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Post-operative Pain clinical trials

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NCT ID: NCT06309693 Not yet recruiting - Clinical trials for Pelvic Organ Prolapse

Postoperative Pain Management Following Robotic Assisted Sacrocolpopexy

Start date: April 2024
Phase: N/A
Study type: Interventional

In the effort to reduce postoperative opioid use, there has been increasing interest in developing multimodal pain regimens to better manage postoperative pain while minimizing opioid use and their subsequent side effects that can be detrimental to the healing process. Standard of care approaches to better manage postoperative pain include the Enhanced Recovery After Surgery (ERAS) protocol and the use of peripheral and truncal nerve blocks. Truncal nerve blocks are widely used as an additional modality to provide longer lasting postoperative analgesia and have been adopted as part of the standard of care. The goal of this clinical trial is to compare the effects of ERAS alone versus the quadratus lumborum (QL) nerve block on the postoperative pain experience for women with pelvic organ prolapse undergoing robotic assisted sacrocolpopexy. Subjects will be randomized to the ERAS protocol or the QL block. The main questions the study aims to answer are: 1) does the QL block decrease patient reported pain scores postoperatively; and 2) does the QL block decrease the amount of opioid pain medications in the immediate postoperative period? The primary outcome measure will be median patient reported pain score in the post-anesthesia care unit (PACU) following surgery.

NCT ID: NCT06294665 Recruiting - Hip Fractures Clinical Trials

Comparison Between Bupivacaine-Dexmedetomidine Versus Bupivacaine-Dexamethasone in Pericapsular Nerve Group (PENG) Block

Start date: March 1, 2024
Phase: Phase 1
Study type: Interventional

The aim of this work is to compare the effectiveness of bupivacaine- dexmedetomidine mixture versus bupivacaine-dexamethasone mixture in PENG Block as Post-operative Analgesia in Hip surgeries

NCT ID: NCT06292273 Completed - Post Operative Pain Clinical Trials

Bupivacaine With Dexmedetomidine Versus Bupivacaine Alone for Transversus Abdominis Plane Block in Caesarean Section

Start date: October 10, 2023
Phase: N/A
Study type: Interventional

Transversus Abdominis plane (TAP) block is a regional technique for providing analgesia of the anterolateral abdominal wall. TAP block are commonly given in patients who have undergone various abdominal as well as pelvic surgeries such as caesarean section, hysterectomy, appendicectomy and various laparoscopic surgeries. this study is conducted to analyse the effect of addition of dexmedetomidine to bupivacaine in Transversus Abdominis Plane (TAP) block.

NCT ID: NCT06286995 Completed - Inflammation Clinical Trials

Postoperative Pain Assessment After Canal Preparation by Different NiTi File Systems

Start date: October 14, 2023
Phase: N/A
Study type: Interventional

The participants were divided into two groups : group one ( Trunatomy file group)(n=10) was mechanically prepared the canals by Trunatomy file and group two ( Edgeendo x7 file group) ( n=10) was prepared the canals by Edgeendo x7 file, the participants were assessed pain preoperatively and postoperatively by Visual Analog Scale(VAS)

NCT ID: NCT06281418 Recruiting - Post Operative Pain Clinical Trials

Postoperative Intraperitoneal Pain Management Following Laparoscopic Cholecystectomy

Start date: February 26, 2024
Phase: Phase 3
Study type: Interventional

Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. No. study has investigated IP granisetron as an adjuvant to standard care for postoperative pain management in patients undergoing LC.

NCT ID: NCT06269770 Recruiting - Chronic Pain Clinical Trials

Tapentadol vs Tramadol in Total Knee Arthroplasty

Start date: May 1, 2023
Phase: Phase 4
Study type: Interventional

Compare the effectiveness of tapentadol and tramadol as part of a multimodal analgesia treatment for Total Knee Replacement (TKR).

NCT ID: NCT06258239 Recruiting - Post-operative Pain Clinical Trials

Influence of the Communication Between the Nursing Staff and the Patient on the Analgesic Treatment Effectiveness After Surgery

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

Acute pain is a normal response to tissue injury or disease and has an important biological function. It is adaptive and promotes recuperation by restricting behaviors that might incur further tissue trauma. In the case of post-operative acute pain, the cause and time of the physical injury are known, and because the condition is self-limiting it requires only short-term care. However, if acute pain responses cannot be adequately suppressed, cardiac, pulmonary and neuroendocrine functions may be compromised, and the immune system suppressed. Inadequate management of post-operative acute pain is a major burden for healthcare services and can contribute to medical complications including inflammation of the respiratory tract, damage to the oxygen supply to the heart muscle, deep vein thrombosis, delayed healing as well as the development of chronic pain, more difficult to treat. In addition, suboptimal management of pain after surgery may impair sleep and have negative psychological effects, such as anxiety, fear and lack of sleep. Proper treatment of pain reduces morbidity, damages, treatment costs, improves the patient's quality of life and his chances of a full recovery. It is therefore essential that all patients undergoing surgery should receive adequate pain management. Despite years of advances in pain management, the mainstay of postoperative pain therapy in many settings is still opioids. Morphine is the most commonly used opioid to treat moderate to severe pain after surgery in the recovery unit. The growing concern about the significant side effects, addictions and costs of opioids as a drug treatment has led to an urgent need to identify other agents and approaches to postoperative pain management that are effective, safe and cheap. The main purpose of this study is to examine whether the type of communication between the nursing staff and the patient will affect the results of pain relief treatment in the postoperative recovery department. As a secondary objective, we will examine whether personality traits will predict the effectiveness of the treatment.

NCT ID: NCT06216951 Recruiting - Post Operative Pain Clinical Trials

Post-Operative Pain After Vital Pulpotomy in Molars With Symptomatic Pulpitis

POPAVPT
Start date: December 15, 2021
Phase:
Study type: Observational

The goal of this clinical trial is to investigate post-operative pain (PEP) in teeth with symptomatic pulpitis following Vital Pulpotomy Treatments (VPT) with Calcium Silicate Cement (CSC). The main questions it aims to answer are: - Is the post-operative pain one week after VPT significantly lower than pre-operative pain in permanent molars with symptomatic pulpitis? - How does post-operative pain in these teeth correlate with patient-related factors, such as age, gender, and painkiller intake? Participants will: - Undergo Vital Pulpotomy Treatment with Calcium Silicate Cement (MTA) - Provide pain level assessments before VPT, immediately post-treatment, and at 24, 72 hours, and 1 week after treatment. If there is a comparison group: Researchers will compare the post-operative pain levels in teeth with symptomatic pulpitis undergoing VPT to assess its effectiveness in reducing pain compared to a control group not undergoing the treatment.

NCT ID: NCT06215859 Recruiting - Pain Clinical Trials

Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Herniorrhaphy

Start date: December 29, 2023
Phase: Phase 3
Study type: Interventional

MR-107A-02 is being studied to investigate its efficacy and safety for treatment of acute pain after herniorrhaphy.

NCT ID: NCT06215820 Recruiting - Pain Clinical Trials

Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Bunionectomy

Start date: December 29, 2023
Phase: Phase 3
Study type: Interventional

MR-107A-02 is being studied to investigate its efficacy and safety for treatment of acute pain after bunionectomy.