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Pain, Postoperative clinical trials

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NCT ID: NCT03907813 Withdrawn - Pain, Postoperative Clinical Trials

Liposomal Bupivacaine After Cesarean Delivery

Start date: May 1, 2019
Phase: Phase 4
Study type: Interventional

The aim of this study is to determine if local wound infiltration with liposomal bupivacaine at the time of cesarean delivery can decrease opioid use and provide adequate post-operative pain control.

NCT ID: NCT03906838 Withdrawn - Surgery Clinical Trials

Regional Anesthesia Block in Fibula Free Flap Reconstruction

Start date: January 1, 2020
Phase: Early Phase 1
Study type: Interventional

Despite many recent advances in pain management, post-operative pain is widely considered to be poorly managed. Furthermore, the mainstay of current pain management is opioids, for which there is strong evidence of ill effects and long-term potential for addiction. There are many studies demonstrating that perineural regional anesthesia can be superior to intravenous opioid analgesia, and that the technique is safe. By using temporary implanted catheters, this method can now deliver prolonged analgesia, thus reducing the need for opioids in the postoperative period. Regional anesthesia is a proven technique and used daily by anesthesiologists, and it is also the first choice for hip and knee replacement surgery for orthopedic surgeons. Patients undergoing head and neck reconstruction with the use of free tissue transfer experience a significant amount of post-operative pain due to the complexity of the surgery, the presence of a head and neck surgical site as well as a secondary donor site, and existing co-morbidities, most commonly malignancy, that also cause significant pain. These patients often require opioids for pain control throughout the hospital stay, and are almost always discharged home with additional opioids. By utilizing regional anesthesia blocks at the donor sites, the investigators can potentially reduce post-operative pain while also reducing the use of opioids.

NCT ID: NCT03893292 Withdrawn - Postoperative Pain Clinical Trials

Preop Cooled Radiofrequency Ablation for Total Knee Replacement

Start date: January 24, 2019
Phase:
Study type: Observational

Total knee replacement surgery is commonly performed for patients suffering from severe knee osteoarthritis. However, 20% of patients continue to experience pain after surgery. There is currently no standardized pain management protocol for pain after total knee replacement. Cooled radiofrequency ablation has been used successfully to alleviate spin-related pain and has recently been approved by the FDA to treat chronic knee arthritic pain. This pilot study aims to collect preliminary data on the use of cooled radiofrequency ablation in patients undergoing total knee replacement.

NCT ID: NCT03877549 Withdrawn - Post Operative Pain Clinical Trials

Dexamethasone Administered Via the Epidural Catheter as an Adjunct in Patients Undergoing Cesarean Delivery

Start date: May 24, 2019
Phase: Phase 4
Study type: Interventional

This study will evaluate the ability of dexamethasone to enhance labor epidurals when administered as an adjunct to local anesthetics via an epidural catheter. Patients undergoing elective cesarean sections will be randomized into three groups, each receiving the same combined spinal epidural (CSE). At surgical closure, Group 1 will receive 10cc bupivacaine 0.0625%, Group 2 will receive 10cc bupivacaine 0.0625% +4mg dexamethasone, and Group 3 will receive 10cc bupivacaine 0.0625% + 8mg dexamethasone (4mg). VAS, sedation, nausea, and satisfaction scoring will be measured on patient follow-up to compare the outcomes of the different treatment groups.

NCT ID: NCT03874806 Withdrawn - Pain, Postoperative Clinical Trials

Pharmacokinetic Profile and Dermatomal Coverage of the Erector Spinae Plane Block

Start date: July 1, 2019
Phase: Phase 4
Study type: Interventional

The goals of this study are as follows: 1. to confirm the safe dosing of ropivacaine for the erector spinae plane block 2. develop a pharmacokinetic profile of the erector spinae plane block, which will help demonstrate how quickly and how closely toxic levels are reached when a routine dose of ropivacaine is given for this nerve block 3. assess numbness created by the erector spinae block when routine doses are administered

NCT ID: NCT03867240 Withdrawn - Pain, Postoperative Clinical Trials

Gabapentin and Chronic Post Surgical Pain

CPSP
Start date: June 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the effect of a common pain medication (gabapentin) on chronic postsurgical pain in pediatric patients who require surgery for idiopathic scoliosis.

NCT ID: NCT03860324 Withdrawn - Pain, Postoperative Clinical Trials

Erector Spinae vs Fascia Iliaca Block in Hip Arthroplasty

ESFIBHA
Start date: April 1, 2019
Phase: N/A
Study type: Interventional

The thoracic erector spinae plane (ESP) block was first described by Forero et al in September 2016. In their article, the authors presented the possibility of using this block as an option for the control of thoracic neuropathic pain as well as post-operative thoracic pain. The ESP block is done by administering local anesthetic in the plane deep to the erector spinae muscle, which spreads through the costotransverse foramen to the dorsal and ventral roots of the spinal nerves. Since then, there have been reports about the successful use of this block for bariatric surgery, ventral hernia repair, radical mastectomy, rib fractures, major abdominal surgery and hip replacement. However, there are no studies in the literature comparing the efficacy of the ESP block to other nerve blocks. The purpose of this study is to compare the post-operative analgesic efficacy of the ESP block to the fascia iliaca (FI) block after total hip replacement (THR).

NCT ID: NCT03832478 Withdrawn - Pain Clinical Trials

Longitudinal Virtual Reality Use in Pediatric Surgical Procedures

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

This study aims to investigate the use of virtual reality guided mindfulness meditation to reduce the pre and post-operative anxiety and pain of pediatric surgical patients.

NCT ID: NCT03797612 Withdrawn - Pain, Postoperative Clinical Trials

Study to Evaluate a Preop Dose of Brivoligide Injection for Pain After Knee Replacement in Patients With High PCS Scores

Start date: January 2021
Phase: Phase 2
Study type: Interventional

This is a multi-center, Phase 2, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of brivoligide injection administered intrathecally before surgery in patients with a Pain Catastrophizing Scale (PCS) score ≥16 undergoing primary unilateral total knee arthroplasty.

NCT ID: NCT03750773 Withdrawn - Postoperative Pain Clinical Trials

Gabapentin for Relief of Immediate Postoperative Pain

GRIPP
Start date: July 2, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to use gabapentin as an additional or alternative treatment for short term pain control following cesarean delivery in order to reduce the use of opioid pain medication and improve overall pain control following surgery.