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Pain clinical trials

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NCT ID: NCT03885596 Not yet recruiting - Pain Clinical Trials

Open-Label CA-008 in Bunionectomy

Start date: March 25, 2019
Phase: Phase 2
Study type: Interventional

A Phase 2, open-label study of CA-008 to evaluate post-surgical pain control with CA-008.

NCT ID: NCT03882541 Completed - Pain Clinical Trials

Could Music be an Alternative to Sedation in Patients Treated Total Knee Arthroplasty With Regional Anesthesia?

Start date: January 8, 2017
Phase: N/A
Study type: Interventional

Background: Anxiety is a common phenomenon in hospitalized patients. In order to reduce it during the surgical procedure, sedatives and anxiolytics are used, which can cause undesirable side effects for patients. Music is described as an effective tool to reduce this anxiety suffered by the patient in the perioperative process. Objectives: To evaluate the effect of music in patients anxiety and pain during perioperative process in surgical intervention with regional anaesthesia without sedatives or anxiolytics. Design: A randomized parallel clinical trial study with single-blinded and three harms. Setting: Operating theater of a public district hospital (serving around 111.000 people) Participants: All patients operated of Total Knee Arthroplasty (TKA) with regional anaesthesia with age between 50 and 85 years old within level I or II of the classification of the American Society of Anaesthesiologists (ASA). Methods: A total of 81 patients for TKA were randomly assigned to: a control group (headphones without music, without sedation), a sedative group (headphones without music, with sedation) and a experimental group (headphones with music, without sedation). 27 participants for each group. All the participants were using headphones so that it was a single-blinded study. The experimental group were provided with the same music, Piano Guys group. The variables of study were: the pain was measured by vale numerical scale (VNS), the anxiety was measured by the use of State-Trait Anxiety Inventory (STAI), heart rate (HR) variability, blood pressure (BP) variability, saturation of oxygen (Sat02). Relevance to Clinical Practice: sedation that can causes unwanted side effects by surgical patients can be replaced by music. The music decrease anxiety and pain values in orthopaedic surgery patients. Keywords: Anxiety, Drugs, Music therapy, Pain, Perioperative, Surgery.

NCT ID: NCT03881293 Completed - Pain Clinical Trials

Effects of Topical Lidocaine During Urodynamic Testing In Women

Start date: December 2013
Phase: N/A
Study type: Interventional

Urodynamic testing is used to help diagnose causes of urinary incontinence and voiding dysfunction. The purpose of the urodynamic test is to gain insight into the patient's urinary symptoms and assist in making a diagnosis. Catheter insertion and manipulation during the test can be uncomfortable for the patient. Lidocaine gel has not been used routinely during urodynamic testing. However, it is used routinely during outpatient cystoscopy and with any urethral catheterization. The investigators proposed that lidocaine numbing gel could be used without compromising test findings. The study included 110 adult women. The purpose was: 1. Determine whether the use of topical lidocaine during urodynamic testing decreases patient discomfort during the procedure. 2. Evaluate whether the use of topical lidocaine affects the urodynamic results.

NCT ID: NCT03880084 Not yet recruiting - Pain Clinical Trials

Delirium, Agitation/Sedation, Pain and Dyspnea in Respiratory Intensive Care Unit (NIVILIUM)

NIVILIUM
Start date: April 1, 2019
Phase:
Study type: Observational

Non-Invasive Mechanical Ventilation (NIV) has been increasingly used in the treatment of acute respiratory failure. Notwithstanding failure rates still remains high, ranging from 5% to 60%. The onset of delirium, agitation, pain and dyspnea may contribute to reduce the success rate of non invasive ventilation treatment. The aim of this study is to assess the incidence and impact of delirium, agitation, pain and dyspnea on clinical outcomes in a population of patient admitted to Respiratory Intensive Care Unit undergoing Non-Invasive Mechanical Ventilation for Acute Respiratory Failure.

NCT ID: NCT03879408 Not yet recruiting - Pain Clinical Trials

Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study

Start date: May 27, 2019
Phase: Phase 2
Study type: Interventional

Study assessing efficacy and safety of concomitantly dosed naproxen sodium with acetaminophen, compared with naproxen sodium, hydrocodone/acetaminophen and Placebo in a postoperative dental pain.

NCT ID: NCT03877991 Not yet recruiting - Pain Clinical Trials

Bioequivalence Assessment of Cannabidiol (CBD) Administrated in Oral Formulations

Start date: April 2019
Phase: Early Phase 1
Study type: Interventional

The oral bio-availability of cannabidiol (CBD) is low due to poor water solubility and susceptibility to extensive first pass metabolism, resulting in relative bio-availability of 6%.This project is designed to evaluate the plasma concentration vs. time profile of a self emulsifying drug delivery system termed Long Chain Nano Lipospheres (LNL) for enhancing the oral bio-availability of cannabidiol (CBD). The main goal of this study is to evaluate the bio-equivalence of CBD in the LNL product, compared to CBD in a sesame oil vehicle and CBD without any formulation, in powder form. Bio-equivalence is measured by AUC 0-24h, Tmax and Cmax.

NCT ID: NCT03877718 Recruiting - Pain Clinical Trials

A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain

Start date: February 1, 2019
Phase: Phase 2
Study type: Interventional

A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain.

NCT ID: NCT03877094 Not yet recruiting - Pain Clinical Trials

e-Nature VR: Evaluation of the Impact of Virtual Reality During Breast Biopsy

e-Nature VR
Start date: April 2019
Phase: N/A
Study type: Interventional

Randomized clinical trial about the evaluation of the impact of the virtual reality intervention on the experience of pain, physical and psychological discomfort, well-being and anxiety of women during breast biopsy use of nature virtual reality video.

NCT ID: NCT03872830 Not yet recruiting - Pain Clinical Trials

A Phase Ⅱ Clinical Study Trial of Felbinac Trometamol Injection in China

Start date: April 2019
Phase: Phase 2
Study type: Interventional

A multicenter, randomized, double-blind, placebo-controlled, dose-exploratory phase II clinical trial to evaluating the efficacy and safety of Felbinac Trometamol Injection in the treatment of moderate to severe pain after surgery.Main purpose is preliminary evaluation the effectiveness of Felbinac Trometamol Injection in the treatment of moderate and severe pain after surgery.Secondary purpose is to explore the dosage regimen of Felbinac Trometamol Injection in the treatment of moderate and severe pain after surgery, and provide data support for later clinical trial.

NCT ID: NCT03871335 Completed - Pain Clinical Trials

Work-related Musculoskeletal System Disorders Among Female Workers in Hazelnut Factory

Start date: June 10, 2018
Phase:
Study type: Observational

The aim of this study is to determine the prevalence of work-related musculoskeletal disorders in female workers in hazelnut factory. The secondary aim is to investigate the relationship between the musculoskeletal disorders severity and working posture, work related factor, psychosocial factor.