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Clinical Trial Summary

Recent evidences have demonstrated improved diagnostic accuracy for detecting coronary artery disease (CAD) when myocardial blood flow (MBF) is quantified in absolute terms using single photon emission tomography (SPECT) compared to conventional myocardial perfusion imaging (MPI). However, there are no uniformly accepted cutoff values of MBF and MFR derived from SPECT for diagnosing hemodynamically significant CAD. Particularly, the diagnostic performance for quantitative SPECT has not been validated using fractional flow reserve (FFR). The aim of this prospective study is to determine optimal cutoff values of absolute MBF and MFR derived from NaI (Tl)-based SPECT and to evaluate the diagnostic efficacy of this quantitative technology utilizing invasive coronary angiography (ICA) in combination with FFR results as the reference standard in patients with suspected or known CAD.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06030596
Study type Observational
Source China National Center for Cardiovascular Diseases
Contact Lei Wang, MD/PhD
Phone 861088322728
Email leiwangfw@126.com
Status Recruiting
Phase
Start date September 9, 2022
Completion date December 2023

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