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Hypertension clinical trials

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NCT ID: NCT05051124 Not yet recruiting - Hypertension Clinical Trials

Peers and Technology for Adherence, Access, Accountability, and Analytics

PT4A
Start date: October 1, 2021
Phase: N/A
Study type: Interventional

The overall objective of this project is to utilize the PRECEDE-PROCEED framework to conduct transdisciplinary, translational implementation research focused on improving medication adherence for hypertension control. The central hypothesis is that peer delivery of medications integrated with HIT (PT4A) will be effective in improving hypertension medication adherence, contributing to improved blood pressure among patients with uncontrolled hypertension in western Kenya. This application will focus on the critical formative components of the overall implementation research objective. This study record will focus on Sub-Aim 2.2: a pilot of the intervention and focus group discussions with patients, peers, and clinical staff will be conducted to evaluate feasibility. The study team will also evaluate impact on systolic blood pressure, medication adherence, and fidelity of implementation.

NCT ID: NCT05050864 Not yet recruiting - Clinical trials for Pseudotumor Cerebri,Cerebrospinal Fluid ,Transverse Sinuses

Stenting Versus Neurosurgical Treatment of Idiopathic Intracranial Hypertension: a Randomized Controlled Trial

HYDROPTIC
Start date: September 20, 2021
Phase: N/A
Study type: Interventional

Idiopathic intracranial hypertension (HTICi) is a pathology, affecting young adults with a predominance of women, due to an increase in intracranial pressure, which may be associated with stenosis of the cerebral venous sinuses and whose origin remains unknown. This hypertension can lead to papillary edema (OP) which can lead to a narrowing of the visual field and progress to blindness. Along with weight reduction, acetazolamide, which reduces the production of cerebrospinal fluid (CSF), is prescribed as a first-line treatment. Its efficacy is inconsistent in resolving papillary edema and there are many side effects. In the event of ineffectiveness or dependence on acetazolamide associated with hygiene and dietetic rules, a second line of therapy is then considered: neurosurgical (internal shunt of the LCS) or endovascular (venous stenting) treatment. These invasive techniques have each proven their effectiveness in the rapid and permanent resorption of OP, allowing improvement or preservation of visual function. In terms of induced morbidity, the superiority of one technique over the other, if it exists, has not been established. In fact, the literature mainly consists of series of cases or case reports suggesting a 98% improvement in OP for the stent versus 90% for the neurosurgical shunt. However, patients and the assessment of outcomes are very heterogeneous. Major complications concern 7.6% and minor complications up to 33% of patients treated by bypass according to Satti et al. in 2015. For stents in 2% of cases major complications occur and minor complications were reported in 4.4% of cases (Aguilar-Perez et al. 2017). Our objective is to compare the efficacy, safety, and safety of LCS bypass surgery versus venous sinus stenting in HTICi with moderate to severe visual impairment after failure of medical treatment defined by the absence of resorption of the OP after several months

NCT ID: NCT05050266 Not yet recruiting - Obesity Clinical Trials

Enhancing Mental and Physical Health of Women Veterans

EMPOWER
Start date: November 1, 2021
Phase: N/A
Study type: Interventional

Women Veterans are the fastest growing segment of VA users. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. This program, EMPOWER QUERI 2.0, uses mixed methods to evaluate two strategies designed to support implementation and sustainment of three preventive evidence-based practices for women Veterans. The evidence-based practices address prevention of type 2 diabetes, cardiovascular disease, and perinatal depression, all of which are high-priority health conditions among women. The investigators will implement these evidence-based practices in 20 VA facilities across four regions; some of the facilities are rural, and some are low-performing in women's health. All three evidence-based practices will be available virtually (e.g., online, by telephone or telehealth) so that women can engage in them at their convenience. This virtual care approach is of great importance to VA because it can increase access to care and thereby improve Veterans' health outcomes.

NCT ID: NCT05049616 Not yet recruiting - Clinical trials for Hypertension in Pregnancy

Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension

ACE
Start date: September 13, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to see if a combined pill of Angiotensin-converting enzyme (ACE) inhibitors (a medication that helps relax your veins and arteries to lower your blood pressure) with diuretics (sometimes called water pills, help rid your body of salt and water) will control blood pressure better than a different blood pressure medication of calcium channel blocker (lower your blood pressure by preventing calcium from entering the cells of your heart and arteries). Both medications are part of our usual care for high blood pressure after delivery.

