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Pain, Postoperative clinical trials

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NCT ID: NCT06139666 Enrolling by invitation - Postoperative Pain Clinical Trials

The Effect of Liposomal Bupivacaine Nerve Block (Exparel) in Rotator Cuff Surgery

Start date: July 11, 2019
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to investigate if there is a difference in pain after an arthroscopic rotator cuff surgery when a nerve block is performed with liposomal bupivacaine versus the standard treatment of bupivacaine alone. The main question aims to answer if patients who receive liposomal bupivacaine have better pain control and lower postoperative opioid consumption compared to bupivacaine alone. Participants be randomized to either the control group to receive a standard interscalene block with bupivacaine (25 cc of bupivacaine) or the experimental group to receive similar dosing of liposomal bupivacaine mixed with bupivacaine (10cc liposomal bupivacaine + 15cc bupivacaine). Data will be prospectively collected and the data from the experimental group will be compared to the control group at the completion of the study period.

NCT ID: NCT06136663 Enrolling by invitation - Clinical trials for Chronic Post Operative Pain

Prevalence and Risk Factors for Postsurgical Pain After the Open Reduction and Internal Fixation of Lower Limbs.

Start date: December 1, 2023
Phase:
Study type: Observational

The objective of this study is to specify the demographic and medical factors that most likely constitute a risk of developing CPSP in the patients with lower limb.

NCT ID: NCT06133933 Enrolling by invitation - Postoperative Pain Clinical Trials

Total Shoulder Arthroplasty Preoperative Pain Threshold and Association With Postoperative Opioid Consumption

Start date: May 21, 2021
Phase:
Study type: Observational

The purpose of this prospective research study is to evaluate the effects of preoperative pain threshold using a pressure algometer and its effects on postoperative patient satisfaction, return to work, and opioid consumption following Total Shoulder Arthroplasty (TSA). Participants will have their pain threshold measured at the preoperative visit. Postoperatively, they will be followed for 3 months and complete a pain journal for 2 weeks, record their medications consumed, and complete surveys at 2 weeks, 6 weeks, and 3 months. The study team will rely on the completion of the questionnaires, opioid consumption journal, and surveys to establish a correlation between pre-operative pain threshold and post-operative outcome.

NCT ID: NCT06118073 Enrolling by invitation - Opioid Use Clinical Trials

Effect of Mindfulness on Pain After Total Knee Arthroplasty

Start date: November 5, 2023
Phase: N/A
Study type: Interventional

This study will be a prospective randomized controlled trial evaluating the effectiveness of using Headspace before and after undergoing total knee replacement surgery. The purpose of this study will be to determine whether using Headspace will help to improve functional outcome scores, decrease pain, and decrease opioid medication use after total knee replacement in patients with depression and/or anxiety. Headspace is a smartphone-based application that guides individuals through various mindfulness sessions and has been shown to reduce symptoms of depression, anxiety, and pain.

NCT ID: NCT06116409 Enrolling by invitation - Postoperative Pain Clinical Trials

Efficacy of Modified Thoracoabdominal Nerves Block Through Perichondrial Approach in Total Laparoscopic Hysterectomies

Start date: September 1, 2023
Phase:
Study type: Observational

TAPA is a new analgesic block technique that involves the injection of local anesthetics into the thoracoabdominal nerves using a perichondrial approach. Application to the undersurface of the rib cartilage is considered as Modified TAPA (M-TAPA). These techniques are commonly applied for postoperative analgesia in surgeries and are effective and safe when performed under ultrasound guidance.

NCT ID: NCT06039150 Enrolling by invitation - Post Operative Pain Clinical Trials

Modified Thoracoabdominal Nerve Block(M-TAPA) in Pediatric Laparoscopic Appendectomies

M-TAPA
Start date: August 21, 2023
Phase: N/A
Study type: Interventional

To compare the effect of M-TAPA block and port-site local anesthetic infiltration on postoperative pain in pediatric laparoscopic appendectomies. The main questions it aims to answer are: - Is M-TAPA block more effective in reducing pain? - How M-TAPA block affects the use of rescue analgesics in the postoperative period? Participants will have the same anaesthetic agents during surgery, before extubation they will have same analgesic agent for postoperative pain. Participants in the M-TAPA group will undergo USG-guided M-TAPA block bilaterally with % 0.025 Bupivacaine max dose of 2 mg/kg by the same experienced anesthesiologist before extubation. Participants in the LAI group will be administered 0.025% Bupivacaine at a maximum dose of 2mg/kg divided equally and administered by the surgeon at 3 port entry sites before the patient is extubated.

NCT ID: NCT06006624 Enrolling by invitation - Postoperative Pain Clinical Trials

Exparel vs Block for ACL Reconstruction

Start date: August 21, 2023
Phase: Phase 4
Study type: Interventional

Liposomal bupivacaine or Exparel (Pacira Biosciences) is a long-lasting nonopioid analgesic that was initially utilized as an infiltrative agent but has more recently become U.S. Food and Drug Administration (FDA) approved for use in interscalene brachial plexus nerve blockade as well as infiltrative blockade. Delivery in this form is reported to provide up to 72 hours of extended-release bupivacaine. Exparel's use as a regional anesthetic has also become increasingly common and has shown promise when utilized in Anterior Cruciate Ligament (ACL) reconstruction.

NCT ID: NCT05982028 Enrolling by invitation - Quality of Life Clinical Trials

Patients' Quality of Life After Pilonidal Cyst Operations.

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

Biomedical research consists of two main parts. In the first part, the pilonidal cyst-specific quality of life questionnaire is compiled, adapted, validated, tested for suitability in assessing patients after pilonidal cyst operations. The second part will compare two pilonidal cyst operations. A prospective, comparative, randomized clinical study will be conducted.

NCT ID: NCT05974423 Enrolling by invitation - Opioid Use Clinical Trials

Randomized Trial of Narcotic vs Non-Narcotic Pain Modulation After Labrum Repair

Start date: December 16, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if patients age 15 to 30 years old being treated for shoulder labrum repair and SLAP lesions have significant differences in pain levels postoperatively when treated with a combination therapy of ibuprofen, and acetaminophen compared to oxycodone. Participants will be randomly placed into either the control arm and receive scripts for non-narcotic medications (Tylenol and Ibuprofen) and opioids, or the experimental arm of the study. receiving only a prescription for the non-narcotic medications. Every patient will receive a preoperative Exparel nerve block as is the standard of care for this procedure. Both groups will fill out a pain journal for 14 days following surgery and complete a pill count at the first postoperative visit to validate the amount of pain medication documented in the pain journal.

NCT ID: NCT05920980 Enrolling by invitation - Colorectal Cancer Clinical Trials

Effect of Lidocaine on Postoperative Pain in Elderlypatients Undergoing Colorectal Cancer Surgery

Start date: June 5, 2023
Phase: N/A
Study type: Interventional

Patients who meet the enrollment criteria will be randomized 1:1 to the lidocaine group or placebo group.