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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT01519973 Terminated - Clinical trials for Coronary Artery Disease

Optimization of SPECT Imaging

OSCARS
Start date: August 2008
Phase: N/A
Study type: Interventional

Single Photon Emission Computed Tomography (SPECT) is a 3D nuclear medicine imaging technique that is used extensively to study the heart and diagnose heart disease. There are three major limitations in SPECT imaging: attenuation or loss of signal, scattering of the signal in the patient tissues and resolution, where the signal gets blurrier the further the nuclear activity is away from the camera. New software, Evolution for CardiacTM, by GE Healthcare and new cameras with computed tomography (CT) decrease the time needed for images to be obtained while maintaining image quality. Evaluation is needed before they become standard of care.

NCT ID: NCT01506960 Terminated - Clinical trials for Coronary Artery Disease

Evaluation of a Combined Near Infrared Spectroscopy (NIRS) and Intravascular Ultrasound (IVUS) Catheter for Detection of Lipid Rich Plaque

Start date: January 2012
Phase: Phase 4
Study type: Interventional

The purpose of this study is to learn more about lipid rich plaque using Near Infrared Spectroscopy (NIRS)/Intravascular Ultrasound (IVUS) imaging in patients who have had coronary artery stenting and Optical coherence tomography (OCT) imaging.

NCT ID: NCT01504945 Terminated - Anemia Clinical Trials

Red Blood Cell Transfusion in Patients With Coronary Artery Disease (CAD)

Start date: February 2010
Phase: Phase 1/Phase 2
Study type: Interventional

Patients with a low blood count (anemia) with stable or unstable coronary artery disease consistently show worse clinical outcomes. It is unclear whether this association is confounded since anemic patients tend to be also sicker i.e. have lower ejection fractions or more comorbidities and this would be the reason for the worse outcomes rather than anemia. The coronary arteries are a unique vascular bed insofar that across the cardiac circulation oxygen extraction is close to maximal at rest. Thus increases in demand can only be met by increases in blood flow and hemoglobin concentration since oxygen extraction is maximal at rest. It is natural to assume that maximization of oxygen delivery in the setting of active coronary syndrome (ACS) is beneficial to the patient since oxygen extraction and coronary blood flow is fixed. In fact, in most intensive care units patients with ACS are transfused to a HCT of 30%. However, retrospective analysis of trial data showed at best mixed results in clinical outcome when patients with ACS were transfused and in fact in some studies showed consistently worse outcomes than non-transfused patients. Similar disappointing results have recently published in patient who underwent coronary artery bypass grafting (CABG). This study is designed to determine the effect of red blood cell (RBC) transfusion on oxygen consumption, cardiac, microcirculatory and endothelial function in patients with active coronary artery disease. For this study active coronary artery disease will be defined as the patient having undergone within the past 4 days of recruitment either a myocardial infarction due to atherothrombosis (AHA type I myocardial infarction) or surgery for coronary artery bypass grafting. In specific this study will test the hypothesis whether RBC transfusions improves cardiac and vascular function in patients with a hematocrit of less than 30% with active coronary artery disease. Aims of this study are to determine whether RBC transfusion in patients with active coronary artery disease and anemia: - increases oxygen delivery to the peripheral tissues. - increases whole-body oxygen consumption. - decreases nitric oxide bioavailability, endothelial, microcirculatory, and myocardial function, and/or increases platelet aggregation

NCT ID: NCT01499654 Terminated - Clinical trials for Myocardial Infarction

Half-Dose Radiopharmaceutical in Wide Beam Reconstruction

REGA-1102
Start date: October 2011
Phase: N/A
Study type: Interventional

This study is recruiting patients already scheduled for a single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) test. SPECT-MPI is a nuclear imaging technique that uses a radioactive substance, or radiotracer, and special equipment to create three-dimensional (3D) images of the heart. Radiotracer is a radioactive dye that will make the structures of the heart visible and is routinely used to view blood flow in the heart, scan for damaged heart tissue, or assess heart function. For a routine SPECT-MPI test, the radiotracer is given in one dose at the beginning of the test, followed by taking resting images of the heart. For this study, researchers would like to administer half of the radiotracer, obtain resting images, administer the remainder of the radiotracer and obtain a second set of resting images. Participants will receive the same amount of radioactive material that would normally be given for this test; however, it will be administered in two half-doses. Participation in this study will add about 30 minutes to the time it takes to complete the routine test. The investigators expect to enroll about 160 subjects in this study at Northwestern.

NCT ID: NCT01489761 Terminated - Clinical trials for Coronary Artery Disease

LONG-DES VI (Drug Eluting Stent for Long Lesions in Coronary Artery)

Start date: January 2012
Phase: Phase 4
Study type: Interventional

This is a multi-center, randomized, study to compare the efficacy of zotarolimus-eluting stent (Resolute Integrity or Resolute Onyx stent) or everolimus-eluting stent (Xience Prime or Xience Xpedition or Xience Alpine stent) for very long coronary lesions.

NCT ID: NCT01474434 Terminated - Clinical trials for Coronary Artery Disease

Efficacy of LCQ908 on Cardiovascular Risk

im
Start date: March 2011
Phase: Phase 2
Study type: Interventional

This is a study designed to evaluate the potential for the LCQ908 to impact cardiovascular risk.

NCT ID: NCT01464671 Terminated - Clinical trials for Coronary Artery Disease

Angiomax® or Unfractionated Heparin for Patients Undergoing Percutaneous Coronary Intervention

STATUS PCI
Start date: July 2009
Phase: Phase 4
Study type: Interventional

The objective of the study is to assess the safety and efficacy of Angiomax® (bivalirudin) versus unfractionated heparin (UFH) in patients presenting with stable angina or silent ischemia (positive stress test without chest pain) that undergo percutaneous coronary intervention (PCI). The primary endpoint of the study will be major and minor bleeding events, defined by the REPLACE-2 trial definition, during the index hospitalization and up to 30 days post discharge.

NCT ID: NCT01462721 Terminated - Clinical trials for Coronary Artery Disease

The eSVS® Mesh Randomized Post-Market Study

Start date: October 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate patency rates of the external Saphenous Vein Support (eSVS) Mesh Saphenous Vein Grafts (SVG) and Control SVG at 3-6 months and 24 months.

NCT ID: NCT01454440 Terminated - Clinical trials for Coronary Artery Disease

The INtegrilin Plus STenting to Avoid Myocardial Necrosis Trial (INSTANT)

INSTANT
Start date: October 2007
Phase: Phase 4
Study type: Interventional

Patients with stable coronary artery disease, undergoing PCI by means of implantation of >33 mm of DES, will be randomized single-blinded to eptifibatide plus unfractioned heparin according to the ESPRIT protocol vs placebo plus unfractioned heparin.

NCT ID: NCT01448005 Terminated - Myocardial Ischemia Clinical Trials

LifeVest Post-CABG Registry

Start date: February 2011
Phase: N/A
Study type: Observational

This is a multi-center prospective registry of patients with an ejection fraction (EF) ≤ 35% following coronary artery bypass graft (CABG) surgery in order to test the hypothesis that wearable defibrillators (WD) will decrease overall mortality after discharge by decreasing arrhythmic death in this select population with high risk for sudden cardiac death (SCD). This is a pilot project to determine the feasibility of a larger-scale study.