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Surgery clinical trials

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NCT ID: NCT03805386 Not yet recruiting - Surgery Clinical Trials

Patient-Directed Postoperative Opioid Prescribing for Gynecologic Surgery

Start date: January 15, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

We would like to evaluate and optimize opioid prescribing after minimally invasive hysterectomy. Currently, our standard prescribing is 150 oral morphine equivalents. However, recent studies show that half of the opioids prescribed are not used. We would like to include the patient in the decision making of the opioid prescribing. We have designed a randomized controlled trial to prescribe standard (150 oral morphine equivalents) or patient directed (less than or equal to 150 oral morphine equivalents) for pain control. We hypothesize that with patient input, there will be a higher utilization of the opioids prescribed. Also, we anticipate a lower number of opioids used overall. This study will help us optimize opioid prescribe and evaluate whether patient input can help in this important measure.

NCT ID: NCT03797976 Recruiting - Parkinson Disease Clinical Trials

The Effects Of DBS Of Subthalamıc Nucleus On Functionality In Patıents With Parkinson's Disease: Short-Term Results

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Parkinson's disease is a progressive chronic neurodegenerative disease. In cases where drug treatment is insufficient and drug use is not possible due to drug side effects, highly effective and low-risk surgical treatment options could be used. In Parkinson's Disease; findings such as chest wall rigidity and weakness of the respiratory muscle strength occur. The aim of this study was to determine the effect of preop and postop DBS surgery on respiratory muscle strength, respiratory function and physical performance in patients with Parkinson's disease.

NCT ID: NCT03797716 Not yet recruiting - Surgery Clinical Trials

Paediatric Peri-operative Anxiety: Does the Little Journey App Help?

Little Journey
Start date: March 1, 2019
Phase: N/A
Study type: Interventional

To evaluate the clinical effectiveness of a virtual reality psychological preparation app at reducing peri-operative anxiety and its associated sequelae in children aged 3-12 years old undergoing ambulatory surgery compared to standard care.

NCT ID: NCT03792932 Not yet recruiting - Pancreatic Cancer Clinical Trials

Laparoscopic vs Open Pancreatectomy for Body and Tail Pancreatic Cancer

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

Open distal pancreatectomy (ODP) has been commonly employed for the treatment of a variety of cancers in body and tail of pancreas. Although many general surgical procedures have been increasingly performed laparoscopically or with laparoscopic assistance, until the current decade, laparoscopic pancreatic surgery had not been performed for its complicated anatomy. But laparoscopic distal pancreatectomy (LDP) has been widely accepted as a standard treatment for body and tail pancreatic cancer because there is no anastomosis in it, and LDP has gradually become the first choice for these cancers in clinical work. Although there are several studies about the comparison between LDP and ODP, most are retrospective and there is no agreement in surgical margin, lymph node numbers and prognosis to identify the oncological differences between the two surgical approaches. The investigators' pilot study showed that patients with body and tail pancreatic cancer underwent LDP had a better prognosis compared with the ones undergoing ODP, with no statistics differences in postoperative complications and mortality. This perspective RCT study is performed to confirm whether LDP would improve the prognosis for patients with body and tail pancreatic cancer compared with ODP.

NCT ID: NCT03792100 Recruiting - Surgery Clinical Trials

Efficacy and Safety of SmofKabiven Emulsion for Infusion Versus Hospital Compounded Emulsion "All in One" for Parenteral Nutrition

