studies have demonstrated the important cardiometabolic impacts of high intensity
exercise in patients at high risk for cardiovascular disease. It is also known that adherence
to exercise regimens is poor within these populations. This study compares the impacts of the
current standard of care, moderate intensity continuous training (MICT) to a novel exercise
regimen called BURST exercise within a population of patients at high risk for cardiovascular
disease. BURST exercise consists of three periods of high intensity physical activity spread
throughout the day. Additionally, as mobile technologies continue to be used more to improve
adherence to exercise regimens, this study also seeks to compare the impacts of text message
reminders in patients prescribed each of the exercise regimens examined in this study. Thus,
patients were also randomized to either receive daily text message reminders, or to receive
no text message reminders.
Recruitment will be conducted at Cambridge Cardiac Rehab in Ontario, Canada. Potential study
subjects are evaluated for inclusion and exclusion criteria, give written informed consent,
and are randomized, in a 1:1 ratio, to either MICT or BURST exercise. Additionally, patients
are then randomized in a 1:1 ratio to either receive text message reminders or not receive
text message reminders.
Patients prescribed the MICT regimen will be asked to exercise for 30 minutes per day at
moderate intensity, at least five days per week. Patients prescribed the BURST exercise
regimen will be asked to exercise for 10 minutes per session, three times a day at high
intensity, at least five days per week. Patients randomized to receive text message reminders
will be sent four daily text message reminders reading: "Please remember to exercise for 30
minutes today."
Adherence to exercise regimens will be measured by daily logbooks. Patients are asked to log
the times they exercised and for what duration. BRUCE protocol stress tests will be conducted
for all patients at baseline (before beginning the study), after three months and after one
year. Hemoglobin A1C blood tests, height and weight measurements and lipid profile blood
tests will also be conducted at baseline (before the beginning of the study), after three
months and after one year.
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