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Coronary Disease clinical trials

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NCT ID: NCT05079958 Recruiting - Clinical trials for Coronary Artery Disease

Effects of Cognitive-behavioral Education and Exercise Interventions on Smoking Cessation

Start date: October 30, 2019
Phase: N/A
Study type: Interventional

The purpose of the study is to adopt the Trans-theoretical Model to facilitate step-by-step changes in a patient's smoking behavior and explore the effect of "Cognitive-Behavioral Education Course" and "Exercise Program" on Smoking cessation, physical health, and mental health of smokers with CAD.

NCT ID: NCT05075317 Not yet recruiting - Clinical trials for Coronary Artery Disease

Time Restricted Eating and Cardiac Rehabilitation

TREat-CR
Start date: November 1, 2021
Phase: N/A
Study type: Interventional

Time restricted eating (TRE) is a form of intermittent fasting where individuals consume ad libitum energy intake within a set window of time, commonly 8 hours, which induces a fasting window of 16 hours per day (i.e., 16:8 TRE). TRE could be an effective addition to cardiac rehabilitation as it has demonstrated cardiovascular health benefits and potential for synergy when combined with exercise training. This study will be a two site (Toronto Rehabilitation Institute and Toronto Western Hospital), 2-arm, parallel group, randomized feasibility trial of cardiac rehabilitation alone or cardiac rehabilitation plus 16:8 TRE. Men and women who are referred through the standard clinical pathways and eligible for either outpatient cardiac rehabilitation program for coronary artery disease and are willing to accept random assignment and complete the study assessments will be enrolled. Both groups will receive the standard, multi-dimensional cardiac rehabilitation program consisting of physician-directed risk factor management, an individualized exercise prescription, and virtual education. All participants will receive an assessment with a registered dietitian and individualized recommendations for a heart healthy diet. During the consultation with the registered dietitian, the TRE group participants will also be counselled to restrict their eating to between 11 am and 7 pm and consume no calories outside of those hours during the program starting the evening of the consultation. The primary outcome is feasibility measured by daily adherence to the 16-hour fast which will be tracked with two daily text messages for the 16 weeks of the cardiac rehabilitation program. The safety outcomes that will be compared between groups include re-hospitalization, death, angina, and nutritional impact symptoms. Before randomization and after completion of the program the following preliminary efficacy outcomes will be assessed: 1) VO2peak; 2) total body and truncal fat, lean mass; 3) metabolic markers: fasted glucose, insulin, hemoglobin A1c, blood pressure and waist circumference. The investigators hypothesize that cardiac rehabilitation and TRE will be feasible, safe, and provide added cardiovascular health benefits compared to cardiac rehabilitation alone.

NCT ID: NCT05071495 Recruiting - Clinical trials for Coronary Artery Disease

TeleDiet Study: The Impact of Dietary Education and Counseling With a Smartphone Application on Secondary Prevention of Coronary Artery Disease

Start date: March 17, 2021
Phase: N/A
Study type: Interventional

Digital cardiology is gaining power in the field of preventive cardiology recently, and several trials have already shown good results of dietary therapy with digital cardiology. However, there has been no reports that showed effect of dietary counseling through digital cardiology for secondary prevention of coronary artery disease. TeleDiet study investigates the impact of dietary therapy with a smartphone application on the content of meals and metabolic parameters for patients with coronary artery disease.

NCT ID: NCT05056662 Recruiting - Coronary Disease Clinical Trials

Post-Revascularization Optimization and PHysiological Evaluation of intermediaTe Lesions

PROPHET-FFR
Start date: June 4, 2020
Phase:
Study type: Observational [Patient Registry]

PROPHET-FFR is a single center ambispective registry aiming to explore the impact of post-revascularization functional assessment on later outcomes.

NCT ID: NCT05051904 Not yet recruiting - Clinical trials for Coronary Artery Disease

A Study Based on Japanese Medical Records That Looks at Bleeding Events in People With Atrial Fibrillation and Coronary Artery Disease Who Start Taking Either Dabigatran, Rivaroxaban, or Warfarin

Start date: October 1, 2021
Phase:
Study type: Observational

The study aims to evaluate the safety and effectiveness comparisons between warfarin, dabigatran, and rivaroxaban in routine clinical practice among Japanese non-valvular atrial fibrillation (NVAF) patients with concomitant coronary artery disease (CAD).

