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Pain, Postoperative clinical trials

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NCT ID: NCT03347266 Recruiting - Post-Operative Pain Clinical Trials

Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injection for Postoperative Pain Following Total Hip Arthroplasty.

Start date: November 2017
Phase: Phase 2
Study type: Interventional

The purpose of this phase 2 study is to evaluate the efficacy and safety of an analgesic drug candidate, VVZ-149 Injections. The study is designed as randomized, double-blind, parallel, and placebo-controlled study.

NCT ID: NCT03345511 Completed - Pain, Postoperative Clinical Trials

Ultrasound Guided Caudal Block for Benign Anal Surgery

Start date: November 1, 2015
Phase: N/A
Study type: Interventional

Interventional study that evaluate analgesia and side effects of Ultrasound guided Caudal block preoperatively in benign canal anal surgery

NCT ID: NCT03343509 Not yet recruiting - Postoperative Pain Clinical Trials

Topical Versus Oral Metronidazole Following Excisional Haemorrhoidectomy

Start date: April 2018
Phase: Phase 4
Study type: Interventional

This study aims to determine if topical metronidazole reduces pain more than oral metronidazole following excisional haemorrhoidectomy. The trial will be a multi-centered, patient and investigator blinded superiority trial with two parallel groups and a primary outcome of pain scores during 14 days after surgery. Group A will receive oral metronidazole and placebo cream. Group B will receive placebo tablets and topical metronidazole cream.

NCT ID: NCT03341533 Not yet recruiting - Pain, Postoperative Clinical Trials

Abdominal Ice Packs for Pain Control and Reduction of Narcotic Use Following Laparoscopic Hysterectomy

Start date: November 27, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effect of using ice packs on the abdomen immediately after laparoscopic hysterectomy surgery on pain control and narcotic pain medication use.

NCT ID: NCT03341234 Completed - Pain, Postoperative Clinical Trials

Superficial Serratus Plane Block for Modified Radical Mastectomy and Axillary Lymph Node Disection

Start date: November 1, 2016
Phase: N/A
Study type: Interventional

Breast cancer is the most common type of cancer in women. Mastectomy and axillary lymph node disection are commonly performed as part of the cancer management. This surgery can cause significant postoperative pain. The serratus plane block (SPB) has been described for analgesia of the hemithorax and reported for many cases such as thoracoscopy, shoulder arthroscopy, breast surgery and axillary lymph node dissections. Serratus plane block may be a viable alternative to current regional anaesthetic techniques such as thoracic paravertebral and central neuraxial blockade. The aim of this study is to determine effectiveness of ultrasound guided superficial serratus plane block in patients undergoing modified radical mastectomy and axillary lymph node dissection surgery.

NCT ID: NCT03339284 Not yet recruiting - Postoperative Pain Clinical Trials

QLB and Laparoscopic Nephrectomy, Postoperative Pain and Recovery

Start date: November 20, 2017
Phase: Phase 4
Study type: Interventional

There are ca 900 new cases of kidney cancer in Finland/year. The curative therapy for kidney cancer is partial or total nephrectomy depending on the localization and the size of tumor. Main of these operations are laparoscopic. Epidural analgesia is considered as most effective for the treatment of postoperative pain after open nephrectomy, but after laparoscopic operation parenteral and enteral opioids combined with paracetamol (acetaminophen) usually offer adequate postoperative pain relief. However, the need for opioids postoperatively may be high and side effects, such as sedation and nausea, are common. On the other hand epidural analgesia has some contraindications and risks for serious complications. Nevertheless, inadequately treated acute postoperative pain is considered as one of the main risk factors for persistent postoperative pain. Recently quadratus lumborum block (QLB) has gained popularity in the treatment of postoperative pain after various surgeries in the area from hip to mamilla. It is more beneficial than other peripheral blocks, since it covers also the visceral nerves. A single shot QLB has reported to last up to 48 hours. Perineural dexamethasone added to local anesthetic has been reported to prolong the duration of analgesia of the perineural nerve block, but it's effect on the duration of QLB is not known. 90 kidney cancer patients with planned laparoscopic nephrectomy aging 18-85 will be recruited based on a power calculation. The primary outcome measure is the postoperative cumulative opioid consumption. Secondary outcomes are acute pain (NRS scale), nausea, vomiting, mobilisation and long term outcomes such as quality of life and persistent pain.

NCT ID: NCT03338322 Not yet recruiting - Postoperative Pain Clinical Trials

Postoperative Pain After Using Reciprocating Motion With Reciproc Files Versus Adaptive Motion With Twisted File Adaptive

Start date: January 2018
Phase: N/A
Study type: Interventional

assess the effect of using reciprocating motion with reciproc files versus adaptive motion using twisted file adaptive on postoperative pain after instrumentation of necrotic mandibular molars.

NCT ID: NCT03332316 Not yet recruiting - Postoperative Pain Clinical Trials

Effect of Perineural Dexamethasone on the Duration of Popliteal Nerve Block for Anesthesia After Ankle Surgery

Start date: November 2017
Phase: Phase 4
Study type: Interventional

Effect of perineural dexamethasone on the duration of popliteal nerve block after ankle/foot surgery

NCT ID: NCT03331588 Recruiting - Clinical trials for Carcinoma, Non-Small-Cell Lung

Comparison of Post-operative Pain and Quality of Life Between Subxiphoid and Intercostal VATS for Lung Cancer

Start date: November 7, 2017
Phase: Phase 3
Study type: Interventional

One-thirds of patients underwent video-assisted thorascopic surgery (VATS) still have severe pain.Uniportal lobectomy or segmentectomies emerged as a promising and exciting approach for minimally invasive thoracic surgery. However, nearly all reported uniportal VATS lobectomies have been performed via the intercostal route, and chest wall trauma has still occurred. Here,the investigators undertook novel uniportal VATS technique involving a subxiphoid route for pulmonary lobectomies or segmentectomies.We would like to evaluate the post-operative pain and quality of life between Subxiphoid and Intercostal VATS for Lung Cancer.

NCT ID: NCT03331315 Completed - Pain, Postoperative Clinical Trials

Toradol v. Celecoxib for Postoperative Pain

POP
Start date: September 1, 2013
Phase: Phase 2
Study type: Interventional

Randomized control trial between ketorolac versus celecoxib for postoperative pain following hysterectomy.