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Pain, Postoperative clinical trials

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NCT ID: NCT03886896 Not yet recruiting - Postoperative Pain Clinical Trials

Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy

Start date: March 2019
Phase: Phase 4
Study type: Interventional

Intravenous lidocaine - a potent local anesthetic with analgesic and anti-inflammatory properties has been shown to be an effective adjunct that reduces intra and postoperative opioid consumption and facilitates pain management in adults. In children population promising but limited evidence is available. The study was planned to evaluate the efficacy of continuous intravenous infusion of lidocaine to reduce opioid consumption during and after laparoscopic appendectomy in children.

NCT ID: NCT03885804 Recruiting - Pain, Postoperative Clinical Trials

Perineural Versus IV Dexmedetomidine as Adjuvant to Quadratus Lamborum Block for Pediatrics Undergoing Pyeloplasty

Start date: February 10, 2019
Phase: Early Phase 1
Study type: Interventional

this prospective parallel group double blinded study will be conducted over 50 pediatric patients ASA (American Association of Anesthesiologists) I and II between the age of 8-13 years old,who will be scheduled for laparoscopic pyeloplasty.Patients will be randomly allocated into 2 study groups: Quadratus lamborum dexmedetomidine intravenous group(QD IV group) and Quadratus lamborum dexmedetomidine perineural group(QD PN group.Patients in both groups will receive quadratus lamborum block .In QD IV group a bolus of 0.5 ml/Kg bupivacaine 0.25% in addition to 2ml normal saline will be injected then dexmedetomidine.1ml/kg loading dose will be given over 10 min followed by 0.5 ml/kg/h infusion maintenance dose till the end of surgery. In QD PN, patients will receive perineural dexmedetomidine of 1μ g/kg diluted to 2 mL with 0.9% saline added to 0.5 ml/kg of 0.25% bupivacaine in addition to saline infusion 1ml/kg IV loading dose followed by by 0.5 ml/kg/h infusion maintenance dose till the end of surgery.Time to first analgesic requirement ( primary outcome) , Wong-Baker FACES Pain Rating Scale scores will be recorded at 2, 6, 8,12, 18 and 24h postoperatively, the degree of sedation will be assessed by Ramsay sedation scores(fig.2)(9) at the same time points, hemo-dynamics as systolic and diastolic blood pressures and heart rates will be recorded at PACU discharge then 4 hourly, total dose of morphine consumption, , the length of hospital stay, incidence of postoperative complications as hypotension, bradycardia, vomiting, pruritis and respiratory depression

NCT ID: NCT03882320 Not yet recruiting - Analgesia Clinical Trials

Medico-economic Evaluation of Sublingual PCA (Zalviso) Versus Oxycodone-PCA in the Management of Postoperative Pain.

MEZO
Start date: March 2019
Phase: N/A
Study type: Interventional

More than 230 million surgical operations are been realized all over the world every year. A surgical intervention can cause postoperative acute pain. The management of postoperative acute pain is multimodal and the use of patient-controlled analgesia (PCA) is often a part of this Pain-Management. Intravenous PCA has established itself as a therapeutic concept and constitutes the reference treatment for the management of postoperative acute pain for the first 48 hours. The PCA offers patients autonomy in managing their pain with the intravenous delivery of morphine on demand. Since 2017 PCA Zalviso is marketed. It allows the sublingual administration of sufentanil and it does not require venous access. It seems interesting to allow the early rehabilitation of patients who are no longer limited in their movements by an infusion. However, its acquisition cost appears to be higher than that of the intravenous PCA. In order to verify this hypothesis, the investigators propose to compare the set of costs associated with the use of sublingual PCA with those of intravenous PCA in the management of acute postoperative pain (less than 72 hours) in the context of patients benefiting from the placement of a total knee arthroplasty.

NCT ID: NCT03881891 Not yet recruiting - Pain, Postoperative Clinical Trials

Optimizing Acute Post-Operative Dental Pain Management Using New Health Information Technology

AHRQPRO
Start date: August 2019
Phase: N/A
Study type: Interventional

The investigators seek to implement a dental patient reported outcomes system using mobile phone and text messaging to target the over-reliance on pre-emptively prescribed opioids by dental providers. If successful, this project will help dentists actively track and manage their patients' pain after hours and enhance the overall care experience.

