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Pain, Postoperative clinical trials

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NCT ID: NCT05315479 Terminated - Post Operative Pain Clinical Trials

Safety and Pharmacokinetics of N1539 in Children 2 to <17 Years of Age Following Surgery

Start date: February 24, 2022
Phase: Phase 4
Study type: Interventional

This study is an open-label, multicenter evaluation of Safety and Pharmacokinetics of N1539 in postoperative Pediatric subjects aged 2 to <17 years.

NCT ID: NCT05172570 Terminated - Pain, Postoperative Clinical Trials

Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy

Start date: April 6, 2021
Phase: Phase 3
Study type: Interventional

Gabapentin is a nerve medication that treats pain. The specific aim of the study is to compare the difference in the postoperative use of no gabapentin, 300 mg gabapentin 3x daily, or 300 mg gabapentin once at night. Our hypothesis is that higher doses of gabapentin will correlate with decreased pain at the incision and chest tube sites and decreased opioid consumption.

NCT ID: NCT05146453 Terminated - Post-operative Pain Clinical Trials

Sternotomies and PectoIntercostal Fascia Blocks in Fast-Track Cardiac Anesthesiology

SPIFFY
Start date: September 22, 2022
Phase: Phase 4
Study type: Interventional

This study is looking to see if a regional block placed on each side of the incision after surgery helps with pain relief. Ultrasound-guided pectointercostal fascia blocks will be placed at the conclusion of surgery following application of dressings. Patients will be in the supine position with the surgical drapes in place. The blocks are performed using a high frequency linear transducer with aseptic technique. The investigators hypothesize that placement of PIF blocks and catheters will decrease acute postoperative pain from midline sternotomy in fast track cardiac surgery patients compared to the current standard of care. A physician will place an ultrasound guided pecto-intercostal fascial plane blocks bilaterally at the conclusion of surgery. They will also leave a catheter, similar to a small IV, between the muscle layers where the freezing medication goes. This will let the investigators give more freezing medication over the first 24 hours after surgery. The freezing medication blocks the pain signals from travelling to your brain from your incision, which might help participants need fewer narcotics after surgery. Some of the research on this block shows a trend toward reduced pain, but the use of a catheter to allow repeat doses of freezing medication has not been studied. The investigators hope to show that this regional block means participants need less opioids (narcotics) in the first 2 days after their heart surgery. In order to see whether the regional block is helpful there will be two groups of study participants. Both groups will receive infusion catheters covered with opaque bandages however one group will receive the study drug (ropivacaine) and the other will not (placebo). To reduce the risks to placebo group participants, those participants will have a catheter taped to their skin surface under an opaque dressing. This will give the illusion of block placement without the risks of a needle poking through skin. Both groups will still be given pain medications by IV or by mouth as needed after the surgery.

NCT ID: NCT05044429 Terminated - Pain, Postoperative Clinical Trials

Postoperative Pain Control Following Renal Transplant

Start date: March 16, 2021
Phase: Phase 4
Study type: Interventional

This study aims to compare the effectiveness of a regional anesthetic block vs systemic intravenous (IV) lidocaine in controlling post-operative pain in kidney transplantation patients. Regional anesthetic blocks and lidocaine infusions are effective alternatives to opioid medications and are already in use at many institutions. However, there has been no prospective study comparing their effectiveness when used in conjunction with the current standard of care patient controlled analgesia (PCA) pumps. This study is a prospective, randomized evaluation of both treatment methods.

NCT ID: NCT05024825 Terminated - Pain, Postoperative Clinical Trials

Effect of Gabapentin on Postoperative Opioid Analgesic Use and Pain in Adolescents Undergoing Tonsillectomy

Start date: August 4, 2017
Phase: Phase 4
Study type: Interventional

This study aims to determine if administration of gabapentin preoperatively followed by a standing postoperative course is effective in reducing and possibly eliminating the use of opioid analgesics following this procedure. As a secondary outcome, it will evaluate the possible improvement in post tonsillectomy pain control with the use of a standing dose of gabapentin.

NCT ID: NCT04855968 Terminated - Rotator Cuff Tears Clinical Trials

The Effect of Mindfulness/Meditation on Post-operative Pain and Opioid Consumption

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

The objective of this study is to examine the effectiveness of mindfulness/meditation using the Headspace App on post-operative pain and opioid consumption in patients after arthroscopic rotator cuff repairs, biceps tenodesis, and Mumford procedures.

NCT ID: NCT04693208 Terminated - Pain, Postoperative Clinical Trials

Analgesic Effect of Laser Therapy in Children

Start date: January 11, 2021
Phase: N/A
Study type: Interventional

Pain management after tonsillectomy could be challenging, with different protocols and various outcome depending on individual patient; moreover, odynophagia due to surgery can, in extreme cases, lead to block oral fluid intake, ending in dehydration and thus hospitalization. A small pilot study demonstrated efficacy of photo-biomodulation (PBM) in managing pain after tonsillectomy and it suggests that PBM can be included in clinical practice. The present research aims to confirm and expand the findings from this study, being the first step in including PBM in clinical routine after tonsillectomy. Use of this treatment, which is non-damaging, non-toxic and easy to supply to patients, could greatly improve individual quality of life after a surgical treatment; its use in the clinical practice could represent an advantage for the institute, leading to more patients' satisfaction, due to the lower pain sensation after surgery and quicker recovery time.

NCT ID: NCT04680286 Terminated - Pain, Postoperative Clinical Trials

Intraoperative Methadone in Children Undergoing Surgery

METACEBO
Start date: November 16, 2020
Phase: Phase 3
Study type: Interventional

A prospective double-blind, randomized controlled trial investigating the effect of a single-dose of intraoperative methadone on postoperative pain and opioid consumption in 96 children undergoing open urological surgery.

NCT ID: NCT04662567 Terminated - Postoperative Pain Clinical Trials

Oral Versus Intravenous Acetaminophen for Postoperative Pain Control

Start date: March 12, 2021
Phase: N/A
Study type: Interventional

The investigators are going to study the difference in postoperative pain control after administration of oral versus intravenous formulation of acetaminophen

NCT ID: NCT04633837 Terminated - Pain, Postoperative Clinical Trials

Examining the Effectiveness of a Connective Tissue Matrix Implant in Reducing Post-operative Pain and Narcotic After Outpatient Arthroscopic Shoulder Surgery

ECM
Start date: December 4, 2020
Phase: N/A
Study type: Interventional

This document is a protocol for a human research study. This study is to be conducted according to United States standards of Good Clinical Practice in accordance with applicable Federal regulations and institutional research policies and procedures. Extracellular matrix grafts have been used to help with postoperative inflammation.