4D CT Scan Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy — RD3D4  

Breast Cancer Clinical Trial

Official title: 4D CT Scan With Respiratory Gating Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy

Status Recruiting

Clinical Trial Summary

To establish if the cardiac radiation dose assesment is well aproximated with routine 3D CT scan compared to 4D CT experimental scan with respiratory gating (breath motion monitoring). The study population relates to left side breast cancers female patients that require a radiation therapy treatment.

Clinical Trial Description

As a standard of care, the postoperative breast cancers radiation therapy is generally based on a 3 dimensions CT scan that does not incorporate the breathing motion by definition. Meanwhile, the patients must commonly receive the treatment in free motion breathing condition. More of that, the Cardiac dose, especially the LAD (left anterior descending artery) dose has been established as the main cause of radiation induced ischemic heart disease (RIHD) and should be consider in the first place. In more concrete terms, the higher the LAD dose is, the greater the RIHD relates: arise the LAD dose by 1 Gy means a 7.4% higher risk to cause a RIHD during the next 5 years. That being said, to determine if the cardiac dosimetry and the dose-volume histograms (specifically for the left side breast cancer treatments including or not the internal mammary artery) obtained from a 3D CT scan reflect well or not the reality (which is widely subject to the breathing motion). Finally, because it has been established that a 4D CT scan can monitor the breathing motion, it seems definitely interesting to compare it with the average 3D CT scan to address this concern. ;

Related Conditions & MeSH terms

• Breast Cancer
• Breast Neoplasms
• Cardiac Ischemia
• Constriction, Pathologic
• Coronary Artery Disease
• Coronary Stenosis
• Ischemia
• Left Anterior Descending Coronary Artery Stenosis
• Left Sided Breast Cancer
• Myocardial Ischemia
• Radiotherapy Side Effect
• Vascular Diseases

• NCT number: NCT05726604
• Study type: Interventional
• Source: Central Hospital Saint Quentin
• Contact: Karim Boulanouar
• Phone: 0323067861
• Email: ak.boulanouar@ch-stquentin.fr
• Status: Recruiting
• Phase: N/A
• Start date: March 2, 2023
• Completion date: June 15, 2023