NCT ID: NCT03879980 Recruiting - Postoperative Pain Clinical Trials

Effect of Quadratus Lumborum Block on Perioperative Analgesia and Inflammatory Responses in Laparoscopic Nephrectomy

Start date: March 18, 2019
Phase: N/A
Study type: Interventional

Quadratus lumborum (QL) block can reduce intraoperative opioid consumption, decrease inflammation responses of IL-6, and reduce acute pain intensity in comparison with non-receiving QL block as the control group.

NCT ID: NCT03879564 Not yet recruiting - Pain, Postoperative Clinical Trials

Ketamine-fentanyl VS Fentanyl for Analgosedation in SICU

Start date: April 2019
Phase: Phase 4
Study type: Interventional

This is a randomized, double-blinded study to evaluate the analgosedative effect of ketamine in a surgical intensive care unit. The patients who will receive continuous fentanyl infusion for either pain control or sedation will be recruited in this trial. Fentanyl will be titrated with initial loading doses of 20 mcg until the numeral rating scale(NRS) less than 4 or critical care pain observation tool (CPOT) less than 3 or Richmond agitation sedation score (RASS) -2-0. Then the patients will be randomised in to receive saline infusion in control group (Group C) or ketamine infusion in ketamine group (Group K). Ketamine will be administered with an initial bolus of 0.3 mg/kg followed by a perfusion of1.5 mcg/kg/min during the first 48 h. The dose of fentanyl will be protocolized adjusted according to NRS or CPOT or RASS.

NCT ID: NCT03878888 Recruiting - Postoperative Pain Clinical Trials

Exparel Use in Bilateral TAP Blocks for Postoperative Pain Control

Start date: January 15, 2019
Phase: Phase 4
Study type: Interventional

To determine if Exparel (Liposomal Bupivacaine, an FDA approved drug) use in ultrasound guided Transversus Abdominis Plane (TAP) blocks may reduce opioid requirement use postoperatively, reduce pain scores postoperatively, reduce incidence of nausea in the postop period, and decrease length of hospital stay

NCT ID: NCT03877549 Not yet recruiting - Post Operative Pain Clinical Trials

Dexamethasone Administered Via the Epidural Catheter as an Adjunct in Patients Undergoing Cesarean Delivery

Start date: April 1, 2019
Phase: N/A
Study type: Interventional

If the patient fails an attempt at labor and a cesarean delivery is deemed necessary, the previously consented patient will be then be randomized to one of three groups. Group 1 will receive 2ml of normal saline. Group 2 will receive 2ml of dexamethasone (8mg). Group 3 will receive 1ml of normal saline and 1ml of dexamethasone (4mg). The patients will be randomized using a random allocation table. Group assignment will be performed by opening a previously prepared numbered opaque envelope containing the assignment. In order to maintain this as a double blinded study, the patient will not be told which medication was administered and the drug will be given by one anesthesiologist and the patient follow up will be preformed by another. The drug/placebo will be given at time of loading of the epidural for cesarean delivery. VAS, sedation, nausea, and satisfaction scoring will be measured on patient follow up.

NCT ID: NCT03875664 Active, not recruiting - Postoperative Pain Clinical Trials

Extended Release Local Anesthetic for Postsurgical Pain After Posterior Colporrhaphy and Perineorrhaphy

Start date: July 23, 2018
Phase: Phase 4
Study type: Interventional

The specific aim of this randomized double-blind clinical trial is to evaluate the effect of intraoperative infiltration of liposomal bupivacaine at the time of posterior colporrhaphy and/or perineorrhaphy on postsurgical pain scores during the first 72 hours after surgery as measured by visual analog scales (VAS) for patients undergoing surgery for pelvic organ prolapse. Study subjects are randomized to 30 mL of liposomal bupivacaine versus 30 mL of injectable normal saline administered in a standardized technique into the posterior vaginal compartment at the time of posterior repair and/or perineorrhaphy.

NCT ID: NCT03875274 Completed - Postoperative Pain Clinical Trials

Morphine Added to Ropivacaine for FICB for Postoperative Analgesia

Start date: April 1, 2017
Phase: Phase 4
Study type: Interventional

prospective, randomized double blinded study to investigate the effects of morphine as an adjuvant to ropivacaine on FICB