NCT ID: NCT05049096 Not yet recruiting - Hypertension Clinical Trials

Focused Power Ultrasound Mediated Inferior Perirenal Adipose Tissue Modification Therapy for Essential Hypertension

PARADISE-HTN
Start date: October 8, 2021
Phase: N/A
Study type: Interventional

This randomized, double blinded, sham-control trial aims to evaluate the efficacy and safety of a novel focused power ultrasound mediated inferior perirenal adipose tissue modification therapy for essential hypertension.

NCT ID: NCT05048836 Not yet recruiting - Hypertension Clinical Trials

Healthy Food First

HFF
Start date: September 2021
Phase: N/A
Study type: Interventional

Socioeconomic barriers to healthy eating, particularly food insecurity, are a major reason for poor blood pressure control and hypertension complications. Healthy diet patterns have been shown to improve health. Unfortunately, food insecurity makes it difficult for individuals to maintain healthy diet patterns. This pragmatic randomized trial will compare two food insecurity interventions (a healthy food subsidy versus a delivered food box), with or without lifestyle support delivered by community health workers, for 6 versus 12 months duration. Key outcomes include blood pressure, food insecurity, and other patient reported outcomes.

NCT ID: NCT05048147 Not yet recruiting - Hypertension Clinical Trials

Community Mobilization for Improved Clean Cookstove Uptake, Household Air Pollution Reduction, and Hypertension Prevention

Start date: April 2022
Phase: N/A
Study type: Interventional

Using a focused implementation research framework, the EPIS (Exploration, Preparation, Implementation and Sustainment) model in a type-2 hybrid design, the study will be conducted in 3 phases: 1) A pre-implementation phase that will use the Exploration and Preparation domains of EPIS to: a) explore barriers and facilitators of Clean Fuel- Clean- Stove (CF-CS) use, and b) develop a culturally-tailored CM strategy for CF-CS use; 2) An Implementation phase that will use the Implementation domain of EPIS to compare in a cluster RCT of 32 peri-urban communities (640 households), the effect of CM vs. a self-directed condition (i.e. receipt of information on CF-CS use without CM) on adoption of CF-CS use; and systolic BP reduction; 3) A post-implementation phase that will use the Sustainment domain of EPIS to evaluate the effect of CM strategy vs. self-directed condition on sustainability of the CF-CS use in 640 households across the randomly assigned 32 peri-urban communities in Nigeria. The University of Ibadan working with the MOH will oversee research coordination in Nigeria.

NCT ID: NCT05047731 Not yet recruiting - Hypertension Clinical Trials

Antihypertensive Deprescribing in Long-term Care

OptimizeBP
Start date: September 20, 2021
Phase: N/A
Study type: Interventional

Frail older adults are commonly prescribed blood pressure medication, yet it is unclear if blood pressure medication is actually beneficial for them. Observational studies in this population suggest blood pressure medication has limited benefit and may even be harmful, including an increased risk for falls and cognitive impairment. Randomized controlled trials are needed to confirm this. This study is a randomized controlled trial of blood pressure medication deprescribing, amongst long-term care residents with systolic blood pressure lower than 135 mmHg. In the intervention group, with physician consent, the facility pharmacist will reduce blood pressure medication until the blood pressure reaches the target systolic blood pressure of 140 ±5 mmHg. The control group will receive usual care. The primary outcome is all-cause mortality but the study will also be tracking all-cause hospitalization or emergency room visits, hip fractures, cost of medication, and quality of life. The hypothesis is that avoiding unnecessarily low systolic blood pressure is beneficial in a frail, end-of-life population.

NCT ID: NCT05043831 Not yet recruiting - Ocular Hypertension Clinical Trials

Direct Selective Laser Trabeculoplasty in Ethnic Chinese Population The Zhuiguang Trial

Start date: October 15, 2021
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate the effectiveness (Intra-Ocular Pressure lowering) and safety of Direct Selective Laser Trabeculoplasty (DSLT) in ethnic Chinese subjects with Primary Open Angle Glaucoma or Ocular Hypertension.

NCT ID: NCT05043454 Not yet recruiting - Hypertension Clinical Trials

Improving Age-Related Cognitive Decline With Exercise in Hypertensive Older Adults

DECLARE
Start date: October 1, 2021
Phase: N/A
Study type: Interventional

The investigator aims to assess the extent to which a brief exercise intervention improves systemic growth factor concentrations, reverses loss of systemic vascular networks and hypertension, and by extension, improves neurocognition. To test the investigator's hypothesis that increased cardiovascular fitness will correlate with improved vascular density, the investigator proposes the innovative use of retinal density scans.