NCT ID: NCT05051774 Recruiting - Clinical trials for Coronary Heart Disease

Effectiveness of a Motivated, Action-based Intervention on Health Outcomes of Coronary Heart Disease Patients

Start date: August 15, 2021
Phase: N/A
Study type: Interventional

Coronary heart disease (CHD), the major group of cardiovascular disorders, is the leading cause of cardiac-associated mortality, causing >9 million death in 2016. American Heart Association (AHA) and the American College of Cardiology Foundation (ACCF) recognized that lifestyle modification including physical activity is the class one-level recommendation for secondary prevention and risk reduction therapy for patients with CHD. The assessment of physical activity and confidence in performing exercise for patients with CHD will help healthcare professionals to develop and implement the appropriate intervention to enhance patients' confidence in performing exercise and physical activity to promote and maintain their health. With the increasing morbidity and mortality from CHD, especially in low and middle-income countries, secondary prevention including exercise-based cardiac rehabilitation (CR) plays an important role to improve the prognosis of CHD patients. High prevalence of physical inactivity, unhealthy dietary practices, poor control of blood glucose, blood pressure (BP), blood lipid, and body weight (BW) was found among CHD patients in the world as well as in Sri Lanka. Therefore, it is important to design and implement an appropriate intervention to improve the physical activity level, exercise self-efficacy, and cardiovascular risk factors in CHD patients in Sri Lanka. This study aims to develop and examine a culturally specific motivated, action-based intervention for improving physical activity level, exercise self-efficacy, and cardiovascular risk factors of CHD patients in Sri Lanka. The participants will be patients who admitted to the coronary care unit (CCU) and medical wards of the Teaching Hospital Batticaloa, Sri Lanka with CHD for the first time confirmed by electrocardiogram with aged 18 years or above, able to reads and speak Tamil, able to attend clinic follow-up, obtain a medical clearance from a cardiologist to perform the exercise and, able to understand and give informed consent. The medical records of the CHD patients will be reviewed to screen for their eligibility. In addition, the cardiologist of the participants will be consulted for their suitability to perform the exercise of the intervention. The purpose of the study, the data collection procedures, the potential risk and benefits, the maintenance of confidentiality, and the voluntary basis of participation will be clearly explained to the participants, and informed written consent will be obtained before data collection. Ethical approval was obtained from The Joint Chinese University of Hong Kong - New Territories East Cluster Clinical Research Ethics Committee and Ethics Review Committee, Faculty of Health Care-sciences, Eastern University, Sri Lanka. The Statistical Package for Social Science version 22.0 software (SPSS 22.0) will be used to analyze the data and the p-value less than 0.5 will be considered as significant. This study will provide evidence on the effectiveness of a motivated, action-based intervention on the physical activity level, cardiovascular risk factors, and exercise self-efficacy of CHD patients in Sri Lanka. Findings from this study could be useful to promote healthy lifestyle behaviors in CHD patients in a low-resource setting. Furthermore, this study will provide information on which level this intervention could be applied and possible constraints that hinder the outcomes of the results.

NCT ID: NCT05044273 Not yet recruiting - Clinical trials for Coronary Artery Disease

Evaluation of Effectiveness and Safety of Synergy XD Stent

IRIS SynergyXD
Start date: October 31, 2021
Phase:
Study type: Observational [Patient Registry]

The objective of this study is to evaluate the effectiveness and safety of Synergy XD stent in the "real world" daily practice as compared with the other drug-eluting stents.

NCT ID: NCT05043948 Recruiting - Coronary Disease Clinical Trials

Genome-wide Association Study of Development of Collateral Circulation for Patients With Coronary or Peripheral Artery Disease

GWAScollateral
Start date: August 21, 2015
Phase:
Study type: Observational

The purpose of this study is to evaluate the genome-wide association for the development of collateral circulation for patients with coronary or peripheral artery disease and to develop the molecular genetic treatment model based on genome-wide association data.

NCT ID: NCT05041218 Not yet recruiting - Clinical trials for Coronary Artery Disease

Neural Interfaces to Monitor Fatigue and Sleepiness in the Cathlab

GAME-ON
Start date: October 1, 2021
Phase:
Study type: Observational [Patient Registry]

Improvement of patients' care and outcome is largely based on development and validation of drugs and technologies, especially in rapidly evolving fields as Interventional Cardiology. In fact, even though the optimal efficiency of a cathlab can be influenced by Interventional Cardiologist's mental workload, stress' accumulation and performance, little if any attention is paid to the monitoring and optimization of his/her mental status. Electroencephalogram (EEG)-based neural-interfaces are able to estimate workload, fatigue and the degree of sleepiness through spectral analysis techniques. In particular, the amplitude of alpha waves is a widely validated indicator of mental engagement's level. Developing a low cost and highly feasible device to monitor and analyze operator's mental engagement level and performance could be extremely appealing, especially considering both the lack of data in literature for interventional disciplines and the recent technology developments.

NCT ID: NCT05039567 Not yet recruiting - Clinical trials for Coronary Artery Disease

Effect of an Optimal Heart Team Protocol on Decision-making Stability

Start date: October 2021
Phase: N/A
Study type: Interventional

This study is aimed to evaluate the effect of the optimal heart team implementation protocol on the stability of decision-making for patients with complex coronary artery disease.