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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT01916902 Withdrawn - Clinical trials for Coronary Artery Disease

Effect of Pretreatment With Ticagrelor on Residual Thrombus After PCI in Patients Presenting With ACS in Comparison With Delayed Treatment at the Time of PCI: an OCT Study

Start date: February 2014
Phase: Phase 4
Study type: Interventional

Subjects presenting with probable acute coronary syndromes scheduled for cardiac catheterization will be enrolled in this study. Consented subjects will be randomized to receive ticagrelor started with a loading dose immediately after enrollment versus receiving a loading dose of ticagrelor during cardiac catheterization after diagnostic angiography but prior to stenting. Optical coherence tomography (OCT) will be performed after stenting and the volume of thrombus within the new stent will be measured and compared between the groups.

NCT ID: NCT01849757 Withdrawn - Clinical trials for Coronary Artery Disease

Comparison of Priming Constituents in Patients Undergoing CPB Assisted Cardiac Surgery: HES 130/0.4 or Albumin 5%

Start date: November 2013
Phase: N/A
Study type: Interventional

The purpose of the study is to determine which priming fluid is the safest for use for priming the heart-lung machine used during cardiopulmonary bypass for patients undergoing cardiac surgery. The fluids to be compared are albumin and voluven. A control group will receive only crystalloid.

NCT ID: NCT01840696 Withdrawn - Clinical trials for Coronary Artery Disease

Phase Analysis and Obstructive CAD on Rubidium PET

Start date: October 2013
Phase: Phase 2
Study type: Interventional

Rubidium myocardial perfusion PET is an imaging test used to diagnose patients with abnormal blood flow to the heart secondary to narrowing of the heart vessels. Phase analysis is a computer method that is applied after the PET test is done. It is used to determine when a region of the heart contracts relative to other heart regions in the heart beating cycle. Initial data suggest that regions of the heart with abnormal blood flow change the pattern of contraction from rest to stress conditions. That is, regions of the heart with abnormal blood supply become dyssynchronous when compared to the normal regions of the heart. This study will investigate whether phase analysis may aid the visual interpretation of rubidium myocardial perfusion PET studies by determining the areas of the heart that are not beating in synchrony with the normal heart regions. This information will be used as a proxy for poor blood supply. The gold standard will be coronary angiography by which the percent narrowing of the heart vessels is assessed.

NCT ID: NCT01830062 Withdrawn - Clinical trials for Coronary Artery Disease

Atherosclerotic Coronary Vulnerable Plaque: Correlation With Coronary Artery Calcium

Start date: November 2013
Phase: N/A
Study type: Interventional

The aim of this study is to compare the relationship between the coronary artery calcification assessed by MDCT with the plaque characteristics and necrotic lipid core content of non-intervened coronary segments assessed with near infrared spectroscopy (NIRS) in patients with symptomatic coronary artery disease (CAD).

NCT ID: NCT01826175 Withdrawn - Clinical trials for Coronary Artery Disease

Comparison of Ticagrelor Versus Clopidogrel on Residual Thrombus Burden During PCI: an OCT Study

Start date: May 2013
Phase: Phase 4
Study type: Interventional

Subjects with acute coronary syndromes scheduled for cardiac catheterization will be enrolled in this study. Subjects that are to be treated clinically with coronary artery stenting will be randomized to receive a loading dose of clopidogrel versus ticagrelor after diagnostic angiography but prior to stenting. Optical coherence tomography (OCT) will be performed after stenting and the presence of blood clots inside the new stent will be measured and compared between the groups.

NCT ID: NCT01809730 Withdrawn - Hypertension Clinical Trials

Pilot Study: Cardiovascular Events in High Risk Orthopedic Surgical Patients

Start date: May 2012
Phase: N/A
Study type: Observational

This is a non-randomized, non-interventional pilot observational study designed to follow high-risk patients through their surgical and hospital stay. The investigators will collect 2 4ml vial's of blood (total of 8ml) prior to surgery to assess CV biomarkers - inflammatory, metabolic, hypercoagulable and platelet.

NCT ID: NCT01798277 Withdrawn - Clinical trials for Coronary Artery Disease

Trial Comparing Ablation With Medical Therapy in Patients With Ventricular Tachycardia

VeTAMed
Start date: April 2013
Phase: Phase 3
Study type: Interventional

This study aims to compare antiarrhythmic drug therapy with catheter ablation using the SmartTOUCH catheter (Biosense Webster Inc.) as treatment for patients with ventricular tachycardia and coronary artery disease

NCT ID: NCT01757262 Withdrawn - Clinical trials for Coronary Heart Disease

A Clinical Study of Safety and P2Y12 Receptor Inhibition Effects of Ticagrelor and Clopidogrel in Vietnamese Patient

Start date: January 2013
Phase: Phase 3
Study type: Interventional

Study in Vietnamese Patients with Coronary Heart Disease to investigate safety and P2Y12 Receptor Inhibition Effects of Ticagrelor and Clopidogrel

NCT ID: NCT01757223 Withdrawn - Clinical trials for Coronary Artery Disease

Administration of AdVEGF-All6A+ to Myocardium of Individuals With Diffuse CAD Via Minimally Invasive Surgery

Start date: December 2020
Phase: Phase 1/Phase 2
Study type: Interventional

The proposed Phase I/II clinical trial will be used to determine the safety and toxicity of direct administration of the vector AdVEGF-All6A+ to the ischemic myocardium and to generate preliminary evidence regarding whether direct administration of AdVEGF-All6A+ to the ischemic myocardium will induce growth of collateral blood vessels and improve cardiac function. This is a three-part, multinational/multi-center, placebo controlled study.

NCT ID: NCT01747525 Withdrawn - Clinical trials for Coronary Artery Disease

Near-Infrared Spectroscopy and Ultrasound Investigation of Coronary Artery Plaque

LUNAR
Start date: October 2011
Phase: N/A
Study type: Observational

The primary objective of this study is to characterize coronary artery blockages as determined by the LipiScan combined NIRS-IVUS catheter using multi-vessel imaging.