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Pain, Postoperative clinical trials

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NCT ID: NCT06300944 Recruiting - Postoperative Pain Clinical Trials

The Effect of Esketamine on Postoperative Pain Relief in Patients Undergoing Laparoscopic Surgery

Start date: December 1, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate whether continuous intraoperative infusion of esketamine combined with the addition of esketamine to postoperative PCIA can improve postoperative pain and sleep quality in patients undergoing laparoscopic uterine surgery under general anesthesia.

NCT ID: NCT06300008 Recruiting - Postoperative Pain Clinical Trials

Cetylated Fatty Acid for Reducing Pain After TKA

Start date: February 12, 2024
Phase: N/A
Study type: Interventional

To compare efficacy of cetylated fatty acid with placebo for reducing postoperative pain after unilateral TKA. The hypothesis is topical cetylated fatty acid can mitigate postoperative pain after TKA.

NCT ID: NCT06298370 Recruiting - Clinical trials for Postoperative Pain Management

The Efficacy of Combined Intrathecal Morphine and PENG Block on Postoperative Pain in Hip Arthroplasty

PENG
Start date: March 18, 2024
Phase: N/A
Study type: Interventional

This study aims to compare the postoperative 48-hour period in terms of morphine consumption, postoperative pain, and quality of recovery scores by combining the Pericapsular Nerve Group (PENG) block with low-dose intrathecal morphine in hip arthroplasty, as opposed to PENG alone and intrathecal morphine alone.

NCT ID: NCT06294665 Recruiting - Hip Fractures Clinical Trials

Comparison Between Bupivacaine-Dexmedetomidine Versus Bupivacaine-Dexamethasone in Pericapsular Nerve Group (PENG) Block

Start date: March 1, 2024
Phase: Phase 1
Study type: Interventional

The aim of this work is to compare the effectiveness of bupivacaine- dexmedetomidine mixture versus bupivacaine-dexamethasone mixture in PENG Block as Post-operative Analgesia in Hip surgeries

NCT ID: NCT06281431 Recruiting - Clinical trials for Chronic Postoperative Pain

A Comparative Effect of Echogenic Needle for Nerve Block on Acute and Chronic Postoperative Pain

Start date: June 12, 2023
Phase: N/A
Study type: Interventional

Surgical pain is a common complication after surgery, affecting patient recovery and treatment quality. >20% of patients suffer from chronic postoperative pain. China has >70 million surgeries yearly. Nerve block manages postoperative pain, with developing nerve block needles now used in clinics. Developed needles may have better pain management effects than non-developed ones, but their effect on reducing chronic pain remains unclear. This study aims to explore the effect of developed nerve block needles on postoperative pain and compare them to non-developed needles, providing new ideas and methods for pain management.

NCT ID: NCT06281418 Recruiting - Post Operative Pain Clinical Trials

Postoperative Intraperitoneal Pain Management Following Laparoscopic Cholecystectomy

Start date: February 26, 2024
Phase: Phase 3
Study type: Interventional

Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. No. study has investigated IP granisetron as an adjuvant to standard care for postoperative pain management in patients undergoing LC.

NCT ID: NCT06277102 Recruiting - Hip Fractures Clinical Trials

Effects of Music on Acute Postoperative Pain Intensity and Mobility After Fragility Hip Fracture

Start date: January 26, 2024
Phase: N/A
Study type: Interventional

Music has been proven to be beneficial in postoperative care by reducing pain. The effects of music listening to reduce pain postoperatively are well studied among cases undergoing elective orthopaedic surgery. No study has been conducted focusing on pain control among cases with fragility hip fractures in an acute ward setting with non-schedule non-elective orthopaedic operation. In Queen Elizabeth Hospital a standardized analgesic protocol is used for all fragility hip fracture cases unless contraindicated, a suboptimal post-operative pain control is not uncommonly seen. Stepping up analgesics is usually a concern in the elderly with a higher rate of side effects, a safe and simple non-pharmacological intervention for pain control is therefore needed. The aim of this study is to study the effectiveness of incorporating music on pain intensity and mobility with the standard postoperative rehabilitation care of fragility hip fracture in Queen Elizabeth Hospital.

NCT ID: NCT06275698 Recruiting - Analgesia Clinical Trials

HONEY for the Treatment of POst-Tonsillectomy Pain

HONEY-POT
Start date: September 4, 2023
Phase: N/A
Study type: Interventional

Double-blind, randomised, placebo controlled, single-site trial in adults to compare the effect of Manuka honey with standard of care compared to placebo with standard of care on post-tonsillectomy pain and postoperative outcomes. Main aim is to investigate a potential improvement in post-tonsillectomy pain control, with a low cost and freely available alternative to conventional analgesics. Recent systematic review and multidisciplinary consensus suggest a potential role for the inclusion of honey for this purpose. Clinical efficacy over placebo remains to be conclusively demonstrated in robust clinical trials.

NCT ID: NCT06269770 Recruiting - Chronic Pain Clinical Trials

Tapentadol vs Tramadol in Total Knee Arthroplasty

Start date: May 1, 2023
Phase: Phase 4
Study type: Interventional

Compare the effectiveness of tapentadol and tramadol as part of a multimodal analgesia treatment for Total Knee Replacement (TKR).

NCT ID: NCT06267638 Recruiting - Knee Osteoarthritis Clinical Trials

Comparison of Postoperative Pain Score Between Perioperative Intravenous Ketamine and Placebo in Patients Undergoing Unilateral Total Knee Arthroplasty Under General Anesthesia

Start date: January 22, 2024
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to compare postoperative pain score between perioperative intravenous ketamine and placebo in patients undergoing unilateral total knee arthroplasty under general anesthesia. The main question[s] it aims to answer are: - Can perioperative intravenous ketamine reduce postoperative pain score during rest and movement at 0, 2, 4, 8, 12, 18, 24 hours better than no administration of Ketamine in patients undergoing Unilateral total knee arthroplasty under general anesthesia? - Can perioperative intravenous ketamine reduce morphine consumption in postoperative 24 hours, length of hospital stay, first time to receive opioid and side effect or complication from ketamine and opioid better than no administration of Ketamine in patients undergoing Unilateral total knee arthroplasty under general anesthesia? Participants will receive intravenous ketamine intraoperative TKA and comparison group will receive placebo that is normal saline. Researchers will compare perioperative intravenous ketamine and placebo to see postoperative pain score, morphine consumption in postoperative 24 hours, length of hospital stay, first time to receive opioid and side effect or complication from ketamine and opioid.