Start date: January 3, 2019
Phase: Phase 3
Study type: Interventional

The present protocol describes a randomized, patient-blinded study in which either SmofKabiven emulsion for infusion or a hospital compounded "All in one" control Total Parenteral Nutrition (TPN) regimen will be given to adult surgical patients for 5 consecutive days. As serum prealbumin is a well-established surrogate efficacy parameter reflecting the patient´s nutritional status, the change of the serum prealbumin level at the day of the final study visit compared to baseline will represent the primary efficacy parameter in the present study. In addition, other variables will be assessed in this study, i.e., postsurgical new onset of nosocomial infection, CRP, free fatty acids, immunology parameters, the results of physical examination, vital signs, relevant nutrition- and safety-related laboratory parameters in venous blood and urine, the results of an Electrocardiography (ECG), and the number, severity, seriousness, clinical relevance, relatedness and outcome of Adverse Events (AEs). The aim of the planned study is to demonstrate that SmofKabiven emulsion for infusion is not inferior to the comparative drug (hospital compounded "All in one" emulsion for parenteral nutrition).

NCT ID: NCT03792087 Recruiting - Surgery Clinical Trials

Efficacy and Safety of SmofKabiven Peripheral Versus Compounded Emulsion

Start date: December 21, 2017
Phase: Phase 3
Study type: Interventional

The present protocol describes a randomized, open-labelled study in which either SmofKabiven Peripheral or a hospital compounded control Parenteral Nutrition (PN) regimen will be given to adult surgical patients for 5 consecutive days. As serum prealbumin is a well-established surrogate efficacy parameter reflecting the patient´s nutritional status, the absolute change of the serum prealbumin level at the day of the final study visit compared to baseline will represent the primary efficacy parameter in the present study. In addition, other variables will be assessed in this study, i.e., C-reactive Protein (CRP), free fatty acids, immunology parameters, taurine, comparison of the time required for Total Parenteral Nutrition (TPN) preparation of the two groups, the results of physical examination, vital signs, relevant nutrition- and safety-related laboratory parameters in venous blood and urine, the results of an Electrocardiography (ECG), and the number, severity, seriousness, clinical relevance, relatedness and outcome of Adverse Events (AEs). The aim of the planned study is to demonstrate that SmofKabiven Peripheral is not inferior to the comparative drug (compounded emulsion).

NCT ID: NCT03790683 Not yet recruiting - Surgery Clinical Trials

Intraoperative Warming During Major Surgical Procedures Using the Esophageal Temperature Management System

Start date: January 2019
Phase: N/A
Study type: Interventional

The aim of this study is to assess the effectiveness of EnsoETM as a supplemental warming device compared to the standard of care warming practice in patients having major surgery.

NCT ID: NCT03776929 Not yet recruiting - Surgery Clinical Trials

Dialectical Behavioral Therapy in High Risk OrthopaedicTrauma Patients

OI-DBT
Start date: January 2019
Phase: N/A
Study type: Interventional

Psychological factors can affect the experience of pain and functional recovery from orthopedic injury. The purpose of this study is to examine the effect of brief Dialectical Behavior Therapy (DBT), a form of psychotherapy, on changing thoughts, feelings, and behaviors that can cause problems in daily living and interfere with recovery from orthopedic injury in patients who are at high risk for chronic pain and disability.

NCT ID: NCT03776188 Recruiting - Surgery Clinical Trials

Endoscopic Suturing (ES) Registry

Start date: October 29, 2018
Phase:
Study type: Observational [Patient Registry]

To determine patient outcomes (survival, additional endoscopic or surgical procedures) with an endoscopic suturing technique at predetermined intervals compared to historical controls when applicable. To evaluate the efficacy, safety, and durability of trans-orifice endoscopic suturing therapy for revision of bariatric procedures as well as study the safety, efficacy, and durability of preventative fixation of GI endoprosthetics.

NCT ID: NCT03774966 Not yet recruiting - Surgery Clinical Trials

IPACK and Adductor Canal Catheter Patient Outcomes for TKAs?

Start date: January 2019
Phase: Early Phase 1
Study type: Interventional

This study evaluates the addition of the IPACK block to the adductor canal block and catheter in the pain management of total knee arthroplasty. Half of participants will receive the adductor canal block and catheter with the IPACK block, while the other half will receive the adductor canal block and catheter only.